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    Method and System for Registration of Ultrasound and Physiological Models to X-ray Fluoroscopic Images
    5.
    发明申请
    Method and System for Registration of Ultrasound and Physiological Models to X-ray Fluoroscopic Images 有权
    超声和生理模型注射X射线荧光镜图像的方法和系统

    公开(公告)号：US20120296202A1

    公开(公告)日：2012-11-22

    申请号：US13475048

    申请日：2012-05-18

    申请人： Peter Mountney ,  Markus Kaiser ,  Ingmar Voigt ,  Matthias John ,  Razvan Ioan Ionasec ,  Jan Boese ,  Dorin Comaniciu

    发明人： Peter Mountney ,  Markus Kaiser ,  Ingmar Voigt ,  Matthias John ,  Razvan Ioan Ionasec ,  Jan Boese ,  Dorin Comaniciu

    IPC分类号： A61B6/02 ,  A61B8/12

    CPC分类号： A61B6/12 ,  A61B6/4417 ,  A61B6/4441 ,  A61B6/487 ,  A61B6/503 ,  A61B6/5247 ,  A61B8/0841 ,  A61B8/0883 ,  A61B8/12 ,  A61B8/4245 ,  A61B8/4416 ,  A61B8/5261

    摘要： A method and system for registering ultrasound images and physiological models to x-ray fluoroscopy images is disclosed. A fluoroscopic image and an ultrasound image, such as a Transesophageal Echocardiography (TEE) image, are received. A 2D location of an ultrasound probe is detected in the fluoroscopic image. A 3D pose of the ultrasound probe is estimated based on the detected 2D location of the ultrasound probe in the fluoroscopic image. The ultrasound image is mapped to a 3D coordinate system of a fluoroscopic image acquisition device used to acquire the fluoroscopic image based on the estimated 3D pose of the ultrasound probe. The ultrasound image can then be projected into the fluoroscopic image using a projection matrix associated with the fluoroscopic image. A patient specific physiological model can be detected in the ultrasound image and projected into the fluoroscopic image.

    摘要翻译： 公开了一种用于将超声图像和生理模型记录到X射线透视图像的方法和系统。 接收透视图像和超声图像，如经食道超声心动图（TEE）图像。 在透视图像中检测超声探头的2D位置。 基于在荧光镜图像中检测到的超声波探头的2D位置来估计超声探头的3D姿态。 超声图像被映射到用于根据超声探头的估计3D姿势获取荧光镜图像的荧光镜图像采集装置的3D坐标系。 然后可以使用与透视图像相关联的投影矩阵将超声图像投影到透视图像中。 可以在超声图像中检测患者特异性生理模型并将其投影到透视图像中。

    Compositions and methods for inhibiting expression of a mutant gene
    6.
    发明授权
    Compositions and methods for inhibiting expression of a mutant gene 有权
    用于抑制突变基因表达的组合物和方法

    公开(公告)号：US08273870B2

    公开(公告)日：2012-09-25

    申请号：US13177316

    申请日：2011-07-06

    申请人： Roland Kreutzer ,  Stefan Limmer ,  Matthias John

    发明人： Roland Kreutzer ,  Stefan Limmer ,  Matthias John

    IPC分类号： C07H21/04

    CPC分类号： C12N15/1131 ,  C12N15/111 ,  C12N2310/14 ,  C12N2310/53 ,  C12N2320/50

    摘要： The present invention relates to a double-stranded ribonucleic acid (dsRNA) for inhibiting the expression of a mutant gene, comprising a first strand that has a complementary region that is complementary to at least a portion of an RNA transcript of at least part of the mutant target gene and a second strand of the dsRNA complementary or substantially complementary to the first strand. The invention further relates to a pharmaceutical composition comprising the dsRNA and a pharmaceutically acceptable carrier. The pharmaceutical compositions are useful for inhibiting the expression of a target mutant gene, as well as for treating diseases caused by expression of the target gene. The invention also relates to methods for inhibiting the expression of a target mutant gene, as well as methods for treating diseases caused by the expression of the target gene.

    摘要翻译： 本发明涉及用于抑制突变基因表达的双链核糖核酸（dsRNA），其包含第一链，该第一链具有与至少部分至少部分的RNA转录物的至少一部分互补的互补区 突变靶基因和与第一链互补或基本上互补的dsRNA的第二链。 本发明还涉及包含dsRNA和药学上可接受的载体的药物组合物。 药物组合物可用于抑制靶突变基因的表达，以及用于治疗由靶基因表达引起的疾病。 本发明还涉及抑制靶突变基因表达的方法，以及用于治疗由靶基因表达引起的疾病的方法。

    Method and System for Pigtail Catheter Motion Prediction
    7.
    发明申请
    Method and System for Pigtail Catheter Motion Prediction 有权
    猪尾导管运动预测方法与系统

    公开(公告)号：US20120123250A1

    公开(公告)日：2012-05-17

    申请号：US13297373

    申请日：2011-11-16

    申请人： Yu Pang ,  Yefeng Zheng ,  Matthias John ,  Jan Boese ,  Dorin Comaniciu

    发明人： Yu Pang ,  Yefeng Zheng ,  Matthias John ,  Jan Boese ,  Dorin Comaniciu

    IPC分类号： A61B6/00

    CPC分类号： A61B6/487 ,  A61B6/12 ,  A61B6/5264 ,  G06T7/246 ,  G06T7/277 ,  G06T2207/10121 ,  G06T2207/30021

    摘要： A method and system for autoregressive model based pigtail catheter motion prediction in a fluoroscopic image sequence is disclosed. Parameters of an autoregressive model are estimated based on observed pigtail catheter tip positions in a plurality of previous frames of a fluoroscopic image sequence. A pigtail catheter tip position in a current frame of the fluoroscopic image sequence is predicted using the fitted autoregressive model. The predicted pigtail catheter tip position can be used to constrain pigtail catheter tip detection in the current frame. The predicted pigtail catheter tip position may also be used to predict abnormal motion in the fluoroscopic image sequence.

    摘要翻译： 公开了一种在透视图像序列中基于自回归模型的尾纤导管运动预测的方法和系统。 基于在透视图像序列的多个先前帧中的观察到的尾纤导管尖端位置来估计自回归模型的参数。 使用拟合的自回归模型预测荧光镜图像序列的当前帧中的尾纤导管尖端位置。 预测的猪尾导管尖端位置可用于限制当前帧中的尾纤导管尖端检测。 预测的猪尾导管尖端位置也可以用于预测荧光镜像图像序列中的异常运动。

    Method for reconstructing a three-dimensional target volume in realtime and displaying it
    8.
    发明授权
    Method for reconstructing a three-dimensional target volume in realtime and displaying it 有权
    实时重建三维目标体积并进行显示的方法

    公开(公告)号：US08077940B2

    公开(公告)日：2011-12-13

    申请号：US11725830

    申请日：2007-03-20

    申请人： Matthias John ,  Norbert Rahn

    发明人： Matthias John ,  Norbert Rahn

    IPC分类号： G06K9/00

    CPC分类号： A61B8/12 ,  A61B5/0066 ,  A61B5/0456 ,  A61B8/543 ,  G06T11/005 ,  G06T2211/428

    摘要： The invention relates to a method for reconstructing a three-dimensional target volume, particularly within the human body, in realtime and displaying it, with a three-dimensional reconstruction volume being determined from a basic set comprising a minimum number of two-dimensional images obtained from an image recording device located within the target volume, wherein, when a new image is included in the basic set, locally limited updating at least of the reconstruction volume's partial areas covered by the new image will under a predefined condition be performed and the updated reconstruction volume will be displayed.

    摘要翻译： 本发明涉及一种用于重建三维目标体积，特别是在人体内实时地显示三维目标体积的方法，并且显示三维目标体积，其中三维重建体积是从包括最小数目的二维图像获得的基本集合确定的 从位于所述目标体积内的图像记录装置，其中，当在所述基本组中包括新图像时，在执行所述新图像所覆盖的至少所述重建体积的部分区域内的局部限制更新将被执行，并且所述更新 重建体积将被显示。

    METHOD OF IMAGING FOR HEART VALVE IMPLANT PROCEDURE
    9.
    发明申请
    METHOD OF IMAGING FOR HEART VALVE IMPLANT PROCEDURE 失效
    心瓣植入手术成像方法

    公开(公告)号：US20110046725A1

    公开(公告)日：2011-02-24

    申请号：US12545435

    申请日：2009-08-21

    申请人： Alois Noettling ,  Jan Boese ,  Matthias John ,  Volkmar Falk ,  Thomas Walther

    发明人： Alois Noettling ,  Jan Boese ,  Matthias John ,  Volkmar Falk ,  Thomas Walther

    IPC分类号： A61F2/24 ,  A61B6/03 ,  A61B6/00 ,  G01N23/04 ,  H05G1/60 ,  G06K9/00 ,  G09G5/00

    CPC分类号： A61B6/032 ,  A61B6/503 ,  A61B8/0883 ,  A61F2/24

    摘要： A method as a workflow for imaging for a heart valve implant procedure includes positioning the patient and an articulated imaging apparatus relative to one another, inducing rapid ventricular pacing in the patient, and imaging a region of the patient's heart to obtain image date for a three-dimensional image. The three-dimensional data is used to construct a three-dimensional image of the region of the patient's heart an the three-dimensional image is displayed for use in the implanting of the replacement heart valve. Optional steps may include obtaining a real time two-dimensional image of the patient's heart and superimposing the real time two-dimensional image with the constructed three dimensional image. The replacement valve is moved into position in the patient's heart during rapid ventricular pacing and breath hold using the superimposed two-dimensional and three-dimensional image information.

    摘要翻译： 作为用于心脏瓣膜植入程序的成像工作流程的方法包括相对于彼此定位患者和关节成像装置，在患者体内引起快速心室起搏，以及对患者心脏的区域进行成像以获得三维图像的图像日期 维度图像。 三维数据用于构建患者心脏区域的三维图像，显示三维图像以用于置换心脏瓣膜的植入。 可选步骤可以包括获得患者心脏的实时二维图像，并且用构建的三维图像叠加实时二维图像。 使用重叠的二维和三维图像信息，在快速心室起搏和呼吸保持期间将置换瓣膜移动到患者心脏中的位置。