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公开(公告)号:US20080085262A1
公开(公告)日:2008-04-10
申请号:US11952802
申请日:2007-12-07
申请人: Daniel Gorman , J. Bazan , Robert Kastelein , Gerard Zurawski
发明人: Daniel Gorman , J. Bazan , Robert Kastelein , Gerard Zurawski
CPC分类号: C07K14/52 , A61K38/00 , C07K14/54 , G01N33/6869
摘要: CTLA-8 related antigens from mammals, reagents related thereto including purified proteins, specific antibodies, and nucleic acids encoding said antigens. Methods of using said reagents and diagnostic kits are also provided.
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公开(公告)号:US20080090993A1
公开(公告)日:2008-04-17
申请号:US11952779
申请日:2007-12-07
申请人: Daniel Gorman , J. Bazan , Robert Kastelein , Gerard Zurawski
发明人: Daniel Gorman , J. Bazan , Robert Kastelein , Gerard Zurawski
CPC分类号: C07K14/52 , A61K38/00 , C07K14/54 , G01N33/6869
摘要: CTLA-8 related antigens from mammals, reagents related thereto including purified proteins, specific antibodies, and nucleic acids encoding said antigens. Methods of using said reagents and diagnostic kits are also provided.
摘要翻译: 来自哺乳动物的CTLA-8相关抗原,与其相关的试剂,包括纯化的蛋白质,特异性抗体和编码所述抗原的核酸。 还提供了使用所述试剂和诊断试剂盒的方法。
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公开(公告)号:US20070065918A1
公开(公告)日:2007-03-22
申请号:US11604559
申请日:2006-11-27
申请人: Daniel Gorman , J. Bazan , Robert Kastelein , Gerard Zurawski
发明人: Daniel Gorman , J. Bazan , Robert Kastelein , Gerard Zurawski
CPC分类号: C07K14/52 , A61K38/00 , C07K14/54 , G01N33/6869
摘要: CTLA-8 related antigens from mammals, reagents related thereto including purified proteins, specific antibodies, and nucleic acids encoding said antigens. Methods of using said reagents and diagnostic kits are also provided.
摘要翻译: 来自哺乳动物的CTLA-8相关抗原,与其相关的试剂,包括纯化的蛋白质,特异性抗体和编码所述抗原的核酸。 还提供了使用所述试剂和诊断试剂盒的方法。
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公开(公告)号:US20050106673A1
公开(公告)日:2005-05-19
申请号:US11016106
申请日:2004-12-17
IPC分类号: C07K14/705 , C07H21/04
CPC分类号: C07K14/705
摘要: Nucleic acids encoding mammalian, e.g., primate, receptors, purified receptor proteins and fragments thereof. Antibodies, both polyclonal and monoclonal, are also provided. Methods of using the compositions for both diagnostic and therapeutic utilities are described.
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公开(公告)号:US20070160579A1
公开(公告)日:2007-07-12
申请号:US11682224
申请日:2007-03-05
申请人: Jochen Schmitz , Martin Oft , Robert Kastelein , J. Bazan
发明人: Jochen Schmitz , Martin Oft , Robert Kastelein , J. Bazan
IPC分类号: A61K38/20 , A61K38/17 , A61K48/00 , A61K39/395
CPC分类号: G01N33/6869 , A61K38/00 , A61K38/20 , A61K2039/505 , C07K16/244 , C07K16/2866 , C07K2317/76 , Y02A50/41 , Y02A50/423
摘要: Provided are methods of modulating cytokine activity, e.g., for the purpose of treating immune and inflammatory disorders, including tumors and cancer. Also provided are methods of administering agonists or antagonists of IL-33 and IL-33 receptor.
摘要翻译: 提供了调节细胞因子活性的方法,例如用于治疗免疫和炎性疾病(包括肿瘤和癌症)的目的。 还提供施用IL-33和IL-33受体的激动剂或拮抗剂的方法。
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公开(公告)号:US20050014199A1
公开(公告)日:2005-01-20
申请号:US10927228
申请日:2004-08-25
申请人: Pedro Reche-Gallardo , Vassilli Soumelis , Yong-Jun Liu , Rene de Waal Malefyt , J. Bazan , Robert Kastelein
发明人: Pedro Reche-Gallardo , Vassilli Soumelis , Yong-Jun Liu , Rene de Waal Malefyt , J. Bazan , Robert Kastelein
IPC分类号: C07K14/54 , C07K14/715 , C12N15/12 , G01N33/53
CPC分类号: C07K16/244 , C07K14/54 , C07K14/7155 , G01N33/6863 , G01N33/6869 , G01N2333/54 , G01N2500/02
摘要: Nucleic acids encoding mammalian cytokine receptor, e.g., for cytokine IL-B50, purified proteins and fragments thereof Antibodies, both polyclonal and monoclonal, are also provided. Methods of using the compositions for both diagnostic and therapeutic utilities are described.
摘要翻译: 编码哺乳动物细胞因子受体的核酸,例如用于细胞因子IL-B50,纯化的蛋白质和其片段。还提供了多克隆和单克隆抗体。 描述了用于诊断和治疗用途的组合物的方法。
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公开(公告)号:US20080025974A1
公开(公告)日:2008-01-31
申请号:US11844179
申请日:2007-08-23
申请人: Gerard Hardiman , Fernando Rock , J. Bazan , Robert Kastelein , Stephen Ho , Yong-Jun Liu
发明人: Gerard Hardiman , Fernando Rock , J. Bazan , Robert Kastelein , Stephen Ho , Yong-Jun Liu
CPC分类号: C07K14/705 , A61K38/00 , C07K2319/00
摘要: Nucleic acids encoding mammalian Toll-like receptors (TLRs) have been identified in human cells. Recombinantly produced TLRs are used in the preparation of antibodies that are capable of binding to the TLRs. The antibodies are advantageously used in the prevention and treatment of septic shock, inflammatory conditions, and viral infections.
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公开(公告)号:US20050112659A1
公开(公告)日:2005-05-26
申请号:US10975909
申请日:2004-10-28
申请人: Gerard Hardiman , Fernando Rock , J. Bazan , Robert Kastelein , Stephen Ho , Yong-Jun Liu
发明人: Gerard Hardiman , Fernando Rock , J. Bazan , Robert Kastelein , Stephen Ho , Yong-Jun Liu
IPC分类号: A61K38/00 , C07K14/705 , C12Q1/68 , C07H21/04 , C07K16/28
CPC分类号: C07K14/705 , A61K38/00 , C07K2319/00
摘要: Nucleic acids encoding mammalian Toll-like receptors (TLRs) have been identified in human cells. Recombinantly produced TLRs are used in the preparation of antibodies that are capable of binding to the TLRs. The antibodies are advantageously used in the prevention and treatment of septic shock, inflammatory conditions, and viral infections.
摘要翻译: 已经在人细胞中鉴定了编码哺乳动物Toll样受体(TLR)的核酸。 重组产生的TLR用于制备能够结合TLR的抗体。 抗体有利地用于预防和治疗败血性休克,炎性病症和病毒感染。
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公开(公告)号:US20060110386A1
公开(公告)日:2006-05-25
申请号:US11297957
申请日:2005-12-09
申请人: Pedro Reche-Gallardo , Vassili Soumelis , Yong-Jun Liu , Rene de Waal Malefyt , J. Bazan , Robert Kastelein
发明人: Pedro Reche-Gallardo , Vassili Soumelis , Yong-Jun Liu , Rene de Waal Malefyt , J. Bazan , Robert Kastelein
IPC分类号: G01N33/567 , A61K39/395 , G01N33/53
CPC分类号: C07K16/244 , C07K14/54 , C07K14/7155 , G01N33/6863 , G01N33/6869 , G01N2333/54 , G01N2500/02
摘要: Nucleic acids encoding mammalian cytokine receptor, e.g., for cytokine IL-B50, purified proteins and fragments thereof. Antibodies, both polyclonal and monoclonal, are also provided. Methods of using the compositions for both diagnostic and therapeutic utilities are described.
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公开(公告)号:US20050048625A1
公开(公告)日:2005-03-03
申请号:US10777789
申请日:2004-02-11
申请人: Birgit Oppmann , Jacqueline Timans , Robert Kastelein , J. Bazan
发明人: Birgit Oppmann , Jacqueline Timans , Robert Kastelein , J. Bazan
摘要: Purified genes encoding cytokine from a mammal, reagents related thereto including purified proteins, specific antibodies, and nucleic acids encoding this molecule are provided. Methods of using said reagents and diagnostic kits are also provided.
摘要翻译: 提供了编码哺乳动物细胞因子的纯化基因,与其相关的试剂,包括纯化蛋白质,特异性抗体和编码该分子的核酸。 还提供了使用所述试剂和诊断试剂盒的方法。
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