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    Benzothiadiazine compounds
    4.
    发明授权
    Benzothiadiazine compounds 失效
    苯并噻二嗪化合物

    公开(公告)号：US06635635B2

    公开(公告)日：2003-10-21

    申请号：US09916479

    申请日：2001-07-27

    申请人： Alex Cordi ,  Patrice Desos ,  François Lefoulon ,  Pierre Lestage

    发明人： Alex Cordi ,  Patrice Desos ,  François Lefoulon ,  Pierre Lestage

    IPC分类号： C07D51304

    CPC分类号： C07D513/04

    摘要： Compound of formula (I): wherein: R1 represents hydroxy, RCO—O— or RCO—NRa—, R2 represents hydrogen, halogen, or hydroxy, R′CO—O or R′CO—NR′a—, R and R′, which may be identical or different, represent linear or branched (C1-C6)alkyl optionally substituted by aryl, linear or branched (C2-C6)alkenyl optionally substituted by aryl, linear or branched (C1-C6)perhaloalkyl, (C3-C7)cycloalkyl, adamantyl, aryl or heteroaryl, Ra and R′a, which may be identical or different, represent hydrogen or linear or branched (C1-C6)alkyl, linear or branched (C1-C6)perhaloalkyl, linear or branched (C1-C6)acyl, aryl or heteroaryl, its isomer and addition salts thereof with a pharmaceutically acceptable acid or base and medicinal products containing the same are useful as AMPA modulators.

    摘要翻译： 式（I）化合物：其中：R1代表羟基，RCO-O-或RCO-NRa-，R2代表氢，卤素或羟基，R'CO-O或R'CO-NR'a-，R和R （C 1 -C 6）烷基，任选被芳基，直链或支链（C 1 -C 6）全卤代烷基取代的直链或支链（C 1 -C 6）烷基，任选被芳基，直链或支链（C 2 -C 6） -C 7）环烷基，金刚烷基，芳基或杂芳基，R a和R a可以相同或不同，表示氢或直链或支链（C1-C6）烷基，直链或支链（C1-C6）全卤代烷基，直链或支链 （C 1 -C 6）酰基，芳基或杂芳基，其异构体和其药学上可接受的酸或碱的加成盐和含有它们的药物可用作AMPA调节剂。