公开(公告)号：US07926945B2

公开(公告)日：2011-04-19

申请号：US11988965

申请日：2006-07-19

申请人： Manfred Dick ,  Thomas Mohr ,  Daniel Bublitz ,  Peter Westphal

发明人： Manfred Dick ,  Thomas Mohr ,  Daniel Bublitz ,  Peter Westphal

IPC分类号： A61B3/14 ,  A61B3/00

CPC分类号： A61B3/14 ,  A61B5/0261 ,  A61B5/0285 ,  A61B5/14555 ,  A61B5/7257

摘要： The present invention is directed to a device and a method for the observation, documentation and/or diagnosis of the fundus in which the diagnosis is carried out by evaluating the documented images of the fundus. The device according to the invention comprises an ophthalmological examination device, a multi-spectral sequential illumination module, an image recording module, a control and safety module, and an evaluating unit. The illumination module which is connected to the ophthalmologic examination device has at least two individual light sources and which can be regulated individually with respect to intensity and duration and which emit monochromatic light of different wavelengths. The light coming from the illumination module is imaged on the image recording module from the ophthalmologic examination device by the eye being examined. The control and safety module controls the chronological sequence, duration and intensity of the individual light sources and monitors the light stress. An evaluating unit evaluates the recordings of the fundus transmitted by the image recording module. The inventive solution serves to record monochromatic images of the retina, for example, red, green, blue, or also infrared, and to record fluorescence images.

摘要翻译： 本发明涉及一种用于观察，记录和/或诊断眼底的装置和方法，其中通过评估眼底记录的图像进行诊断。 根据本发明的装置包括眼科检查装置，多光谱顺序照明模块，图像记录模块，控制和安全模块以及评估单元。 连接到眼科检查装置的照明模块具有至少两个单独的光源，并且可以相对于强度和持续时间单独地调节并且发射不同波长的单色光。 来自照明模块的光被眼睛检查从眼科检查装置成像在图像记录模块上。 控制和安全模块控制各个光源的时间顺序，持续时间和强度，并监控光应力。 评估单元评估由图像记录模块发送的眼底的记录。 本发明的解决方案用于记录视网膜的单色图像，例如红色，绿色，蓝色或红外，并记录荧光图像。

公开(公告)号：US20090153798A1

公开(公告)日：2009-06-18

申请号：US11988965

申请日：2006-07-19

申请人： Manfred Dick ,  Thomas Mohr ,  Daniel Bublitz ,  Peter Westphal

发明人： Manfred Dick ,  Thomas Mohr ,  Daniel Bublitz ,  Peter Westphal

IPC分类号： A61B3/12 ,  A61B3/14

CPC分类号： A61B3/14 ,  A61B5/0261 ,  A61B5/0285 ,  A61B5/14555 ,  A61B5/7257

摘要： The present invention is directed to a device and a method for the observation, documentation and/or diagnosis of the fundus in which the diagnosis is carried out by evaluating the documented images of the fundus. The device according to the invention comprises an ophthalmological examination device, a multi-spectral sequential illumination module, an image recording module, a control and safety module, and an evaluating unit. The illumination module which is connected to the ophthalmologic examination device has at least two individual light sources and which can be regulated individually with respect to intensity and duration and which emit monochromatic light of different wavelengths. The light coming from the illumination module is imaged on the image recording module from the ophthalmologic examination device by the eye being examined. The control and safety module controls the chronological sequence, duration and intensity of the individual light sources and monitors the light stress. An evaluating unit evaluates the recordings of the fundus transmitted by the image recording module. The inventive solution serves to record monochromatic images of the retina, for example, red, green, blue, or also infrared, and to record fluorescence images.

摘要翻译： 本发明涉及一种用于观察，记录和/或诊断眼底的装置和方法，其中通过评估眼底记录的图像进行诊断。 根据本发明的装置包括眼科检查装置，多光谱顺序照明模块，图像记录模块，控制和安全模块以及评估单元。 连接到眼科检查装置的照明模块具有至少两个单独的光源，并且可以相对于强度和持续时间单独地调节并且发射不同波长的单色光。 来自照明模块的光被眼睛检查从眼科检查装置成像在图像记录模块上。 控制和安全模块控制各个光源的时间顺序，持续时间和强度，并监控光应力。 评估单元评估由图像记录模块发送的眼底的记录。 本发明的解决方案用于记录视网膜的单色图像，例如红色，绿色，蓝色或红外，并记录荧光图像。

公开(公告)号：US07871164B2

公开(公告)日：2011-01-18

申请号：US12281134

申请日：2007-02-22

申请人： Egon Luther ,  Ingo Koschmieder ,  Manfred Dick ,  Joachim Winter ,  Uwe Mohrholz ,  Thomas Mohr ,  Daniel Bublitz ,  Enrico Geissler

发明人： Egon Luther ,  Ingo Koschmieder ,  Manfred Dick ,  Joachim Winter ,  Uwe Mohrholz ,  Thomas Mohr ,  Daniel Bublitz ,  Enrico Geissler

IPC分类号： A61B3/10 ,  A61B3/14

CPC分类号： A61B3/14 ,  G02B27/0927 ,  G02B27/0961 ,  G02B27/0994

摘要： A homogeneously illuminating ophthalmic instrument includes an illumination device having a source of illumination, a homogenizing unit and a projection device, at least one organic or inorganic source of radiation with spectrally selective emission being used as a source of illumination. The illumination generated in this way enables correspondingly adapted visual and/or digital observation, recording or display of the examined regions of the eye by a visualizing unit.

摘要翻译： 均匀照明的眼科仪器包括具有照明源的照明装置，均质单元和投影装置，至少一个有机或无机光谱辐射源被用作光源。 以这种方式产生的照明使视觉和/或数字观察，可视化单元记录或显示被检查的眼睛的区域。

公开(公告)号：US20090257024A1

公开(公告)日：2009-10-15

申请号：US12281134

申请日：2007-02-22

申请人： Egon Luther ,  Ingo Koschmieder ,  Manfred Dick ,  Joachim Winter ,  Uwe Mohrholz ,  Thomas Mohr ,  Daniel Bublitz ,  Enrico Geissler

发明人： Egon Luther ,  Ingo Koschmieder ,  Manfred Dick ,  Joachim Winter ,  Uwe Mohrholz ,  Thomas Mohr ,  Daniel Bublitz ,  Enrico Geissler

IPC分类号： A61B3/14 ,  A61B3/10

CPC分类号： A61B3/14 ,  G02B27/0927 ,  G02B27/0961 ,  G02B27/0994

摘要： A homogeneously illuminating ophthalmic instrument includes an illumination device having a source of illumination, a homogenizing unit and a projection device, at least one organic or inorganic source of radiation with spectrally selective emission being used as a source of illumination. The illumination generated in this way enables correspondingly adapted visual and/or digital observation, recording or display of the examined regions of the eye by a visualizing unit.

摘要翻译： 均匀照明的眼科仪器包括具有照明源的照明装置，均质单元和投影装置，至少一个有机或无机光谱辐射源被用作光源。 以这种方式产生的照明使视觉和/或数字观察，可视化单元记录或显示被检查的眼睛的区域。

公开(公告)号：US08289382B2

公开(公告)日：2012-10-16

申请号：US12517414

申请日：2007-11-24

申请人： Daniel Bublitz ,  Thomas Mohr ,  Uwe Mohrholz ,  Michael Trost ,  Martin Wiechmann ,  Manfred Dick

发明人： Daniel Bublitz ,  Thomas Mohr ,  Uwe Mohrholz ,  Michael Trost ,  Martin Wiechmann ,  Manfred Dick

IPC分类号： H04N7/18

CPC分类号： G03B15/03 ,  A61B3/12 ,  A61B3/14

摘要： The present invention makes it possible to make high-quality recordings of the anterior and/or posterior segments of the eye as an individual image or also as a sequence of images without increasing the radiation load on the eye to be examined. In the method according to the invention, at least one pre-flash is used in order to determine an optimal exposure time for the main flash based on the recording of the pre-flash which is reflected by the object to be recorded. Both the pre-flash and the main flash are controllable and the recordings of the pre-flash and main flash are recorded with the same sensor of the electronic camera and are evaluated electronically by a control unit, and the recording of the main flash and, as the case may be, of the pre-flash is analyzed and/or corrected and displayed to the user.

摘要翻译： 本发明使得可以将眼睛的前部和/或后部段的高质量记录作为单独的图像或者作为一系列图像，而不增加要检查的眼睛上的辐射负荷。 在根据本发明的方法中，使用至少一个预闪光，以便基于被记录的对象反射的预闪光的记录来确定主闪光灯的最佳曝光时间。 预闪光和主闪光都是可控的，并且使用相同的电子照相机的传感器记录预闪光和主闪光的记录，并且通过控制单元进行电子评估，并且记录主闪光灯， （例如可能的话）对闪速闪光进行分析和/或校正并显示给用户。

公开(公告)号：US20100060728A1

公开(公告)日：2010-03-11

申请号：US12517414

申请日：2007-11-24

申请人： Daniel Bublitz ,  Thomas Mohr ,  Uwe Mohrholz ,  Michael Trost ,  Martin Wiechmann ,  Manfred Dick

发明人： Daniel Bublitz ,  Thomas Mohr ,  Uwe Mohrholz ,  Michael Trost ,  Martin Wiechmann ,  Manfred Dick

IPC分类号： H04N7/18

CPC分类号： G03B15/03 ,  A61B3/12 ,  A61B3/14

摘要： The present invention makes it possible to make high-quality recordings of the anterior and/or posterior segments of the eye as an individual image or also as a sequence of images without increasing the radiation load on the eye to be examined. In the method according to the invention, at least one pre-flash is used in order to determine an optimal exposure time for the main flash based on the recording of the pre-flash which is reflected by the object to be recorded. Both the pre-flash and the main flash are controllable and the recordings of the pre-flash and main flash are recorded with the same sensor of the electronic camera and are evaluated electronically by a control unit, and the recording of the main flash and, as the case may be, of the pre-flash is analyzed and/or corrected and displayed to the user.

摘要翻译： 本发明使得可以将眼睛的前部和/或后部段的高质量记录作为单独的图像或者作为一系列图像，而不增加要检查的眼睛上的辐射负荷。 在根据本发明的方法中，使用至少一个预闪光，以便基于被记录的对象反射的预闪光的记录来确定主闪光灯的最佳曝光时间。 预闪光和主闪光都是可控的，并且使用相同的电子照相机的传感器记录预闪光和主闪光的记录，并且通过控制单元进行电子评估，并且记录主闪光灯， （例如可能的话）对闪速闪光进行分析和/或校正并显示给用户。

公开(公告)号：US20070102620A1

公开(公告)日：2007-05-10

申请号：US10554899

申请日：2004-04-27

申请人： Daniel Bublitz ,  Dieter Graefe ,  Peter Westphal

发明人： Daniel Bublitz ,  Dieter Graefe ,  Peter Westphal

IPC分类号： G02B27/40 ,  G02B27/64 ,  G02B7/04

CPC分类号： G02B21/244 ,  G02B7/32 ,  G02B21/245

摘要： The invention refers to a process for determining the focus position when imaging a specimen (4) with a field stop imaged onto the specimen detecting this image using a position-sensitive receiving-device inclined relative to the field stop defining the focus position by means of intensity distribution in the receiving device. The invention also refers to set-ups as regards implementation of the process according to the invention. According to the invention, in a process of the above-mentioned type, imaging of the field stop onto the specimen (4) is at least partially superposed by an optical lattice; the position-sensitive receiving device is used to determine intensity values for the light reflected by the specimen; these intensity values are assigned to positions in the receiving device; position-related contrast values are determined from the position-related intensity values; the position of the contrast focus in the receiving device as equivalent of the current focus position is determined using these contrast values.

摘要翻译： 一种用于通过利用接收装置中的强度分布相对于通过强度分布定义聚焦位置的场停止而倾斜的位置敏感的接收装置对具有使用场停止成像的样本成像到检测该图像的样本上的确定焦点位置的处理。 本发明还包括用于实施根据本发明的方法的装置。 根据本发明，在上述类型的过程中，场停止物到样本上的成像至少部分地被光栅重叠; 位置敏感接收装置用于确定由样本反射的光的强度值; 这些强度值被分配给接收装置中的位置; 与位置相关的强度值确定位置相关的对比度值; 使用这些对比度值确定接收装置中的对比度聚焦的位置等同于当前焦点位置。

公开(公告)号：US08643946B2

公开(公告)日：2014-02-04

申请号：US12305183

申请日：2007-06-15

申请人： Peter Westphal ,  Daniel Bublitz ,  Reiner Mitzkus

发明人： Peter Westphal ,  Daniel Bublitz ,  Reiner Mitzkus

IPC分类号： G02B21/00

CPC分类号： G02B7/36 ,  G02B21/244

摘要： A microscope including an objective, which images a sample along a microscope beam path, and an autofocus device, which is coupled into the microscope beam path via a beam splitter at a location behind the objective. A light modulator for generating a two-dimensional, intensity-modulated modulation object, is located in the autofocus beam path in a plane conjugated to the focal plane of the objective or intersects the latter and is imaged into the focal plane of the objective. A camera records a two-dimensional image onto which the modulation object's image is imaged. The image plane of the camera intersects a plane that is conjugated to the modulation object or is located in the plane and the camera detecting the contrast of the modulation object's image located in the sample.

摘要翻译： 显微镜，其包括沿着显微镜光束路径对样品进行成像的物镜和自动聚焦装置，该自动对焦装置经由目标背后的位置处的分束器耦合到显微镜光束路径中。 用于产生二维强度调制调制对象的光调制器位于与物镜的焦平面共轭的平面中的自动聚焦光束路径中，或者与物镜的焦平面相交，并被成像到物镜的焦平面。 照相机记录调制对象的图像成像到的二维图像。 相机的图像平面与共轭于调制对象的平面相交，或位于平面中，相机检测位于样本中的调制对象的图像的对比度。

公开(公告)号：US08097865B2

公开(公告)日：2012-01-17

申请号：US12083980

申请日：2006-11-09

申请人： Peter Westphal ,  Daniel Bublitz

发明人： Peter Westphal ,  Daniel Bublitz

IPC分类号： G01N33/48

CPC分类号： G01N21/64 ,  F21V9/08 ,  G01N21/6458 ,  G02B19/0028 ,  G02B19/0066 ,  G02B19/0095 ,  G02B21/06 ,  G02B21/16 ,  G02B27/1006 ,  G02B27/141 ,  G02B27/145

摘要： An illumination device includes at least four semiconductor radiation sources (18) for emitting optical radiation in respectively different emission wavelength ranges. At least one color splitter (22.1, 22.2, 22.3), which is reflective for optical radiation of the respective semiconductor radiation source (18), is assigned to each of at least three of the semiconductor radiation sources (18). The semiconductor radiation sources (18) and the color splitters (22.1, 22.2, 22.3) are arranged such that the optical radiation, which is emitted in each case from each of the semiconductor radiation sources (18), is coupled into a common illumination beam path section (24). In each case, one collimating unit (20.1, 20.2, 20.3, 20.4), which collimates the optical radiation emitted by the respective semiconductor radiation source (18), is arranged in the beam path sections from the semiconductor radiation sources (18) to the color splitters (22.1, 22.2, 22.3).

摘要翻译： 照明装置包括用于分别发射不同发射波长范围内的光辐射的至少四个半导体辐射源（18）。 对于半导体辐射源（18）中的至少三个中的每一个分配至少一个用于相应半导体辐射源（18）的光学辐射的颜色分离器（22.1,22.2,22.3）。 半导体辐射源（18）和分色器（22.1,22.2,22.3）被布置成使得从每个半导体辐射源（18）在每种情况下发射的光辐射被耦合到公共照明光束 路径部分（24）。 在每种情况下，将从半导体辐射源（18）发射的光辐射准直的一个准直单元（20.1,20.2,20.3,20.4）设置在从半导体辐射源（18）到 分色机（22.1,22.2,22.3）。

公开(公告)号：US20090121154A1

公开(公告)日：2009-05-14

申请号：US12083980

申请日：2006-11-09

申请人： Peter Westphal ,  Daniel Bublitz

发明人： Peter Westphal ,  Daniel Bublitz

IPC分类号： H05B33/00 ,  F21V9/00

CPC分类号： G01N21/64 ,  F21V9/08 ,  G01N21/6458 ,  G02B19/0028 ,  G02B19/0066 ,  G02B19/0095 ,  G02B21/06 ,  G02B21/16 ,  G02B27/1006 ,  G02B27/141 ,  G02B27/145

摘要： An illumination device includes at least four semiconductor radiation sources (18) for emitting optical radiation in respectively different emission wavelength ranges. At least one color splitter (22.1, 22.2, 22.3), which is reflective for optical radiation of the respective semiconductor radiation source (18), is assigned to each of at least three of the semiconductor radiation sources (18). The semiconductor radiation sources (18) and the color splitters (22.1, 22.2, 22.3) are arranged such that the optical radiation, which is emitted in each case from each of the semiconductor radiation sources (18), is coupled into a common illumination beam path section (24). In each case, one collimating unit (20.1, 20.2, 20.3, 20.4), which collimates the optical radiation emitted by the respective semiconductor radiation source (18), is arranged in the beam path sections from the semiconductor radiation sources (18) to the color splitters (22.1, 22.2, 22.3).

摘要翻译： 照明装置包括用于分别发射不同发射波长范围内的光辐射的至少四个半导体辐射源（18）。 对于半导体辐射源（18）中的至少三个中的每一个分配至少一个用于相应半导体辐射源（18）的光学辐射的颜色分离器（22.1,22.2,22.3）。 半导体辐射源（18）和分色器（22.1,22.2,22.3）被布置成使得从每个半导体辐射源（18）在每种情况下发射的光辐射被耦合到公共照明光束 路径部分（24）。 在每种情况下，将从半导体辐射源（18）发射的光辐射准直的一个准直单元（20.1,20.2,20.3,20.4）设置在从半导体辐射源（18）到 分色机（22.1,22.2,22.3）。