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公开(公告)号：US20130165371A1
公开(公告)日：2013-06-27
申请号：US13820494
申请日：2011-09-01
申请人： Daniel E. Dobry , James M. Mullin , Douglas L. Millard , Dwayne T. Friesen , David D. Newbold , John M. Baumann , Devon B. Dubose
发明人： Daniel E. Dobry , James M. Mullin , Douglas L. Millard , Dwayne T. Friesen , David D. Newbold , John M. Baumann , Devon B. Dubose
IPC分类号： B01D1/20
摘要： A spray-drying apparatus includes a drying chamber that has a first end, a second end, and at least one side wall extending between the first and second ends to define an interior of the drying chamber having a center axis. A nozzle can be positioned at the first end of the drying chamber and be configured to atomize liquid and spray the atomized liquid into the interior of the drying chamber at a maximum spray pattern angle relative to the center axis. A heating device can be provided to heat the liquid prior to introduction into the drying chamber.
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公开(公告)号：US09084976B2
公开(公告)日：2015-07-21
申请号：US13820494
申请日：2011-09-01
申请人： Daniel E. Dobry , James M. Mullin , Douglas L. Millard , Dwayne T. Friesen , David D. Newbold , John M. Baumann , Devon B. Dubose
发明人： Daniel E. Dobry , James M. Mullin , Douglas L. Millard , Dwayne T. Friesen , David D. Newbold , John M. Baumann , Devon B. Dubose
摘要： A spray-drying apparatus includes a drying chamber that has a first end, a second end, and at least one side wall extending between the first and second ends to define an interior of the drying chamber having a center axis. A nozzle can be positioned at the first end of the drying chamber and be configured to atomize liquid and spray the atomized liquid into the interior of the drying chamber at a maximum spray pattern angle relative to the center axis. A heating device can be provided to heat the liquid prior to introduction into the drying chamber.
摘要翻译： 喷雾干燥设备包括干燥室，其具有第一端，第二端和在第一和第二端之间延伸的至少一个侧壁，以限定具有中心轴线的干燥室的内部。 喷嘴可以位于干燥室的第一端处，并且被配置成雾化液体并且以相对于中心轴线的最大喷射图形角度将雾化的液体喷射到干燥室的内部。 可以提供加热装置以在引入干燥室之前加热液体。
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公开(公告)号：US09724664B2
公开(公告)日：2017-08-08
申请号：US13259082
申请日：2010-03-19
IPC分类号： B01J2/04
CPC分类号： B01J2/04
摘要： The process comprises delivering a spray solution comprising an active agent and a matrix material in an organic solvent to a spray-drying apparatus, atomizing the spray solution into droplets within the spray-drying apparatus to remove at least a portion of the organic solvent from the droplets to form a plurality of particles, and collecting the particles. The spray solution may be formed by forming a feed suspension comprising the active agent, the matrix material, and the organic solvent, wherein the feed suspension is at a temperature T1, and directing the feed suspension to a heat exchanger, thereby increasing the temperature of the feed suspension to a temperature T2, wherein T2 is greater than T1, and the spray solution is at a pressure greater than the vapor pressure of the organic solvent at T2, such that the active agent and matrix material are soluble in the organic solvent at T2.
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公开(公告)号：US09248584B2
公开(公告)日：2016-02-02
申请号：US13825770
申请日：2011-09-22
摘要： The process comprises delivering a spray solution comprising at least one solute in a solvent to a spray-drying apparatus, using a flash nozzle to atomize the spray solution into droplets within the spray-drying apparatus to remove at least a portion of the solvent from the droplets to form a plurality of particles, and collecting the particles. The spray solution is directed to a heat exchanger, thereby increasing the temperature of the spray solution to a temperature T2, wherein T2 is greater than T1. The flash nozzle comprises a central tube through which the spray solution is delivered and an outer tube through which a sweep gas is delivered. The central tube may have a first outer diameter at an inlet and a second outer diameter at an outlet, wherein the first outer diameter is greater than the second outer diameter.
摘要翻译： 该方法包括将包含至少一种溶剂的溶液在溶剂中输送到喷雾干燥装置，使用闪蒸喷嘴将喷雾溶液雾化成喷雾干燥装置内的液滴，以从溶剂中除去至少一部分溶剂 液滴形成多个颗粒，并收集颗粒。 喷雾溶液被引导到热交换器，从而将喷雾溶液的温度升高到T2，其中T2大于T1。 闪光喷嘴包括中心管，喷射溶液通过该中心管和外部管，吹扫气体通过该外部管输送。 中心管可以在入口处具有第一外径，在出口处可以具有第二外径，其中第一外径大于第二外径。
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公开(公告)号：US20120015924A1
公开(公告)日：2012-01-19
申请号：US13259082
申请日：2010-03-19
CPC分类号： B01J2/04
摘要： The process comprises delivering a spray solution comprising an active agent and a matrix material in an organic solvent to a spray-drying apparatus, atomizing the spray solution into droplets within the spray-drying apparatus to remove at least a portion of the organic solvent from the droplets to form a plurality of particles, and collecting the particles. The spray solution may be formed by forming a feed suspension comprising the active agent, the matrix material, and the organic solvent, wherein the feed suspension is at a temperature T1, and directing the feed suspension to a heat exchanger, thereby increasing the temperature of the feed suspension to a temperature T2, wherein T2 is greater than T1, and the spray solution is at a pressure greater than the vapor pressure of the organic solvent at T2, such that the active agent and matrix material are soluble in the organic solvent at T2.
摘要翻译： 该方法包括将包含活性剂和基质材料的喷雾溶液在有机溶剂中输送到喷雾干燥装置，将喷雾溶液雾化成喷雾干燥装置内的液滴，以将至少一部分有机溶剂从 液滴形成多个颗粒，并收集颗粒。 喷雾溶液可以通过形成包含活性剂，基质材料和有机溶剂的进料悬浮液形成，其中进料悬浮液处于温度T1，并将进料悬浮液引导至热交换器，从而提高 进料悬浮液温度T2，其中T2大于T1，并且喷雾溶液的压力大于T2处的有机溶剂的蒸气压，使得活性剂和基质材料可溶于有机溶剂中 T2。
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公开(公告)号：US20130193598A1
公开(公告)日：2013-08-01
申请号：US13825770
申请日：2011-09-22
IPC分类号： B29B9/00
摘要： The process comprises delivering a spray solution comprising at least one solute in a solvent to a spray-drying apparatus, using a flash nozzle to atomize the spray solution into droplets within the spray-drying apparatus to remove at least a portion of the solvent from the droplets to form a plurality of particles, and collecting the particles. The spray solution is directed to a heat exchanger, thereby increasing the temperature of the spray solution to a temperature T2, wherein T2 is greater than T1. The flash nozzle comprises a central tube through which the spray solution is delivered and an outer tube through which a sweep gas is delivered. The central tube may have a first outer diameter at an inlet and a second outer diameter at an outlet, wherein the first outer diameter is greater than the second outer diameter.
摘要翻译： 该方法包括将包含至少一种溶剂的溶液在溶剂中输送到喷雾干燥装置，使用闪蒸喷嘴将喷雾溶液雾化成喷雾干燥装置内的液滴，以从溶剂中除去至少一部分溶剂 液滴形成多个颗粒，并收集颗粒。 喷雾溶液被引导到热交换器，从而将喷雾溶液的温度升高到T2，其中T2大于T1。 闪光喷嘴包括中心管，喷射溶液通过该中心管和外部管，吹扫气体通过该外部管输送。 中心管可以在入口处具有第一外径，在出口处可以具有第二外径，其中第一外径大于第二外径。
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公开(公告)号：US09084944B2
公开(公告)日：2015-07-21
申请号：US13820483
申请日：2011-09-01
CPC分类号： B01D1/20 , A61K9/16 , A61K9/1682 , A61K31/137 , A61K38/22 , A61K38/28 , B01D1/18 , B01J2/04
摘要： A spray-drying apparatus includes a drying chamber that has a first end, a second end, and at least one side wall extending between the first and second ends to define an interior of the drying chamber having a center axis. A nozzle can be positioned at the first end of the drying chamber and be configured to atomize liquid and spray the atomized liquid into the interior of the drying chamber at a maximum spray pattern angle relative to the center axis. A ratio of the length between the first end and second end to a maximum width between opposing internal surfaces of the interior of the drying chamber can be at least 5 to 1.
摘要翻译： 喷雾干燥设备包括干燥室，其具有第一端，第二端和在第一和第二端之间延伸的至少一个侧壁，以限定具有中心轴线的干燥室的内部。 喷嘴可以位于干燥室的第一端处，并且被配置成雾化液体并且以相对于中心轴线的最大喷射图形角度将雾化的液体喷射到干燥室的内部。 第一端部和第二端部之间的长度与干燥室内部的相对的内表面之间的最大宽度的比率可以为至少5比1。
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公开(公告)号：US20130153157A1
公开(公告)日：2013-06-20
申请号：US13820483
申请日：2011-09-01
IPC分类号： B01D1/20
CPC分类号： B01D1/20 , A61K9/16 , A61K9/1682 , A61K31/137 , A61K38/22 , A61K38/28 , B01D1/18 , B01J2/04
摘要： A spray-drying apparatus includes a drying chamber that has a first end, a second end, and at least one side wall extending between the first and second ends to define an interior of the drying chamber having a center axis. A nozzle can be positioned at the first end of the drying chamber and be configured to atomize liquid and spray the atomized liquid into the interior of the drying chamber at a maximum spray pattern angle relative to the center axis. A ratio of the length between the first end and second end to a maximum width between opposing internal surfaces of the interior of the drying chamber can be at least 5 to 1.
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公开(公告)号：US07030338B2
公开(公告)日：2006-04-18
申请号：US10625949
申请日：2003-07-23
申请人： Mark S. Carruthers , Christopher D. Craig , Douglas L. Millard , David D. Newbold , Kenny R. Spence , Avinash G. Thombre
发明人： Mark S. Carruthers , Christopher D. Craig , Douglas L. Millard , David D. Newbold , Kenny R. Spence , Avinash G. Thombre
CPC分类号： B23K26/032 , A61J3/005 , A61J2205/20 , B23K26/04 , B23K26/0648 , B23K26/0665 , B23K26/0838 , B23K26/142 , B23K26/1462 , B23K26/1476 , B23K26/382 , B23K26/40 , B23K2101/35
摘要： A laser drilling system forms an opening in the coating of a pharmaceutical dosage form and includes an orienting assembly to correctly orient dosage forms, a debris removal assembly to reduce buildup of and reduce exposure to drilling debris and a quality control assembly to verify that the opening formed conforms to predetermined specifications.
摘要翻译： 激光钻孔系统在药物剂型的涂层中形成开口，并且包括定向组件以正确地定向剂型，碎屑去除组件以减少钻孔碎片的积聚和减少暴露于钻屑中;以及质量控制组件，以验证开口 形成符合预定规格。
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10.发明授权公开(公告)号：US09499782B2
公开(公告)日：2016-11-22
申请号：US14116123
申请日：2012-05-04
CPC分类号： G01N1/2035 , C12M33/04 , C12M37/00 , G01N1/10 , G01N1/14 , G01N1/20 , G01N2001/1445 , G01N2001/205
摘要： A sample can be collected from an enclosed container by opening a sample collection valve and drawing the sample from the enclosed container. After delivery of the sample out of a fluid flow path, a sanitizing fluid can be directed along the fluid flow path to sanitize the fluid flow path.
摘要翻译： 通过打开样品收集阀并从封闭的容器中抽出样品，可以从封闭的容器收集样品。 在将样品从流体流路传送出去之后，可以沿流体流动路径引导消毒流体以消除流体流动路径。
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