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1.发明申请公开(公告)号：US20120142747A1
公开(公告)日：2012-06-07
申请号：US13309759
申请日：2011-12-02
申请人： Jared T. Wilsey , Danielle L. Biggs , Jonathan K. Gray , Jeffrey C. Marx , William F. McKay , Josee Roy , John Myers Zanella
发明人： Jared T. Wilsey , Danielle L. Biggs , Jonathan K. Gray , Jeffrey C. Marx , William F. McKay , Josee Roy , John Myers Zanella
IPC分类号： A61K31/4168 , A61P29/00
CPC分类号： A61K31/4168 , A61K9/00 , A61K9/0024
摘要： Effective treatments of pain for extended periods of time are provided. Through the administration of an effective amount of immediate release clonidine and a sustained release clonidine at or near a target site, one can relieve pain caused by diverse sources, including but not limited to spinal disc herniation (i.e. sciatica), spondilothesis, stenosis, discogenic back pain and joint pain. When appropriate formulations are provided within biodegradable polymers, this relief can be continued for at least three days. In some embodiments, the relief can be for at least twenty-five days, at least fifty days, at least one hundred days, at least one hundred and thirty-five days or at least one hundred and eighty days or longer.
摘要翻译： 提供长时间有效的疼痛治疗。 通过在目标部位或其附近施用有效量的立即释放可乐定和持续释放的可乐定，可以减轻由不同来源引起的疼痛，包括但不限于脊椎椎间盘突出症（即坐骨神经痛），脊柱狭窄，狭窄，椎间盘突出 背痛和关节疼痛。 当在可生物降解的聚合物中提供适当的制剂时，这种缓解可以持续至少三天。 在一些实施方案中，缓解可以是至少二十五天，至少五十天，至少一百天，至少一百三十五天或至少一百八十天或更长。
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2.发明申请METHODS FOR DELIVERING CLONIDINE COMPOSITIONS IN BIODEGRADABLE POLYMER CARRIER AND LOCAL STERIODS TO A TARGET TISSUE SITE 审中-公开将生物可降解聚合物载体和局部体内的螯合物组合物递送到目标组织位点的方法公开(公告)号：US20120142648A1
公开(公告)日：2012-06-07
申请号：US13309725
申请日：2011-12-02
申请人： Danielle L. Biggs , Jonathan K. Gray , Jeffrey C. Marx , William F. McKay , Josee Roy , Jared T. Wilsey , John Myers Zanella
发明人： Danielle L. Biggs , Jonathan K. Gray , Jeffrey C. Marx , William F. McKay , Josee Roy , Jared T. Wilsey , John Myers Zanella
CPC分类号： A61K45/06 , A61K9/0019 , A61K9/0024 , A61K31/4168 , A61K31/573 , A61K47/34 , A61K2300/00
摘要： Effective treatments of pain for extended periods of time are provided. Through the administration of an effective amount of clonidine and a steroid at or near a target site, one can relieve pain caused by diverse sources, including but not limited to spinal disc herniation (i.e. sciatica), spondilothesis, stenosis, discogenic back pain and joint pain. When appropriate formulations are provided within biodegradable polymers, this relief can be continued for at least three days. In some embodiments, the relief can be for at least twenty-five days, at least fifty days, at least one hundred days, at least one hundred and thirty-five days or at least one hundred and eighty days.
摘要翻译： 提供长时间有效的疼痛治疗。 通过在目标部位或附近施用有效量的可乐定和类固醇，可以减轻由多种来源引起的疼痛，包括但不限于脊椎椎间盘突出症（即坐骨神经痛），脊椎脱位，狭窄，椎间盘背痛和关节 疼痛。 当在可生物降解的聚合物中提供适当的制剂时，这种缓解可以持续至少三天。 在一些实施方案中，缓解可以是至少二十五天，至少五十天，至少一百天，至少一百三十五天或至少一百八十天。
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3.发明授权Compositions and methods for delivering clonidine and bupivacaine to a target tissue site 有权将可乐定和布比卡因递送至目标组织部位的组合物和方法公开(公告)号：US08623396B2
公开(公告)日：2014-01-07
申请号：US13310240
申请日：2011-12-02
申请人： Jonathan K. Gray , Jeffrey C. Marx , William F. McKay , Josee Roy , Danielle L. Clay , Jared T. Wilsey , John Myers Zanella
发明人： Jonathan K. Gray , Jeffrey C. Marx , William F. McKay , Josee Roy , Danielle L. Clay , Jared T. Wilsey , John Myers Zanella
CPC分类号： A61K9/0024 , A61K31/167 , A61K31/4168 , A61K31/445 , A61K47/34 , A61K2300/00
摘要： Effective treatments of pain for extended periods of time are provided. Through the administration of an effective amount of immediate release bupivacaine or lidocaine and a sustained release clonidine at or near a target site, one can relieve pain caused by diverse sources, including but not limited to spinal disc herniation (i.e. sciatica), spondilothesis, stenosis, discogenic back pain and joint pain. When appropriate formulations are provided within biodegradable polymers, this relief can be continued for at least three days. In some embodiments, the relief can be for at least twenty-five days, at least fifty days, at least one hundred days, at least one hundred and thirty-five days or at least one hundred and eighty days or longer.
摘要翻译： 提供长时间有效的疼痛治疗。 通过施用有效量的即时释放布比卡因或利多卡因和持续释放的可乐定，可以缓解由不同来源引起的疼痛，包括但不限于脊椎椎间盘突出症（即坐骨神经痛），脊椎脱位，狭窄 ，造成背痛和关节疼痛。 当在可生物降解的聚合物中提供适当的制剂时，这种缓解可以持续至少三天。 在一些实施方案中，缓解可以是至少二十五天，至少五十天，至少一百天，至少一百三十五天或至少一百八十天或更长。
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4.发明申请COMPOSITIONS AND METHODS FOR DELIVERING CLONIDINE AND BUPIVACAINE TO A TARGET TISSUE SITE 有权将CLONIDINE和BUPIVACAINE递送至目标组织网站的组合物和方法公开(公告)号：US20120142649A1
公开(公告)日：2012-06-07
申请号：US13310240
申请日：2011-12-02
申请人： Jonathan K. Gray , Jeffrey C. Marx , William F. McKay , Josee Roy , Danielle L. Clay , Jared T. Wilsey , John Myers Zanella
发明人： Jonathan K. Gray , Jeffrey C. Marx , William F. McKay , Josee Roy , Danielle L. Clay , Jared T. Wilsey , John Myers Zanella
IPC分类号： A61K31/56 , A61P29/00 , A61K31/445
CPC分类号： A61K9/0024 , A61K31/167 , A61K31/4168 , A61K31/445 , A61K47/34 , A61K2300/00
摘要： Effective treatments of pain for extended periods of time are provided. Through the administration of an effective amount of immediate release bupivacaine or lidocaine and a sustained release clonidine at or near a target site, one can relieve pain caused by diverse sources, including but not limited to spinal disc herniation (i.e. sciatica), spondilothesis, stenosis, discogenic back pain and joint pain. When appropriate formulations are provided within biodegradable polymers, this relief can be continued for at least three days. In some embodiments, the relief can be for at least twenty-five days, at least fifty days, at least one hundred days, at least one hundred and thirty-five days or at least one hundred and eighty days or longer.
摘要翻译： 提供长时间有效的疼痛治疗。 通过施用有效量的即时释放布比卡因或利多卡因和持续释放的可乐定，可以缓解由不同来源引起的疼痛，包括但不限于脊椎椎间盘突出症（即坐骨神经痛），脊椎脱位，狭窄 ，造成背痛和关节疼痛。 当在可生物降解的聚合物中提供适当的制剂时，这种缓解可以持续至少三天。 在一些实施方案中，缓解可以是至少二十五天，至少五十天，至少一百天，至少一百三十五天或至少一百八十天或更长。
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