公开(公告)号：US09638769B2

公开(公告)日：2017-05-02

申请号：US14233811

申请日：2012-07-16

申请人： Daniel Wirtz ,  Christoph Leussler ,  Sascha Krueger

发明人： Daniel Wirtz ,  Christoph Leussler ,  Sascha Krueger

IPC分类号： G01V3/00 ,  G01R33/28 ,  G01R33/58

CPC分类号： G01R33/28 ,  G01R33/287 ,  G01R33/58

摘要： A fiducial position marker (1) for use in a magnetic resonance (MR) imaging apparatus is disclosed for exciting and/or receiving MR signals in/from a local volume which at least substantially surrounds or adjoins the position marker, in order to determine and/or image from these MR signals the position of the position marker in an MR image of an examination object. Such a position marker (1) is especially used for determining and/or imaging a position of an interventional or non-interventional instrument to which the position marker may be attached, like a catheter, a surgical device, a biopsy needle, a pointer, a stent or another invasive or any non-invasive device in an MR image of an examination object. Further, a position marker system comprising such a position marker (1) and a circuit arrangement (5, 6, 6a, 8) for driving the position marker (1) for exciting MR signals and/or for processing MR signals received by the position marker is disclosed.

公开(公告)号：US20140159728A1

公开(公告)日：2014-06-12

申请号：US14233811

申请日：2012-07-16

申请人： Daniel Wirtz ,  Christoph Leussler ,  Sascha Krueger

发明人： Daniel Wirtz ,  Christoph Leussler ,  Sascha Krueger

IPC分类号： G01R33/28

CPC分类号： G01R33/28 ,  G01R33/287 ,  G01R33/58

摘要： A fiducial position marker (1) for use in a magnetic resonance (MR) imaging apparatus is disclosed for exciting and/or receiving MR signals in/from a local volume which at least substantially surrounds or adjoins the position marker, in order to determine and/or image from these MR signals the position of the position marker in an MR image of an examination object. Such a position marker (1) is especially used for determining and/or imaging a position of an interventional or non-interventional instrument to which the position marker may be attached, like a catheter, a surgical device, a biopsy needle, a pointer, a stent or another invasive or any non-invasive device in an MR image of an examination object. Further, a position marker system comprising such a position marker (1) and a circuit arrangement (5, 6, 6a, 8) for driving the position marker (1) for exciting MR signals and/or for processing MR signals received by the position marker is disclosed.

摘要翻译： 公开了一种用于在磁共振（MR）成像设备中使用的基准位置标记（1），用于激励和/或接收来自本地体积的MR信号，所述本地体积至少基本上围绕或邻接位置标记，以便确定和 /或来自这些MR的图像信号将检查对象的MR图像中的位置标记的位置。 这样的位置标记（1）特别用于确定和/或成像位置标记可以附着的介入或非介入性仪器的位置，如导管，手术装置，活检针，指针， 支架或检查对象的MR图像中的另一侵入性或任何非侵入性装置。 此外，包括这样的位置标记（1）和用于驱动用于激励MR信号的位置标记（1）和/或用于处理由位置接收的MR信号的电路装置（5,6,6a，8）的位置标记系统 标记被公开。

公开(公告)号：US20120256630A1

公开(公告)日：2012-10-11

申请号：US13516747

申请日：2010-12-28

申请人： Christoph Leussler ,  Daniel Wirtz ,  Peter Boernert ,  Jochen Keupp ,  Holger Eggers ,  Bernd David ,  Johannes Adrianus Overweg ,  Rainer Eckart

发明人： Christoph Leussler ,  Daniel Wirtz ,  Peter Boernert ,  Jochen Keupp ,  Holger Eggers ,  Bernd David ,  Johannes Adrianus Overweg ,  Rainer Eckart

IPC分类号： G01R33/28

CPC分类号： G01R33/62 ,  G01R33/282 ,  G01R33/5601 ,  G01R33/5605 ,  G01R33/5608 ,  G01R33/56366 ,  G01R33/56383

摘要： The invention relates to a dynamic nuclear polarization apparatus (116) for continuous provision of hyperpolarized samples (114) comprising dynamically nuclear polarized nuclear spins, the apparatus (116) comprising a polarization region (106) for polarization of said nuclear spins resulting in said hyperpolarized samples, wherein the apparatus (116) further comprises: a cryostat (102) for cooling the samples (114) in the polarization region (106), a magnet (100) for providing a magnetic field to the cooled samples in the polarization region (106), a radiation source (112) for concurrently to the magnetic field provision providing a nuclear polarizing radiation to the polarization region (106) for receiving the hyperpolarized samples, a sample transport system (104) for continuously receiving unpolarized samples (114), transporting the unpolarized samples to the polarization region (106) for nuclear spin polarization and providing the resulting hyperpolarized samples (114).

摘要翻译： 本发明涉及用于连续提供包括动态核偏振核自旋的超极化样本（114）的动态核极化装置（116），所述装置（116）包括用于所述核自旋的极化的偏振区域（106），导致所述超极化 样品，其中所述装置（116）还包括：用于冷却所述偏振区域（106）中的样品（114）的低温恒温器（102），用于向所述偏振区域中的所述冷却样品提供磁场的磁体（100） 106），用于与磁场提供同时提供用于接收超极化样本的偏振区域（106）的核偏振辐射的辐射源（112），用于连续接收非偏振样本（114）的样本传输系统（104） 将非偏振样品运送到用于核自旋极化的偏振区域（106），并提供所得到的超极化样本（114）。

公开(公告)号：US20120169340A1

公开(公告)日：2012-07-05

申请号：US13394969

申请日：2010-09-14

申请人： Christoph Leussler ,  Daniel Wirtz

发明人： Christoph Leussler ,  Daniel Wirtz

IPC分类号： G01R33/48 ,  G01R33/32

CPC分类号： G01R33/345 ,  G01R33/341 ,  G01R33/343 ,  G01R33/4802

摘要： The invention relates to a magnetic resonance imaging system (1) comprising: a main magnet for generating a uniform, steady magnetic field within an examination volume (21), an RF waveguide (19) for guiding travelling RF waves along an axis of the examination volume (21) in at least one travelling mode of the RF waveguide (19), at least one RF antenna (9) for transmitting RF pulses to and/or receiving MR signals from a body (10) of a patient positioned in the examination volume (21), wherein the RF antenna (9) is configured to couple to the at least one travelling mode of the RF waveguide (19), and wherein the RF antenna (9) is located on the imaging system such that the examination volume (21) is freely accessible, a control unit (15) for controlling the temporal succession of RF pulses, and a reconstruction unit (17) for reconstructing an MR image from the received MR signals. Further, the invention relates to an RF antenna (9) for an MR imaging system (1), wherein the RF antenna (9) is formed by an electrically conductive plate (22) comprising at least one recess (23).

摘要翻译： 本发明涉及一种磁共振成像系统（1），包括：用于在检查体积（21）内产生均匀的稳定磁场的主磁体，用于沿检查轴引导行波RF波的RF波导（19） 在RF波导（19）的至少一个行进模式中的体积（21），用于将RF脉冲发送到和/或接收来自位于检查中的患者的身体（10）的MR信号的至少一个RF天线（9） （21），其中所述RF天线（9）被配置为耦合到所述RF波导（19）的所述至少一个行进模式，并且其中所述RF天线（9）位于所述成像系统上，使得所述检查体积 （21）可自由访问，用于控制RF脉冲的时间连续的控制单元（15），以及用于从所接收的MR信号重建MR图像的重建单元（17）。 此外，本发明涉及一种用于MR成像系统（1）的RF天线（9），其中RF天线（9）由包括至少一个凹部（23）的导电板（22）形成。

公开(公告)号：US20120089010A1

公开(公告)日：2012-04-12

申请号：US13377831

申请日：2010-06-23

申请人： Christoph Leussler ,  Peter Boernert ,  Daniel Wirtz ,  Bernd David ,  Holger Eggers ,  Jochen Keupp ,  Johannes Adrianus Overweg ,  Rainer Eckart

发明人： Christoph Leussler ,  Peter Boernert ,  Daniel Wirtz ,  Bernd David ,  Holger Eggers ,  Jochen Keupp ,  Johannes Adrianus Overweg ,  Rainer Eckart

IPC分类号： A61B5/055

CPC分类号： A61M16/10 ,  A61B5/055 ,  A61M16/14 ,  A61M2016/0015 ,  A61M2202/066

摘要： A dispenser (132), a magnetic resonance imaging system (100), and a method for using hyperpolarized contrast agent (304) during a magnetic resonance imaging examination. The dispenser comprises an attachment component (136) for a face piece (138). The face piece is adapted for receiving the surface of a subject (114) such that when the subject inhales hyperpolarized contrast agent enters the respiratory system of the subject. The dispenser further comprises a reservoir (300) adapted for receiving the hyperpolarized contrast agent. The dispenser further comprises a gas flow (406) tube connected to the attachment component and a vaporizer (406, 408, 412, 510, 602, 606) for vaporizing the hyperpolarized contrast agent in the gas flow tube into a hyperpolarized vapor. The dispenser further comprises a controller (402) for controlling when the vaporizer vaporizes the hyperpolarized contrast agent.

摘要翻译： 分配器（132），磁共振成像系统（100）以及在磁共振成像检查期间使用超极化造影剂（304）的方法。 分配器包括用于面件（138）的附接部件（136）。 面部件适于接纳被检体（114）的表面，使得当受试者吸入超极化造影剂进入受试者的呼吸系统时。 分配器还包括适于接收超极化造影剂的贮存器（300）。 分配器还包括连接到附接部件的气流（406）管和用于将气体流管中的超极化造影剂蒸发成超极化蒸气的蒸发器（406,408,412,510,602,606）。 分配器还包括控制器（402），用于控制何时蒸发器蒸发超极化造影剂。

公开(公告)号：US20130131433A1

公开(公告)日：2013-05-23

申请号：US13521228

申请日：2011-01-05

申请人： Ulrich Katscher ,  Oliver Lips ,  Christian Findeklee ,  Christoph Leussler ,  Kay Nehrke ,  Daniel Wirtz ,  Johannes Adrianus Overweg

发明人： Ulrich Katscher ,  Oliver Lips ,  Christian Findeklee ,  Christoph Leussler ,  Kay Nehrke ,  Daniel Wirtz ,  Johannes Adrianus Overweg

IPC分类号： A61N5/10

CPC分类号： A61N5/1064 ,  A61B2017/00084 ,  A61B2090/374 ,  A61N1/403 ,  A61N5/10 ,  A61N5/1084 ,  A61N7/00 ,  A61N7/02 ,  A61N2005/007 ,  A61N2005/1055 ,  G01R33/4804 ,  G01R33/4808

摘要： The invention provides for a therapeutic apparatus comprising a tissue heating system (302, 480, 482). The therapeutic apparatus further comprises a magnetic resonance imaging system (300) for acquiring magnetic resonance thermometry data (366) from nuclei of a subject (318) located within an imaging volume (330). The therapeutic apparatus further comprises a radiation therapy system (304, 592) for irradiating an irradiation volume (316, 516) of the subject, wherein the irradiation volume is within the imaging volume. The therapeutic apparatus further comprises a controller (354) for controlling the therapeutic apparatus. The controller is adapted for acquiring (100, 210) magnetic resonance thermometry data repeatedly using the magnetic resonance imaging system. The controller is adapted for heating (102, 208) at least the irradiation volume using the tissue heating system. The heating is controlled using the magnetic resonance thermometry data. The controller is adapted for irradiating (104, 208) the irradiation volume.

摘要翻译： 本发明提供一种包括组织加热系统（302,480,482）的治疗设备。 治疗装置还包括用于从位于成像体积（330）内的对象（318）的核获取磁共振测温数据（366）的磁共振成像系统（300）。 治疗装置还包括用于照射受试者的照射体积（316,516）的放射治疗系统（304,592），其中照射体积在成像体积内。 治疗装置还包括用于控制治疗装置的控制器（354）。 控制器适于使用磁共振成像系统重复地获取（100,210）磁共振测温数据。 控制器适于使用组织加热系统加热（102,208）至少照射体积。 使用磁共振测温数据来控制加热。 控制器适于照射（104,208）照射体积。

公开(公告)号：US20110133729A1

公开(公告)日：2011-06-09

申请号：US13058547

申请日：2009-08-07

申请人： Peter Vernickel ,  Peter Mazurkewitz ,  Daniel Wirtz ,  Christoph Leussler ,  Ulrich Katscher

发明人： Peter Vernickel ,  Peter Mazurkewitz ,  Daniel Wirtz ,  Christoph Leussler ,  Ulrich Katscher

IPC分类号： G01R33/14

CPC分类号： A61B5/0536 ,  A61B5/0522

摘要： A method and a monitoring device for performing an RF-safe MIT scan is disclosed in which it is prevented that an RF exposure, especially a specific absorption rate (SAR), imposed on an examination object, especially a patient, exceeds certain limit values during a magnetic induction tomography (MIT) scan. This is achieved on the one hand by an RF simulation method for simulating intended MIT operating parameters and calculating a resulting RF exposure of the object, and on the other hand by a monitoring device for monitoring the RF power which is applied to the object.

摘要翻译： 公开了用于执行RF安全MIT扫描的方法和监视装置，其中防止施加在检查对象，特别是患者上的RF暴露，特别是特定吸收率（SAR）超过某些限制值 磁感应断层扫描（MIT）扫描。 这一方面通过用于模拟预期的MIT操作参数并计算所得到的对象的RF曝光的RF模拟方法，另一方面由用于监视施加到对象的RF功率的监视装置来实现。

公开(公告)号：US20100312091A1

公开(公告)日：2010-12-09

申请号：US12808404

申请日：2008-12-22

申请人： Sascha Krueger ,  Daniel Wirtz ,  Steffen Weiss

发明人： Sascha Krueger ,  Daniel Wirtz ,  Steffen Weiss

IPC分类号： A61B5/055 ,  G08B23/00

CPC分类号： G01R33/285 ,  G01R33/288

摘要： A magnetic resonance method comprises applying a radio frequency excitation in an examination region (14), measuring a magnetic resonance signal generated by the applied radio frequency excitation in a subject (16) in the examination region, monitoring a radio frequency parameter during the applying, and evaluating subject safety based on the monitoring. A magnetic resonance safety monitor (40) comprises an analyzer (42, 44, 46, 50) configured to (i) receive a radio frequency signal during magnetic resonance excitation, (ii) extract a radio frequency parameter from the received radio frequency signal, and (iii) evaluate subject safety based on the extracted radio frequency parameter, and a remediation module (54) configured to perform a remediation of the magnetic resonance excitation responsive to the evaluation (iii) indicating a potentially unsafe condition.

摘要翻译： 磁共振方法包括在检查区域（14）中施加射频激励，测量由所述检查区域中的被检体（16）施加的射频激励产生的磁共振信号，在施加期间监视射频参数， 并根据监测评估受试者的安全性。 磁共振安全监视器（40）包括分析器（42,44,46,50），其被配置为（i）在磁共振激励期间接收射频信号，（ii）从所接收的射频信号中提取射频参数， 以及（iii）基于提取的射频参数来评估对象安全性;以及修复模块（54），其被配置为响应于指示潜在不安全状况的评估（iii）来执行磁共振激励的修复。

公开(公告)号：US20100181109A1

公开(公告)日：2010-07-22

申请号：US12665947

申请日：2008-06-27

申请人： Sascha Krueger ,  Bernd David ,  Oliver Lips ,  Steffen Weiss ,  Daniel Wirtz

发明人： Sascha Krueger ,  Bernd David ,  Oliver Lips ,  Steffen Weiss ,  Daniel Wirtz

IPC分类号： H01B7/00

CPC分类号： G01R33/36 ,  A61B18/14 ,  A61B2018/00178 ,  A61B2090/374 ,  A61N1/086 ,  G01R33/287 ,  G01R33/288 ,  G01R33/3664

摘要： A transmission cable for use in an elongate medical device (420) such as a catheter, guide wire, etc., wherein the transmission cable is capable of being switched to an MR-safe mode only when necessary, while retaining its optimal electrical transmission properties otherwise, is disclosed herein. The transmission cable comprises a transmission line including at least two electrically conductive line segments (104a, 104b) separated by a non-conductive gap (106a), a bridging unit comprising at least one electrically conductive bridge segment (108a) capable of bridging the non-conductive gap, and a switching unit (112) arranged to move the bridging unit and/or the transmission line to electrically connect the two line segments by closing the non-conductive gap using the bridge segment or to electrically disconnect the two line segments by opening the non-conductive gap.

摘要翻译： 一种用于诸如导管，导丝等细长医疗设备（420）的传输电缆，其中传输电缆仅在必要时能够切换到MR安全模式，同时保持其最佳电气传输特性 否则，在此公开。 传输电缆包括传输线，传输线包括由非导电间隙（106a）隔开的至少两个导电线段（104a，104b）;桥接单元，包括至少一个导电桥段（108a） 以及开关单元（112），其布置成使桥接单元和/或传输线移动以通过使用桥接段闭合非导电间隙来电连接两个线段，或者通过 打开非导电间隙。

公开(公告)号：US20100041977A1

公开(公告)日：2010-02-18

申请号：US12440252

申请日：2007-09-07

申请人： Oliver Lips ,  Bernd David ,  Bernhard Gleich ,  Sascha Krueger ,  Steffen Weiss ,  Daniel Wirtz

发明人： Oliver Lips ,  Bernd David ,  Bernhard Gleich ,  Sascha Krueger ,  Steffen Weiss ,  Daniel Wirtz

IPC分类号： A61N1/375 ,  A61B5/0408 ,  A61B5/055

CPC分类号： A61B5/042 ,  A61B5/0428 ,  A61B5/055 ,  A61B2562/222 ,  A61N1/056 ,  A61N1/086 ,  A61N1/3625 ,  A61N1/3718 ,  G01R33/287

摘要： The present invention relates to a catheter (6) comprising: a connector (65, 66) at a proximal side of the catheter for connecting the catheter to an external signal transmission/receiving unit (10) for transmitting and/or receiving signals, an electrode (63, 64) at a distal side of the catheter, and an electrical connection including an electrical wire (61, 62) for electrically connecting the electrode and the connector for the transmission of signals between the electrode and the connector, wherein the electrical connection has a high electrical resistance of at least 1 kΩ, in particular of at least 5 kΩ. Thus, the present invention provides a solution to prevent excessive heating during EP interventions under MR guidance by using by using highly resistive wires and or lumped resistors as connections within catheters.

摘要翻译： 本发明涉及一种导管（6），包括：在导管的近侧的连接器（65,66），用于将导管连接到用于传输和/或接收信号的外部信号传输/接收单元（10）， 电极（63,64），以及包括用于电连接电极和连接器以用于在电极和连接器之间传输信号的电线（61,62）的电连接，其中电气 连接具有至少1kΩ和OHgr的高电阻，特别是至少5kΩ。 因此，本发明提供了一种用于在MR引导下的EP干预期间通过使用高电阻丝和/或集中电阻器作为导管内的连接使用来防止过度加热的解决方案。