利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

12 条记录 (耗时 0.043 秒)

    Use of biomolecular targets in the treatment and visualization of tumors
    6.
    发明授权
    Use of biomolecular targets in the treatment and visualization of tumors 有权
    在肿瘤治疗和可视化中使用生物分子靶标

    公开(公告)号：US07368098B2

    公开(公告)日：2008-05-06

    申请号：US10328544

    申请日：2002-12-23

    申请人： Sabine Mueller ,  Mirella Gonzalez-Zulueta ,  Erik Foehr ,  Daniel J. Chin

    发明人： Sabine Mueller ,  Mirella Gonzalez-Zulueta ,  Erik Foehr ,  Daniel J. Chin

    IPC分类号： G01N33/574

    CPC分类号： A61K49/0004 ,  C12Q1/6886 ,  C12Q2600/136 ,  C12Q2600/158 ,  G01N33/574

    摘要： The present invention relates to the use of a protein that is differentially expressed in primary brain tumor tissues, as compared to normal brain tissues, as a biomolecular target for tumor treatment therapies. The protein is also expressed in tissues from adenocarcinoma, non-melanoma, and renal carcinoma cells. Immunotherapeutic and immunoimaging agents that specifically bind to an identified brain tumor target protein are provided. The present invention also provides compounds and pharmaceutically acceptable compositions for administration in the methods of the invention.

    摘要翻译： 本发明涉及与正常脑组织相比，在原发性脑肿瘤组织中差异表达的蛋白质作为肿瘤治疗疗法的生物分子靶标的用途。 该蛋白质也在来自腺癌，非黑素瘤和肾癌细胞的组织中表达。 提供特异性结合鉴定的脑肿瘤靶蛋白的免疫治疗和免疫成像剂。 本发明还提供了用于本发明方法中给药的化合物和药学上可接受的组合物。

    Use of biomolecular targets in the treatment and visualization of brain tumors
    7.
    发明申请
    Use of biomolecular targets in the treatment and visualization of brain tumors 审中-公开
    在脑肿瘤的治疗和可视化中使用生物分子靶标

    公开(公告)号：US20070025997A1

    公开(公告)日：2007-02-01

    申请号：US11413566

    申请日：2006-04-27

    申请人： Usha Nagavarapu ,  David Shivak ,  Daniel Chin ,  Erik Foehr ,  Mirella Gonzalez-Zulueta

    发明人： Usha Nagavarapu ,  David Shivak ,  Daniel Chin ,  Erik Foehr ,  Mirella Gonzalez-Zulueta

    IPC分类号： A61K39/395 ,  C12Q1/68 ,  G01N33/574

    CPC分类号： C12Q1/6886 ,  A61K2039/505 ,  C07K16/2851 ,  C12Q2600/112 ,  C12Q2600/136 ,  C12Q2600/158 ,  G01N33/57407

    摘要： The present invention relates to the use of proteins that are differentially expressed in primary brain tumor tissues, as compared to normal brain tissues, as biomolecular targets for brain tumor treatment therapies. Specifically, the present invention relates to the use of therapeutic and imaging agents, which specifically bind to one or more of the identified brain tumor protein targets. The present invention also provides compounds and pharmaceutically acceptable compositions for administration in the methods of the invention. Nucleic acid probes specific for the spliced mRNA encoding these variants and affinity reagents specific for the novel proteins are also provided.

    摘要翻译： 本发明涉及与正常脑组织相比，在原发性脑肿瘤组织中差异表达的蛋白质作为脑肿瘤治疗疗法的生物分子靶标的用途。 具体地，本发明涉及特异性结合一种或多种所鉴定的脑肿瘤蛋白靶标的治疗和显像剂的用途。 本发明还提供了用于本发明方法中给药的化合物和药学上可接受的组合物。 还提供了针对编码这些变体的剪接mRNA特异性的核酸探针和对新蛋白特异的亲和试剂。

    Use of biomolecular targets in the treatment and visualization of brain tumors
    8.
    发明授权
    Use of biomolecular targets in the treatment and visualization of brain tumors 有权
    在脑肿瘤的治疗和可视化中使用生物分子靶标

    公开(公告)号：US07014838B2

    公开(公告)日：2006-03-21

    申请号：US10329258

    申请日：2002-12-23

    申请人： Sabine Mueller ,  Mirella Gonzalez-Zulueta ,  Erik Foehr ,  Daniel J. Chin

    发明人： Sabine Mueller ,  Mirella Gonzalez-Zulueta ,  Erik Foehr ,  Daniel J. Chin

    IPC分类号： A61K51/00 ,  A61M36/14

    CPC分类号： A61K49/0004 ,  C12Q1/6886 ,  C12Q2600/136 ,  C12Q2600/158 ,  G01N33/574

    摘要： The present invention relates to the use of proteins that are differentially expressed in primary brain tumor tissues, as compared to normal brain tissues, as biomolecular targets for brain tumor treatment therapies. Specifically, the present invention relates to the use of immunotherapeutic and immunoimaging agents, which specifically bind to one or more of the identified brain tumor protein targets. The present invention also provides compounds and pharmaceutically acceptable compositions for administration in the methods of the invention. Nucleic acid probes specific for the spliced mRNA encoding these variants and affinity reagents specific for the novel proteins are also provided.

    摘要翻译： 本发明涉及与正常脑组织相比，在原发性脑肿瘤组织中差异表达的蛋白质作为脑肿瘤治疗疗法的生物分子靶标的用途。 具体地，本发明涉及特异性结合一种或多种所鉴定的脑肿瘤蛋白靶标的免疫治疗和免疫成像剂的用途。 本发明还提供了用于本发明方法中给药的化合物和药学上可接受的组合物。 还提供了针对编码这些变体的剪接mRNA特异性的核酸探针和对新蛋白特异的亲和试剂。