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公开(公告)号：US20110090316A1
公开(公告)日：2011-04-21
申请号：US12947794
申请日：2010-11-16
CPC分类号： G01N21/763 , A61K49/0013 , G01B9/02004 , G01B9/0203 , G01B9/02041 , G01B11/24 , G01B11/2518 , G01N21/6456 , H04N13/204 , H04N13/25 , H04N13/271
摘要： The present invention provides systems and methods for obtaining a three-dimensional (3D) representation of one or more light sources inside a sample, such as a mammal. Mammalian tissue is a turbid medium, meaning that photons are both absorbed and scattered as they propagate through tissue. In the case where scattering is large compared with absorption, such as red to near-infrared light passing through tissue, the transport of light within the sample is described by diffusion theory. Using imaging data and computer-implemented photon diffusion models, embodiments of the present invention produce a 3D representation of the light sources inside a sample, such as a 3D location, size, and brightness of such light sources.
摘要翻译： 本发明提供用于获得样品（例如哺乳动物）内的一个或多个光源的三维（3D）表示的系统和方法。 哺乳动物组织是一种混浊的培养基，这意味着光子在通过组织传播时被吸收和分散。 在与吸收相比散射大的情况下，例如通过组织的红色至近红外光，通过扩散理论描述样品内的光的传输。 使用成像数据和计算机实现的光子扩散模型，本发明的实施例产生样品内的光源的3D表示，例如这种光源的3D位置，尺寸和亮度。
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公开(公告)号：US07860549B2
公开(公告)日：2010-12-28
申请号：US12569842
申请日：2009-09-29
CPC分类号： G01N21/763 , A61K49/0013 , G01B9/02004 , G01B9/0203 , G01B9/02041 , G01B11/24 , G01B11/2518 , G01N21/6456 , H04N13/204 , H04N13/25 , H04N13/271
摘要： The present invention provides systems and methods for obtaining a three-dimensional (3D) representation of one or more light sources inside a sample, such as a mammal. Mammalian tissue is a turbid medium, meaning that photons are both absorbed and scattered as they propagate through tissue. In the case where scattering is large compared with absorption, such as red to near-infrared light passing through tissue, the transport of light within the sample is described by diffusion theory. Using imaging data and computer-implemented photon diffusion models, embodiments of the present invention produce a 3D representation of the light sources inside a sample, such as a 3D location, size, and brightness of such light sources.
摘要翻译： 本发明提供用于获得样品（例如哺乳动物）内的一个或多个光源的三维（3D）表示的系统和方法。 哺乳动物组织是一种混浊的培养基，这意味着光子在通过组织传播时被吸收和分散。 在与吸收相比散射大的情况下，例如通过组织的红色至近红外光，通过扩散理论描述样品内的光的传输。 使用成像数据和计算机实现的光子扩散模型，本发明的实施例产生样品内的光源的3D表示，例如这种光源的3D位置，尺寸和亮度。
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公开(公告)号：US07616985B2
公开(公告)日：2009-11-10
申请号：US10606976
申请日：2003-06-25
CPC分类号： G01N21/763 , A61K49/0013 , G01B9/02004 , G01B9/0203 , G01B9/02041 , G01B11/24 , G01B11/2518 , G01N21/6456 , H04N13/204 , H04N13/25 , H04N13/271
摘要： The present invention provides systems and methods for obtaining a three-dimensional (3D) representation of one or more light sources inside a sample, such as a mammal. Mammalian tissue is a turbid medium, meaning that photons are both absorbed and scattered as they propagate through tissue. In the case where scattering is large compared with absorption, such as red to near-infrared light passing through tissue, the transport of light within the sample is described by diffusion theory. Using imaging data and computer-implemented photon diffusion models, embodiments of the present invention produce a 3D representation of the light sources inside a sample, such as a 3D location, size, and brightness of such light sources.
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公开(公告)号：US07603167B2
公开(公告)日：2009-10-13
申请号：US11829919
申请日：2007-07-29
CPC分类号： G01N21/763 , A61K49/0013 , G01B9/02004 , G01B9/0203 , G01B9/02041 , G01B11/24 , G01B11/2518 , G01N21/6456 , H04N13/204 , H04N13/25 , H04N13/271
摘要： The present invention provides systems and methods for obtaining a three-dimensional (3D) representation of one or more light sources inside a sample, such as a mammal. Mammalian tissue is a turbid medium, meaning that photons are both absorbed and scattered as they propagate through tissue. In the case where scattering is large compared with absorption, such as red to near-infrared light passing through tissue, the transport of light within the sample is described by diffusion theory. Using imaging data and computer-implemented photon diffusion models, embodiments of the present invention produce a 3D representation of the light sources inside a sample, such as a 3D location, size, and brightness of such light sources.
摘要翻译： 本发明提供用于获得样品（例如哺乳动物）内的一个或多个光源的三维（3D）表示的系统和方法。 哺乳动物组织是一种混浊的培养基，这意味着光子在通过组织传播时被吸收和分散。 在与吸收相比散射大的情况下，例如通过组织的红色至近红外光，通过扩散理论描述样品内的光的传输。 使用成像数据和计算机实现的光子扩散模型，本发明的实施例产生样品内的光源的3D表示，例如这种光源的3D位置，尺寸和亮度。
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公开(公告)号：US08909326B2
公开(公告)日：2014-12-09
申请号：US12947794
申请日：2010-11-16
CPC分类号： G01N21/763 , A61K49/0013 , G01B9/02004 , G01B9/0203 , G01B9/02041 , G01B11/24 , G01B11/2518 , G01N21/6456 , H04N13/204 , H04N13/25 , H04N13/271
摘要： The present invention provides systems and methods for obtaining a three-dimensional (3D) representation of one or more light sources inside a sample, such as a mammal. Mammalian tissue is a turbid medium, meaning that photons are both absorbed and scattered as they propagate through tissue. In the case where scattering is large compared with absorption, such as red to near-infrared light passing through tissue, the transport of light within the sample is described by diffusion theory. Using imaging data and computer-implemented photon diffusion models, embodiments of the present invention produce a 3D representation of the light sources inside a sample, such as a 3D location, size, and brightness of such light sources.
摘要翻译： 本发明提供用于获得样品（例如哺乳动物）内的一个或多个光源的三维（3D）表示的系统和方法。 哺乳动物组织是一种混浊的培养基，这意味着光子在通过组织传播时被吸收和分散。 在与吸收相比散射大的情况下，例如通过组织的红色至近红外光，通过扩散理论描述样品内的光的传输。 使用成像数据和计算机实现的光子扩散模型，本发明的实施例产生样品内的光源的3D表示，例如这种光源的3D位置，尺寸和亮度。
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公开(公告)号：US08279334B2
公开(公告)日：2012-10-02
申请号：US11871062
申请日：2007-10-11
申请人： David Nilson , Michael D. Cable , Bradley W. Rice , Kevin Kearney
发明人： David Nilson , Michael D. Cable , Bradley W. Rice , Kevin Kearney
CPC分类号： G01B11/2513 , A61B5/0059 , A61B5/0064 , A61B5/107 , A61B5/6888 , A61B2503/40 , G01B11/2518 , G01N21/6456 , G01N21/763 , G06T7/521 , H04N13/254
摘要： The present invention integrates a structured light source into an imaging system for reconstructing surface topography of an object being imaged. The structured light source includes a mechanism for transmitting a set of lines onto the object from an angle. The lines are displaced, or phase shifted relative to a stage, when they encounter an object with finite height, such as a mouse. This phase shift provides structured light information for the object. A camera captures the structured light information. Using software that employs a structured light analysis, surface topography data for the object is determined from the phase shift of the lines.
摘要翻译： 本发明将结构化光源集成到成像系统中，用于重建被成像物体的表面形貌。 结构化光源包括用于从一角度将一组线传送到物体上的机构。 当它们遇到具有有限高度的对象（例如鼠标）时，线相对于舞台移位或相移。 该相移提供了对象的结构光信息。 相机拍摄结构光信息。 使用采用结构光分析的软件，根据线的相移确定物体的表面形貌数据。
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公开(公告)号：US07589786B2
公开(公告)日：2009-09-15
申请号：US11486239
申请日：2006-07-12
申请人： David Nilson , Michael D. Cable , Bradley W. Rice
发明人： David Nilson , Michael D. Cable , Bradley W. Rice
CPC分类号： G01N21/6456 , A61B5/0059 , A61B2503/40 , G01N21/763
摘要： Systems and methods are provided for taking images of a sample. The sample is placed in an imaging box comprising a moveable stage that allows images of the sample to be taken from various positions and angles within the imaging box. The images are taken by a camera and sent to a processor. Structured light images obtained from one or more views within the imaging box may be used to build a structured light representations of the sample.
摘要翻译： 提供了用于拍摄样本图像的系统和方法。 将样品放置在包括可移动台的成像盒中，该移动台允许从成像盒内的各种位置和角度拍摄样品的图像。 图像由相机拍摄并发送到处理器。 可以使用从成像盒内的一个或多个视图获得的结构化光图像来构建样品的结构光表示。
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公开(公告)号：US07881773B2
公开(公告)日：2011-02-01
申请号：US11485920
申请日：2006-07-12
申请人： Michael D. Cable , Bradley W. Rice , David Nilson
发明人： Michael D. Cable , Bradley W. Rice , David Nilson
IPC分类号： A61B5/00
CPC分类号： G01N21/76 , A61B5/0035 , A61B5/0059 , A61B5/0077 , A61B6/032 , A61B6/037 , A61B6/4417 , A61B6/5247 , A61B8/13 , A61B8/4416 , G01N21/6456 , G01N35/0099 , G01T1/1603 , G01T1/1648 , G01T1/2985
摘要： The invention described herein provides systems and methods for multi-modal imaging with light and a second form of imaging. Light imaging involves the capture of low intensity light from a light-emitting object. A camera obtains a two-dimensional spatial distribution of the light emitted from the surface of the subject. Software operated by a computer in communication with the camera may then convert two-dimensional spatial distribution data from one or more images into a three-dimensional spatial representation. The second imaging mode may include any imaging technique that compliments light imaging. Examples include magnetic resonance imaging (MRI) and computer topography (CT). An object handling system moves the object to be imaged between the light imaging system and the second imaging system, and is configured to interface with each system.
摘要翻译： 本文描述的本发明提供了用于具有光和第二形式的成像的多模式成像的系统和方法。 光成像涉及捕获来自发光物体的低强度光。 相机获得从被摄体的表面发射的光的二维空间分布。 由与摄像机通信的计算机操作的软件然后可以将二维空间分布数据从一个或多个图像转换为三维空间表示。 第二成像模式可以包括补充光成像的任何成像技术。 实例包括磁共振成像（MRI）和计算机地形（CT）。 物体处理系统将要成像的对象移动到光成像系统和第二成像系统之间，并且被配置为与每个系统接口。
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公开(公告)号：US07190991B2
公开(公告)日：2007-03-13
申请号：US10881707
申请日：2004-06-29
申请人： Michael D. Cable , Bradley W. Rice , David Nilson
发明人： Michael D. Cable , Bradley W. Rice , David Nilson
IPC分类号： A61B5/05
CPC分类号： G01N21/76 , A61B5/0035 , A61B5/0059 , A61B5/0077 , A61B6/032 , A61B6/037 , A61B6/4417 , A61B6/5247 , A61B8/13 , A61B8/4416 , G01N21/6456 , G01N35/0099 , G01T1/1603 , G01T1/1648 , G01T1/2985
摘要： The invention described herein provides systems and methods for multi-modal imaging with light and a second form of imaging. Light imaging involves the capture of low intensity light from a light-emitting object. A camera obtains a two-dimensional spatial distribution of the light emitted from the surface of the subject. Software operated by a computer in communication with the camera may then convert two-dimensional spatial distribution data from one or more images into a three-dimensional spatial representation. The second imaging mode may include any imaging technique that compliments light imaging. Examples include magnetic resonance imaging (MRI) and computer topography (CT). An object handling system moves the object to be imaged between the light imaging system and the second imaging system, and is configured to interface with each system.
摘要翻译： 本文描述的本发明提供了用于具有光和第二形式的成像的多模式成像的系统和方法。 光成像涉及捕获来自发光物体的低强度光。 相机获得从被摄体的表面发射的光的二维空间分布。 由与摄像机通信的计算机操作的软件然后可以将二维空间分布数据从一个或多个图像转换为三维空间表示。 第二成像模式可以包括补充光成像的任何成像技术。 实例包括磁共振成像（MRI）和计算机地形（CT）。 物体处理系统将要成像的对象移动到光成像系统和第二成像系统之间，并且被配置为与每个系统接口。
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公开(公告)号：US07797034B2
公开(公告)日：2010-09-14
申请号：US11127346
申请日：2005-05-11
申请人： Bradley W. Rice , Michael D. Cable , Kevin Kearney
发明人： Bradley W. Rice , Michael D. Cable , Kevin Kearney
CPC分类号： G01N21/763 , A61K49/0013 , G01B9/02004 , G01B9/0203 , G01B9/02041 , G01B11/24 , G01B11/2518 , G01N21/6456 , H04N13/204 , H04N13/25 , H04N13/271
摘要： The present invention provides systems and methods for obtaining a three-dimensional (3D) representation of one or more light sources inside a sample, such as a mammal. Mammalian tissue is a turbid medium, meaning that photons are both absorbed and scattered as they propagate through tissue. In the case where scattering is large compared with absorption, such as red to near-infrared light passing through tissue, the transport of light within the sample is described by diffusion theory. Using imaging data and computer-implemented photon diffusion models, embodiments of the present invention produce a 3D representation of the light sources inside a sample, such as a 3D location, size, and brightness of such light sources.
摘要翻译： 本发明提供用于获得样品（例如哺乳动物）内的一个或多个光源的三维（3D）表示的系统和方法。 哺乳动物组织是一种混浊的培养基，这意味着光子在通过组织传播时被吸收和分散。 在与吸收相比散射大的情况下，例如通过组织的红色至近红外光，通过扩散理论描述样品内的光的传输。 使用成像数据和计算机实现的光子扩散模型，本发明的实施例产生样品内的光源的3D表示，例如这种光源的3D位置，尺寸和亮度。
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