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    Closed-loop feedback-driven neuromodulation
    1.
    发明申请
    Closed-loop feedback-driven neuromodulation 有权
    闭环反馈驱动神经调节

    公开(公告)号：US20060293720A1

    公开(公告)日：2006-12-28

    申请号：US11159842

    申请日：2005-06-22

    申请人： Daniel DiLorenzo

    发明人： Daniel DiLorenzo

    IPC分类号： A61N1/00

    CPC分类号： A61N1/36082 ,  A61N1/0529 ,  A61N1/0531 ,  A61N1/0539

    摘要： A neurological control system for modulating activity of any component or structure comprising the entirety or portion of the nervous system, or any structure interfaced thereto, generally referred to herein as a “nervous system component.” The neurological control system generates neural modulation signals delivered to a nervous system component through one or more neuromodulators, comprising intracranial (IC) stimulating electrodes and other actuators, in accordance with treatment parameters. Such treatment parameters may be derived from a neural response to previously delivered neural modulation signals sensed by one or more sensors, each configured to sense a particular characteristic indicative of a neurological or psychiatric condition.

    摘要翻译： 用于调节包括​​神经系统的全部或部分或与其接合的任何结构的任何组件或结构的活性的神经控制系统，在本文中通常称为“神经系统组分”。 神经系统控制系统根据治疗参数产生通过一个或多个神经调节器递送至神经系统组分的神经调制信号，包括颅内（IC）刺激电极和其它致动器。 这样的治疗参数可以从对由一个或多个传感器感测到的先前传递的神经调制信号的神经反应导出，每个传感器被配置为感测指示神经系统或精神病状态的特定特征。

    Controlling a Subject's Susceptibility to a Seizure
    3.
    发明申请
    Controlling a Subject's Susceptibility to a Seizure 有权
    控制受试者对癫痫发作的敏感性

    公开(公告)号：US20070208212A1

    公开(公告)日：2007-09-06

    申请号：US11743607

    申请日：2007-05-02

    申请人： Daniel DiLorenzo

    发明人： Daniel DiLorenzo

    IPC分类号： A61M21/00

    CPC分类号： A61B5/4094 ,  A61B5/04001 ,  A61B5/04012 ,  A61B5/0476 ,  A61B5/0488 ,  A61B5/0816 ,  A61B5/1101 ,  A61B5/4082 ,  A61B5/4839 ,  A61B5/6852 ,  A61B5/6864 ,  A61B5/6868 ,  A61B5/6882 ,  A61B5/7203 ,  A61N1/0529 ,  A61N1/0531 ,  A61N1/0539 ,  A61N1/36064 ,  A61N1/36067 ,  A61N1/36082 ,  A61N1/36114 ,  A61N1/36139 ,  A61N1/372 ,  A61N1/3787 ,  G06F19/00

    摘要： A neurological control system for modulating activity of any component or structure comprising the entirety or portion of the nervous system, or any structure interfaced thereto, generally referred to herein as a “nervous system component.” The neurological control system generates neural modulation signals delivered to a nervous system component through one or more neuromodulators to control neurological state and prevent neurological signs and symptoms. Such treatment parameters may be derived from a neural response to previously delivered neural modulation signals sensed by one or more sensors, each configured to sense a particular characteristic indicative of a neurological or psychiatric condition.

    摘要翻译： 用于调节包含神经系统的全部或部分或与其接合的任何结构的任何组件或结构的活性的神经控制系统，在本文中通常称为“神经系统组分”。 神经系统控制系统通过一个或多个神经调节器产生递送至神经系统组分的神经调制信号，以控制神经系统状态并预防神经系统症状和体征。 这样的治疗参数可以从对由一个或多个传感器感测到的先前传递的神经调制信号的神经反应导出，每个传感器被配置为感测指示神经系统或精神病状态的特定特征。

    Monitoring efficacy of neural modulation therapy
    5.
    发明申请
    Monitoring efficacy of neural modulation therapy 有权
    监测神经调节疗法的疗效

    公开(公告)号：US20070162086A1

    公开(公告)日：2007-07-12

    申请号：US11647900

    申请日：2006-12-29

    申请人： Daniel DiLorenzo

    发明人： Daniel DiLorenzo

    IPC分类号： A61N1/32

    CPC分类号： A61B5/4094 ,  A61B5/04001 ,  A61B5/04012 ,  A61B5/0476 ,  A61B5/0488 ,  A61B5/0816 ,  A61B5/1101 ,  A61B5/4082 ,  A61B5/4839 ,  A61B5/6852 ,  A61B5/6864 ,  A61B5/6868 ,  A61B5/6882 ,  A61B5/7203 ,  A61N1/0529 ,  A61N1/0531 ,  A61N1/0539 ,  A61N1/36064 ,  A61N1/36067 ,  A61N1/36082 ,  A61N1/36114 ,  A61N1/36139 ,  A61N1/372 ,  A61N1/3787 ,  G06F19/00

    摘要： A neurological control system for modulating activity of any component or structure comprising the entirety or portion of the nervous system, or any structure interfaced thereto, generally referred to herein as a “nervous system component.” The neurological control system generates neural modulation signals delivered to a nervous system component through one or more neuromodulators to control neurological state and prevent neurological signs and symptoms. Such treatment parameters may be derived from a neural response to previously delivered neural modulation signals sensed by one or more sensors, each configured to sense a particular characteristic indicative of a neurological or psychiatric condition.

    摘要翻译： 用于调节包括​​神经系统的全部或部分或与其接合的任何结构的任何组件或结构的活性的神经控制系统，在本文中通常称为“神经系统组分”。 神经系统控制系统通过一个或多个神经调节器产生递送至神经系统组分的神经调制信号，以控制神经系统状态并预防神经系统症状和体征。 这样的治疗参数可以从对由一个或多个传感器感测到的先前传递的神经调制信号的神经反应导出，每个传感器被配置为感测指示神经系统或精神病状态的特定特征。

    Method, apparatus, and surgical technique for autonomic neuromodulation for the treatment of disease
    6.
    发明申请
    Method, apparatus, and surgical technique for autonomic neuromodulation for the treatment of disease 审中-公开
    用于治疗疾病的自主神经调节的方法，装置和手术技术

    公开(公告)号：US20060167498A1

    公开(公告)日：2006-07-27

    申请号：US11151816

    申请日：2005-06-13

    申请人： Daniel DiLorenzo

    发明人： Daniel DiLorenzo

    IPC分类号： A61N1/08 ,  A61N1/362 ,  A61N1/34 ,  A61N1/05

    CPC分类号： A61N1/36007 ,  A61B17/3468 ,  A61N1/0551 ,  A61N1/36071 ,  A61N1/36082 ,  A61N1/36114

    摘要： The present invention teaches a method and apparatus for physiological modulation, including neural and gastrointestinal modulation, for the purposes of treating several disorders, including obesity, depression, epilepsy, and diabetes. This includes chronically implanted neural and neuromuscular modulators, used to modulate the afferent neurons of the sympathetic nervous system to induce satiety. Furthermore, this includes neuromuscular stimulation of the stomach to effect baseline and intermittent smooth muscle contraction to increase gastric intraluminal pressure, which induces satiety, and stimulate sympathetic afferent fibers, including those in the sympathetic trunk, splanchnic nerves, and greater curvature of the stomach, to augment the perception of satiety.

    摘要翻译： 本发明教导了一种用于生理调节的方法和装置，包括神经和胃肠调节，用于治疗包括肥胖症，抑郁症，癫痫和糖尿病在内的几种疾病。 这包括长期植入的神经和神经肌肉调节剂，用于调节交感神经系统的传入神经元以诱导饱腹感。 此外，这包括对胃的神经肌肉刺激以实现基线和间歇性平滑肌收缩以增加胃管腔内压力，其诱导饱腹感，并且刺激交感神经传入纤维，包括交感神经干，内脏神经和胃弯曲更大的交感神经纤维， 增加饱腹感。

    Method, apparatus, and surgical technique for autonomic neuromodulation for the treatment of obesity
    7.
    发明申请
    Method, apparatus, and surgical technique for autonomic neuromodulation for the treatment of obesity 审中-公开
    用于治疗肥胖症的自主神经调节的方法，装置和手术技术

    公开(公告)号：US20060116736A1

    公开(公告)日：2006-06-01

    申请号：US11317099

    申请日：2005-12-22

    申请人： Daniel DiLorenzo

    发明人： Daniel DiLorenzo

    IPC分类号： A61N1/08

    CPC分类号： A61N1/0551 ,  A61N1/0556 ,  A61N1/36007 ,  A61N1/36082 ,  A61N1/36114 ,  A61N2/00 ,  A61N5/00 ,  A61N7/00

    摘要： The present invention teaches a method and apparatus for physiological modulation, including neural and gastrointestinal modulation, for the purposes of treating several disorders, including obesity, depression, epilepsy, and diabetes. This includes chronically implanted neural and neuromuscular modulators, used to modulate the afferent neurons of the sympathetic nervous system to induce satiety. Furthermore, this includes neuromuscular stimulation of the stomach to effect baseline and intermittent smooth muscle contraction to increase gastric intraluminal pressure, which induces satiety, and stimulate sympathetic afferent fibers, including those in the sympathetic trunk, splanchnic nerves, and greater curvature of the stomach, to augment the perception of satiety.

    摘要翻译： 本发明教导了一种用于生理调节的方法和装置，包括神经和胃肠调节，用于治疗包括肥胖症，抑郁症，癫痫和糖尿病在内的几种疾病。 这包括长期植入的神经和神经肌肉调节剂，用于调节交感神经系统的传入神经元以诱导饱腹感。 此外，这包括对胃的神经肌肉刺激以实现基线和间歇性平滑肌收缩以增加胃管腔内压力，其诱导饱腹感，并且刺激交感神经传入纤维，包括交感神经干，内脏神经和胃弯曲更大的交感神经纤维， 增加饱腹感。

    Closed-loop feedback-driven neuromodulation
    8.
    发明申请
    Closed-loop feedback-driven neuromodulation 有权
    闭环反馈驱动神经调节

    公开(公告)号：US20050240242A1

    公开(公告)日：2005-10-27

    申请号：US10889844

    申请日：2004-07-12

    申请人： Daniel DiLorenzo

    发明人： Daniel DiLorenzo

    IPC分类号： A61N1/18

    CPC分类号： A61N1/3605 ,  A61N1/0529 ,  A61N1/0531 ,  A61N1/0534 ,  A61N1/36064 ,  A61N1/36067 ,  A61N1/36082

    摘要： A neurological control system for modulating activity of any component or structure comprising the entirety or portion of the nervous system, or any structure interfaced thereto, generally referred to herein as a “nervous system component.” The neurological control system generates neural modulation signals delivered to a nervous system component through one or more neuromodulators to control neurological state and prevent neurological signs and symptoms. Such treatment parameters may be derived from a neural response to previously delivered neural modulation signals sensed by one or more sensors, each configured to sense a particular characteristic indicative of a neurological or psychiatric condition.

    摘要翻译： 用于调节包括​​神经系统的全部或部分或与其接合的任何结构的任何组件或结构的活性的神经控制系统，在本文中通常称为“神经系统组分”。 神经系统控制系统通过一个或多个神经调节器产生递送至神经系统组分的神经调制信号，以控制神经系统状态并预防神经系统症状和体征。 这样的治疗参数可以从对由一个或多个传感器感测到的先前传递的神经调制信号的神经反应导出，每个传感器被配置为感测指示神经系统或精神病状态的特定特征。

    Cloosed-loop feedback-driven neuromodulation
    9.
    发明申请
    Cloosed-loop feedback-driven neuromodulation 有权
    闭环反馈驱动神经调节

    公开(公告)号：US20050222626A1

    公开(公告)日：2005-10-06

    申请号：US11138621

    申请日：2005-05-25

    申请人： Daniel DiLorenzo

    发明人： Daniel DiLorenzo

    IPC分类号： A61N1/08 ,  A61N1/36 ,  H03C3/06

    CPC分类号： A61N1/3605 ,  A61N1/0529 ,  A61N1/0531 ,  A61N1/0534 ,  A61N1/36064 ,  A61N1/36067 ,  A61N1/36082

    摘要： A neurological control system for modulating activity of any component or structure comprising the entirety or portion of the nervous system, or any structure interfaced thereto, generally referred to herein as a “nervous system component.” The neurological control system generates neural modulation signals delivered to a nervous system component through one or more neuromodulators, comprising intracranial (IC) stimulating electrodes and other actuators, in accordance with treatment parameters. Such treatment parameters may be derived from a neural response to previously delivered neural modulation signals sensed by one or more sensors, each configured to sense a particular characteristic indicative of a neurological or psychiatric condition.

    摘要翻译： 用于调节包括​​神经系统的全部或部分或与其接合的任何结构的任何组件或结构的活性的神经控制系统，在本文中通常称为“神经系统组分”。 神经系统控制系统根据治疗参数产生通过一个或多个神经调节器递送至神经系统组分的神经调制信号，包括颅内（IC）刺激电极和其它致动器。 这样的治疗参数可以从对由一个或多个传感器感测到的先前传递的神经调制信号的神经反应导出，每个传感器被配置为感测指示神经系统或精神病状态的特定特征。

    Method, apparatus, surgical technique, and stimulation parameters for autonomic neuromodulation for the treatment of obesity
    10.
    发明申请
    Method, apparatus, surgical technique, and stimulation parameters for autonomic neuromodulation for the treatment of obesity 审中-公开
    用于治疗肥胖的自主神经调节的方法，装置，手术技术和刺激参数

    公开(公告)号：US20070162085A1

    公开(公告)日：2007-07-12

    申请号：US11716451

    申请日：2007-03-09

    申请人： Daniel DiLorenzo

    发明人： Daniel DiLorenzo

    IPC分类号： A61N1/36

    CPC分类号： A61N1/36007 ,  A61N1/0529 ,  A61N1/0531 ,  A61N1/0534 ,  A61N1/0551

    摘要： The present invention teaches a method and apparatus for physiological modulation, including neural and gastrointestinal modulation, for the purposes of treating several disorders, including obesity, depression, epilepsy, and diabetes. This includes chronically implanted neural and neuromuscular modulators, used to modulate the afferent neurons of the sympathetic nervous system to induce satiety. Furthermore, this includes neuromuscular stimulation of the stomach to effect baseline and intermittent smooth muscle contraction to increase gastric intraluminal pressure, which induces satiety, and stimulate sympathetic afferent fibers, including those in the sympathetic trunk, splanchnic nerves, and greater curvature of the stomach, to augment the perception of satiety.

    摘要翻译： 本发明教导了一种用于生理调节的方法和装置，包括神经和胃肠调节，用于治疗包括肥胖症，抑郁症，癫痫和糖尿病在内的几种疾病。 这包括长期植入的神经和神经肌肉调节剂，用于调节交感神经系统的传入神经元以诱导饱腹感。 此外，这包括对胃的神经肌肉刺激以实现基线和间歇性平滑肌收缩以增加胃管腔内压力，其诱导饱腹感，并且刺激交感神经传入纤维，包括交感神经干，内脏神经和胃弯曲更大的交感神经纤维， 增加饱腹感。