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    PROTEASES COMPRISING ONE OR MORE COMBINABLE MUTATIONS
    3.
    发明申请
    PROTEASES COMPRISING ONE OR MORE COMBINABLE MUTATIONS 审中-公开
    包含一个或多个组合突变的标签

    公开(公告)号：US20150065412A1

    公开(公告)日：2015-03-05

    申请号：US14537660

    申请日：2014-11-10

    Applicant: DANISCO US INC.

    Inventor： Luis G. Cascao-Pereira ,  David A. Estell ,  James T. Kellis, JR.

    IPC: C12N9/54 ,  C11D3/386

    CPC classification number: C12N9/54 ,  C11D3/386 ,  C11D3/38609 ,  C11D3/38618 ,  C11D3/38663 ,  C11D3/38681 ,  C12N15/52 ,  C12Y304/21062

    Abstract: The present invention provides engineered protease variants. In particular, the protease variants comprise combinable mutations at selected surface positions that affect the charge and/or hydrophobicity of the enzyme to enhance at least one desired property of the resulting variant enzyme in a chosen application. Compositions comprising the protease variants, and methods for using the same are also provided.

    Abstract translation: 本发明提供工程蛋白酶变体。 特别地，蛋白酶变体在选定的表面位置包含影响酶的电荷和/或疏水性的可组合突变，以在所选择的应用中增强所得变体酶的至少一种所需性质。 还提供了包含蛋白酶变体的组合物及其使用方法。

    Multiply-Substituted Protease Variants
    5.
    发明申请
    Multiply-Substituted Protease Variants 审中-公开
    多重取代的蛋白酶变体

    公开(公告)号：US20130171717A1

    公开(公告)日：2013-07-04

    申请号：US13723970

    申请日：2012-12-21

    Applicant: Danisco US Inc.

    Inventor： Ayrookaran J. Poulose ,  David A. Estell ,  James T. Kellis, JR. ,  Richard R. Bott

    IPC: C12N9/54

    CPC classification number: C12N9/54 ,  C11D3/386 ,  C11D3/38609 ,  C12Y304/21062

    Abstract: Novel enzyme variants including protease variants derived from the DNA sequences of naturally-occurring or recombinant non-human proteases are disclosed. The variant proteases, in general, are obtained by in vitro modification of a precursor DNA sequence encoding the naturally-occurring or recombinant protease to generate the substitution of a plurality of amino acid residues in the amino acid sequence of a precursor protease. Such variant proteases have properties which are different from those of the precursor protease, such as altered wash performance. The substituted amino acid residue correspond to positions 27, 45, 170, 181, 251 and 271 of Bacillus amyloliquefaciens subtilisin. Additional variants comprising at least one additional substitution at a position selected from 1, 14, 49, 61, 87, 100, 102, 118, 128, 204 and 258 of Bacillus amyloliquefaciens subtilisin are also described.

    Abstract translation: 公开了包含衍生自天然或重组非人蛋白酶的DNA序列的蛋白酶变体的新型酶变体。 一般来说，变体蛋白酶通过体外修饰编码天然存在或重组蛋白酶的前体DNA序列获得，以产生前体蛋白酶的氨基酸序列中的多个氨基酸残基的取代。 这种变体蛋白酶具有与前体蛋白酶不同的性质，例如改变的洗涤性能。 取代的氨基酸残基对应于解淀粉芽孢杆菌枯草杆菌蛋白酶的位置27,45,170,181,251和271。 还描述了包含在解淀粉芽孢杆菌枯草杆菌蛋白酶的1,4,14,69,61,87,100,102,118,128,204和258的位置上的至少一个另外的取代的其它变体。

    PROTEASES COMPRISING ONE OR MORE COMBINABLE MUTATIONS
    10.
    发明申请
    PROTEASES COMPRISING ONE OR MORE COMBINABLE MUTATIONS 有权
    包含一个或多个组合突变的标签

    公开(公告)号：US20140308736A1

    公开(公告)日：2014-10-16

    申请号：US14268488

    申请日：2014-05-02

    Applicant: Danisco US Inc.

    Inventor： Luis G. Cascao-Pereira ,  David A. Estell ,  James T. Kellis, JR.

    IPC: C11D3/386 ,  C12N9/54

    CPC classification number: C12N9/54 ,  C11D3/386 ,  C11D3/38609 ,  C11D3/38618 ,  C11D3/38663 ,  C11D3/38681 ,  C12N15/52 ,  C12Y304/21062

    Abstract: The present invention provides engineered protease variants. In particular, the protease variants comprise combinable mutations at selected surface positions that affect the charge and/or hydrophobicity of the enzyme to enhance at least one desired property of the resulting variant enzyme in a chosen application. Compositions comprising the protease variants, and methods for using the same are also provided.

    Abstract translation: 本发明提供工程蛋白酶变体。 特别地，蛋白酶变体在选定的表面位置包含影响酶的电荷和/或疏水性的可组合突变，以在所选择的应用中增强所得变体酶的至少一种所需性质。 还提供了包含蛋白酶变体的组合物及其使用方法。

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