公开(公告)号：US20070025997A1

公开(公告)日：2007-02-01

申请号：US11413566

申请日：2006-04-27

申请人： Usha Nagavarapu ,  David Shivak ,  Daniel Chin ,  Erik Foehr ,  Mirella Gonzalez-Zulueta

发明人： Usha Nagavarapu ,  David Shivak ,  Daniel Chin ,  Erik Foehr ,  Mirella Gonzalez-Zulueta

IPC分类号： A61K39/395 ,  C12Q1/68 ,  G01N33/574

CPC分类号： C12Q1/6886 ,  A61K2039/505 ,  C07K16/2851 ,  C12Q2600/112 ,  C12Q2600/136 ,  C12Q2600/158 ,  G01N33/57407

摘要： The present invention relates to the use of proteins that are differentially expressed in primary brain tumor tissues, as compared to normal brain tissues, as biomolecular targets for brain tumor treatment therapies. Specifically, the present invention relates to the use of therapeutic and imaging agents, which specifically bind to one or more of the identified brain tumor protein targets. The present invention also provides compounds and pharmaceutically acceptable compositions for administration in the methods of the invention. Nucleic acid probes specific for the spliced mRNA encoding these variants and affinity reagents specific for the novel proteins are also provided.

摘要翻译： 本发明涉及与正常脑组织相比，在原发性脑肿瘤组织中差异表达的蛋白质作为脑肿瘤治疗疗法的生物分子靶标的用途。 具体地，本发明涉及特异性结合一种或多种所鉴定的脑肿瘤蛋白靶标的治疗和显像剂的用途。 本发明还提供了用于本发明方法中给药的化合物和药学上可接受的组合物。 还提供了针对编码这些变体的剪接mRNA特异性的核酸探针和对新蛋白特异的亲和试剂。

公开(公告)号：US20060024233A1

公开(公告)日：2006-02-02

申请号：US10329258

申请日：2002-12-23

申请人： Sabine Mueller ,  Mirella Gonzalez-Zulueta ,  Erik Foehr ,  Daniel Chin

发明人： Sabine Mueller ,  Mirella Gonzalez-Zulueta ,  Erik Foehr ,  Daniel Chin

IPC分类号： A61K51/00 ,  A61K49/00

CPC分类号： A61K49/0004 ,  C12Q1/6886 ,  C12Q2600/136 ,  C12Q2600/158 ,  G01N33/574

摘要： The present invention relates to the use of proteins that are differentially expressed in primary brain tumor tissues, as compared to normal brain tissues, as biomolecular targets for brain tumor treatment therapies. Specifically, the present invention relates to the use of immunotherapeutic and immunoimaging agents, which specifically bind to one or more of the identified brain tumor protein targets. The present invention also provides compounds and pharmaceutically acceptable compositions for administration in the methods of the invention. Nucleic acid probes specific for the spliced mRNA encoding these variants and affinity reagents specific for the novel proteins are also provided.

摘要翻译： 本发明涉及与正常脑组织相比，在原发性脑肿瘤组织中差异表达的蛋白质作为脑肿瘤治疗疗法的生物分子靶标的用途。 具体地，本发明涉及特异性结合一种或多种所鉴定的脑肿瘤蛋白靶标的免疫治疗和免疫成像剂的用途。 本发明还提供了用于本发明方法中给药的化合物和药学上可接受的组合物。 还提供了针对编码这些变体的剪接mRNA特异性的核酸探针和对新蛋白特异的亲和试剂。

公开(公告)号：US06670138B2

公开(公告)日：2003-12-30

申请号：US10001051

申请日：2001-10-31

申请人： Mirella Gonzalez-Zulueta ,  Mehrdad Shamloo ,  K.C. McFarland ,  Daniel Chin ,  Tadeusz Wieloch ,  Thorsten Melcher

发明人： Mirella Gonzalez-Zulueta ,  Mehrdad Shamloo ,  K.C. McFarland ,  Daniel Chin ,  Tadeusz Wieloch ,  Thorsten Melcher

IPC分类号： C12Q170

CPC分类号： C12Q1/6883 ,  C12Q2600/158

摘要： The present invention identifies a gene whose gene product provides a protective effect against neurological disorders or neuronal injuries. Further, the invention provides methods for diagnosing or assessing an individual's susceptibility to a neuronal injury such as stroke. Also provided are therapeutic methods for treating patients, and methods for prophylactically treating individuals susceptible to various neurological disorders or neuronal injuries. Additionally, the invention describes screening methods for identifying agents that can be administered to treat individuals that have suffered or are at risk to suffer such disorders or injuries.

摘要翻译： 本发明鉴定其基因产物对神经系统疾病或神经元损伤具有保护作用的基因。 此外，本发明提供了用于诊断或评估个体对诸如中风的神经元损伤的易感性的方法。 还提供了用于治疗患者的治疗方法，以及用于预防性治疗对各种神经障碍或神经元损伤敏感的个体的方法。 另外，本发明描述了用于鉴定可以被施用以治疗遭受或有遭受这种障碍或损伤风险的个体的药剂的筛选方法。

公开(公告)号：US06841351B2

公开(公告)日：2005-01-11

申请号：US10027807

申请日：2001-10-19

申请人： Li Gan ,  Mirella Gonzalez-Zulueta ,  Kristin Anton ,  Richa Wilson ,  Thorsten Melcher ,  Daniel Chin

发明人： Li Gan ,  Mirella Gonzalez-Zulueta ,  Kristin Anton ,  Richa Wilson ,  Thorsten Melcher ,  Daniel Chin

IPC分类号： C12N15/10 ,  C12Q1/68 ,  C07H21/04 ,  C12P19/34 ,  G01N33/566

CPC分类号： C12N15/1086

摘要： Methods for correlating genes and gene function are provided. Such methods generally involve selecting a candidate gene that appears to be correlated with a particular cellular state or activity and then validating the role of the candidate gene in establishment of such a cellular state or activity. Certain methods utilized RNA interference techniques in the validation process.

摘要翻译： 提供了相关基因和基因功能的方法。 这样的方法通常包括选择似乎与特定细胞状态或活性相关的候选基因，然后验证候选基因在建立这种细胞状态或活性中的作用。 某些方法在验证过程中使用RNA干扰技术。

公开(公告)号：US20050260132A1

公开(公告)日：2005-11-24

申请号：US11097728

申请日：2005-03-31

申请人： Daniel Chin ,  Erik Foehr ,  Sabine Mueller ,  Thorsten Melcher

发明人： Daniel Chin ,  Erik Foehr ,  Sabine Mueller ,  Thorsten Melcher

IPC分类号： A61K39/395 ,  A61K47/48 ,  A61K51/00 ,  C07K16/28 ,  C07K16/30

CPC分类号： C07K16/3023 ,  A61K47/6819 ,  A61K47/6849 ,  A61K47/6855 ,  A61K47/6857 ,  A61K47/6861 ,  A61K47/6865 ,  A61K2039/505 ,  C07K16/28 ,  C07K16/3015 ,  C07K16/3038 ,  C07K16/3053 ,  C07K2317/73 ,  C07K2317/76 ,  C07K2317/77 ,  C07K2317/92

摘要： The present invention relates to a method of inhibiting growth of tumor cells which overexpress a receptor protein tyrosine phosphatase zeta (PTPζ) by treatment of the cells with antibodies which recognize PTPζ and/or inhibit PTPζ function. The present invention also provides compounds and pharmaceutically acceptable compositions for administration in the methods of the invention. The present invention also provides novel splice variants of protein PTPζ, PTPζ SM1 and PTPζ SM2. Nucleic acid probes specific for the spliced mRNA encoding these variants and affinity reagents specific for the novel proteins are also provided.

摘要翻译： 本发明涉及通过用识别PTPzeta和/或抑制PTPzeta功能的抗体处理细胞来抑制过表达受体蛋白酪氨酸磷酸酶ζ（PTPzeta）的肿瘤细胞生长的方法。 本发明还提供了用于本发明方法中给药的化合物和药学上可接受的组合物。 本发明还提供蛋白质PTPzeta，PTPzeta SM1和PTPzeta SM2的新型剪接变体。 还提供了针对编码这些变体的剪接mRNA特异性的核酸探针和对新蛋白特异的亲和试剂。

公开(公告)号：US06328638B1

公开(公告)日：2001-12-11

申请号：US09491684

申请日：2000-01-26

申请人： Jordan J. Hopkins ,  Jonathan M. Stewart ,  Felice M. Sciulli ,  Katherine Zaring ,  Daniel Chin ,  John Massenburg ,  Daniel Devine

发明人： Jordan J. Hopkins ,  Jonathan M. Stewart ,  Felice M. Sciulli ,  Katherine Zaring ,  Daniel Chin ,  John Massenburg ,  Daniel Devine

IPC分类号： B24B900

CPC分类号： B01D21/2416 ,  B01D21/0039 ,  B01D21/0045 ,  B01D21/0063 ,  B01D21/009 ,  B01D21/2494 ,  B24C1/045 ,  B24C9/003 ,  B24C9/006 ,  B26F3/008 ,  Y02P70/179

摘要： An improved apparatus and methods for recovering abrasive from an abrasive-laden fluid are shown and described. An abrasive-laden fluid handling device is coupled to a catcher tank to collect abrasive-laden fluid and transport it to a hydro-classifier. Wet recovered abrasive is discharged from the hydro-classifier and transferred to a de-watering device. The de-watering device removes water from the abrasive by decanting fluid and via use of an air eduction system. De-watered abrasive is then ejected from the de-watering device to a dryer unit, to be further dried and processed for reuse.

摘要翻译： 显示和描述了一种改进的从含磨料流体中回收磨料的设备和方法。 装载磨料的流体处理装置联接到捕集罐以收集磨料载流体并将其输送到加氢分级器。 湿回收的磨料从加氢分级机排出并转移到脱水装置。 脱水装置通过倾析流体和通过使用空气排出系统从磨料中除去水分。 然后将脱水的研磨剂从脱水装置喷射到干燥器单元，以进一步干燥和处理以便重新使用。

公开(公告)号：US07060275B2

公开(公告)日：2006-06-13

申请号：US10652981

申请日：2003-08-28

申请人： Sabine Mueller ,  Thorsten Melcher ,  Daniel Chin

发明人： Sabine Mueller ,  Thorsten Melcher ,  Daniel Chin

IPC分类号： A61K39/395 ,  A61K39/40 ,  C07H21/02

CPC分类号： A61K49/0002

摘要： The present invention relates to the use of proteins which are differentially expressed in primary brain tumor tissues, as compared to normal brain tissues, as biomolecular targets for brain tumor treatment therapies. Specifically, the present invention relates to the use of immunotherapeutic and immunoimaging agents which specifically bind to one or more of human proteins angiopoietin related protein 2 (ARP-2,) secreted protein acidic, rich in cysteine (SPARC,) c-met proto-oncogene (C-MET,) brevican (BEHAB,) CD-44 antigen (CD-44,) tetraspanin 3 (TSPN3,) pleiotrophin (PTN,) osteopontin (OPN,) vasoactive intestinal peptide receptor-2 (VIPR-2,) and receptor protein tyrosine phosphatase zeta (PTPζ) for the treatment and visualization of brain tumors in patients. The present invention also provides compounds and pharmaceutically acceptable compositions for administration in the methods of the invention. The present invention also provides novel splice variants of protein PTPζ, PTPζ SM1 and PTPζ SM2. Nucleic acid probes specific for the spliced mRNA encoding these variants and affinity reagents specific for the novel proteins are also provided.

公开(公告)号：US06379214B1

公开(公告)日：2002-04-30

申请号：US09382554

申请日：1999-08-25

申请人： Jonathan M. Stewart ,  Thomas Pesek ,  Volker Kern ,  Chien Chou Wu ,  Daniel Chin ,  Felice M. Sciulli

发明人： Jonathan M. Stewart ,  Thomas Pesek ,  Volker Kern ,  Chien Chou Wu ,  Daniel Chin ,  Felice M. Sciulli

IPC分类号： B24C100

CPC分类号： B26F3/004 ,  B23Q5/58 ,  B23Q11/04 ,  B23Q17/005 ,  B24C1/045 ,  B26D7/22 ,  B26D7/24 ,  Y10T83/0443 ,  Y10T83/0591 ,  Y10T83/096 ,  Y10T83/145 ,  Y10T83/364

摘要： This invention relates to apparatus and methods for z-axis control and collision detection and recovery for waterjet and abrasive-jet cutting systems. In one embodiment, an apparatus includes a linear rail, a slide member coupleable to a cutting head and slideably coupled to the linear rail, at least one actuator having a first end coupled to the slide member and a second end fixed with respect to the linear rail, a position sensor, and a controller. The actuator provides an adjustable support force that supports the weight of the cutting head, allowing the cutting head to be controllably positioned at a desired height above the workpiece. The actuator may include a pneumatic cylinder, or alternately, a linear motor. In another aspect, an apparatus includes a first mount member coupleable to a controllably positionable mounting surface of the waterjet cutting system, a second mount member coupleable to the cutting head and disengageably coupled to the first mount member, and a sensing circuit having a plurality of first conductive elements disposed on the first mount member and a plurality of second conductive elements disposed on the second mount member. In the event of a collision between the cutting head and an obstruction, the second mount member disengages from the first mount member to prevent breakage of the cutting head. Following the collision, the second mount member is quickly and easily re-engaged with the first mount member without time-consuming re-calibration. In one embodiment, re-engagement of the second end first mount members is automatically performed by a biasing member.

摘要翻译： 本发明涉及用于水射流和磨料喷射切割系统的z轴控制和碰撞检测和回收的装置和方法。 在一个实施例中，一种装置包括线性轨道，可耦合到切割头并且可滑动地联接到线性轨道的滑动构件，至少一个致动器，其具有联接到滑动构件的第一端和相对于线性轨道固定的第二端 导轨，位置传感器和控制器。 致动器提供可调节的支撑力，其支撑切割头的重量，允许切割头被可控地定位在工件上方的期望高度处。 致动器可以包括气缸，或者可以包括线性马达。 在另一方面，一种装置包括可连接到水刀切割系统的可控地定位的安装表面的第一安装构件，可耦合到切割头并且可分离地联接到第一安装构件的第二安装构件，以及具有多个 设置在第一安装构件上的第一导电元件和设置在第二安装构件上的多个第二导电元件。 在切割头和障碍物之间发生碰撞的情况下，第二安装构件与第一安装构件脱离，以防止切割头的断裂。 在碰撞之后，第二安装构件快速且容易地与第一安装构件重新接合，而不需要耗时的重新校准。 在一个实施例中，第二端部第一安装构件的再接合由偏置构件自动执行。

公开(公告)号：US08809293B2

公开(公告)日：2014-08-19

申请号：US13535454

申请日：2012-06-28

申请人： Daniel Chin ,  Jochen Deckert ,  Markus Hossbach ,  Matthias John

发明人： Daniel Chin ,  Jochen Deckert ,  Markus Hossbach ,  Matthias John

IPC分类号： C12N15/11 ,  A61K48/00 ,  C07H21/02 ,  C07H21/04

CPC分类号： A61K31/713 ,  C12N15/1131 ,  C12N2310/14 ,  C12N2310/315 ,  C12N2310/321 ,  C12N2310/335 ,  C12N2310/3521 ,  A61K2300/00

摘要： The invention relates to a double-stranded ribonucleic acid (dsRNA) for inhibiting the expression of a Hepatitis B Virus gene. The invention also relates to a pharmaceutical composition comprising the dsRNA or nucleic acid molecules or vectors encoding the same together with a pharmaceutically acceptable carrier; methods for treating diseases caused by Hepatitis B Virus infection using said pharmaceutical composition; and methods for inhibiting the expression of a Hepatitis B Virus gene in a cell.

摘要翻译： 本发明涉及用于抑制乙型肝炎病毒基因表达的双链核糖核酸（dsRNA）。 本发明还涉及包含dsRNA或核酸分子的药物组合物或其编码与其药学上可接受的载体的载体; 使用所述药物组合物治疗由乙型肝炎病毒感染引起的疾病的方法; 以及抑制细胞中乙型肝炎病毒基因表达的方法。

公开(公告)号：US20080049034A1

公开(公告)日：2008-02-28

申请号：US11822734

申请日：2007-07-09

申请人： Daniel Chin ,  Robert Lube

发明人： Daniel Chin ,  Robert Lube

IPC分类号： G06F13/18

CPC分类号： G06F3/1438 ,  G06F3/1446 ,  G09G2320/0233 ,  G09G2320/0606 ,  G09G2320/0626

摘要： Methods and systems for equalizing visual characteristics of images displayed on display units arranged proximate each other. The method may includes generating first and second video signals for first and second display units, respectively, displaying images on the first and second display units based on the first and second video signals, respectively, deriving first and second display correction information for the first and second display units, respectively, deriving image equalization information for the second display unit based on the first and second display correction information, respectively, adjusting the first video signal based on the first display correction information, adjusting the second video signal based on the image equalization information, and displaying images on the first and second images based on the adjusted first and second video signals.

摘要翻译： 用于均衡显示在彼此靠近布置的显示单元上的图像的视觉特征的方法和系统。 该方法可以包括分别为第一和第二显示单元产生第一和第二视频信号，分别基于第一和第二视频信号在第一和第二显示单元上显示图像，导出第一和第二显示校正信息， 第二显示单元，分别基于第一和第二显示校正信息导出第二显示单元的图像均衡信息，基于第一显示校正信息调整第一视频信号，基于图像均衡来调整第二视频信号 信息，并且基于经调整的第一和第二视频信号在第一和第二图像上显示图像。