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公开(公告)号：US09175294B2
公开(公告)日：2015-11-03
申请号：US13745630
申请日：2013-01-18
Applicant: Danisco US Inc.
Inventor： Eugenio Ferrari , Carole Harbison , M. Harunur Rashid , Walter Weyler
Abstract: The present invention provides cells that have been genetically manipulated to have an altered capacity to produce expressed proteins. In particular, the present invention relates to Gram-positive microorganisms, such as Bacillus species having enhanced expression of a protein of interest, wherein one or more chromosomal genes have been inactivated, and preferably wherein one or more chromosomal genes have been deleted from the Bacillus chromosome. In some further embodiments, one or more indigenous chromosomal regions have been deleted from a corresponding wild-type Bacillus host chromosome.
Abstract translation: 本发明提供已被遗传操作以具有改变产生表达蛋白质的能力的细胞。 特别地，本发明涉及革兰氏阳性微生物，例如具有增强的感兴趣蛋白表达的芽孢杆菌属物种，其中一个或多个染色体基因已被灭活，并且优选其中一个或多个染色体基因已经从芽孢杆菌中缺失 染色体。 在一些另外的实施方案中，一个或多个本征染色体区已经从相应的野生型芽孢杆菌宿主染色体中缺失。
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公开(公告)号：US09282746B2
公开(公告)日：2016-03-15
申请号：US14273384
申请日：2014-05-08
Applicant: Danisco US Inc.
Inventor： Neelam S. Amin , Matthew G. Boston , Richard R. Bott , Maguerite A. Cervin , Edward M. Concar , Marc E. Gustwiller , Brian E. Jones , Klaus Liebeton , Gregory S. Miracle , Hiroshi Oh , Ayrookaran J. Poulose , Sandra W. Ramer , Jeffrey J. Scheibel , Walter Weyler , Gregory M. Whited
IPC: C12N9/14 , C12N9/18 , C12P21/06 , C12N1/20 , C11D3/386 , C11D3/00 , C07H21/04 , A01N63/00 , C12N9/16 , C12N9/50 , C12N9/52
CPC classification number: A01N63/00 , C11D3/38636 , C12N9/16 , C12N9/50 , C12N9/52
Abstract: The present invention provides methods and compositions comprising at least one perhydrolase enzyme for cleaning and other applications. In some particularly preferred embodiments, the present invention provides methods and compositions for generation of peracids. The present invention finds particular use in applications involving cleaning, bleaching and disinfecting.
Abstract translation: 本发明提供包含至少一种用于清洁和其它应用的过水解酶的方法和组合物。 在一些特别优选的实施方案中，本发明提供了用于产生过酸的方法和组合物。 本发明特别用于涉及清洗，漂白和消毒的应用中。
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3.发明申请ISOPRENE SYNTHASE VARIANTS FOR IMPROVED MICROBIAL PRODUCTION OF ISOPRENE 审中-公开用于改善微生物生产异烟肼的异丙肾上腺素变异体公开(公告)号：US20150191712A1
公开(公告)日：2015-07-09
申请号：US14543628
申请日：2014-11-17
Applicant: Danisco US Inc. , The Goodyear Tire & Rubber Company
Inventor： Richard R. BOTT , Marguerite A. Cervin , James T. Kellis, JR. , Joseph C. Mcauliffe , Andrei Miasnikov , Caroline M. Peres , Christopher L. Rife , Derek H. Wells , Walter Weyler , Gregory M. Whited
IPC: C12N9/88
CPC classification number: C12N9/88 , C12P5/007 , C12Y402/03027
Abstract: The present invention provides methods and compositions comprising at least one isoprene synthase enzyme with improved catalytic activity and/or solubility. In particular, the present invention provides variant plant isoprene synthases for increased isoprene production in microbial host cells. Biosynthetically produced isoprene of the present invention finds use in the manufacture of rubber and elastomers.
Abstract translation: 本发明提供包含至少一种具有改善的催化活性和/或溶解度的异戊二烯合酶的方法和组合物。 特别地，本发明提供用于在微生物宿主细胞中增加异戊二烯生产的变体植物异戊二烯合酶。 本发明的生物合成生产的异戊二烯可用于制造橡胶和弹性体。
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Patent Agency Ranking
公开(公告)号：US09617549B2
公开(公告)日：2017-04-11
申请号：US14857343
申请日：2015-09-17
Applicant: Danisco US Inc.
Inventor： Eugenio Ferrari , Carole Harbison , M. Harunur Rashid , Walter Weyler
Abstract: The present invention provides cells that have been genetically manipulated to have an altered capacity to produce expressed proteins. In particular, the present invention relates to Gram-positive microorganisms, such as Bacillus species having enhanced expression of a protein of interest, wherein one or more chromosomal genes have been inactivated, and preferably wherein one or more chromosomal genes have been deleted from the Bacillus chromosome. In some further embodiments, one or more indigenous chromosomal regions have been deleted from a corresponding wild-type Bacillus host chromosome.
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公开(公告)号：US08962283B2
公开(公告)日：2015-02-24
申请号：US13899057
申请日：2013-05-21
Applicant: Danisco US Inc.
Inventor： Luis G. Cascao-Pereira , Claudine Chang , Clement Choy , James T. Kellis, Jr. , Brian E. Jones , Melodie Estabrook , Marc Kolkman , Chris Leeflang , Casper Vroemen , Walter Weyler
IPC: C12P21/06 , C12N9/00 , C12N9/28 , C12N1/20 , C12N15/00 , C11D3/386 , C07H21/04 , A21D8/04 , A23K1/165 , A23K1/18 , A23L1/03
CPC classification number: C12N9/2417 , A21D8/042 , A23K20/189 , A23K50/75 , A23L29/06
Abstract: Described are variants (mutants) of a parent alpha-amylase having alpha-amylase activity and exhibiting altered properties relative to the parent alpha-amylase, and methods of use, thereof.
Abstract translation: 描述了具有α-淀粉酶活性并且相对于母体α-淀粉酶具有改变的性质的亲本α-淀粉酶的变体（突变体）及其使用方法。
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公开(公告)号：US20140011234A1
公开(公告)日：2014-01-09
申请号：US13745630
申请日：2013-01-18
Applicant: DANISCO US INC.
Inventor： Eugenio Ferrari , Carole Harbison , M. Harunur Rashid , Walter Weyler
Abstract: The present invention provides cells that have been genetically manipulated to have an altered capacity to produce expressed proteins. In particular, the present invention relates to Gram-positive microorganisms, such as Bacillus species having enhanced expression of a protein of interest, wherein one or more chromosomal genes have been inactivated, and preferably wherein one or more chromosomal genes have been deleted from the Bacillus chromosome. In some further embodiments, one or more indigenous chromosomal regions have been deleted from a corresponding wild-type Bacillus host chromosome.
Abstract translation: 本发明提供已被遗传操作以具有改变产生表达蛋白质的能力的细胞。 特别地，本发明涉及革兰氏阳性微生物，例如具有增强的感兴趣蛋白表达的芽孢杆菌属物种，其中一个或多个染色体基因已被灭活，并且优选其中一个或多个染色体基因已经从芽孢杆菌中缺失 染色体。 在一些另外的实施方案中，一个或多个本征染色体区已经从相应的野生型芽孢杆菌宿主染色体中缺失。
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公开(公告)号：US20140302003A1
公开(公告)日：2014-10-09
申请号：US14273384
申请日：2014-05-08
Applicant: DANISCO US INC.
Inventor： Neelam S. Amin , Matthew G. Boston , Richard R. Bott , Maguerite A. Cervin , Edward M. Concar , Marc E. Gustwiller , Brian E. Jones , Klaus Liebeton , Gregory S. Miracle , Hiroshi Oh , Ayrookaran J. Poulose , Sandra W. Ramer , Jeffrey J. Scheibel , Walter Weyler , Gregory M. Whited
CPC classification number: A01N63/00 , C11D3/38636 , C12N9/16 , C12N9/50 , C12N9/52
Abstract: The present invention provides methods and compositions comprising at least one perhydrolase enzyme for cleaning and other applications. In some particularly preferred embodiments, the present invention provides methods and compositions for generation of peracids. The present invention finds particular use in applications involving cleaning, bleaching and disinfecting.
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公开(公告)号：US20130344542A1
公开(公告)日：2013-12-26
申请号：US13899057
申请日：2013-05-21
Applicant: DANISCO US INC.
Inventor： Luis G. Cascao-Pereira , Claudine Chang , Clement Choy , James T. Kellis, JR. , Brian E. Jones , Melodie Estabrook , Marc Kolkman , Chris Leeflang , Casper Vroemen , Walter Weyler
IPC: C12N9/28
CPC classification number: C12N9/2417 , A21D8/042 , A23K20/189 , A23K50/75 , A23L29/06
Abstract: Described are variants (mutants) of a parent alpha-amylase having alpha-amylase activity and exhibiting altered properties relative to the parent alpha-amylase, and methods of use, thereof.
Abstract translation: 描述了具有α-淀粉酶活性并且相对于母体α-淀粉酶具有改变的性质的亲本α-淀粉酶的变体（突变体）及其使用方法。
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