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    COMPOSITIONS AND METHODS FOR DELIVERING CLONIDINE TO A TARGET TISSUE SITE
    1.
    发明申请
    COMPOSITIONS AND METHODS FOR DELIVERING CLONIDINE TO A TARGET TISSUE SITE 审中-公开
    组合物和方法将克隆定为目标组织位点

    公开(公告)号：US20120142747A1

    公开(公告)日：2012-06-07

    申请号：US13309759

    申请日：2011-12-02

    申请人： Jared T. Wilsey ,  Danielle L. Biggs ,  Jonathan K. Gray ,  Jeffrey C. Marx ,  William F. McKay ,  Josee Roy ,  John Myers Zanella

    发明人： Jared T. Wilsey ,  Danielle L. Biggs ,  Jonathan K. Gray ,  Jeffrey C. Marx ,  William F. McKay ,  Josee Roy ,  John Myers Zanella

    IPC分类号： A61K31/4168 ,  A61P29/00

    CPC分类号： A61K31/4168 ,  A61K9/00 ,  A61K9/0024

    摘要： Effective treatments of pain for extended periods of time are provided. Through the administration of an effective amount of immediate release clonidine and a sustained release clonidine at or near a target site, one can relieve pain caused by diverse sources, including but not limited to spinal disc herniation (i.e. sciatica), spondilothesis, stenosis, discogenic back pain and joint pain. When appropriate formulations are provided within biodegradable polymers, this relief can be continued for at least three days. In some embodiments, the relief can be for at least twenty-five days, at least fifty days, at least one hundred days, at least one hundred and thirty-five days or at least one hundred and eighty days or longer.

    摘要翻译： 提供长时间有效的疼痛治疗。 通过在目标部位或其附近施用有效量的立即释放可乐定和持续释放的可乐定，可以减轻由不同来源引起的疼痛，包括但不限于脊椎椎间盘突出症（即坐骨神经痛），脊柱狭窄，狭窄，椎间盘突出 背痛和关节疼痛。 当在可生物降解的聚合物中提供适当的制剂时，这种缓解可以持续至少三天。 在一些实施方案中，缓解可以是至少二十五天，至少五十天，至少一百天，至少一百三十五天或至少一百八十天或更长。

    CLONIDINE AND GABA COMPOUNDS IN A BIODEGRADABLE POLYMER CARRIER
    3.
    发明申请
    CLONIDINE AND GABA COMPOUNDS IN A BIODEGRADABLE POLYMER CARRIER 有权
    可生物降解聚合物载体中的克隆和加巴化合物

    公开(公告)号：US20120142643A1

    公开(公告)日：2012-06-07

    申请号：US13309766

    申请日：2011-12-02

    申请人： Jared T. Wilsey ,  Danielle L. Biggs ,  Jeffrey C. Marx ,  William F. McKay ,  Josee Roy ,  John Myers Zanella

    发明人： Jared T. Wilsey ,  Danielle L. Biggs ,  Jeffrey C. Marx ,  William F. McKay ,  Josee Roy ,  John Myers Zanella

    IPC分类号： A61K31/662 ,  A61P29/00 ,  A61K31/4168

    CPC分类号： A61K31/195 ,  A61K9/0024 ,  A61K31/4168 ,  A61K31/662 ,  A61K45/06 ,  A61K47/34

    摘要： Effective treatments of pain for extended periods of time are provided. Through the administration of an effective amount of clonidine and a gamma-aminobutyric acid compound at or near a target site, one can relieve pain caused by diverse sources, including but not limited to spinal disc herniation (i.e. sciatica), spondilothesis, stenosis, discogenic back pain and joint pain, as well as pain that is incidental to surgery. When appropriate formulations are provided within biodegradable polymers, this relief can be continued for at least three days. In some embodiments, the relief can be for at least twenty-five days, at least fifty days, at least one hundred days, at least one hundred and thirty-five days or at least one hundred and eighty days.

    摘要翻译： 提供长时间有效的疼痛治疗。 通过在目标部位或其附近施用有效量的可乐定和γ-氨基丁酸化合物，可以缓解由不同来源引起的疼痛，包括但不限于脊椎椎间盘突出症（即坐骨神经痛），脊椎脱位，狭窄，椎间盘突出 背痛和关节疼痛，以及手术附带的疼痛。 当在可生物降解的聚合物中提供适当的制剂时，这种缓解可以持续至少三天。 在一些实施方案中，缓解可以是至少二十五天，至少五十天，至少一百天，至少一百三十五天或至少一百八十天。

    Clonidine and GABA compounds in a biodegradable polymer carrier
    4.
    发明授权
    Clonidine and GABA compounds in a biodegradable polymer carrier 有权
    可乐定和GABA化合物在可生物降解的聚合物载体中

    公开(公告)号：US09301946B2

    公开(公告)日：2016-04-05

    申请号：US13309766

    申请日：2011-12-02

    申请人： Jared T. Wilsey ,  Danielle L. Biggs ,  Jeffrey C. Marx ,  William F. McKay ,  Josee Roy ,  John Myers Zanella

    发明人： Jared T. Wilsey ,  Danielle L. Biggs ,  Jeffrey C. Marx ,  William F. McKay ,  Josee Roy ,  John Myers Zanella

    IPC分类号： A61K31/66 ,  A61K31/415 ,  A61K31/4168 ,  A61K9/00 ,  A61K45/06 ,  A61K31/662 ,  A61K47/34

    CPC分类号： A61K31/195 ,  A61K9/0024 ,  A61K31/4168 ,  A61K31/662 ,  A61K45/06 ,  A61K47/34

    摘要： Effective treatments of pain for extended periods of time are provided. Through the administration of an effective amount of clonidine and a gamma-aminobutyric acid compound at or near a target site, one can relieve pain caused by diverse sources, including but not limited to spinal disc herniation (i.e. sciatica), spondilothesis, stenosis, discogenic back pain and joint pain, as well as pain that is incidental to surgery. When appropriate formulations are provided within biodegradable polymers, this relief can be continued for at least three days. In some embodiments, the relief can be for at least twenty-five days, at least fifty days, at least one hundred days, at least one hundred and thirty-five days or at least one hundred and eighty days.

    摘要翻译： 提供长时间有效的疼痛治疗。 通过在目标部位或其附近施用有效量的可乐定和γ-氨基丁酸化合物，可以缓解由不同来源引起的疼痛，包括但不限于脊椎椎间盘突出症（即坐骨神经痛），脊椎脱位，狭窄，椎间盘突出 背痛和关节疼痛，以及手术附带的疼痛。 当在可生物降解的聚合物中提供适当的制剂时，这种缓解可以持续至少三天。 在一些实施方案中，缓解可以是至少二十五天，至少五十天，至少一百天，至少一百三十五天或至少一百八十天。

    Method of treating neuronal injury by administering magnesium chloride and PEG
    7.
    发明授权
    Method of treating neuronal injury by administering magnesium chloride and PEG 有权
    通过施用氯化镁和PEG治疗神经元损伤的方法

    公开(公告)号：US08840933B2

    公开(公告)日：2014-09-23

    申请号：US11418153

    申请日：2006-05-03

    申请人： Josee Roy ,  William F. McKay ,  Jeffrey C Marx

    发明人： Josee Roy ,  William F. McKay ,  Jeffrey C Marx

    IPC分类号： A61K33/14 ,  A61K31/765 ,  A61K9/08 ,  A61K9/00 ,  A61K31/717 ,  A61K31/787 ,  A61K33/06

    CPC分类号： A61K33/14 ,  A61K9/0019 ,  A61K9/0085 ,  A61K31/717 ,  A61K31/765 ,  A61K31/787 ,  A61K33/06 ,  A61K2300/00

    摘要： The invention provides methods and kits for treatment of pain or inflammation. In one embodiment, the kit comprises a biomembrane sealing agent, such as PEG, and a bioactive agent, such as a magnesium compound. The biomembrane sealing agent and/or the bioactive agent an intravenous administration, an intramuscular administration, an intrathecal administration, a subcutaneous administration, an epidural administration, a parenteral administration, an intra-articular administration, a direct application onto or adjacent to a site of the pathological condition, and any combinations thereof. Alternatively, the biomembrane sealing agent and/or the bioactive agent may be delivered from a pump or an implant.

    摘要翻译： 本发明提供了治疗疼痛或炎症的方法和试剂盒。 在一个实施方案中，试剂盒包含生物膜密封剂，例如PEG，以及生物活性剂，例如镁化合物。 生物膜密封剂和/或生物活性剂，静脉内给药，肌内给药，鞘内给药，皮下给药，硬膜外给药，胃肠外给药，关节内给药，直接施用于或邻近 病理状况及其任何组合。 或者，生物膜密封剂和/或生物活性剂可以从泵或植入物递送。

    Compositions comprising biomembrane sealing agent for treatment of neuronal injury, and methods of use
    8.
    发明授权
    Compositions comprising biomembrane sealing agent for treatment of neuronal injury, and methods of use 有权
    包含用于治疗神经元损伤的生物膜密封剂的组合物和使用方法

    公开(公告)号：US08945623B2

    公开(公告)日：2015-02-03

    申请号：US11418152

    申请日：2006-05-03

    申请人： Josee Roy ,  William F. McKay ,  Jeffrey C. Marx

    发明人： Josee Roy ,  William F. McKay ,  Jeffrey C. Marx

    IPC分类号： A61K38/20 ,  A61K38/18 ,  A61K38/11 ,  A61K38/05 ,  A61K31/65 ,  A61K31/56 ,  A61K9/14 ,  A61K9/00 ,  A61K33/06 ,  A61K47/10

    CPC分类号： A61K33/06 ,  A61K9/0019 ,  A61K31/56 ,  A61K31/65 ,  A61K31/765 ,  A61K47/10

    摘要： The invention provides compositions, kits, and methods for treatment of neuronal injury. In one embodiment, the composition comprises a biomembrane sealing agent, such as PEG, and a bioactive agent, such as a magnesium compound. The biomembrane sealing agent and/or the bioactive agent an intravenous administration, an intramuscular administration, an intrathecal administration, a subcutaneous administration, an epidural administration, a parenteral administration, a direct application onto or adjacent to a site of the pathological condition, and any combinations thereof. Alternatively, the biomembrane sealing agent and/or the bioactive agent may be delivered from a pump or an implant.

    摘要翻译： 本发明提供用于治疗神经元损伤的组合物，试剂盒和方法。 在一个实施方案中，组合物包含生物膜密封剂，例如PEG，以及生物活性剂，例如镁化合物。 静脉内给药，肌内给药，鞘内给药，皮下给药，硬膜外给药，胃肠外给药，直接施用于病理状况的部位或其附近的生物膜密封剂和/或生物活性剂，以及任何 其组合。 或者，生物膜密封剂和/或生物活性剂可以从泵或植入物递送。