公开(公告)号：US20240368573A1

公开(公告)日：2024-11-07

申请号：US17961007

申请日：2022-10-06

Applicant: Danisco US Inc.

Inventor： Lilia Maria Babe ,  Richard R. Bott ,  David A. Estell ,  Harm Mulder ,  Frits Goedegebuur ,  Jian Yao ,  Sina Pricelius ,  Miles Scotcher

IPC: C12N9/54 ,  C11D3/386

Abstract: Disclosed herein is one or more subtilisin variant, nucleic acid encoding same, and compositions and methods related to the production and use thereof, including one or more Bacillus gibsonii-clade subtilisin variant that has improved stability and/or soil removal compared to one or more reference subtilisin.

公开(公告)号：US20180073006A1

公开(公告)日：2018-03-15

申请号：US15725627

申请日：2017-10-05

Applicant: DANISCO US INC.

Inventor： Lilia M. Babe ,  Richard R. Bott ,  Roopa Ghirnikar ,  Frits Goedegebuur ,  Xiaogang Gu ,  Marc Kolkman ,  Jian Yao ,  Shukun Yu

IPC: C12N9/54 ,  C11D3/386

CPC classification number: C12N9/54 ,  C11D3/386 ,  C12Y304/24 ,  C12Y304/24027

Abstract: Aspects of the present compositions and methods relate to novel metalloproteases polynucleotides encoding the novel metalloprotease, compositions and methods for use thereof.

公开(公告)号：US20180023068A1

公开(公告)日：2018-01-25

申请号：US15726719

申请日：2017-10-06

Applicant: DANISCO US INC.

Inventor： Lilia M. Babe ,  Roopa Ghirnikar ,  Frits Goedegebuur ,  Xiaogang Gu ,  Marc Kolkman ,  Jian Yao ,  Shukun Yu

IPC: C12N9/52 ,  C11D3/386

CPC classification number: C12N9/52 ,  A23K10/14 ,  A23K20/189 ,  C11D3/386 ,  C12Y304/24

Abstract: Aspects of the present compositions and methods relate to novel metalloproteases polynucleotides encoding the novel metalloprotease, compositions and methods for use thereof.

公开(公告)号：US09523087B2

公开(公告)日：2016-12-20

申请号：US14189943

申请日：2014-02-25

Applicant: Danisco US Inc.

Inventor： Wolfgang Aehle ,  Richard R. Bott ,  Benjamin S. Bower ,  Jonathan Caspi ,  David A. Estell ,  Frits Goedegebuur ,  Ronaldus Wilhelmus Joannes Hommes ,  Thijs Kaper ,  Bradley R. Kelemen ,  Slavko Kralj ,  Johannes Franciscus Thomas Van Lieshout ,  Igor Nikolaev ,  Sander Van Stigt Thans ,  Louise Wallace ,  Gudrun Vogtentanz ,  Mats Sandgren

IPC: C12N9/42 ,  C12N9/52 ,  C07H21/04

CPC classification number: C12N9/2437 ,  C12Y302/01091 ,  Y02E50/17

Abstract: The present disclosure relates to cellulase variants. In particular the present disclosure relates to cellulase variants having improved expression, activity and/or stability. Also described are nucleic acids encoding the cellulase variants, compositions comprising the cellulase variants, and methods of use thereof.

Abstract translation: 本公开涉及纤维素酶变体。 特别地，本公开涉及具有改善的表达，活性和/或稳定性的纤维素酶变体。 还描述了编码纤维素酶变体的核酸，包含纤维素酶变体的组合物及其使用方法。

公开(公告)号：US20160222368A1

公开(公告)日：2016-08-04

申请号：US15021681

申请日：2014-09-11

Applicant: DANISCO US INC.

Inventor： Lilia M. Babe ,  David A. Estell ,  Frits Goedegebuur ,  Richard R. Bott ,  Marc Kolkman ,  Harm Mulder ,  Brian F. Schmidt ,  Katherine Augustyn ,  Munroop Atwal ,  Abby Marquez

IPC: C12N9/54 ,  C12N5/071 ,  A23K20/189 ,  D06M16/00 ,  C14C1/06 ,  D21C9/10 ,  C11D3/386

CPC classification number: C12N9/54 ,  A23K20/189 ,  C11D3/386 ,  C11D3/38681 ,  C12N5/0602 ,  C12Y304/21062 ,  C14C1/065 ,  D06M16/003 ,  D21C9/1063

Abstract: The present invention provides serine protease enzymes produced from LG12-clade enzymes. In addition, the present invention provides compositions comprising these protease enzymes. In some embodiments, the present invention provides cleaning compositions comprising at least one of these protease enzymes.

Abstract translation: 本发明提供了由LG12-分支酶产生的丝氨酸蛋白酶。 此外，本发明提供包含这些蛋白酶的组合物。 在一些实施方案中，本发明提供了包含这些蛋白酶中的至少一种的清洁组合物。

公开(公告)号：US20160122738A1

公开(公告)日：2016-05-05

申请号：US14893473

申请日：2014-05-29

Applicant: DANISCO US INC.

Inventor： Lilia M. Babe ,  Roopa Ghirnikar ,  Frits Goedegebuur ,  Xiaogang Gu ,  Marc Kolkman ,  Jian Yao

IPC: C12N9/52 ,  C11D3/386

CPC classification number: C12N9/52 ,  C11D3/386 ,  C11D3/38681 ,  C12N9/485 ,  C12N9/54 ,  C12Y304/24

Abstract: Aspects of the present compositions and methods relate to novel metalloproteases, polynucleotides encoding the novel metalloproteases, and compositions and methods for use thereof.

Abstract translation: 本发明组合物和方法的方面涉及新型金属蛋白酶，编码新型金属蛋白酶的多核苷酸，及其组合物及其使用方法。

公开(公告)号：US20160010072A1

公开(公告)日：2016-01-14

申请号：US14754355

申请日：2015-06-29

Applicant: Danisco US Inc.

Inventor： Wolfgang Aehle ,  Luis G. Cascao-Pereira ,  David A. Estell ,  Frits Goedegebuur ,  James T. Kellis ,  Ayrookaran J. Poulose ,  Brian F. Schmidt

IPC: C12N9/54

CPC classification number: C12N9/54 ,  C11D3/386 ,  C11D3/38609 ,  C11D3/38618 ,  C11D3/38663 ,  C11D3/38681 ,  C12N15/52 ,  C12Y304/21062

Abstract: The present invention provides engineered protease variants. In particular, the protease variants comprise combinable mutations at selected surface positions that affect the charge and/or hydrophobicity of the enzyme to enhance at least one desired property of the resulting variant enzyme in a chosen application. Compositions comprising the protease variants, and methods for using the same are also provided.

公开(公告)号：US20140295527A1

公开(公告)日：2014-10-02

申请号：US14258909

申请日：2014-04-22

Applicant: DANISCO US INC.

Inventor： David A. Estell ,  Frits Goedegebuur ,  Ayrookaran J. Poulose

IPC: C11D3/386 ,  C12N9/54

CPC classification number: C11D3/386 ,  C11D3/38609 ,  C11D3/38618 ,  C11D3/38681 ,  C11D3/3942 ,  C12N9/54 ,  C12Y304/21062

Abstract: The present invention provides a Bacillus sp. subtilisin variant. In addition, the present invention provides automatic dishwashing compositions comprising this serine protease variant.

Abstract translation: 本发明提供芽孢杆菌属 枯草杆菌蛋白酶变体。 此外，本发明提供了包含该丝氨酸蛋白酶变体的自动餐具洗涤组合物。

公开(公告)号：US11473075B2

公开(公告)日：2022-10-18

申请号：US16720106

申请日：2019-12-19

Applicant: DANISCO US INC

Inventor： David A. Estell ,  Frits Goedegebuur ,  Marc Anton Bernhard Kolkman ,  Rie Mejldal ,  Katherine Augustyn ,  Lilia Maria Babe ,  Richard R Bott ,  Jian Yao ,  Roopa Santosh Ghirnikar

IPC: C12N9/54 ,  C11D3/386

Abstract: The present disclosure provides AprL-clade protease enzymes, including variant AprL-clade protease enzymes, nucleic acids encoding same, and compositions and methods related to the production and use thereof, including an AprL-clade variant subtilisin enzyme that has improved stability and/or soil removal compared to a parent AprL-clade subtilisin enzyme.

公开(公告)号：US11384348B2

公开(公告)日：2022-07-12

申请号：US16703053

申请日：2019-12-04

Applicant: DANISCO US INC

Inventor： Marc Kolkman ,  Frits Goedegebuur ,  Lilia Maria Babe ,  Rie Mejldal ,  Harm Mulder ,  Anja Hemmingsen Kellett-Smith ,  Richard R Bott ,  Miles Christopher Scotcher

IPC: C12N9/54 ,  A47L15/00 ,  C11D3/386

Abstract: The present disclosure relates to serine proteases cloned from Bacillus gibsonii, and variants thereof. Compositions containing the serine proteases are suitable for use in cleaning fabrics and hard surfaces, as well as in a variety of industrial applications.