公开(公告)号：US20050058695A1

公开(公告)日：2005-03-17

申请号：US10740373

申请日：2003-12-17

申请人： Angela Anigbogu ,  Ana Ruiz ,  Danyi Quan

发明人： Angela Anigbogu ,  Ana Ruiz ,  Danyi Quan

IPC分类号： A61F13/00 ,  A61K9/70 ,  A61K31/56 ,  A61K31/565 ,  A61K31/567

CPC分类号： A61K9/7061 ,  A61K31/56 ,  A61K31/565 ,  A61K31/567

摘要： Sustained delivery formulations of norethindrone are disclosed and described. In one aspect, the formulation may be a transdermal formulation that includes both norethindrone and norethindrone acetate. In another aspect, the formulation may further include a penetration enhancer. Coadministration of norethindrone and norethindrone acetate has been found to provide a number of advantages, such as achievement of peak norethindrone serum levels substantially within 24 hours after initiation of administration.

摘要翻译： 公开和描述炔诺酮的持续递送制剂。 一方面，制剂可以是包括炔诺酮和醋酸炔诺酮二者的透皮制剂。 在另一方面，制剂还可包含渗透增强剂。 已经发现炔诺酮和醋酸炔诺酮的共同施用提供了许多优点，例如在开始给药后24小时内达到顶点炔诺酮血清水平。

公开(公告)号：US06585963B1

公开(公告)日：2003-07-01

申请号：US09832349

申请日：2001-04-10

申请人： Danyi Quan ,  Ana Ruiz

发明人： Danyi Quan ,  Ana Ruiz

IPC分类号： A61K704

CPC分类号： A61Q3/02 ,  A01N25/02 ,  A01N25/10 ,  A01N43/653 ,  A61K8/375 ,  A61K8/42 ,  A61K8/46 ,  A61K8/494 ,  A61K8/4973 ,  A61K8/8164 ,  A61Q3/00 ,  A01N43/90 ,  A01N41/10 ,  A01N37/20 ,  A01N37/18 ,  A01N37/12 ,  A01N2300/00

摘要： Nail compositions and methods of use thereof are disclosed. Additionally, nail kits comprising a nail composition and pre-treatment compositions are disclosed. Further, supportive devices such as bandages for use in the administering a nail composition are disclosed. In one aspect of the invention, the nail compositions comprise an antifungal agent, including fluconazole, a non-cellulosic polymeric carrier, and an enhancer, while being substantially free of urea, sulfhydryl-containing amino acids, or vasodilators.

摘要翻译： 公开了指甲组合物及其使用方法。 另外，公开了包含指甲组合物和预处理组合物的指甲试剂盒。 此外，公开了用于施用指甲组合物的支撑装置，例如绷带。 在本发明的一个方面，指甲组合物包含抗真菌剂，包括氟康唑，非纤维素聚合物载体和增强剂，同时基本上不含尿素，含巯基的氨基酸或血管扩张剂。

公开(公告)号：US06727401B1

公开(公告)日：2004-04-27

申请号：US09022504

申请日：1998-02-12

申请人： Srinivasan Venkateshwaran ,  Danyi Quan

发明人： Srinivasan Venkateshwaran ,  Danyi Quan

IPC分类号： A61F1300

CPC分类号： A61K9/7061 ,  A61F13/105 ,  A61K8/4946 ,  A61Q3/00

摘要： A device for treating antifungal infections of toenails and fingernails is made up of an occlusive backing layer and a pressure sensitive adhesive matrix layer in which is uniformly dispersed an effective amount of an antifungal agent and, optionally, a chemical enhancer. The matrix layer has a first surface adhering to the backing layer and a second surface adapted to be in diffusional contact with the infected nail and surrounding skin area. The device is configured, when applied, to cover and adhere to the nail and surrounding skin areas for an extended period of time without causing irritation to the skin or inhibiting normal physical activity while providing a continuous delivery of antifungal agent to the infected area.

摘要翻译： 用于治疗脚趾甲和指甲的真菌感染的装置由闭塞背衬层和压敏粘合剂基质层组成，其中均匀分散有效量的抗真菌剂和任选的化学增强剂。 基质层具有粘附到背衬层的第一表面和适于与受感染的指甲和周围皮肤区域扩散接触的第二表面。 该装置在施用时被配置为在延长的时间段内覆盖并粘附到指甲和周围皮肤区域，而不会对皮肤产生刺激或抑制正常的身体活动，同时提供抗真菌剂到感染区域的连续递送。

公开(公告)号：US06730318B2

公开(公告)日：2004-05-04

申请号：US09924564

申请日：2001-08-08

申请人： Danyi Quan ,  Srinivasan Venkateshwaran ,  Charles D. Ebert

发明人： Danyi Quan ,  Srinivasan Venkateshwaran ,  Charles D. Ebert

IPC分类号： A61F1302

CPC分类号： A61K8/891 ,  A61F9/04 ,  A61F13/122 ,  A61F2013/00374 ,  A61F2013/00497 ,  A61F2013/00906 ,  A61K8/0208 ,  A61K8/676 ,  A61K8/678 ,  A61K9/7053 ,  A61K9/7061 ,  A61Q19/00 ,  A61Q19/08

摘要： The adhesive capability of matrix-type transdermal devices for the delivery of drugs, cosmetics, emollients and the like is altered by incorporating into the pressure-sensitive adhesive an effective amount of a polydiorganosiloxane polymer fluid adhesion adjusting agent. The properties of the pressure-sensitive adhesive are modified to enable a matrix-type patch to adhere temporarily to the skin for a period sufficient to accomplish its desired delivery purpose and then be removed without causing skin damage or irritation and without leaving substantial adhesive residue on the skin. Polydimethylsiloxanes (dimethicones) are preferred adhesion adjusting agents and acrylic-based polymers are preferred pressure-sensitive adhesives. Matrix-type patches containing anti-wrinkle agents formulated with dimethicones in the adhesive for application to areas on the face and particularly around the eyes are especially useful.

摘要翻译： 用于递送药物，化妆品，润肤剂等的基质型透皮装置的粘合能力通过将有效量的聚二有机硅氧烷聚合物流体粘附调节剂并入压敏粘合剂而改变。 修改压敏粘合剂的性能以使基质型贴片能够临时粘附到皮肤上足够长的时间以实现其期望的递送目的，然后在不引起皮肤损伤或刺激的情况下被除去并且不会留下大量的粘合剂残留物 皮。 聚二甲基硅氧烷（二甲基硅氧烷）是优选的粘合调节剂，丙烯酸类聚合物是优选的压敏粘合剂。 在粘合剂中用二甲硅油配制的抗皱剂的基质型贴剂适用于脸部和特别是眼睛周围的区域是特别有用的。

公开(公告)号：US5601839A

公开(公告)日：1997-02-11

申请号：US429757

申请日：1995-04-26

申请人： Danyi Quan ,  Ninad A. Deshpanday ,  Srinivasan Venkateshwaran ,  Charles D. Ebert

发明人： Danyi Quan ,  Ninad A. Deshpanday ,  Srinivasan Venkateshwaran ,  Charles D. Ebert

IPC分类号： A61K9/00 ,  A61K9/70 ,  A61K31/137 ,  A61K31/138 ,  A61K31/167 ,  A61K31/216 ,  A61K31/404 ,  A61K31/4458 ,  A61K31/46 ,  A61K31/485 ,  A61K31/5415 ,  A61K31/55 ,  A61K47/10 ,  A61K47/14 ,  A61K47/30 ,  A61K47/32 ,  A61P9/00 ,  A61P9/06 ,  A61P21/02 ,  A61P23/02 ,  A61P25/04 ,  A61P25/24 ,  A61P25/26 ,  A61P27/02 ,  A61F13/02

CPC分类号： A61K9/7053 ,  A61K47/14 ,  A61K9/0014 ,  A61K9/7061 ,  A61K9/7069 ,  Y10S514/946

摘要： A composition and method for enhancing transdermal penetration of a basic drug are described. The composition comprises a matrix patch comprising an effective amount of a basic drug, preferably having a pK.sub.a of about 8.0 or greater, an effective amount of penetration enhancer consisting essentially of triacetin, and a polymer later preferably comprising a pressure-sensitive adhesive. A preferred basic drug is oxybutynin and acid addition salts thereof. The method for enhancing transdermal penetration comprises applying the matrix patch to a selected area of skin.

摘要翻译： 描述了用于增强基础药物透皮渗透的组合物和方法。 所述组合物包含基质贴片，其包含有效量的碱性药物，优选具有约8.0或更大的pKa，有效量的基本上由三醋精组成的渗透促进剂，以及稍后优选包含压敏粘合剂的聚合物。 优选的碱性药物是奥昔布宁及其酸加成盐。 用于增强透皮渗透的方法包括将基质片施加到选定的皮肤区域。

公开(公告)号：US20050287278A1

公开(公告)日：2005-12-29

申请号：US10877757

申请日：2004-06-24

申请人： Danyi Quan ,  Wade Xiong

发明人： Danyi Quan ,  Wade Xiong

IPC分类号： A23F3/00 ,  A23F3/16 ,  A23F3/18

CPC分类号： A23F3/18 ,  A23F3/163

摘要： Green tea formulations and methods for the preparation thereof are disclosed and described. Generally speaking, the method of preparation includes the mixing of fresh tea leaves in an amount of cold water, followed by pulverization of the leaves to release their intracellular material from the cells of the green tea leaves into the water and form an aqueous extract component. The remaining cellular material forms a leaf residue component which is removed from the mixture. Once the leaf residue is removed, the aqueous extract component is collected and may be dried or further processed to produce a final tea extract that has good natural color, robust natural flavor, and pleasant organoleptic properties, which also is high in polyphenol content, and may be used for various purposes such as the creation of a green tea beverage.

摘要翻译： 公开和描述了绿茶制剂及其制备方法。 一般来说，制备方法包括以一定量的冷水混合新鲜茶叶，然后粉碎叶子以将其细胞内物质从绿茶叶的细胞释放到水中并形成水提取物组分。 剩余的细胞材料形成从混合物中除去的叶残渣成分。 一旦叶片残留物被去除，收集水提取物组分，并且可以将其干燥或进一步加工以产生具有良好的天然色彩，强壮的天然风味和愉悦的感官特性的最终茶提取物，其也具有高的多酚含量，以及 可以用于各种目的，例如创建绿茶饮料。

公开(公告)号：US06180133B2

公开(公告)日：2001-01-30

申请号：US09198734

申请日：1998-11-24

申请人： Danyi Quan ,  Srinivasan Venkateshwaran ,  Charles D. Ebert

发明人： Danyi Quan ,  Srinivasan Venkateshwaran ,  Charles D. Ebert

IPC分类号： A61K970

CPC分类号： A61Q19/08 ,  A61F9/04 ,  A61F13/122 ,  A61F2013/00374 ,  A61F2013/00497 ,  A61F2013/00906 ,  A61K8/0208 ,  A61K8/676 ,  A61K8/678 ,  A61K2800/522 ,  Y10S514/844 ,  Y10S514/848 ,  Y10S514/975

摘要： An anti-wrinkle skin treating composition comprises a pressure sensitive matrix patch having dissolved in the adhesive a mixture of antioxidants in the form of a Vitamins C ester and Vitamin E. Also preferably dissolved in the adhesive are glycerine and a polydiorganosiloxane adhesion-adjusting agent. Optionally dissolved in the adhesive is also one or more members selected from the group consisting of moisturizing agents, skin collagen synthesis promoting agents and exfoliating agents. When applied to a wrinkled skin area the composition acts to diminish fine wrinkles and improves the overall thickness, elasticity, firmness and smoothness of the skin. The modified adhesive properties of the patch are sufficient to maintain the patch in place on the skin for the recommended treatment period while allowing the patch to be readily removed without causing skin irritation or leaving adhesive residue on the skin.

摘要翻译： 抗皱皮肤处理组合物包含在维生素C酯和维生素E形式的溶解在粘合剂中的抗氧化剂混合物的压敏基质贴片。还优选溶解在粘合剂中的是甘油和聚二有机硅氧烷粘合调节剂。 任选地溶解在粘合剂中也是选自保湿剂，皮肤胶原合成促进剂和去角质剂的一种或多种。 当应用于起皱的皮肤区域时，组合物起减少细小皱纹的作用，并提高皮肤的整体厚度，弹性，坚固度和平滑度。 贴剂的改性粘合剂性能足以将贴片保持在皮肤上适合推荐的治疗期，同时允许容易地去除贴片而不引起皮肤刺激或在皮肤上留下粘合剂残留物。

公开(公告)号：US07815960B2

公开(公告)日：2010-10-19

申请号：US11820482

申请日：2007-06-18

申请人： Danyi Quan ,  Wade W. Xiong

发明人： Danyi Quan ,  Wade W. Xiong

IPC分类号： A23F3/18

CPC分类号： A23F3/18 ,  A23F3/163

摘要： Green tea formulations and methods for the preparation thereof are shown and described. Generally speaking, the method of preparation includes the mixing of fresh tea leaves in an amount of cold water, followed by pulverization of the leaves to release their intracellular material from the cells of the green tea leaves into the water and form an aqueous extract component. The remaining cellular material forms a leaf residue component which is removed from the mixture. Once the leaf residue is removed, the aqueous extract component is collected and may be dried or further processed to produce a final tea extract that has good natural color, robust natural flavor, and pleasant organoleptic properties, which also is high in polyphenol content, and may be used for various purposes such as the creation of a green tea beverage.

摘要翻译： 绿茶配方及其制备方法的显示和描述。 一般来说，制备方法包括以一定量的冷水混合新鲜茶叶，然后粉碎叶子以将其细胞内物质从绿茶叶的细胞释放到水中并形成水提取物组分。 剩余的细胞材料形成从混合物中除去的叶残渣成分。 一旦叶片残留物被去除，收集水提取物组分，并且可以将其干燥或进一步加工以产生具有良好的天然色彩，强壮的天然风味和愉悦的感官特性的最终茶提取物，其也具有高的多酚含量，以及 可以用于各种目的，例如创建绿茶饮料。

公开(公告)号：US20070292560A1

公开(公告)日：2007-12-20

申请号：US11820482

申请日：2007-06-18

申请人： Danyi Quan ,  Wade Xiong

发明人： Danyi Quan ,  Wade Xiong

IPC分类号： A23F3/18

CPC分类号： A23F3/18 ,  A23F3/163

摘要： Green tea formulations and methods for the preparation thereof are disclosed and described. Generally speaking, the method of preparation includes the mixing of fresh tea leaves in an amount of cold water, followed by pulverization of the leaves to release their intracellular material from the cells of the green tea leaves into the water and form an aqueous extract component. The remaining cellular material forms a leaf residue component which is removed from the mixture. Once the leaf residue is removed, the aqueous extract component is collected and may be dried or further processed to produce a final tea extract that has good natural color, robust natural flavor, and pleasant organoleptic properties, which also is high in polyphenol content, and may be used for various purposes such as the creation of a green tea beverage.

摘要翻译： 公开和描述了绿茶制剂及其制备方法。 一般来说，制备方法包括以一定量的冷水混合新鲜茶叶，然后粉碎叶子以将其细胞内物质从绿茶叶的细胞释放到水中并形成水提取物组分。 剩余的细胞材料形成从混合物中除去的叶残渣成分。 一旦叶片残留物被去除，收集水提取物组分，并且可以将其干燥或进一步加工以产生具有良好的天然色彩，强壮的天然风味和愉悦的感官特性的最终茶提取物，其也具有高的多酚含量，以及 可以用于各种目的，例如创建绿茶饮料。

公开(公告)号：US20070141204A1

公开(公告)日：2007-06-21

申请号：US11305316

申请日：2005-12-15

申请人： Wade Xiong ,  Danyi Quan

发明人： Wade Xiong ,  Danyi Quan

IPC分类号： A23L1/30

CPC分类号： A23L2/52

摘要： A beverage and supplement system includes a beverage container having: i) a liquid contained therein; and ii) a dispensive opening. A removable envelope is in communication with the dispensive opening of the container, and has a first side sealed to a second side with the supplement being contained therebetween. The second side of the envelope is rupturable upon application of force to the first side in an amount sufficient to rupture the second side without rupturing the first side, in order to dispense the supplement from the envelope without contacting the supplement with an external object.

摘要翻译： 饮料和补充系统包括饮料容器，其具有：i）其中容纳的液体; 和ii）安静的开放。 可拆卸的外壳与容器的可调开口连通，并且具有密封到第二侧的第一侧，其间容纳有补充物。 在向第一侧施加足以使第二侧破裂而不破坏第一侧的量的情况下，信封的第二侧是可破裂的，以便从外壳分配补充物而不将附件与外部物体接触。