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1.发明申请公开(公告)号：US20080193458A1
公开(公告)日：2008-08-14
申请号：US11857405
申请日：2007-09-18
申请人： Mary Faris , Pia M. Challita-Eid , Steve Chappell Mitchell , Daniel E.H. Afar , Arthur B. Raitano , Aya Jakobovits
发明人： Mary Faris , Pia M. Challita-Eid , Steve Chappell Mitchell , Daniel E.H. Afar , Arthur B. Raitano , Aya Jakobovits
CPC分类号： C07K14/47 , A61K38/00 , A61K39/00 , Y02A50/466
摘要： A novel gene (designated 125P5C8) and its encoded protein are described. While 125P5C8 exhibits tissue specific expression in normal adult tissue, it is aberrantly expressed multiple cancers including prostate, bladder, kidney and colon cancers. Consequently, 125P5C8 provides a diagnostic and/or therapeutic target for cancers, and the 125P5C8 gene or fragment thereof, or its encoded protein or a fragment thereof used to elicit an immune response.
摘要翻译： 描述了一种新型基因（称为125P5C8）及其编码的蛋白质。 虽然125P5C8在正常成人组织中表现出组织特异性表达，但是异常表达多种癌症，包括前列腺癌，膀胱癌，肾癌和结肠癌。 因此，125P5C8提供癌症的诊断和/或治疗靶标，以及用于引发免疫应答的125P5C8基因或其片段，或其编码的蛋白质或其片段。
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2.发明授权Method of inhibiting growth or survival of a cell by providing an anti-108P5H8 antibody 失效通过提供抗-108P5H8抗体来抑制细胞生长或存活的方法公开(公告)号：US07510840B1
公开(公告)日：2009-03-31
申请号：US10280711
申请日：2002-10-25
申请人： Pia M. Challita-Eid , Mary Faris , Daniel E. H. Afar , Rene S. Hubert , Steve Chappell Mitchell , Elana Levin , Karen Jane Meyrick Morrison , Arthur B. Raitano , Aya Jakobovits
发明人： Pia M. Challita-Eid , Mary Faris , Daniel E. H. Afar , Rene S. Hubert , Steve Chappell Mitchell , Elana Levin , Karen Jane Meyrick Morrison , Arthur B. Raitano , Aya Jakobovits
IPC分类号： G01N33/53 , G01N33/574 , C07K16/00 , A61K39/395
CPC分类号： C07K14/705 , A01K2217/05 , A61K2039/505 , A61K2039/53 , C07K16/18 , C07K2317/21 , Y10S530/809
摘要： A novel gene (designated 108P5H8) and its encoded protein, and variants thereof, are described wherein 108P5H8 exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, 108P5H8 provides a diagnostic, prognostic, prophylactic and/or therapeutic target for cancer. The 108P5H8 gene or fragment thereof, or its encoded protein, or variants thereof, or a fragment thereof, can be used to elicit a humoral or cellular immune response; antibodies or T cells reactive with 191P1E1B can be used in active or passive immunization.
摘要翻译： 描述了一种新型基因（称为108P5H8）及其编码的蛋白及其变体，其中108P5H8在正常成人组织中表现出组织特异性表达，并且在表I中列出的癌症中异常表达。因此，108P5H8提供诊断，预后， 癌症的预防和/或治疗靶标。 108P5H8基因或其片段或其编码的蛋白质或其变体或其片段可用于引发体液或细胞免疫应答; 与191P1E1B反应的抗体或T细胞可用于主动或被动免疫。
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公开(公告)号：US07459539B2
公开(公告)日：2008-12-02
申请号：US10024652
申请日：2001-12-17
申请人： Pia M. Challita-Eid , Mary Faris , Daniel E. H. Afar , Rene S. Hubert , Steve Chappell Mitchell , Elana Levin , Karen Jane Meyrick Morrison , Arthur B. Raitano , Aya Jakobovits
发明人： Pia M. Challita-Eid , Mary Faris , Daniel E. H. Afar , Rene S. Hubert , Steve Chappell Mitchell , Elana Levin , Karen Jane Meyrick Morrison , Arthur B. Raitano , Aya Jakobovits
CPC分类号： C07K14/705 , A01K2217/05 , A61K2039/505 , A61K2039/53 , C07K16/18 , C07K2317/21 , Y10S530/809
摘要： A novel gene (designated 108P5H8) and its encoded protein, and variants thereof, are described wherein 108P5H8 exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, 108P5H8 provides a diagnostic, prognostic, prophylactic and/or therapeutic target for cancer. The 108P5H8 gene or fragment thereof, or its encoded protein, or variants thereof, or a fragment thereof, can be used to elicit a humoral or cellular immune response; antibodies or T cells reactive with 191P1E1B can be used in active or passive immunization.
摘要翻译： 描述了一种新型基因（称为108P5H8）及其编码的蛋白及其变体，其中108P5H8在正常成人组织中表现出组织特异性表达，并且在表I中列出的癌症中异常表达。因此，108P5H8提供诊断，预后， 癌症的预防和/或治疗靶标。 108P5H8基因或其片段或其编码的蛋白质或其变体或其片段可用于引发体液或细胞免疫应答; 与191P1E1B反应的抗体或T细胞可用于主动或被动免疫。
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4.发明申请Nucleic acid and corresponding protein entitled 121P2A3 useful in treatment and detection of cancer 审中-公开核酸和相应的蛋白质121P2A3可用于治疗和检测癌症公开(公告)号：US20080233598A1
公开(公告)日：2008-09-25
申请号：US11704092
申请日：2007-02-06
申请人： Pia M. Challita-Eid , Arthur B. Raitano , Mary Faris , Rene S. Hubert , Steve Chappell Mitchell , Daniel E. H. Afar , Doulas Saffran , Karen Jane Meyrick Morrison , Robert Kendall Morrison , Wangmao Ge , Aya Jakobovits
发明人： Pia M. Challita-Eid , Arthur B. Raitano , Mary Faris , Rene S. Hubert , Steve Chappell Mitchell , Daniel E. H. Afar , Doulas Saffran , Karen Jane Meyrick Morrison , Robert Kendall Morrison , Wangmao Ge , Aya Jakobovits
IPC分类号： G01N33/567 , C07H21/04 , C12N15/00 , C12N5/02
CPC分类号： C07K14/47
摘要： A novel gene (designated 121P2A3) and its encoded protein, and variants thereof, are described wherein 121P2A3 exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, 121P2A3 provides a diagnostic, prognostic, prophylactic and/or therapeutic target for cancer. The 121P2A3 gene or fragment thereof, or its encoded protein, or variants thereof, or a fragment thereof, can be used to elicit a humoral or cellular immune response; antibodies or T cells reactive with 121P2A3 can be used in active or passive immunization.
摘要翻译： 描述了一种新型基因（命名为121P2A3）及其编码的蛋白质及其变体，其中121P2A3在正常成人组织中表现出组织特异性表达，并且在表I中列出的癌症中异常表达。因此，121P2A3提供诊断，预后， 癌症的预防和/或治疗靶标。 121P2A3基因或其片段或其编码的蛋白质或其变体或其片段可用于引发体液或细胞免疫应答; 与121P2A3反应的抗体或T细胞可用于主动或被动免疫。
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公开(公告)号：US07199220B2
公开(公告)日：2007-04-03
申请号：US10283903
申请日：2002-10-29
申请人： Arthur B. Raitano , Daniel E. H. Afar , Gazelle S. Rastegar , Steve Chappell Mitchell , Rene S. Hubert , Pia M. Challita-Eid , Mary Faris , Aya Jakobovits
发明人： Arthur B. Raitano , Daniel E. H. Afar , Gazelle S. Rastegar , Steve Chappell Mitchell , Rene S. Hubert , Pia M. Challita-Eid , Mary Faris , Aya Jakobovits
IPC分类号： C07K14/47 , C07K14/705
CPC分类号： C07K16/30 , A61K2039/505 , C07K16/3069 , C07K2317/622 , C12Q1/6886 , C12Q2600/106 , C12Q2600/136
摘要： A novel gene (designated 103P2D6) and its encoded protein are described. 103P2D6 is not expressed in normal adult tissue, but is highly expressed in prostate tissue xenografts, providing evidence that it is turned on in prostate cancer. 103P2D6 is also expressed in some fetal tissues, and in breast, bladder, lung, bone, colon, pancreatic, testicular, cervical and ovarian cancers. Consequently, 103P2D6 provides a diagnostic and/or therapeutic target for cancers, and the 103P2D6 gene or fragment thereof, or its encoded protein or a fragment thereof can be used to elicit an immune response.
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6.发明授权公开(公告)号：US07834156B2
公开(公告)日：2010-11-16
申请号：US11857405
申请日：2007-09-18
申请人： Mary Faris , Pia M. Challita-Eid , Steve Chappell Mitchell , Daniel E. H. Afar , Arthur B. Raitano , Aya Jakobovits
发明人： Mary Faris , Pia M. Challita-Eid , Steve Chappell Mitchell , Daniel E. H. Afar , Arthur B. Raitano , Aya Jakobovits
CPC分类号： C07K14/47 , A61K38/00 , A61K39/00 , Y02A50/466
摘要： A novel gene (designated 125P5C8) and its encoded protein are described. While 125P5C8 exhibits tissue specific expression in normal adult tissue, it is aberrantly expressed multiple cancers including prostate, bladder, kidney and colon cancers. Consequently, 125P5C8 provides a diagnostic and/or therapeutic target for cancers, and the 125P5C8 gene or fragment thereof, or its encoded protein or a fragment thereof used to elicit an immune response.
摘要翻译： 描述了一种新型基因（称为125P5C8）及其编码的蛋白质。 虽然125P5C8在正常成人组织中表现出组织特异性表达，但是异常表达多种癌症，包括前列腺癌，膀胱癌，肾癌和结肠癌。 因此，125P5C8提供癌症的诊断和/或治疗靶标，以及用于引发免疫应答的125P5C8基因或其片段，或其编码的蛋白质或其片段。
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7.发明授权公开(公告)号：US07534417B2
公开(公告)日：2009-05-19
申请号：US09793451
申请日：2001-02-26
申请人： Arthur B. Raitano , Daniel E. H. Afar , Gazelle S. Rastegar , Steve Chappell Mitchell , Rene S. Hubert , Pia M. Challita-Eid , Mary Faris , Aya Jakobovits
发明人： Arthur B. Raitano , Daniel E. H. Afar , Gazelle S. Rastegar , Steve Chappell Mitchell , Rene S. Hubert , Pia M. Challita-Eid , Mary Faris , Aya Jakobovits
IPC分类号： A61K51/10 , A61K39/395 , C07H21/04 , C07K14/00
CPC分类号： C07K16/30 , A61K2039/505 , C07K16/3069 , C07K2317/622 , C12Q1/6886 , C12Q2600/106 , C12Q2600/136
摘要： A novel gene (designated 103P2D6) and its encoded protein are described. 103P2D6 is not expressed in normal adult tissue, but is highly expressed in prostate tissue xenografts, providing evidence that it is turned on in prostate cancer. 103P2D6 is also expressed in some fetal tissues, and in breast, bladder, lung, bone, colon, pancreatic, testicular, cervical and ovarian cancers. Consequently, 103P2D6 provides a diagnostic and/or therapeutic target for cancers, and the 103P2D6 gene or fragment thereof, or its encoded protein or a fragment thereof can be used to elicit an immune response.
摘要翻译： 描述了一种新型基因（称为103P2D6）及其编码的蛋白质。 103P2D6在正常成人组织中不表达，但在前列腺组织异种移植物中高度表达，提供了在前列腺癌中开启的证据。 103P2D6也在一些胎儿组织，乳腺，膀胱，肺，骨，结肠，胰腺，睾丸，宫颈和卵巢癌中表达。 因此，103P2D6为癌症提供诊断和/或治疗靶标，103P2D6基因或其片段或其编码的蛋白质或其片段可用于引发免疫应答。
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8.发明授权125P5C8: a tissue specific protein highly expressed in various cancers 失效125P5C8：在各种癌症中高度表达的组织特异性蛋白质公开(公告)号：US07271240B2
公开(公告)日：2007-09-18
申请号：US09809638
申请日：2001-03-14
申请人： Mary Faris , Pia M. Challita-Eid , Steve Chappell Mitchell , Daniel E. H. Afar , Arthur B. Raitano , Aya Jakobovits
发明人： Mary Faris , Pia M. Challita-Eid , Steve Chappell Mitchell , Daniel E. H. Afar , Arthur B. Raitano , Aya Jakobovits
CPC分类号： C07K14/47 , A61K38/00 , A61K39/00 , Y02A50/466
摘要： A novel gene (designated 125P5C8) and its encoded protein are described. While 125P5C8 exhibits tissue specific expression in normal adult tissue, it is aberrantly expressed multiple cancers including prostate, bladder, kidney and colon cancers. Consequently, 125P5C8 provides a diagnostic and/or therapeutic target for cancers, and the 125P5C8 gene or fragment thereof, or its encoded protein or a fragment thereof used to elicit an immune response.
摘要翻译： 描述了一种新型基因（称为125P5C8）及其编码的蛋白质。 虽然125P5C8在正常成人组织中表现出组织特异性表达，但是异常表达多种癌症，包括前列腺癌，膀胱癌，肾癌和结肠癌。 因此，125P5C8提供癌症的诊断和/或治疗靶标，以及用于引发免疫应答的125P5C8基因或其片段，或其编码的蛋白质或其片段。
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9.发明授权公开(公告)号：US07172898B2
公开(公告)日：2007-02-06
申请号：US10283722
申请日：2002-10-29
申请人： Arthur B. Raitano , Daniel E. H. Afar , Gazelle S. Rastegar , Steve Chappell Mitchell , Rene S. Hubert , Pia M. Challita-Eid , Mary Faris , Aya Jakobovits
发明人： Arthur B. Raitano , Daniel E. H. Afar , Gazelle S. Rastegar , Steve Chappell Mitchell , Rene S. Hubert , Pia M. Challita-Eid , Mary Faris , Aya Jakobovits
CPC分类号： C07K16/30 , A61K2039/505 , C07K16/3069 , C07K2317/622 , C12Q1/6886 , C12Q2600/106 , C12Q2600/136
摘要： A novel gene (designated 103P2D6) and its encoded protein are described. 103P2D6 is not expressed in normal adult tissue, but is highly expressed in prostate tissue xenografts, providing evidence that it is turned on in prostate cancer. 103P2D6 is also expressed in some fetal tissues, and in breast, bladder, lung, bone, colon, pancreatic, testicular, cervical and ovarian cancers. Consequently, 103P2D6 provides a diagnostic and/or therapeutic target for cancers, and the 103P2D6 gene or fragment thereof, or its encoded protein or a fragment thereof can be used to elicit an immune response.
摘要翻译： 描述了一种新型基因（称为103P2D6）及其编码的蛋白质。 103P2D6在正常成人组织中不表达，但在前列腺组织异种移植物中高度表达，提供了在前列腺癌中开启的证据。 103P2D6也在一些胎儿组织，乳腺，膀胱，肺，骨，结肠，胰腺，睾丸，宫颈和卵巢癌中表达。 因此，103P2D6为癌症提供诊断和/或治疗靶标，103P2D6基因或其片段或其编码的蛋白质或其片段可用于引发免疫应答。
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10.发明授权121P1F1: a tissue specific protein highly expressed in various cancers 失效121P1F1：在各种癌症中高度表达的组织特异性蛋白公开(公告)号：US06924358B2
公开(公告)日：2005-08-02
申请号：US09799250
申请日：2001-03-05
申请人： Pia M. Challita-Eid , Rene S. Hubert , Steve Chappell Mitchell , Arthur B. Raitano , Mary Faris , Daniel E. H. Afar , Aya Jakobovits
发明人： Pia M. Challita-Eid , Rene S. Hubert , Steve Chappell Mitchell , Arthur B. Raitano , Mary Faris , Daniel E. H. Afar , Aya Jakobovits
CPC分类号： G01N33/574 , A61K38/00 , C07K14/47 , Y02A50/465 , Y02A50/473
摘要： A novel gene (designated 121P1F1) and its encoded protein are described. While 121P1F1 exhibits tissue specific expression in normal adult tissue, it is aberrantly expressed in multiple cancers including prostate, bladder, kidney, brain, bone, cervical, uterine, ovarian, breast, pancreatic, stomach, colon, rectal, leukocytic, liver and lung cancers. Consequently, 121P1F1 provides a diagnostic and/or therapeutic target for cancers, and the 121P1F1 gene or fragment thereof, or its encoded protein or a fragment thereof used to elicit an immune response.
摘要翻译： 描述了一种新型基因（称为121P1F1）及其编码的蛋白质。 121P1F1在正常成人组织中表现出组织特异性表达，但其在前列腺，膀胱，肾，脑，骨，子宫颈，子宫，卵巢，乳腺，胰腺，胃，结肠，直肠，白细胞，肝，肺等多种癌症中异常表达 癌症 因此，121P1F1提供癌症的诊断和/或治疗靶标，以及用于引发免疫应答的121P1F1基因或其片段，或其编码的蛋白质或其片段。
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