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公开(公告)号：US09175294B2
公开(公告)日：2015-11-03
申请号：US13745630
申请日：2013-01-18
Applicant: Danisco US Inc.
Inventor： Eugenio Ferrari , Carole Harbison , M. Harunur Rashid , Walter Weyler
Abstract: The present invention provides cells that have been genetically manipulated to have an altered capacity to produce expressed proteins. In particular, the present invention relates to Gram-positive microorganisms, such as Bacillus species having enhanced expression of a protein of interest, wherein one or more chromosomal genes have been inactivated, and preferably wherein one or more chromosomal genes have been deleted from the Bacillus chromosome. In some further embodiments, one or more indigenous chromosomal regions have been deleted from a corresponding wild-type Bacillus host chromosome.
Abstract translation: 本发明提供已被遗传操作以具有改变产生表达蛋白质的能力的细胞。 特别地，本发明涉及革兰氏阳性微生物，例如具有增强的感兴趣蛋白表达的芽孢杆菌属物种，其中一个或多个染色体基因已被灭活，并且优选其中一个或多个染色体基因已经从芽孢杆菌中缺失 染色体。 在一些另外的实施方案中，一个或多个本征染色体区已经从相应的野生型芽孢杆菌宿主染色体中缺失。
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公开(公告)号：US09617549B2
公开(公告)日：2017-04-11
申请号：US14857343
申请日：2015-09-17
Applicant: Danisco US Inc.
Inventor： Eugenio Ferrari , Carole Harbison , M. Harunur Rashid , Walter Weyler
Abstract: The present invention provides cells that have been genetically manipulated to have an altered capacity to produce expressed proteins. In particular, the present invention relates to Gram-positive microorganisms, such as Bacillus species having enhanced expression of a protein of interest, wherein one or more chromosomal genes have been inactivated, and preferably wherein one or more chromosomal genes have been deleted from the Bacillus chromosome. In some further embodiments, one or more indigenous chromosomal regions have been deleted from a corresponding wild-type Bacillus host chromosome.
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公开(公告)号：US20140011234A1
公开(公告)日：2014-01-09
申请号：US13745630
申请日：2013-01-18
Applicant: DANISCO US INC.
Inventor： Eugenio Ferrari , Carole Harbison , M. Harunur Rashid , Walter Weyler
Abstract: The present invention provides cells that have been genetically manipulated to have an altered capacity to produce expressed proteins. In particular, the present invention relates to Gram-positive microorganisms, such as Bacillus species having enhanced expression of a protein of interest, wherein one or more chromosomal genes have been inactivated, and preferably wherein one or more chromosomal genes have been deleted from the Bacillus chromosome. In some further embodiments, one or more indigenous chromosomal regions have been deleted from a corresponding wild-type Bacillus host chromosome.
Abstract translation: 本发明提供已被遗传操作以具有改变产生表达蛋白质的能力的细胞。 特别地，本发明涉及革兰氏阳性微生物，例如具有增强的感兴趣蛋白表达的芽孢杆菌属物种，其中一个或多个染色体基因已被灭活，并且优选其中一个或多个染色体基因已经从芽孢杆菌中缺失 染色体。 在一些另外的实施方案中，一个或多个本征染色体区已经从相应的野生型芽孢杆菌宿主染色体中缺失。
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