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    Urate oxidase activity protein, recombinant gene coding therefor, expression vector, micro-organisms and transformed cells
    2.
    发明授权
    Urate oxidase activity protein, recombinant gene coding therefor, expression vector, micro-organisms and transformed cells 失效
    Urate氧化酶活性蛋白，编码重组基因，表达载体，微生物和转化细胞

    公开(公告)号：US5382518A

    公开(公告)日：1995-01-17

    申请号：US920519

    申请日：1992-07-28

    申请人： Daniel Caput ,  Pascual Ferrara ,  Jean-Claude Guillemot ,  Mourad Kaghad ,  Richard Legoux ,  Gerard Loison ,  Elisabeth Larbre ,  Johannes Lupker ,  Pascal Leplatois ,  Marc Salome ,  Patrick Laurent

    发明人： Daniel Caput ,  Pascual Ferrara ,  Jean-Claude Guillemot ,  Mourad Kaghad ,  Richard Legoux ,  Gerard Loison ,  Elisabeth Larbre ,  Johannes Lupker ,  Pascal Leplatois ,  Marc Salome ,  Patrick Laurent

    IPC分类号： C07K20060101 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N5/16 ,  C12N9/06 ,  C12N15/53 ,  C12N15/63 ,  C12N9/00 ,  C12P21/00

    CPC分类号： C12N9/0046

    摘要： The invention concerns a new urate oxidase activity protein which has the following sequence:______________________________________ Ser Ala Val Lys Ala Ala Arg Tyr Gly Lys Asp Asn Val Arg Val Tyr Lys Val His Lys Asp Glu Lys Thr Gly Val Gln Thr Val Tyr Glu Met Thr Val Cys Val Leu Leu Glu Gly Glu Ile Glu Thr Ser Tyr Thr Lys Ala Asp Asn Ser Val Ile Val Ala Thr Asp Ser Ile Lys Asn Thr Ile Tyr Ile Thr Ala Lys Gln Asn Pro Val Thr Pro Pro Glu Leu Phe Gly Ser Ile Leu Gly Thr His Phe Ile Glu Lys Tyr Asn His Ile His Ala Ala His Val Asn Ile Val Cys His Arg Trp Thr Arg Met Asp Ile Asp Gly Lys Pro His Pro His Ser Phe Ile Arg Asp Ser Glu Glu Lys Arg Asn Val Gln Val Asp Val Val Glu Gly Lys Gly Ile Asp Ile Lys Ser Ser Leu Ser Gly Leu Thr Val Leu Lys Ser Thr Asn Ser Gln Phe Trp Gly Phe Leu Arg Asp Glu Tyr Thr Thr Leu Lys Glu Thr Trp Asp Arg Ile Leu Ser Thr Asp Val Asp Ala Thr Trp Gln Trp Lys Asn Phe Ser Gly Leu Gln Glu Val Arg Ser His Val Pro Lys Phe Asp Ala Thr Trp Ala Thr Ala Arg Glu Val Thr Leu Lys Thr Phe Ala Glu Asp Asn Ser Ala Ser Val Gln Ala Thr Met Tyr Lys Met Ala Glu Gln Ile Leu Ala Arg Gln Gln Leu Ile Glu Thr Val Glu Tyr Ser Leu Pro Asn Lys His Tyr Phe Glu Ile Asp Leu Ser Trp His Lys Gly Leu Gln Asn Thr Gly Lys Asn Ala Glu Val Phe Ala Pro Gln Ser Asp Pro Asn Gly Leu Ile Lys Cys Thr Val Gly Arg Ser Ser Leu Lys Ser Lys Leu ______________________________________ optionally preceeded by a methionine, or in that it may present a degree of substantial homology with this sequence.The invention is also aimed at medicines containing this protein as well as the genetic engineering implements to obtain it.

    摘要翻译： PCT No.PCT / FR90 / 00532 Sec。 371日期：1991年4月25日 102（e）日期1991年4月25日PCT提交1990年7月13日PCT公布。 公开号WO91 / 00909 1991年1月24日。本发明涉及新的尿酸氧化酶活性蛋白，其具有以下序列： - Ser Ala Val Lys Ala Ala Arg Tyr Gly -Lys Asp Asn Val Arg Val Tyr Lys Val His -Lys Asp Glu Lys Thr Gly Val Gln Thr Val -Tyr Glu Met Thr Val Cys Val Leu Leu Glu -Gly Glu Ile Glu Thr Ser Tyr Thr Lys Ala -Asp Asn Ser Val Ile Val Ala Thr Asp SerIle Lys Asn Thr Ile Tyr Ile Thr Ala Lys -Gln Asn Pro Val Thr Pro Pro Glu Leu Phe -Gly Ser Ile Leu Gly Thr His Phe Ile Glu -Lys Tyr Asn His Ile His Ala Ala His Val-Asn Ile Val Cys His Arg Trp Thr Arg Met -Asp Ile Asp Gly Lys Pro His Pro His Ser -Phe Ile Arg Asp Ser Glu Glu Lys Arg Asn -Val Gln Val Asp Val Val Glu Gly Lys Gly -Ile Asp Ile Lys Ser Ser Leu Ser Gly Leu -Thr Val Leu Lys Ser Thr Asn Ser Gln Phe -Trp Gly Phe Leu Arg Asp Glu Tyr Thr Thr -Leu Lys Glu Thr Trp Asp Arg Ile Leu Ser -Thr Asp Val Asp Ala Thr Trp Gln Trp Lys-Asn Phe Ser Gly Leu Gln Glu Val Arg Ser -His Val Pro Lys Phe Asp Ala Thr Trp Ala -Thr Ala Arg Glu Val Thr Leu Lys Thr Phe -Ala Glu Asp Asn Ser Ala Ser Val Gln Ala -Thr Met Tyr Lys Met Ala Glu Gln Ile Leu -Ala Arg Gln Gln Leu Ile Glu Thr Val Glu -Tyr Ser Leu Pro Asn Lys His Tyr Phe Glu -Ile Asp Leu Ser Trp His Lys Gly Leu Gln-Asn Thr Gly Lys Asn Ala Glu Val Phe Ala -Pro Gln Ser Asp Pro Asn Gly Leu Ile Lys -Cys Thr Val Gly Arg Ser Ser Leu Lys Ser -Lys Leu - 任选地被甲硫氨酸 ，或者它可以呈现与该序列一定程度的基本同源性。 本发明还涉及含有该蛋白质的药物以及获得该蛋白质的遗传工程工具。