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公开(公告)号：US20100255535A1
公开(公告)日：2010-10-07
申请号：US12817089
申请日：2010-06-16
申请人： Daniel E.H. AFAR , Arthur B. Raitano , Rene S. Hubert , Steve Chappell Mitchell , Aya Jakobovits
发明人： Daniel E.H. AFAR , Arthur B. Raitano , Rene S. Hubert , Steve Chappell Mitchell , Aya Jakobovits
CPC分类号： C07K14/47 , A61K38/00 , C12N2799/026 , Y02A50/465 , Y02A50/473
摘要： The present invention relates to a novel protein designated 20P2H8 which shares homology with several heterogeneous nuclear ribonucleoproteins (hnRNPs). A full length approximately 3600 by 20P2H8 cDNA (SEQ ID NO: 1, encoding a 517 amino acid open reading frame (SEQ ID NO: 2), is provided herein.
摘要翻译： 本发明涉及一种与几种异质核核糖核蛋白（hnRNPs）具有同源性的命名为20P2H8的新型蛋白质。 本文提供了全长约3600×20P2H8的cDNA（SEQ ID NO：1，编码517个氨基酸的开放阅读框（SEQ ID NO：2））。
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公开(公告)号：US20090203024A1
公开(公告)日：2009-08-13
申请号：US12393936
申请日：2009-02-26
申请人： Arthur B. RAITANO , Aya Jakobovits , Mary Faris , Daniel E.H. Afar , Rene S. Hubert , Steve Chappell Mitchell
发明人： Arthur B. RAITANO , Aya Jakobovits , Mary Faris , Daniel E.H. Afar , Rene S. Hubert , Steve Chappell Mitchell
CPC分类号： A61K39/0011 , A61K38/00 , A61K39/00 , A61K2039/505 , A61K2039/53 , C07K14/47 , C07K16/18 , C07K16/3069 , C12Q1/6886 , C12Q2600/106 , C12Q2600/136 , C12Q2600/154 , G01N33/574 , G01N33/57419 , G01N33/57434 , G01N33/57484 , Y02A50/466
摘要： Described is a gene and its encoded secreted tumor antigen, termed 36P6D5, and to diagnostic and therapeutic methods and compositions useful in the management of various cancers which express 36P6D5, particularly including cancers of the bladder, kidney, prostate, breast, colon, ovary, and pancreas.
摘要翻译： 描述了一种基因及其编码的分泌的肿瘤抗原，称为36P6D5，以及可用于治疗表达36P6D5的各种癌症的诊断和治疗方法和组合物，特别包括膀胱，肾，前列腺，乳腺，结肠，卵巢， 和胰腺。
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3.发明申请公开(公告)号：US20080193458A1
公开(公告)日：2008-08-14
申请号：US11857405
申请日：2007-09-18
申请人： Mary Faris , Pia M. Challita-Eid , Steve Chappell Mitchell , Daniel E.H. Afar , Arthur B. Raitano , Aya Jakobovits
发明人： Mary Faris , Pia M. Challita-Eid , Steve Chappell Mitchell , Daniel E.H. Afar , Arthur B. Raitano , Aya Jakobovits
CPC分类号： C07K14/47 , A61K38/00 , A61K39/00 , Y02A50/466
摘要： A novel gene (designated 125P5C8) and its encoded protein are described. While 125P5C8 exhibits tissue specific expression in normal adult tissue, it is aberrantly expressed multiple cancers including prostate, bladder, kidney and colon cancers. Consequently, 125P5C8 provides a diagnostic and/or therapeutic target for cancers, and the 125P5C8 gene or fragment thereof, or its encoded protein or a fragment thereof used to elicit an immune response.
摘要翻译： 描述了一种新型基因（称为125P5C8）及其编码的蛋白质。 虽然125P5C8在正常成人组织中表现出组织特异性表达，但是异常表达多种癌症，包括前列腺癌，膀胱癌，肾癌和结肠癌。 因此，125P5C8提供癌症的诊断和/或治疗靶标，以及用于引发免疫应答的125P5C8基因或其片段，或其编码的蛋白质或其片段。
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4.发明申请84P2A9: A PROSTATE AND TESTIS SPECIFIC PROTEIN HIGHLY EXPRESSED IN PROSTATE CANCER 有权84P2A9：前列腺癌高表达的前列腺特异性蛋白公开(公告)号：US20090170191A1
公开(公告)日：2009-07-02
申请号：US12324707
申请日：2008-11-26
申请人： Aya Jakobovits , Daniel E.H. Afar , Pia M. Challita-Eid , Elana Levin , Steve Chappell Mitchell , Rene S. Hubert
发明人： Aya Jakobovits , Daniel E.H. Afar , Pia M. Challita-Eid , Elana Levin , Steve Chappell Mitchell , Rene S. Hubert
CPC分类号： C07K14/47 , A01K2217/05 , A61K38/00 , A61K39/00 , Y02A50/466
摘要： A novel gene (designated 84P2A9) and its encoded protein is described. While 84P2A9 exhibits prostate and testis specific expression in normal adult tissue, it is aberrantly expressed multiple cancers including prostate, testis, kidney, brain, bone, skin, ovarian, breast, pancreas, colon, lymphocytic and lung cancers. Consequently, 84P2A9 provides a diagnostic and/or therapeutic target for cancers, and the 84P2A9 gene or fragment thereof, or its encoded protein or a fragment thereof used to elicit an immune response.
摘要翻译： 描述了一种新型基因（称为84P2A9）及其编码的蛋白质。 虽然84P2A9在正常成人组织中表现出前列腺和睾丸特异性表达，但是异常表达多种癌症，包括前列腺，睾丸，肾，脑，骨，皮肤，卵巢，乳腺，胰腺，结肠，淋巴细胞和肺癌。 因此，84P2A9提供了用于癌症的诊断和/或治疗靶标，以及用于引发免疫应答的84P2A9基因或其片段或其编码的蛋白质或其片段。
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公开(公告)号：US08101372B2
公开(公告)日：2012-01-24
申请号：US12343170
申请日：2008-12-23
申请人： Rene S. Hubert , Arthur B. Raitano , Daniel E. H. Afar , Steve Chappell Mitchell , Mary Faris , Aya Jakobovits
发明人： Rene S. Hubert , Arthur B. Raitano , Daniel E. H. Afar , Steve Chappell Mitchell , Mary Faris , Aya Jakobovits
IPC分类号： G01N33/574
CPC分类号： G01N33/57434 , A01K2217/05 , A61K39/00 , C07K14/47 , C07K16/18 , C07K16/3069 , C07K2319/00 , C12Q1/6886 , C12Q2600/106 , C12Q2600/112 , C12Q2600/136 , C12Q2600/154 , C12Q2600/158
摘要： The present invention relates to methods and compositions for the diagnosis and therapy of prostate cancer which utilize isolated polynucleotides corresponding to the human SGP28 gene, proteins encoded by the SGP28 gene and fragments thereof, and antibodies capable of specifically recognizing and binding to SGP28 proteins.
摘要翻译： 本发明涉及用于诊断和治疗前列腺癌的方法和组合物，其利用对应于人SGP28基因的分离的多核苷酸，由SGP28基因及其片段编码的蛋白质，以及能够特异性识别和结合SGP28蛋白质的抗体。
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公开(公告)号：US07507541B2
公开(公告)日：2009-03-24
申请号：US11805969
申请日：2007-05-24
申请人： Arthur B. Raitano , Aya Jakobovits , Mary Faris , Daniel E. H. Afar , Rene S. Hubert , Steve Chappell Mitchell
发明人： Arthur B. Raitano , Aya Jakobovits , Mary Faris , Daniel E. H. Afar , Rene S. Hubert , Steve Chappell Mitchell
IPC分类号： G01N33/53
CPC分类号： A61K39/0011 , A61K38/00 , A61K39/00 , A61K2039/505 , A61K2039/53 , C07K14/47 , C07K16/18 , C07K16/3069 , C12Q1/6886 , C12Q2600/106 , C12Q2600/136 , C12Q2600/154 , G01N33/574 , G01N33/57419 , G01N33/57434 , G01N33/57484 , Y02A50/466
摘要： Described is a gene and its encoded secreted tumor antigen, termed 36P6D5, and to diagnostic and therapeutic methods and compositions useful in the management of various cancers which express 36P6D5, particularly including cancers of the bladder, kidney, prostate, breast, colon, ovary and pancreas.
摘要翻译： 描述了一种基因及其编码的分泌型肿瘤抗原，称为36P6D5，以及用于治疗表达36P6D5的各种癌症的诊断和治疗方法和组合物，特别包括膀胱，肾脏，前列腺，乳腺，结肠，卵巢和 胰腺。
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公开(公告)号：US06566078B1
公开(公告)日：2003-05-20
申请号：US09702114
申请日：2000-10-30
申请人： Arthur B. Raitano , Aya Jakobovits , Mary Faris , Daniel E. H. Afar , Rene S. Hubert , Steve Chappell Mitchell
发明人： Arthur B. Raitano , Aya Jakobovits , Mary Faris , Daniel E. H. Afar , Rene S. Hubert , Steve Chappell Mitchell
IPC分类号： G01N3353
CPC分类号： A61K39/0011 , A61K38/00 , A61K39/00 , A61K2039/505 , A61K2039/53 , C07K14/47 , C07K16/18 , C07K16/3069 , C12Q1/6886 , C12Q2600/106 , C12Q2600/136 , C12Q2600/154 , G01N33/574 , G01N33/57419 , G01N33/57434 , G01N33/57484 , Y02A50/466
摘要： Described is a gene and its encoded secreted tumor antigen, termed 36P6D5, and to diagnostic and therapeutic methods and compositions useful in the management of various cancers which express 36P6D5, particularly including cancers of the bladder, kidney, prostate, breast, colon, ovary and pancreas.
摘要翻译： 描述了一种基因及其编码的分泌型肿瘤抗原，称为36P6D5，以及用于治疗表达36P6D5的各种癌症的诊断和治疗方法和组合物，特别包括膀胱，肾脏，前列腺，乳腺，结肠，卵巢和 胰腺。
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公开(公告)号：US07223542B2
公开(公告)日：2007-05-29
申请号：US10365254
申请日：2003-02-11
申请人： Arthur B. Raitano , Aya Jakobovits , Mary Faris , Daniel E. H. Afar , Rene S. Hubert , Steve Chappell Mitchell
发明人： Arthur B. Raitano , Aya Jakobovits , Mary Faris , Daniel E. H. Afar , Rene S. Hubert , Steve Chappell Mitchell
CPC分类号： A61K39/0011 , A61K38/00 , A61K39/00 , A61K2039/505 , A61K2039/53 , C07K14/47 , C07K16/18 , C07K16/3069 , C12Q1/6886 , C12Q2600/106 , C12Q2600/136 , C12Q2600/154 , G01N33/574 , G01N33/57419 , G01N33/57434 , G01N33/57484 , Y02A50/466
摘要： Described is a gene and its encoded secreted tumor antigen, termed 36P6D5, and to diagnostic and therapeutic methods and compositions useful in the management of various cancers which express 36P6D5, particularly including cancers of the bladder, kidney, prostate, breast, colon, ovary and pancreas.
摘要翻译： 描述了一种基因及其编码的分泌型肿瘤抗原，称为36P6D5，以及用于治疗表达36P6D5的各种癌症的诊断和治疗方法和组合物，特别包括膀胱，肾脏，前列腺，乳腺，结肠，卵巢和 胰腺。
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公开(公告)号：US07771968B2
公开(公告)日：2010-08-10
申请号：US12170208
申请日：2008-07-09
申请人： Daniel E. H. Afar , Arthur B. Raitano , Rene S. Hubert , Steve Chappell Mitchell , Aya Jakobovits
发明人： Daniel E. H. Afar , Arthur B. Raitano , Rene S. Hubert , Steve Chappell Mitchell , Aya Jakobovits
IPC分类号： C12N15/00
CPC分类号： C07K14/47 , A61K38/00 , C12N2799/026 , Y02A50/465 , Y02A50/473
摘要： The present invention relates to a novel protein designated 20P2H8 which shares homology with several heterogeneous nuclear ribonucleoproteins (hnRNPs). A full length approximately 3600 bp 20P2H8 cDNA (SEQ ID NO: 1, encoding a 517 amino acid open reading frame (SEQ ID NO: 2), is provided herein.
摘要翻译： 本发明涉及一种与几种异质核核糖核蛋白（hnRNPs）具有同源性的命名为20P2H8的新型蛋白质。 本文提供了全长约3600bp的20P2H8 cDNA（SEQ ID NO：1，编码517个氨基酸的开放阅读框（SEQ ID NO：2））。
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10.发明授权Method of inhibiting growth or survival of a cell by providing an anti-108P5H8 antibody 失效通过提供抗-108P5H8抗体来抑制细胞生长或存活的方法公开(公告)号：US07510840B1
公开(公告)日：2009-03-31
申请号：US10280711
申请日：2002-10-25
申请人： Pia M. Challita-Eid , Mary Faris , Daniel E. H. Afar , Rene S. Hubert , Steve Chappell Mitchell , Elana Levin , Karen Jane Meyrick Morrison , Arthur B. Raitano , Aya Jakobovits
发明人： Pia M. Challita-Eid , Mary Faris , Daniel E. H. Afar , Rene S. Hubert , Steve Chappell Mitchell , Elana Levin , Karen Jane Meyrick Morrison , Arthur B. Raitano , Aya Jakobovits
IPC分类号： G01N33/53 , G01N33/574 , C07K16/00 , A61K39/395
CPC分类号： C07K14/705 , A01K2217/05 , A61K2039/505 , A61K2039/53 , C07K16/18 , C07K2317/21 , Y10S530/809
摘要： A novel gene (designated 108P5H8) and its encoded protein, and variants thereof, are described wherein 108P5H8 exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, 108P5H8 provides a diagnostic, prognostic, prophylactic and/or therapeutic target for cancer. The 108P5H8 gene or fragment thereof, or its encoded protein, or variants thereof, or a fragment thereof, can be used to elicit a humoral or cellular immune response; antibodies or T cells reactive with 191P1E1B can be used in active or passive immunization.
摘要翻译： 描述了一种新型基因（称为108P5H8）及其编码的蛋白及其变体，其中108P5H8在正常成人组织中表现出组织特异性表达，并且在表I中列出的癌症中异常表达。因此，108P5H8提供诊断，预后， 癌症的预防和/或治疗靶标。 108P5H8基因或其片段或其编码的蛋白质或其变体或其片段可用于引发体液或细胞免疫应答; 与191P1E1B反应的抗体或T细胞可用于主动或被动免疫。
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