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公开(公告)号：US09493834B2
公开(公告)日：2016-11-15
申请号：US13387174
申请日：2010-07-29
CPC分类号： C12Q1/6883 , C12Q2600/156 , C12Q2600/158 , G01N33/6896 , G01N2800/2821 , G01N2800/60
摘要： The present invention relates to development, validation and application of new sets of biomarkers for diagnosis of Alzheimer's disease (AD) and related disorders including early diagnosis of MCI and early prodrome of AD, identification of disease sub types, prediction of their response to disease management procedures, drugs and their combinations and for monitoring response for these treatments, including validation of biomarkers for clinical trials.
摘要翻译： 本发明涉及用于诊断阿尔茨海默病（AD）的新型生物标志物的发展，验证和应用以及相关疾病，包括MCI的早期诊断和AD的早期前驱症，疾病亚型的鉴定，对疾病管理的反应的预测 程序，药物及其组合，并监测这些治疗的反应，包括验证临床试验的生物标志物。
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公开(公告)号：US20120283114A1
公开(公告)日：2012-11-08
申请号：US13387174
申请日：2010-07-29
CPC分类号： C12Q1/6883 , C12Q2600/156 , C12Q2600/158 , G01N33/6896 , G01N2800/2821 , G01N2800/60
摘要： The present invention relates to development, validation and application of new sets of biomarkers for diagnosis of Alzheimer's disease (AD) and related disorders including early diagnosis of MCI and early prodrome of AD, identification of disease sub types, prediction of their response to disease management procedures, drugs and their combinations and for monitoring response for these treatment, including validation of biomarkers for clinical trials.
摘要翻译： 本发明涉及用于诊断阿尔茨海默病（AD）的新型生物标志物的发展，验证和应用以及相关疾病，包括MCI的早期诊断和AD的早期前驱症，疾病亚型的鉴定，对疾病管理的反应的预测 程序，药物及其组合，并监测这些治疗的反应，包括验证临床试验的生物标志物。
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3.发明申请THERAPEUTIC APPROACHES FOR TREATING ALZHEIMER DISEASE AND RELATED DISORDERS THROUGH A MODULATION OF ANGIOGENESIS 审中-公开通过调节血管生成治疗阿尔茨海默病和相关疾病的治疗方法公开(公告)号：US20120058992A1
公开(公告)日：2012-03-08
申请号：US12915709
申请日：2010-10-29
IPC分类号： A61K31/55 , C07C57/30 , A61K31/197 , A61K31/42 , C12Q1/02 , A61K31/435 , A61K31/50 , A61K31/155 , A61P25/28 , C12Q1/32 , C07C211/27 , A61K31/4365
CPC分类号： A61K31/55 , A61K31/155 , A61K31/195 , A61K31/37 , A61K31/42 , A61K31/4365 , A61K31/64 , A61K45/06 , A61K2300/00
摘要： The present invention relates to compositions and methods for the treatment of Alzheimer's disease and related disorders. More particularly, the invention relates to combined therapies that modulate angiogenesis for treating said disease.
摘要翻译： 本发明涉及治疗阿尔茨海默病和相关疾病的组合物和方法。 更具体地，本发明涉及调节血管生成以治疗所述疾病的组合疗法。
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4.发明申请COMBINATION OF PILOCARPIN AND METHIMAZOL FOR TREATING CHARCOT-MARIETOOTH DISEASE AND RELATED DISORDERS 有权吡喹酮和甲巯咪唑联合治疗嗜酸性粒细胞病和相关疾病公开(公告)号：US20120040940A1
公开(公告)日：2012-02-16
申请号：US12999125
申请日：2009-06-17
IPC分类号： A61K31/56 , A61K31/4164 , A61P25/00 , A61K31/4178
CPC分类号： A61K31/047 , A61K31/192 , A61K31/197 , A61K31/4164 , A61K31/4178 , A61K31/436 , A61K31/439 , A61K31/485 , A61K31/575 , A61K45/06 , A61K2300/00
摘要： The present invention relates to compositions and methods for the treatment of the Charcot-Marie-Tooth disease and related peripheral neuropathies. More particularly, the invention relates to combined therapies for treating said disease by affecting simultaneously muscarinic receptor signaling and thyroid hormone pathway in a subject.
摘要翻译： 本发明涉及治疗Charcot-Marie-Tooth病和相关周围神经病的组合物和方法。 更具体地，本发明涉及通过同时影响受试者中毒蕈碱受体信号传导和甲状腺激素途径来治疗所述疾病的组合疗法。
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公开(公告)号：US08992891B2
公开(公告)日：2015-03-31
申请号：US12744962
申请日：2008-11-28
IPC分类号： A61K31/197 , A61K31/4164 , A61K39/395 , A61K31/485 , A61K9/127 , A61K9/00 , A61K9/08 , A61K9/48 , A61K31/7004
CPC分类号： A61K31/485 , A61K9/0095 , A61K9/08 , A61K9/4866 , A61K31/047 , A61K31/197 , A61K31/7004
摘要： The present invention relates to compositions and methods for the treatment of the Charcot-Marie-Tooth disease and related disorders. More particularly, the invention relates to combined therapies for treating said disease by affecting PMP22 expression in a subject.
摘要翻译： 本发明涉及治疗Charcot-Marie-Tooth疾病和相关疾病的组合物和方法。 更具体地，本发明涉及通过影响受试者中的PMP22表达来治疗所述疾病的组合疗法。
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6.发明授权Combination of pilocarpin and methimazol for treating Charcot-Marietooth disease and related disorders 有权组合毛果芸香碱和甲巯咪唑治疗Charcot-Marietooth疾病及相关疾病公开(公告)号：US08716269B2
公开(公告)日：2014-05-06
申请号：US12999125
申请日：2009-06-17
IPC分类号： A61K31/56 , A61K31/4164 , A61P25/00 , A61K31/4178
CPC分类号： A61K31/047 , A61K31/192 , A61K31/197 , A61K31/4164 , A61K31/4178 , A61K31/436 , A61K31/439 , A61K31/485 , A61K31/575 , A61K45/06 , A61K2300/00
摘要： The present invention relates to compositions and methods for the treatment of the Charcot-Marie-Tooth disease and related peripheral neuropathies. More particularly, the invention relates to combined therapies for treating said disease by affecting simultaneously muscarinic receptor signaling and thyroid hormone pathway in a subject.
摘要翻译： 本发明涉及治疗Charcot-Marie-Tooth病和相关周围神经病的组合物和方法。 更具体地，本发明涉及通过同时影响受试者中毒蕈碱受体信号传导和甲状腺激素途径来治疗所述疾病的组合疗法。
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7.发明授权Therapeutic approaches for treating alzheimer disease and related disorders through a modulation of cell stress response 有权通过调节细胞应激反应治疗阿尔茨海默病和相关疾病的治疗方法公开(公告)号：US08552041B2
公开(公告)日：2013-10-08
申请号：US12915689
申请日：2010-10-29
IPC分类号： A61K31/137 , A61K31/42 , A61P25/28
CPC分类号： A61K45/06 , A61K31/137 , A61K31/155 , A61K31/167 , A61K31/185 , A61K31/343 , A61K31/423 , A61K31/4985 , A61K2300/00
摘要： The present invention relates to compositions and methods for the treatment of Alzheimer's disease and related disorders. More particularly, the invention relates to combined therapies that modulate cell stress response for treating said disease.
摘要翻译： 本发明涉及治疗阿尔茨海默病和相关疾病的组合物和方法。 更具体地，本发明涉及调节细胞应激反应以治疗所述疾病的组合疗法。
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8.发明申请THERAPEUTIC APPROACHES FOR TREATING ALZHEIMER DISEASE AND RELATED DISORDERS THROUGH A MODULATION OF CELL STRESS RESPONSE 有权通过调节细胞应力反应来治疗阿尔茨海默病和相关疾病的治疗方法公开(公告)号：US20120071483A1
公开(公告)日：2012-03-22
申请号：US12915689
申请日：2010-10-29
IPC分类号： A61K31/42 , A61K31/50 , G01N33/566 , C07D471/14 , A61P25/28 , C12Q1/02 , C07D261/16 , A61K31/423
CPC分类号： A61K45/06 , A61K31/137 , A61K31/155 , A61K31/167 , A61K31/185 , A61K31/343 , A61K31/423 , A61K31/4985 , A61K2300/00
摘要： The present invention relates to compositions and methods for the treatment of Alzheimer's disease and related disorders. More particularly, the invention relates to combined therapies that modulate cell stress response for treating said disease.
摘要翻译： 本发明涉及治疗阿尔茨海默病和相关疾病的组合物和方法。 更具体地，本发明涉及调节治疗所述疾病的细胞应激反应的组合疗法。
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9.发明申请THERAPEUTIC APPROACHES FOR TREATING ALZHEIMER DISEASE AND RELATED DISORDERS THROUGH A MODULATION OF SYNAPSE FUNCTION 审中-公开通过调节功能的方法治疗阿尔茨海默病和相关疾病的治疗方法公开(公告)号：US20110269764A1
公开(公告)日：2011-11-03
申请号：US12915722
申请日：2010-10-29
IPC分类号： A61K31/4985 , A61K31/423 , A61P25/28 , A61K31/4709 , A61K31/255 , A61K31/42 , C07D261/20 , A61K31/522
CPC分类号： A61K31/42 , A61K31/155 , A61K31/255 , A61K45/06 , C07C279/26 , C07D261/20 , A61K2300/00
摘要： The present invention relates to compositions and methods for the treatment of Alzheimer's disease and related disorders. More particularly, the invention relates to combined therapies that modulate synapse function for treating said disease.
摘要翻译： 本发明涉及治疗阿尔茨海默病和相关疾病的组合物和方法。 更具体地，本发明涉及调节用于治疗所述疾病的突触功能的组合疗法。
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公开(公告)号：US11291670B2
公开(公告)日：2022-04-05
申请号：US12915709
申请日：2010-10-29
IPC分类号： A61K31/55 , A61K31/42 , A61K31/37 , A61K31/4365 , A61K45/06 , A61K31/155 , A61K31/195 , A61K31/64
摘要： The present invention relates to compositions and methods for the treatment of Alzheimer's disease and related disorders. More particularly, the invention relates to combined therapies that modulate angiogenesis for treating said disease.
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