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公开(公告)号：US20130165371A1
公开(公告)日：2013-06-27
申请号：US13820494
申请日：2011-09-01
申请人： Daniel E. Dobry , James M. Mullin , Douglas L. Millard , Dwayne T. Friesen , David D. Newbold , John M. Baumann , Devon B. Dubose
发明人： Daniel E. Dobry , James M. Mullin , Douglas L. Millard , Dwayne T. Friesen , David D. Newbold , John M. Baumann , Devon B. Dubose
IPC分类号： B01D1/20
摘要： A spray-drying apparatus includes a drying chamber that has a first end, a second end, and at least one side wall extending between the first and second ends to define an interior of the drying chamber having a center axis. A nozzle can be positioned at the first end of the drying chamber and be configured to atomize liquid and spray the atomized liquid into the interior of the drying chamber at a maximum spray pattern angle relative to the center axis. A heating device can be provided to heat the liquid prior to introduction into the drying chamber.
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公开(公告)号：US09724664B2
公开(公告)日：2017-08-08
申请号：US13259082
申请日：2010-03-19
IPC分类号： B01J2/04
CPC分类号： B01J2/04
摘要： The process comprises delivering a spray solution comprising an active agent and a matrix material in an organic solvent to a spray-drying apparatus, atomizing the spray solution into droplets within the spray-drying apparatus to remove at least a portion of the organic solvent from the droplets to form a plurality of particles, and collecting the particles. The spray solution may be formed by forming a feed suspension comprising the active agent, the matrix material, and the organic solvent, wherein the feed suspension is at a temperature T1, and directing the feed suspension to a heat exchanger, thereby increasing the temperature of the feed suspension to a temperature T2, wherein T2 is greater than T1, and the spray solution is at a pressure greater than the vapor pressure of the organic solvent at T2, such that the active agent and matrix material are soluble in the organic solvent at T2.
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公开(公告)号：US09248584B2
公开(公告)日：2016-02-02
申请号：US13825770
申请日：2011-09-22
摘要： The process comprises delivering a spray solution comprising at least one solute in a solvent to a spray-drying apparatus, using a flash nozzle to atomize the spray solution into droplets within the spray-drying apparatus to remove at least a portion of the solvent from the droplets to form a plurality of particles, and collecting the particles. The spray solution is directed to a heat exchanger, thereby increasing the temperature of the spray solution to a temperature T2, wherein T2 is greater than T1. The flash nozzle comprises a central tube through which the spray solution is delivered and an outer tube through which a sweep gas is delivered. The central tube may have a first outer diameter at an inlet and a second outer diameter at an outlet, wherein the first outer diameter is greater than the second outer diameter.
摘要翻译： 该方法包括将包含至少一种溶剂的溶液在溶剂中输送到喷雾干燥装置，使用闪蒸喷嘴将喷雾溶液雾化成喷雾干燥装置内的液滴，以从溶剂中除去至少一部分溶剂 液滴形成多个颗粒，并收集颗粒。 喷雾溶液被引导到热交换器，从而将喷雾溶液的温度升高到T2，其中T2大于T1。 闪光喷嘴包括中心管，喷射溶液通过该中心管和外部管，吹扫气体通过该外部管输送。 中心管可以在入口处具有第一外径，在出口处可以具有第二外径，其中第一外径大于第二外径。
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公开(公告)号：US20120015924A1
公开(公告)日：2012-01-19
申请号：US13259082
申请日：2010-03-19
CPC分类号： B01J2/04
摘要： The process comprises delivering a spray solution comprising an active agent and a matrix material in an organic solvent to a spray-drying apparatus, atomizing the spray solution into droplets within the spray-drying apparatus to remove at least a portion of the organic solvent from the droplets to form a plurality of particles, and collecting the particles. The spray solution may be formed by forming a feed suspension comprising the active agent, the matrix material, and the organic solvent, wherein the feed suspension is at a temperature T1, and directing the feed suspension to a heat exchanger, thereby increasing the temperature of the feed suspension to a temperature T2, wherein T2 is greater than T1, and the spray solution is at a pressure greater than the vapor pressure of the organic solvent at T2, such that the active agent and matrix material are soluble in the organic solvent at T2.
摘要翻译： 该方法包括将包含活性剂和基质材料的喷雾溶液在有机溶剂中输送到喷雾干燥装置，将喷雾溶液雾化成喷雾干燥装置内的液滴，以将至少一部分有机溶剂从 液滴形成多个颗粒，并收集颗粒。 喷雾溶液可以通过形成包含活性剂，基质材料和有机溶剂的进料悬浮液形成，其中进料悬浮液处于温度T1，并将进料悬浮液引导至热交换器，从而提高 进料悬浮液温度T2，其中T2大于T1，并且喷雾溶液的压力大于T2处的有机溶剂的蒸气压，使得活性剂和基质材料可溶于有机溶剂中 T2。
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公开(公告)号：US09084976B2
公开(公告)日：2015-07-21
申请号：US13820494
申请日：2011-09-01
申请人： Daniel E. Dobry , James M. Mullin , Douglas L. Millard , Dwayne T. Friesen , David D. Newbold , John M. Baumann , Devon B. Dubose
发明人： Daniel E. Dobry , James M. Mullin , Douglas L. Millard , Dwayne T. Friesen , David D. Newbold , John M. Baumann , Devon B. Dubose
摘要： A spray-drying apparatus includes a drying chamber that has a first end, a second end, and at least one side wall extending between the first and second ends to define an interior of the drying chamber having a center axis. A nozzle can be positioned at the first end of the drying chamber and be configured to atomize liquid and spray the atomized liquid into the interior of the drying chamber at a maximum spray pattern angle relative to the center axis. A heating device can be provided to heat the liquid prior to introduction into the drying chamber.
摘要翻译： 喷雾干燥设备包括干燥室，其具有第一端，第二端和在第一和第二端之间延伸的至少一个侧壁，以限定具有中心轴线的干燥室的内部。 喷嘴可以位于干燥室的第一端处，并且被配置成雾化液体并且以相对于中心轴线的最大喷射图形角度将雾化的液体喷射到干燥室的内部。 可以提供加热装置以在引入干燥室之前加热液体。
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公开(公告)号：US20130193598A1
公开(公告)日：2013-08-01
申请号：US13825770
申请日：2011-09-22
IPC分类号： B29B9/00
摘要： The process comprises delivering a spray solution comprising at least one solute in a solvent to a spray-drying apparatus, using a flash nozzle to atomize the spray solution into droplets within the spray-drying apparatus to remove at least a portion of the solvent from the droplets to form a plurality of particles, and collecting the particles. The spray solution is directed to a heat exchanger, thereby increasing the temperature of the spray solution to a temperature T2, wherein T2 is greater than T1. The flash nozzle comprises a central tube through which the spray solution is delivered and an outer tube through which a sweep gas is delivered. The central tube may have a first outer diameter at an inlet and a second outer diameter at an outlet, wherein the first outer diameter is greater than the second outer diameter.
摘要翻译： 该方法包括将包含至少一种溶剂的溶液在溶剂中输送到喷雾干燥装置，使用闪蒸喷嘴将喷雾溶液雾化成喷雾干燥装置内的液滴，以从溶剂中除去至少一部分溶剂 液滴形成多个颗粒，并收集颗粒。 喷雾溶液被引导到热交换器，从而将喷雾溶液的温度升高到T2，其中T2大于T1。 闪光喷嘴包括中心管，喷射溶液通过该中心管和外部管，吹扫气体通过该外部管输送。 中心管可以在入口处具有第一外径，在出口处可以具有第二外径，其中第一外径大于第二外径。
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公开(公告)号：US5843209A
公开(公告)日：1998-12-01
申请号：US910409
申请日：1997-08-13
CPC分类号： B01D53/22 , B01D53/229 , B01D53/268 , B01D63/02 , B01D63/06 , B01D63/087 , B01D2313/18
摘要： Membrane-based vapor permeation system for selective removal of a vapor from a fluid feed stream, wherein a countercurrent sweep stream is used that has a particular partial pressure of the vapor to be removed.
摘要翻译： 用于从流体进料流中选择性除去蒸汽的膜基蒸汽渗透系统，其中使用具有要除去的蒸气的特定分压的逆流吹扫流。
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公开(公告)号：US5108464A
公开(公告)日：1992-04-28
申请号：US673128
申请日：1991-03-20
CPC分类号： B01D53/22 , B01D53/268 , B01D63/02 , B01D2313/04
摘要： A gas dehydration method and apparatus are disclosed which utilize lumen-side feed, hydrophilic polymer-inside-coated, thin-film composite hollow fiber membranes, the support fiber of which is highly permeable, such composite membranes being used in a module wherein the permeate flows countercurrent to the flow of the feed, and in which dried raffinate gas is mixed with water-containing permeate at a point opposite the feed end of the module.
摘要翻译： 公开了一种利用管腔侧进料，亲水聚合物内涂层，薄膜复合中空纤维膜的气体脱水方法和装置，其中载体纤维是高度可渗透的，这种复合膜用于模块中，其中渗透物 与进料的流动逆流流动，其中在与模块的进料端相对的点处将干燥的残液气体与含水渗透物混合。
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公开(公告)号：US5002590A
公开(公告)日：1991-03-26
申请号：US409428
申请日：1989-09-19
IPC分类号： B01D69/08 , B01D53/22 , B01D53/26 , B01D63/02 , B01D71/02 , B01D71/26 , B01D71/34 , B01D71/54 , B01D71/56 , B01D71/64 , B01D71/66 , B01D71/68 , B01D71/70 , D01D5/24 , D01F6/00 , D01F8/00 , D06M13/51 , D06M13/513 , D06M15/643 , D06M101/00 , D06M101/16 , D06M101/18 , D06M101/30 , D06M101/34
CPC分类号： B01D53/268 , B01D53/22 , B01D63/02 , B01D2319/04
摘要： A gas dehydration method and apparatus are disclosed which utilize lumen-side feed, thin-film which is highly permeable, such composite membranes being used in a module wherein the permeate flows countercurrent to the flow of the feed.
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10.发明授权公开(公告)号：US07625507B2
公开(公告)日：2009-12-01
申请号：US11004165
申请日：2004-12-03
申请人： Roderick J. Ray , Leah E. Appel , David D. Newbold , Dwayne T. Friesen , Scott B. McCray , David K. Lyon , James B. West , Marshall D. Crew , Joshua R. Shockey
发明人： Roderick J. Ray , Leah E. Appel , David D. Newbold , Dwayne T. Friesen , Scott B. McCray , David K. Lyon , James B. West , Marshall D. Crew , Joshua R. Shockey
IPC分类号： B29B9/00
CPC分类号： A61K9/1664 , A61K9/0095 , A61K9/1617 , A61K9/1641 , A61K9/1694 , A61K31/00
摘要： Reduced levels of drug degradation in drug-containing multiparticulates are obtained by an extrusion/melt-congeal process.
摘要翻译： 通过挤出/熔融凝结过程获得含药多颗粒药物降解水平降低。
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