公开(公告)号：US20120142747A1

公开(公告)日：2012-06-07

申请号：US13309759

申请日：2011-12-02

申请人： Jared T. Wilsey ,  Danielle L. Biggs ,  Jonathan K. Gray ,  Jeffrey C. Marx ,  William F. McKay ,  Josee Roy ,  John Myers Zanella

发明人： Jared T. Wilsey ,  Danielle L. Biggs ,  Jonathan K. Gray ,  Jeffrey C. Marx ,  William F. McKay ,  Josee Roy ,  John Myers Zanella

IPC分类号： A61K31/4168 ,  A61P29/00

CPC分类号： A61K31/4168 ,  A61K9/00 ,  A61K9/0024

摘要： Effective treatments of pain for extended periods of time are provided. Through the administration of an effective amount of immediate release clonidine and a sustained release clonidine at or near a target site, one can relieve pain caused by diverse sources, including but not limited to spinal disc herniation (i.e. sciatica), spondilothesis, stenosis, discogenic back pain and joint pain. When appropriate formulations are provided within biodegradable polymers, this relief can be continued for at least three days. In some embodiments, the relief can be for at least twenty-five days, at least fifty days, at least one hundred days, at least one hundred and thirty-five days or at least one hundred and eighty days or longer.

摘要翻译： 提供长时间有效的疼痛治疗。 通过在目标部位或其附近施用有效量的立即释放可乐定和持续释放的可乐定，可以减轻由不同来源引起的疼痛，包括但不限于脊椎椎间盘突出症（即坐骨神经痛），脊柱狭窄，狭窄，椎间盘突出 背痛和关节疼痛。 当在可生物降解的聚合物中提供适当的制剂时，这种缓解可以持续至少三天。 在一些实施方案中，缓解可以是至少二十五天，至少五十天，至少一百天，至少一百三十五天或至少一百八十天或更长。

公开(公告)号：US20120142648A1

公开(公告)日：2012-06-07

申请号：US13309725

申请日：2011-12-02

申请人： Danielle L. Biggs ,  Jonathan K. Gray ,  Jeffrey C. Marx ,  William F. McKay ,  Josee Roy ,  Jared T. Wilsey ,  John Myers Zanella

发明人： Danielle L. Biggs ,  Jonathan K. Gray ,  Jeffrey C. Marx ,  William F. McKay ,  Josee Roy ,  Jared T. Wilsey ,  John Myers Zanella

IPC分类号： A61K31/56 ,  A61P29/00

CPC分类号： A61K45/06 ,  A61K9/0019 ,  A61K9/0024 ,  A61K31/4168 ,  A61K31/573 ,  A61K47/34 ,  A61K2300/00

摘要： Effective treatments of pain for extended periods of time are provided. Through the administration of an effective amount of clonidine and a steroid at or near a target site, one can relieve pain caused by diverse sources, including but not limited to spinal disc herniation (i.e. sciatica), spondilothesis, stenosis, discogenic back pain and joint pain. When appropriate formulations are provided within biodegradable polymers, this relief can be continued for at least three days. In some embodiments, the relief can be for at least twenty-five days, at least fifty days, at least one hundred days, at least one hundred and thirty-five days or at least one hundred and eighty days.

摘要翻译： 提供长时间有效的疼痛治疗。 通过在目标部位或附近施用有效量的可乐定和类固醇，可以减轻由多种来源引起的疼痛，包括但不限于脊椎椎间盘突出症（即坐骨神经痛），脊椎脱位，狭窄，椎间盘背痛和关节 疼痛。 当在可生物降解的聚合物中提供适当的制剂时，这种缓解可以持续至少三天。 在一些实施方案中，缓解可以是至少二十五天，至少五十天，至少一百天，至少一百三十五天或至少一百八十天。

公开(公告)号：US20120142643A1

公开(公告)日：2012-06-07

申请号：US13309766

申请日：2011-12-02

申请人： Jared T. Wilsey ,  Danielle L. Biggs ,  Jeffrey C. Marx ,  William F. McKay ,  Josee Roy ,  John Myers Zanella

发明人： Jared T. Wilsey ,  Danielle L. Biggs ,  Jeffrey C. Marx ,  William F. McKay ,  Josee Roy ,  John Myers Zanella

IPC分类号： A61K31/662 ,  A61P29/00 ,  A61K31/4168

CPC分类号： A61K31/195 ,  A61K9/0024 ,  A61K31/4168 ,  A61K31/662 ,  A61K45/06 ,  A61K47/34

摘要： Effective treatments of pain for extended periods of time are provided. Through the administration of an effective amount of clonidine and a gamma-aminobutyric acid compound at or near a target site, one can relieve pain caused by diverse sources, including but not limited to spinal disc herniation (i.e. sciatica), spondilothesis, stenosis, discogenic back pain and joint pain, as well as pain that is incidental to surgery. When appropriate formulations are provided within biodegradable polymers, this relief can be continued for at least three days. In some embodiments, the relief can be for at least twenty-five days, at least fifty days, at least one hundred days, at least one hundred and thirty-five days or at least one hundred and eighty days.

摘要翻译： 提供长时间有效的疼痛治疗。 通过在目标部位或其附近施用有效量的可乐定和γ-氨基丁酸化合物，可以缓解由不同来源引起的疼痛，包括但不限于脊椎椎间盘突出症（即坐骨神经痛），脊椎脱位，狭窄，椎间盘突出 背痛和关节疼痛，以及手术附带的疼痛。 当在可生物降解的聚合物中提供适当的制剂时，这种缓解可以持续至少三天。 在一些实施方案中，缓解可以是至少二十五天，至少五十天，至少一百天，至少一百三十五天或至少一百八十天。

公开(公告)号：US09301946B2

公开(公告)日：2016-04-05

申请号：US13309766

申请日：2011-12-02

申请人： Jared T. Wilsey ,  Danielle L. Biggs ,  Jeffrey C. Marx ,  William F. McKay ,  Josee Roy ,  John Myers Zanella

发明人： Jared T. Wilsey ,  Danielle L. Biggs ,  Jeffrey C. Marx ,  William F. McKay ,  Josee Roy ,  John Myers Zanella

IPC分类号： A61K31/66 ,  A61K31/415 ,  A61K31/4168 ,  A61K9/00 ,  A61K45/06 ,  A61K31/662 ,  A61K47/34

CPC分类号： A61K31/195 ,  A61K9/0024 ,  A61K31/4168 ,  A61K31/662 ,  A61K45/06 ,  A61K47/34

摘要： Effective treatments of pain for extended periods of time are provided. Through the administration of an effective amount of clonidine and a gamma-aminobutyric acid compound at or near a target site, one can relieve pain caused by diverse sources, including but not limited to spinal disc herniation (i.e. sciatica), spondilothesis, stenosis, discogenic back pain and joint pain, as well as pain that is incidental to surgery. When appropriate formulations are provided within biodegradable polymers, this relief can be continued for at least three days. In some embodiments, the relief can be for at least twenty-five days, at least fifty days, at least one hundred days, at least one hundred and thirty-five days or at least one hundred and eighty days.

摘要翻译： 提供长时间有效的疼痛治疗。 通过在目标部位或其附近施用有效量的可乐定和γ-氨基丁酸化合物，可以缓解由不同来源引起的疼痛，包括但不限于脊椎椎间盘突出症（即坐骨神经痛），脊椎脱位，狭窄，椎间盘突出 背痛和关节疼痛，以及手术附带的疼痛。 当在可生物降解的聚合物中提供适当的制剂时，这种缓解可以持续至少三天。 在一些实施方案中，缓解可以是至少二十五天，至少五十天，至少一百天，至少一百三十五天或至少一百八十天。

公开(公告)号：US20120142649A1

公开(公告)日：2012-06-07

申请号：US13310240

申请日：2011-12-02

申请人： Jonathan K. Gray ,  Jeffrey C. Marx ,  William F. McKay ,  Josee Roy ,  Danielle L. Clay ,  Jared T. Wilsey ,  John Myers Zanella

发明人： Jonathan K. Gray ,  Jeffrey C. Marx ,  William F. McKay ,  Josee Roy ,  Danielle L. Clay ,  Jared T. Wilsey ,  John Myers Zanella

IPC分类号： A61K31/56 ,  A61P29/00 ,  A61K31/445

CPC分类号： A61K9/0024 ,  A61K31/167 ,  A61K31/4168 ,  A61K31/445 ,  A61K47/34 ,  A61K2300/00

摘要： Effective treatments of pain for extended periods of time are provided. Through the administration of an effective amount of immediate release bupivacaine or lidocaine and a sustained release clonidine at or near a target site, one can relieve pain caused by diverse sources, including but not limited to spinal disc herniation (i.e. sciatica), spondilothesis, stenosis, discogenic back pain and joint pain. When appropriate formulations are provided within biodegradable polymers, this relief can be continued for at least three days. In some embodiments, the relief can be for at least twenty-five days, at least fifty days, at least one hundred days, at least one hundred and thirty-five days or at least one hundred and eighty days or longer.

摘要翻译： 提供长时间有效的疼痛治疗。 通过施用有效量的即时释放布比卡因或利多卡因和持续释放的可乐定，可以缓解由不同来源引起的疼痛，包括但不限于脊椎椎间盘突出症（即坐骨神经痛），脊椎脱位，狭窄 ，造成背痛和关节疼痛。 当在可生物降解的聚合物中提供适当的制剂时，这种缓解可以持续至少三天。 在一些实施方案中，缓解可以是至少二十五天，至少五十天，至少一百天，至少一百三十五天或至少一百八十天或更长。

公开(公告)号：US08623396B2

公开(公告)日：2014-01-07

申请号：US13310240

申请日：2011-12-02

申请人： Jonathan K. Gray ,  Jeffrey C. Marx ,  William F. McKay ,  Josee Roy ,  Danielle L. Clay ,  Jared T. Wilsey ,  John Myers Zanella

发明人： Jonathan K. Gray ,  Jeffrey C. Marx ,  William F. McKay ,  Josee Roy ,  Danielle L. Clay ,  Jared T. Wilsey ,  John Myers Zanella

IPC分类号： A61F2/00 ,  A61K9/00

CPC分类号： A61K9/0024 ,  A61K31/167 ,  A61K31/4168 ,  A61K31/445 ,  A61K47/34 ,  A61K2300/00

摘要： Effective treatments of pain for extended periods of time are provided. Through the administration of an effective amount of immediate release bupivacaine or lidocaine and a sustained release clonidine at or near a target site, one can relieve pain caused by diverse sources, including but not limited to spinal disc herniation (i.e. sciatica), spondilothesis, stenosis, discogenic back pain and joint pain. When appropriate formulations are provided within biodegradable polymers, this relief can be continued for at least three days. In some embodiments, the relief can be for at least twenty-five days, at least fifty days, at least one hundred days, at least one hundred and thirty-five days or at least one hundred and eighty days or longer.

摘要翻译： 提供长时间有效的疼痛治疗。 通过施用有效量的即时释放布比卡因或利多卡因和持续释放的可乐定，可以缓解由不同来源引起的疼痛，包括但不限于脊椎椎间盘突出症（即坐骨神经痛），脊椎脱位，狭窄 ，造成背痛和关节疼痛。 当在可生物降解的聚合物中提供适当的制剂时，这种缓解可以持续至少三天。 在一些实施方案中，缓解可以是至少二十五天，至少五十天，至少一百天，至少一百三十五天或至少一百八十天或更长。

公开(公告)号：US08945623B2

公开(公告)日：2015-02-03

申请号：US11418152

申请日：2006-05-03

申请人： Josee Roy ,  William F. McKay ,  Jeffrey C. Marx

发明人： Josee Roy ,  William F. McKay ,  Jeffrey C. Marx

IPC分类号： A61K38/20 ,  A61K38/18 ,  A61K38/11 ,  A61K38/05 ,  A61K31/65 ,  A61K31/56 ,  A61K9/14 ,  A61K9/00 ,  A61K33/06 ,  A61K47/10

CPC分类号： A61K33/06 ,  A61K9/0019 ,  A61K31/56 ,  A61K31/65 ,  A61K31/765 ,  A61K47/10

摘要： The invention provides compositions, kits, and methods for treatment of neuronal injury. In one embodiment, the composition comprises a biomembrane sealing agent, such as PEG, and a bioactive agent, such as a magnesium compound. The biomembrane sealing agent and/or the bioactive agent an intravenous administration, an intramuscular administration, an intrathecal administration, a subcutaneous administration, an epidural administration, a parenteral administration, a direct application onto or adjacent to a site of the pathological condition, and any combinations thereof. Alternatively, the biomembrane sealing agent and/or the bioactive agent may be delivered from a pump or an implant.

摘要翻译： 本发明提供用于治疗神经元损伤的组合物，试剂盒和方法。 在一个实施方案中，组合物包含生物膜密封剂，例如PEG，以及生物活性剂，例如镁化合物。 静脉内给药，肌内给药，鞘内给药，皮下给药，硬膜外给药，胃肠外给药，直接施用于病理状况的部位或其附近的生物膜密封剂和/或生物活性剂，以及任何 其组合。 或者，生物膜密封剂和/或生物活性剂可以从泵或植入物递送。

公开(公告)号：US20120310366A1

公开(公告)日：2012-12-06

申请号：US13489173

申请日：2012-06-05

申请人： Ping Li ,  Jeffrey C. Marx ,  William F. McKay

发明人： Ping Li ,  Jeffrey C. Marx ,  William F. McKay

IPC分类号： A61F2/28

CPC分类号： A61K31/366 ,  A61F2002/2839 ,  A61F2002/30677 ,  A61K31/22 ,  A61K31/40 ,  A61K31/405 ,  A61K31/44 ,  A61K31/47 ,  A61K31/505 ,  A61K33/42 ,  A61K47/22

摘要： Implantable medical devices and methods are provided that have one or more statins disposed therein. The medical devices may be implanted at near or in a bone defect to enhance bone growth. In some embodiments, the medical device provided allows for sustain release of the statin and facilitates bone formation and repair of the fracture site.

摘要翻译： 提供了植入式医疗装置和方法，其中设置有一个或多个他汀类药物。 医疗装置可以植入在骨缺损附近或骨缺损处以增强骨生长。 在一些实施方案中，所提供的医疗装置允许持续释放他汀类并促进骨形成部位的骨形成和修复。

公开(公告)号：US09789161B2

公开(公告)日：2017-10-17

申请号：US11414689

申请日：2006-04-28

申请人： Josee Roy ,  Susan J. Drapeau ,  Jeffrey C. Marx

发明人： Josee Roy ,  Susan J. Drapeau ,  Jeffrey C. Marx

IPC分类号： A61K38/00 ,  A61K39/00 ,  A61K38/16 ,  A61K38/18 ,  A61K38/20 ,  A61K38/21

CPC分类号： A61K38/1825 ,  A61K38/185 ,  A61K38/1858 ,  A61K38/2093 ,  A61K38/212

摘要： The invention provides a method for alleviating discogenic pain by administering a therapeutic agent that disrupts neuronal and/or vascular elements in the disc, which is typically a degenerated disc. Disruption of neuronal elements in the disk includes destroying nerve endings without substantially affecting the central body of the nerve, suppressing activation of the nerve endings, and inhibiting the growth of nerve endings into the disk. Disruption of vascular elements includes causing the vascular extensions to retract from the disk, or suppressing the formation of such extensions. The therapeutic agent may be administered locally via an interbody pump, a bolus or a depot, or may be administered systemically.

公开(公告)号：US09597352B2

公开(公告)日：2017-03-21

申请号：US11444077

申请日：2006-05-31

申请人： Josee Roy ,  Jeffrey C. Marx

发明人： Josee Roy ,  Jeffrey C. Marx

IPC分类号： A61K31/075 ,  A61K31/765 ,  A61K9/00 ,  A61K31/00 ,  A61K47/10 ,  A61L31/06 ,  A61L31/16 ,  A61K45/06

CPC分类号： A61K31/765 ,  A61K9/0014 ,  A61K9/0019 ,  A61K31/00 ,  A61K45/06 ,  A61K47/10 ,  A61L31/06 ,  A61L31/16 ,  A61L2300/402 ,  A61L2400/06 ,  C08L71/02

摘要： In the present invention, Applicants demonstrate the effect of a biomembrane sealing agent on the development of chronic pain following tissue injury as well as acute pain in a model of acute inflammation. Applicants demonstrate the ability of this class of agents referred to as “biomembrane sealing agents” to reduce the severity of hyperalgesia and allodynia following mechanical insult to the nervous system as well as their ability to reduce acute pain in a model of acute inflammation. Applicant describes the use of injectable or depot formulations of biomembrane sealing agent(s) for prophylactic treatment such as they could be administered after the insult (i.e. post-injury or post-surgery) but before the onset of acute or chronic pain. Alternatively, biomembrane sealing agents could be used to reduce the severity of acute or chronic pain after onset.