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公开(公告)号：US5188830A
公开(公告)日：1993-02-23
申请号：US517915
申请日：1990-04-02
申请人： Joseph G. Atkinson , David A. Claremon , John J. Baldwin , Paul A. Friedman , David C. Remy , Andrew M. Stern
发明人： Joseph G. Atkinson , David A. Claremon , John J. Baldwin , Paul A. Friedman , David C. Remy , Andrew M. Stern
IPC分类号： A61K31/335 , A61K31/41 , A61K31/415 , A61K31/42 , A61K31/425 , A61K31/445 , A61K31/535 , A61K38/43
CPC分类号： A61K38/49 , A61K31/335 , A61K31/41 , A61K31/415 , A61K31/42 , A61K31/425 , A61K31/445 , A61K31/535 , C12Y304/21068
摘要： Certain Factor XIIIa inhibitor compounds have been discovered which have been found to be useful in the lysis of blood clots and thus adaptable for administration in thrombolytic therapy either alone or together with plasminogen activator.
摘要翻译： 已经发现已经发现某些因子XIIIa抑制剂化合物可用于溶血裂解血凝块，因此适用于单独或与纤溶酶原激活剂一起在溶栓治疗中施用。
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公开(公告)号：US4968494A
公开(公告)日：1990-11-06
申请号：US507013
申请日：1990-04-10
IPC分类号： A61K31/335 , A61K31/41 , A61K31/415 , A61K31/42 , A61K31/425 , A61K31/445 , A61K31/535 , A61K38/43
CPC分类号： A61K31/415 , A61K31/335 , A61K31/41 , A61K31/42 , A61K31/425 , A61K31/445 , A61K31/535 , A61K38/166 , A61K38/49
摘要： Certain Factor XIIIa inhibitor compounds have been discovered which have been found to be useful in the lysis of blood clots and thus adaptable for administration in thrombolytic therapy either alone or together with plasminogen activator.
摘要翻译： 已经发现已经发现某些因子XIIIa抑制剂化合物可用于溶血裂解血凝块，因此适用于单独或与纤溶酶原激活剂一起在溶栓治疗中的施用。
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公开(公告)号：US5185149A
公开(公告)日：1993-02-09
申请号：US503028
申请日：1990-04-02
IPC分类号： A61K31/335 , A61K31/41 , A61K31/415 , A61K31/42 , A61K31/425 , A61K31/445 , A61K31/535 , A61K38/43
CPC分类号： C12Y304/21068 , A61K31/335 , A61K31/41 , A61K31/415 , A61K31/42 , A61K31/425 , A61K31/445 , A61K31/535 , A61K38/49
摘要： Certain Factor XIIIa inhibitor compounds have been discovered which have been found to be useful in the lysis of blood clots and thus adaptable for administration in thrombolytic therapy either alone or together with plasminogen activator.
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4.发明申请METHODS FOR INDUCING POLYPLOIDIZATION OF MEGAKARYOCYTES AND FOR TREATING BLOOD AND BONE MARROW DISEASES AND DISORDERS 有权诱导多糖的多分支化合物和治疗血液和骨髓疾病和疾病的方法公开(公告)号：US20100120750A1
公开(公告)日：2010-05-13
申请号：US12613996
申请日：2009-11-06
申请人： John D. Crispino , Qiang Wen , Zan Huang , Andrew M. Stern , Robert J. Gould
发明人： John D. Crispino , Qiang Wen , Zan Huang , Andrew M. Stern , Robert J. Gould
IPC分类号： A61K31/5513 , C12N5/071 , C12N5/02 , A61K31/4439 , A61P7/00
CPC分类号： A61K31/5513 , A61K31/551
摘要： Disclosed are methods for inducing polyploidization of megakaryocyte cells and for promoting differentiation of megakaryocyte cells into platelet-producing cells. The methods may be utilized for treating blood and bone marrow diseases and disorders in a subject in need thereof and for identifying agents for treating blood and bone marrow diseases and disorders.
摘要翻译： 公开了诱导巨核细胞多倍体化和促进巨核细胞分化成血小板产生细胞的方法。 该方法可用于治疗有需要的受试者中的血液和骨髓疾病和病症，以及用于鉴定用于治疗血液和骨髓疾病和病症的药剂。
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公开(公告)号：US20100159455A1
公开(公告)日：2010-06-24
申请号：US12441672
申请日：2007-09-18
申请人： Tanya Landsman , David J. Livingston , Richard A. Martinelli , Yumei Huang , Benjamin Adam Seigal , Dingxue Yan , James M. Coull , Andrew M. Stern
发明人： Tanya Landsman , David J. Livingston , Richard A. Martinelli , Yumei Huang , Benjamin Adam Seigal , Dingxue Yan , James M. Coull , Andrew M. Stern
IPC分类号： C12Q1/68
CPC分类号： G01N33/542 , C12Q1/6804 , G01N33/566 , G01N2333/71 , C12Q2565/101 , C12Q2563/179 , C12Q2563/131
摘要： The invention provides compositions and methods, e.g., assay technologies and their use in biodetection and diagnostics. More particularly, the invention provides compositions and methods based on nucleic acid-templated chemistry in biodetection and profiling of receptors (and their families) and proteins (and their families), and the use of same in diagnostics.
摘要翻译： 本发明提供组合物和方法，例如测定技术及其在生物检测和诊断中的应用。 更具体地，本发明提供了基于生物检测和受体（及其家族）和蛋白质（及其家族）的生物检测和分析的核酸模板化学的组合物和方法，以及其在诊断中的用途。
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公开(公告)号：US20090163371A1
公开(公告)日：2009-06-25
申请号：US11915533
申请日：2006-05-31
CPC分类号： C12Q1/6804 , C12Q2563/179
摘要： The invention provides methods for compound and lead generation and discovery. In particular, the present invention provides a method for generating compounds and for selecting compounds that bind to a target. The present invention provides a way by which anchors (e.g., weak binders) and anchor-scaffold conjugates can be evolved into new generations of compounds having improved target binding and other desired pharmaceutical properties through control of both synthetic input and selection criteria.
摘要翻译： 本发明提供了化合物和引物产生和发现的方法。 特别地，本发明提供了一种产生化合物和选择与靶标结合的化合物的方法。 本发明提供了通过控制合成输入和选择标准，锚（例如，弱粘合剂）和锚 - 支架共轭物可以通过其改进的靶结合和其它期望的药物性质而演变成新一代化合物的方式。
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7.发明授权Dimethyl fasudil for inducing polyploidization of megakaryocytes and for treating blood and bone marrow diseases and disorders 有权二甲基法舒地尔诱导巨核细胞的多倍体化和治疗血液和骨髓疾病和病症公开(公告)号：US08933071B2
公开(公告)日：2015-01-13
申请号：US12613996
申请日：2009-11-06
申请人： John D. Crispino , Qiang Wen , Zan Huang , Andrew M. Stern , Robert J. Gould
发明人： John D. Crispino , Qiang Wen , Zan Huang , Andrew M. Stern , Robert J. Gould
IPC分类号： A61K31/551 , A61K31/5513
CPC分类号： A61K31/5513 , A61K31/551
摘要： Disclosed are methods for inducing polyploidization of megakaryocyte cells and for promoting differentiation of megakaryocyte cells into platelet-producing cells. The methods may be utilized for treating blood and bone marrow diseases and disorders in a subject in need thereof and for identifying agents for treating blood and bone marrow diseases and disorders.
摘要翻译： 公开了诱导巨核细胞多倍体化和促进巨核细胞分化成血小板产生细胞的方法。 该方法可用于治疗有需要的受试者中的血液和骨髓疾病和病症，以及用于鉴定用于治疗血液和骨髓疾病和病症的药剂。
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公开(公告)号：US20130084561A1
公开(公告)日：2013-04-04
申请号：US13467698
申请日：2012-05-09
IPC分类号： G01N21/64
CPC分类号： G01N21/6486 , C12Q1/6818 , C12Q1/6823 , G01N33/532 , G01N33/58 , C12Q2565/501 , C12Q2523/101
摘要： The invention provides compositions and methods for the detection of biological targets, (e.g. nucleic acids and proteins) by nucleic acid templated chemistry, for example, by generating fluorescent, chemiluminescent and/or chromophoric signals.
摘要翻译： 本发明提供了通过核酸模板化学，例如通过产生荧光，化学发光和/或发色信号来检测生物学靶标（例如核酸和蛋白质）的组合物和方法。
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