-
公开(公告)号：US20060040981A1
公开(公告)日：2006-02-23
申请号：US10536250
申请日：2003-11-19
申请人： Daniel Dube , Michel Gallant , Patrick Lacombe , Yves Girard , Dwight Macdonald , Richard Friesen , Yves Ducharme , Bernard Cote , Marc Blouin , Evelyn Martins , Daniel Guay , Pierre Hamel , Mario Girard , Richard Frenette , Sebastien Laliberte , Annette Robichaud , Anthony Mastracchio , Helene Perrier
发明人： Daniel Dube , Michel Gallant , Patrick Lacombe , Yves Girard , Dwight Macdonald , Richard Friesen , Yves Ducharme , Bernard Cote , Marc Blouin , Evelyn Martins , Daniel Guay , Pierre Hamel , Mario Girard , Richard Frenette , Sebastien Laliberte , Annette Robichaud , Anthony Mastracchio , Helene Perrier
IPC分类号： A61K31/4709 , A61K31/47
CPC分类号： A61K31/4709 , A61K31/277 , A61K31/4375 , A61K31/44 , A61K31/47
摘要： The present invention is directed to a method of enhancing cognition in a healthy subject comprising administering a safe cognition enhancing amount of a phosphodiesterase-4 inhibitor. In particular, this invention is directed to a method of enhancing memory, learning, retention, recall, awareness and judgement in health subjects comprising administering a safe and effective amount of a phosphodiesterase-4 inhibitor.
摘要翻译： 本发明涉及增强健康受试者的认知的方法，其包括施用安全认知增加量的磷酸二酯酶-4抑制剂。 特别地，本发明涉及增加健康受试者的记忆，学习，保留，召回，意识和判断的方法，包括施用安全有效量的磷酸二酯酶-4抑制剂。
-
公开(公告)号：US06841564B2
公开(公告)日：2005-01-11
申请号：US10102552
申请日：2002-03-20
申请人： Richard Freisen , Yves Ducharme , Bernard Cote , Marc Blouin , Evelyn Martins , Daniel Guay , Pierre Hamel , Mario Girard , Richard Frenette , Sebastien Laliberte
发明人： Richard Freisen , Yves Ducharme , Bernard Cote , Marc Blouin , Evelyn Martins , Daniel Guay , Pierre Hamel , Mario Girard , Richard Frenette , Sebastien Laliberte
IPC分类号： C07D417/04 , A61K31/4439 , A61K31/444 , A61K45/00 , A61P1/00 , A61P1/04 , A61P3/10 , A61P3/12 , A61P7/00 , A61P9/10 , A61P11/00 , A61P11/02 , A61P11/06 , A61P11/08 , A61P11/14 , A61P13/02 , A61P13/12 , A61P17/00 , A61P17/02 , A61P17/04 , A61P17/06 , A61P19/02 , A61P19/08 , A61P19/10 , A61P21/00 , A61P25/04 , A61P25/24 , A61P25/28 , A61P27/14 , A61P29/00 , A61P29/02 , A61P31/04 , A61P35/00 , A61P37/00 , A61P37/02 , A61P37/08 , A61P39/02 , A61P43/00 , C07D417/06 , C07D417/14 , A61K31/44
CPC分类号： C07D417/06
摘要： Novel ethanes substituted with i) a phenyl, ii) a thiazole, and iii) a pyridyl moiety are PDE4 inhibitors.
摘要翻译： 用I）苯基取代的新型乙烷，ii）噻唑，和iii）吡啶基部分是PDE4抑制剂。
-
公开(公告)号：US06399636B2
公开(公告)日：2002-06-04
申请号：US09810119
申请日：2001-03-16
申请人： Richard Freisen , Yves Ducharme , Bernard Cote , Marc Blouin , Evelyn Martins , Daniel Guay , Pierre Hamel , Mario Girard , Richard Frenette , Sebastien Laliberte
发明人： Richard Freisen , Yves Ducharme , Bernard Cote , Marc Blouin , Evelyn Martins , Daniel Guay , Pierre Hamel , Mario Girard , Richard Frenette , Sebastien Laliberte
IPC分类号： A61K314439
CPC分类号： C07D417/06
摘要： Novel ethanes substituted with i) a phenyl, ii) a thiazole, and iii) a pyridyl moiety are PDE4 inhibitors.
-
![2-(Phenyl or Heterocyclic)-1H-Phenanthro[9,10-D]Imidazoles](/abs-image/US/2009/11/19/US20090286772A1/abs.jpg.150x150.jpg)
公开(公告)号：US20090286772A1
公开(公告)日：2009-11-19
申请号：US12224275
申请日：2007-02-22
申请人： Anh Chau , Bernard Cote , Yves Ducharme , Richard Frenette , Richard Friesen , Marc Gagnon , Andre Giroux , Evelyn Martins , Hongping Yu , Pierre Hamel
发明人： Anh Chau , Bernard Cote , Yves Ducharme , Richard Frenette , Richard Friesen , Marc Gagnon , Andre Giroux , Evelyn Martins , Hongping Yu , Pierre Hamel
IPC分类号： A61K31/4184 , C07D235/04 , C07D401/04 , C07D413/02 , C07D417/02 , A61K31/4439 , A61K31/5377 , A61K31/541 , A61P25/00 , A61P19/00
CPC分类号： C07D235/02 , C07D401/04 , C07D403/04 , C07D409/04 , C07D409/14 , C07D413/04 , C07D417/04
摘要： The invention encompasses novel compounds of Formula (I) or pharmaceutically acceptable salts thereof. These compounds are inhibitors of the microsomal prostaglandin E synthase-1 (mPGES-1) enzyme and are therefore useful to treat pain and/or inflammation from a variety of diseases or conditions, such as osteoarthritis, rheumatoid arthritis and acute or chronic pain. Methods of treating diseases or conditions mediated by the mPGES-1 enzyme and pharmaceutical compositions are also encompassed.
摘要翻译： 本发明包括式（I）的新化合物或其药学上可接受的盐。 这些化合物是微粒体前列腺素E合酶-1（mPGES-1）酶的抑制剂，因此可用于治疗各种疾病或病症如骨关节炎，类风湿性关节炎和急性或慢性疼痛的疼痛和/或炎症。 还包括治疗由mPGES-1酶和药物组合物介导的疾病或病症的方法。
-
公开(公告)号：US20090209571A1
公开(公告)日：2009-08-20
申请号：US12227338
申请日：2007-05-15
申请人： Bernard Cote , Yves Ducharme , Richard Frenette , Richard Friesen , Andre Giroux , Evelyn Martins , Pierre Hamel
发明人： Bernard Cote , Yves Ducharme , Richard Frenette , Richard Friesen , Andre Giroux , Evelyn Martins , Pierre Hamel
IPC分类号： A61K31/4188 , C07D495/04 , C07D487/04 , C07D471/04 , A61K31/437 , A61K31/4439 , A61P29/00
CPC分类号： C07D491/04 , C07D471/04 , C07D495/04 , C07D495/14
摘要： The invention encompasses novel compounds of Formula or pharmaceutically acceptable salts thereof. These compounds are inhibitors of the microsomal prostaglandin E synthase-1 (mPGES-1) enzyme and are therefore useful to treat pain and/or inflammation from a variety of diseases or conditions, such as osteoarthritis, rheumatoid arthritis and acute or chronic pain. Methods of treating diseases or conditions mediated by the mPGES-1 enzyme and pharmaceutical compositions are also encompassed.
摘要翻译： 本发明包括式的新型化合物或其药学上可接受的盐。 这些化合物是微粒体前列腺素E合酶-1（mPGES-1）酶的抑制剂，因此可用于治疗各种疾病或病症如骨关节炎，类风湿性关节炎和急性或慢性疼痛的疼痛和/或炎症。 还包括治疗由mPGES-1酶和药物组合物介导的疾病或病症的方法。
-
![2-(phenyl or heterocyclic)-1H-phenantrho[9,10-d]imidazoles as mPGES-1 inhibitors](/abs-image/US/2011/05/17/US07943649B2/abs.jpg.150x150.jpg)
6.发明授权2-(phenyl or heterocyclic)-1H-phenantrho[9,10-d]imidazoles as mPGES-1 inhibitors 有权2-（苯基或杂环）-1H-吡唑并[9,10-d]咪唑，为mPGES-1抑制剂公开(公告)号：US07943649B2
公开(公告)日：2011-05-17
申请号：US12288947
申请日：2008-10-24
申请人： Anh Chau , Bernard Cote , Yves Ducharme , Richard Frenette , Richard Friesen , Marc Gagnon , Andre Giroux , Evelyn Martins , Hongping Yu , Tom Wu
发明人： Anh Chau , Bernard Cote , Yves Ducharme , Richard Frenette , Richard Friesen , Marc Gagnon , Andre Giroux , Evelyn Martins , Hongping Yu , Tom Wu
IPC分类号： A61K31/4184 , A61K31/5377 , C07D235/02 , C07D413/14
CPC分类号： C07D235/02 , C07D235/18 , C07D401/04 , C07D401/06 , C07D401/14 , C07D403/06 , C07D405/06 , C07D413/04 , C07D413/06
摘要： The invention encompasses novel compounds of Formula I or pharmaceutically acceptable salts thereof. These compounds are inhibitors of the microsomal prostaglandin E synthase-1 (mPGES-1) enzyme and are therefore useful to treat pain and/or inflammation from a variety of diseases or conditions, such as osteoarthritis, rheumatoid arthritis and acute or chronic pain. Methods of treating diseases or conditions mediated by the mPGES-1 enzyme and pharmaceutical compositions are also encompassed.
摘要翻译： 本发明包括式I的新化合物或其药学上可接受的盐。 这些化合物是微粒体前列腺素E合酶-1（mPGES-1）酶的抑制剂，因此可用于治疗各种疾病或病症如骨关节炎，类风湿性关节炎和急性或慢性疼痛的疼痛和/或炎症。 还包括治疗由mPGES-1酶和药物组合物介导的疾病或病症的方法。
-
![2-(Phenyl or heterocyclic)-1H-phenantrho[9,10-d]imidazoles as mPGES-1 inhibitors](/abs-image/US/2007/09/06/US20070208017A1/abs.jpg.150x150.jpg)
7.发明申请2-(Phenyl or heterocyclic)-1H-phenantrho[9,10-d]imidazoles as mPGES-1 inhibitors 有权作为mPGES-1抑制剂的2-（苯基或杂环）-1H-苯并[9,10-d]咪唑公开(公告)号：US20070208017A1
公开(公告)日：2007-09-06
申请号：US11374288
申请日：2005-11-23
申请人： Anh Chau , Bernard Cote , Yves Ducharme , Richard Frenette , Richard Friesen , Marc Gagnon , Andre Giroux , Evelyn Martins , Hongping Yu , Tom Wu
发明人： Anh Chau , Bernard Cote , Yves Ducharme , Richard Frenette , Richard Friesen , Marc Gagnon , Andre Giroux , Evelyn Martins , Hongping Yu , Tom Wu
IPC分类号： A61K31/5377 , A61K31/4439 , A61K31/4245 , A61K31/4188 , C07D403/14 , C07D413/14
CPC分类号： C07D235/02 , C07D235/18 , C07D401/04 , C07D401/06 , C07D401/14 , C07D403/06 , C07D405/06 , C07D413/04 , C07D413/06
摘要： The invention encompasses novel compounds of Formula I or pharmaceutically acceptable salts thereof. These compounds are inhibitors of the microsomal prostaglandin E synthase-1 (mPGES-1) enzyme and are therefore useful to treat pain and/or inflammation from a variety of diseases or conditions, such as osteoarthritis, rheumatoid arthritis and acute or chronic pain. Methods of treating diseases or conditions mediated by the mPGES-1 enzyme and pharmaceutical compositions are also encompassed.
摘要翻译： 本发明包括式I的新化合物或其药学上可接受的盐。 这些化合物是微粒体前列腺素E合酶-1（mPGES-1）酶的抑制剂，因此可用于治疗各种疾病或病症如骨关节炎，类风湿性关节炎和急性或慢性疼痛的疼痛和/或炎症。 还包括治疗由mPGES-1酶和药物组合物介导的疾病或病症的方法。
-
![2-(phenyl or heterocyclic)-1H-phenantrho[9,10-d]imidazoles as mPGES-1 inhibitors](/abs-image/US/2009/03/19/US20090075998A1/abs.jpg.150x150.jpg)
8.发明申请2-(phenyl or heterocyclic)-1H-phenantrho[9,10-d]imidazoles as mPGES-1 inhibitors 有权2-（苯基或杂环）-1H-吡唑并[9,10-d]咪唑，为mPGES-1抑制剂公开(公告)号：US20090075998A1
公开(公告)日：2009-03-19
申请号：US12288947
申请日：2008-10-24
申请人： Anh Chau , Bernard Cote , Yves Ducharme , Richard Frenette , Richard Friesen , Marc Gagnon , Andre Giroux , Evelyn Martins , Hongping Yu , Tom Wu
发明人： Anh Chau , Bernard Cote , Yves Ducharme , Richard Frenette , Richard Friesen , Marc Gagnon , Andre Giroux , Evelyn Martins , Hongping Yu , Tom Wu
IPC分类号： A61K31/5377 , A61K31/4184 , A61K31/4439 , A61K31/4245 , A61K31/501 , A61K31/41
CPC分类号： C07D235/02 , C07D235/18 , C07D401/04 , C07D401/06 , C07D401/14 , C07D403/06 , C07D405/06 , C07D413/04 , C07D413/06
摘要： The invention encompasses novel compounds of Formula I or pharmaceutically acceptable salts thereof. These compounds are inhibitors of the microsomal prostaglandin E synthase-1 (mPGES-1) enzyme and are therefore useful to treat pain and/or inflammation from a variety of diseases or conditions, such as osteoarthritis, rheumatoid arthritis and acute or chronic pain. Methods of treating diseases or conditions mediated by the mPGES-1 enzyme and pharmaceutical compositions are also encompassed.
摘要翻译： 本发明包括式I的新化合物或其药学上可接受的盐。 这些化合物是微粒体前列腺素E合酶-1（mPGES-1）酶的抑制剂，因此可用于治疗各种疾病或病症如骨关节炎，类风湿性关节炎和急性或慢性疼痛的疼痛和/或炎症。 还包括治疗由mPGES-1酶和药物组合物介导的疾病或病症的方法。
-
![2-(phenyl or heterocyclic)-1H-phenantrho[9,10-d]imidazoles as mPGES-1 inhibitors](/abs-image/US/2008/10/28/US07442716B2/abs.jpg.150x150.jpg)
9.发明授权2-(phenyl or heterocyclic)-1H-phenantrho[9,10-d]imidazoles as mPGES-1 inhibitors 有权2-（苯基或杂环）-1H-吡唑并[9,10-d]咪唑，为mPGES-1抑制剂公开(公告)号：US07442716B2
公开(公告)日：2008-10-28
申请号：US11374288
申请日：2005-11-23
申请人： Anh Chau , Bernard Cote , Yves Ducharme , Richard Frenette , Richard Friesen , Marc Gagnon , Andre Giroux , Evelyn Martins , Hongping Yu , Tom Wu
发明人： Anh Chau , Bernard Cote , Yves Ducharme , Richard Frenette , Richard Friesen , Marc Gagnon , Andre Giroux , Evelyn Martins , Hongping Yu , Tom Wu
IPC分类号： A61K31/4184 , A61K31/5377 , C07D235/02 , C07D413/14
CPC分类号： C07D235/02 , C07D235/18 , C07D401/04 , C07D401/06 , C07D401/14 , C07D403/06 , C07D405/06 , C07D413/04 , C07D413/06
摘要： The invention encompasses novel compounds of Formula I or pharmaceutically acceptable salts thereof. These compounds are inhibitors of the microsomal prostaglandin E synthase-1 (mPGES-1) enzyme and are therefore useful to treat pain and/or inflammation from a variety of diseases or conditions, such as osteoarthritis, rheumatoid arthritis and acute or chronic pain. Methods of treating diseases or conditions mediated by the mPGES-1 enzyme and pharmaceutical compositions are also encompassed.
摘要翻译： 本发明包括式I的新化合物或其药学上可接受的盐。 这些化合物是微粒体前列腺素E合酶-1（mPGES-1）酶的抑制剂，因此可用于治疗各种疾病或病症如骨关节炎，类风湿性关节炎和急性或慢性疼痛的疼痛和/或炎症。 还包括治疗由mPGES-1酶和药物组合物介导的疾病或病症的方法。
-
公开(公告)号：US06639077B2
公开(公告)日：2003-10-28
申请号：US10112535
申请日：2002-03-29
申请人： Bernard Cote , Evelyn Martins , Richard Frenette , Rick Friesen , Yves Ducharme
发明人： Bernard Cote , Evelyn Martins , Richard Frenette , Rick Friesen , Yves Ducharme
IPC分类号： C07D40110
CPC分类号： C07D417/06
摘要： Novel ethanes substituted with i) a phenyl, ii) a thiazole, and iii) a pyridyl moiety are PDE4 inhibitors.
-
-
-
-
-
-
-
-
-
搜索结果
13 条记录 (耗时 0.063 秒)
