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公开(公告)号：US20090111869A1
公开(公告)日：2009-04-30
申请号：US12141732
申请日：2008-06-18
申请人： Daniel SANTI , David C. Myles , Zong-Qiang Tian , C. Richard Hutchinson , Robert Johnson , Yi-Qing Zhou , Li Feng
发明人： Daniel SANTI , David C. Myles , Zong-Qiang Tian , C. Richard Hutchinson , Robert Johnson , Yi-Qing Zhou , Li Feng
IPC分类号： A61K31/395 , A61P35/00 , A61K31/337 , A61K31/366
CPC分类号： C07D491/08 , C07D225/06
摘要： The invention relates to benzoquinone ansamycin analogs useful for the treatment of cancer and other diseases or conditions characterized by undesired cellular proliferation or hyperproliferation. Therapies involving the administration of such benzoquinone ansamycin analogs, optionally in combination with an inhibitor of an HSP90 client protein, are useful to treat cancer and non-cancerous disease conditions.
摘要翻译： 本发明涉及可用于治疗癌症和其它特征在于不期望的细胞增殖或过度增殖的其它疾病或病症的苯醌安莎霉素类似物。 涉及施用这样的苯醌安莎霉素类似物（任选地与HSP90客户蛋白质的抑制剂组合）的治疗可用于治疗癌症和非癌性疾病状况。
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公开(公告)号：US06872715B2
公开(公告)日：2005-03-29
申请号：US10212962
申请日：2002-08-05
申请人： Daniel Santi , David C. Myles , Zong-Qiang Tian , C. Richard Hutchinson , Robert Johnson , Yi-Qing Zhou , Li Feng
发明人： Daniel Santi , David C. Myles , Zong-Qiang Tian , C. Richard Hutchinson , Robert Johnson , Yi-Qing Zhou , Li Feng
IPC分类号： C07D225/06 , C07D491/08
CPC分类号： C07D491/08 , C07D225/06
摘要： The invention relates to benzoquinone ansamycin analogs useful for the treatment of cancer and other diseases or conditions characterized by undesired cellular proliferation or hyperproliferation. Therapies involving the administration of such benzoquinone ansamycin analogs, optionally in combination with an inhibitor of an HSP90 client protein, are useful to treat cancer and non-cancerous disease conditions.
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公开(公告)号：US07405208B2
公开(公告)日：2008-07-29
申请号：US11056470
申请日：2005-02-11
申请人： Daniel Santi , David C. Myles , Zong-Qiang Tian , C. Richard Hutchinson , Robert Johnson , Yi-Qing Zhou , Li Feng
发明人： Daniel Santi , David C. Myles , Zong-Qiang Tian , C. Richard Hutchinson , Robert Johnson , Yi-Qing Zhou , Li Feng
IPC分类号： A61K31/397
CPC分类号： C07D491/08 , C07D225/06
摘要： The invention relates to benzoquinone ansamycin analogs useful for the treatment of cancer and other diseases or conditions characterized by undesired cellular proliferation or hyperproliferation. Therapies involving the administration of such benzoquinone ansamycin analogs, optionally in combination with an inhibitor of an HSP90 client protein, are useful to treat cancer and non-cancerous disease conditions.
摘要翻译： 本发明涉及可用于治疗癌症和其它特征在于不期望的细胞增殖或过度增殖的其它疾病或病症的苯醌安莎霉素类似物。 涉及施用这样的苯醌安莎霉素类似物（任选地与HSP90客户蛋白质的抑制剂组合）的治疗可用于治疗癌症和非癌性疾病状况。
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公开(公告)号：US07427493B2
公开(公告)日：2008-09-23
申请号：US10611442
申请日：2003-06-30
申请人： C. Richard Hutchinson , Leonard Katz , Ralph Reid , Zhihao Hu , Hugo Gramajo
发明人： C. Richard Hutchinson , Leonard Katz , Ralph Reid , Zhihao Hu , Hugo Gramajo
IPC分类号： C12P21/06
CPC分类号： C12N9/0077 , C12N15/52
摘要： Materials and methods to produce modified polyketides are disclosed. The biosynthesis, transfer and regulator genes for various sugars to effectuate polyketide modification are disclosed.
摘要翻译： 公开了生产改性聚酮化合物的材料和方法。 公开了用于各种糖的生物合成，转移和调节基因以实现聚酮化合物修饰。
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公开(公告)号：US20100004234A1
公开(公告)日：2010-01-07
申请号：US12536884
申请日：2009-08-06
IPC分类号： A61K31/365 , C12N5/00 , A61K31/5377 , A61K31/496 , A61K31/4523 , C07D493/04 , A61P35/00
CPC分类号： A61K31/33 , A61K31/365 , A61K31/4178 , A61K31/5377 , C07D493/04
摘要： Resorcylic acid lactones having a C5-C6 cis double bond and a ketone at C7 and other compounds capable of Michael adduct formation are potent and stable inhibitors of a subset of protein kinases having a specific cysteine residue in the ATP binding site.
摘要翻译： 具有C 5 -C 6顺式双键和在C7上的酮和能够形成迈克尔加合物的其它化合物的间苯二甲酸内酯是在ATP结合位点具有特异性半胱氨酸残基的蛋白激酶子集的有效且稳定的抑制剂。
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公开(公告)号：US06210930B1
公开(公告)日：2001-04-03
申请号：US09180271
申请日：1999-01-14
申请人： Silvia Filippini , Natalia Lomovskaya , Leonid Fonstein , Anna Luisa Colombo , C. Richard Hutchinson , Sharee L. Otten , Umberto Breme
发明人： Silvia Filippini , Natalia Lomovskaya , Leonid Fonstein , Anna Luisa Colombo , C. Richard Hutchinson , Sharee L. Otten , Umberto Breme
IPC分类号： C12P1956
CPC分类号： C12P19/56
摘要： The present invention is directed to a process for improving daunorubicin and doxorubicin production by means of a recombinant microorganism in which a gene of daunorubicin metabolism is mutated. The mutated gene is preferably dnrU and/or dnrX.
摘要翻译： 本发明涉及通过其中将柔红霉素代谢基因突变的重组微生物来改善柔红霉素和多柔比星产生的方法。 突变基因优选为dnRU和/或dnrX。
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公开(公告)号：US5989869A
公开(公告)日：1999-11-23
申请号：US812412
申请日：1997-03-06
申请人： Silvia Filippini , Natalia Lomovskaya , Leonid Fonstein , Anna Luisa Colombo , C. Richard Hutchinson
发明人： Silvia Filippini , Natalia Lomovskaya , Leonid Fonstein , Anna Luisa Colombo , C. Richard Hutchinson
CPC分类号： C12P19/56
摘要： The present invention is directed to a process for improving daunorubicin and doxorubicin production by means of a recombinant microorganism in which a gene of daunorubicin metabolism involved in the glycosylation of daunorubicin to acid-sensitive, baumycin-like compounds is inactivated.
摘要翻译： 本发明涉及通过重组微生物来改善柔红霉素和多柔比星产生的方法，其中涉及柔红霉素糖基化的柔红霉素代谢基因对酸敏感的鲍曼霉素样化合物失活。
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