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公开(公告)号：US20050037468A1
公开(公告)日：2005-02-17
申请号：US10957135
申请日：2004-09-30
申请人： David Anderson , Xinzhong Dong , Mark Zylka , Sang-kyou Han , Melvin Simon
发明人： David Anderson , Xinzhong Dong , Mark Zylka , Sang-kyou Han , Melvin Simon
IPC分类号： A61K38/00 , C07K14/705 , C12N15/12
CPC分类号： C07K14/70571 , A61K38/00 , C07K14/705 , G01N33/5041 , G01N33/5058 , G01N33/5082 , G01N33/54366 , G01N2333/726 , G01N2500/02
摘要： The invention relates generally to novel genes expressed in normal but not Neurogenin-1-deficient animals. The invention relates specifically to a novel family of G protein-coupled receptors and a novel family of two-transmembrane segment proteins that are expressed in dorsal root ganglia, and a method of screening for genes specifically expressed in nociceptive sensory neurons.
摘要翻译： 本发明一般涉及在正常但不是神经元素-1缺陷的动物中表达的新基因。 本发明具体涉及G蛋白偶联受体的新家族和在背根神经节中表达的双跨膜区段蛋白质的新家族，以及筛选在伤害性感觉神经元中特异性表达的基因的方法。
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公开(公告)号：US20050208047A1
公开(公告)日：2005-09-22
申请号：US11117746
申请日：2005-04-27
申请人： David Anderson , Xinzhong Dong , Mark Zylka , Sang-Kyou Han , Melvin Simon
发明人： David Anderson , Xinzhong Dong , Mark Zylka , Sang-Kyou Han , Melvin Simon
IPC分类号： C07K14/72 , C12Q1/68 , A61K39/395 , C07H21/04 , C07K14/705 , C12N15/09
CPC分类号： C07K14/723 , C07K2319/00
摘要： A novel G protein-coupled receptor called MrgC11 has been identified that is expressed in dorsal root ganglia and that is activated by RF amide related peptides.
摘要翻译： 已经鉴定了称为MrgC11的新型G蛋白偶联受体，其表达于背根神经节，并被RF酰胺相关肽激活。
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公开(公告)号：US20070196873A1
公开(公告)日：2007-08-23
申请号：US11703062
申请日：2007-02-05
申请人： David Anderson , Xinzhong Dong , Mark Zylka , Sang-kyou Han , Melvin Simon
发明人： David Anderson , Xinzhong Dong , Mark Zylka , Sang-kyou Han , Melvin Simon
IPC分类号： G01N33/567
CPC分类号： C07K14/70571 , A61K38/00 , C07K14/705 , G01N33/5041 , G01N33/5058 , G01N33/5082 , G01N33/54366 , G01N2333/726 , G01N2500/02
摘要： The invention relates generally to novel genes expressed in normal but not Neurogenin-1-deficient animals. The invention relates specifically to a novel family of G protein-coupled receptors and a novel family of two-transmembrane segment proteins that are expressed in dorsal root ganglia, and a method of screening for genes specifically expressed in nociceptive sensory neurons.
摘要翻译： 本发明一般涉及在正常但不是神经元素-1缺陷的动物中表达的新基因。 本发明具体涉及G蛋白偶联受体的新家族和在背根神经节中表达的双跨膜区段蛋白质的新家族，以及筛选在伤害性感觉神经元中特异性表达的基因的方法。
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公开(公告)号：US20050164288A1
公开(公告)日：2005-07-28
申请号：US11083611
申请日：2005-03-17
申请人： David Anderson , Xinzhong Dong , Mark Zylka , Sang-Kyou Han , Melvin Simon
发明人： David Anderson , Xinzhong Dong , Mark Zylka , Sang-Kyou Han , Melvin Simon
IPC分类号： A61K38/00 , C07K14/705 , C12Q1/68 , C12N5/06 , G01N33/53 , G01N33/567
CPC分类号： C07K14/70571 , A61K38/00
摘要： The invention relates generally to novel genes expressed in normal but not Neurogenin-1-deficient animals. The invention relates specifically to a novel family of G protein-coupled receptors and a novel family of two-transmembrane segment proteins that are expressed in dorsal root ganglia, and a method of screening for genes specifically expressed in nociceptive sensory neurons.
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公开(公告)号：US08916355B2
公开(公告)日：2014-12-23
申请号：US11703062
申请日：2007-02-05
申请人： David J. Anderson , Xinzhong Dong , Mark Zylka , Sang-kyou Han , Melvin I. Simon
发明人： David J. Anderson , Xinzhong Dong , Mark Zylka , Sang-kyou Han , Melvin I. Simon
IPC分类号： G01N33/567 , G01N33/50 , G01N33/543 , C07K14/705 , A61K38/00
CPC分类号： C07K14/70571 , A61K38/00 , C07K14/705 , G01N33/5041 , G01N33/5058 , G01N33/5082 , G01N33/54366 , G01N2333/726 , G01N2500/02
摘要： The invention relates generally to novel genes expressed in normal but not Neurogenin-1-deficient animals. The invention relates specifically to a novel family of G protein-coupled receptors and a novel family of two-transmembrane segment proteins that are expressed in dorsal root ganglia, and a method of screening for genes specifically expressed in nociceptive sensory neurons.
摘要翻译： 本发明一般涉及在正常但不是神经元素-1缺陷的动物中表达的新基因。 本发明具体涉及G蛋白偶联受体的新家族和在背根神经节中表达的双跨膜区段蛋白质的新家族，以及筛选在伤害性感觉神经元中特异性表达的基因的方法。
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6.发明申请IDENTIFICATION OF A RECEPTOR CONTROLLING MIGRATION AND METASTASIS OF SKIN CANCER CELLS 审中-公开控制皮肤癌细胞迁移和转移的受体的鉴定公开(公告)号：US20080014586A1
公开(公告)日：2008-01-17
申请号：US11777907
申请日：2007-07-13
申请人： Mark Zylka , Xinzhong Dong , David Anderson
发明人： Mark Zylka , Xinzhong Dong , David Anderson
IPC分类号： C12Q1/68
CPC分类号： C07K14/705
摘要： The invention relates generally to genes expressed in skin cancer cells, particularly melanoma tumor cells, and their role in migration and metastasis. Methods for identifying melanoma cells are provided, as are methods of treating melanoma. Methods for identifying compounds that are useful in the treatment of melanoma are also provided.
摘要翻译： 本发明一般涉及在皮肤癌细胞，特别是黑素瘤肿瘤细胞中表达的基因及其在迁移和转移中的作用。 提供用于鉴定黑素瘤细胞的方法，以及治疗黑素瘤的方法。 还提供了用于鉴定可用于治疗黑素瘤的化合物的方法。
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7.发明申请Identification of a receptor controlling migration and metastasis of skin cancer cells 审中-公开识别控制皮肤癌细胞迁移和转移的受体公开(公告)号：US20050196757A1
公开(公告)日：2005-09-08
申请号：US10601305
申请日：2003-06-19
申请人： Mark Zylka , Xinzhong Dong , David Anderson
发明人： Mark Zylka , Xinzhong Dong , David Anderson
IPC分类号： C07K14/705 , C12Q1/68 , G01N33/574
CPC分类号： C07K14/705
摘要： The invention relates generally to genes expressed in skin cancer cells, particularly melanoma tumor cells, and their role in migration and metastasis. Methods for identifying melanoma cells are provided, as are methods of treating melanoma. Methods for identifying compounds that are useful in the treatment of melanoma are also provided.
摘要翻译： 本发明一般涉及在皮肤癌细胞，特别是黑素瘤肿瘤细胞中表达的基因及其在迁移和转移中的作用。 提供用于鉴定黑素瘤细胞的方法，以及治疗黑素瘤的方法。 还提供了用于鉴定可用于治疗黑素瘤的化合物的方法。
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8.发明授权Assay employing G protein-coupled receptor expressed in dorsal root ganglia 有权使用在背根神经节中表达的G蛋白偶联受体的测定公开(公告)号：US07510845B2
公开(公告)日：2009-03-31
申请号：US11083611
申请日：2005-03-17
IPC分类号： G01N33/566 , C07K14/705
CPC分类号： C07K14/70571 , A61K38/00
摘要： The invention relates generally to novel genes expressed in normal but not Neurogenin-1-deficient animals. The invention relates specifically to a novel family of G protein-coupled receptors and a novel family of two-transmembrane segment proteins that are expressed in dorsal root ganglia, and a method of screening for genes specifically expressed in nociceptive sensory neurons.
摘要翻译： 本发明一般涉及在正常但不是神经元素-1缺陷的动物中表达的新基因。 本发明具体涉及G蛋白偶联受体的新家族和在背根神经节中表达的双跨膜区段蛋白质的新家族，以及筛选在伤害性感觉神经元中特异性表达的基因的方法。
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公开(公告)号：US20120073001A1
公开(公告)日：2012-03-22
申请号：US13132268
申请日：2009-11-30
申请人： Xinzhong Dong , Qin Liu , David J. Anderson
发明人： Xinzhong Dong , Qin Liu , David J. Anderson
IPC分类号： A61K49/00 , A61K31/439 , C07D453/02 , C07H21/00 , C07H21/02 , C12N15/113 , C12N15/63 , C12N15/85 , C12N5/10 , A61K31/56 , C12Q1/68 , G01N33/566 , C12Q1/02 , A61P17/04 , A61K31/7088
CPC分类号： C12N15/1138 , A61K31/439 , A61K31/46 , A61K31/56 , A61K31/7088 , A61K31/713 , A61K45/06 , C07K14/705 , G01N33/5023 , G01N33/5041 , A61K2300/00
摘要： The invention features therapeutic compositions comprising agents useful for the treatment or prevention of pruritis, and methods useful for identifying such agents.
摘要翻译： 本发明的特征在于包含可用于治疗或预防瘙痒症的药剂的治疗组合物，以及用于鉴定这些药物的方法。
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公开(公告)号：US20110150769A1
公开(公告)日：2011-06-23
申请号：US12851436
申请日：2010-08-05
申请人： David J. Anderson , Xinzhong Dong , Qin Liu , Yun Guan
发明人： David J. Anderson , Xinzhong Dong , Qin Liu , Yun Guan
IPC分类号： A61K49/00 , A61K31/7088 , A61K38/02 , A61K31/501 , A61K31/5517 , A61P25/04 , A61P29/00
摘要： The present application provides methods and compositions that can be used to treat persistent pain and to identify compounds that can be used for treating persistent pain. More specifically, agonists of members of the Mrgpr receptor family, particularly agonists of MrgprX1, can identified and screened for use in treating persistent pain, such as pain caused by inflammation or nerve injury.
摘要翻译： 本申请提供了可用于治疗持续性疼痛并鉴定可用于治疗持续性疼痛的化合物的方法和组合物。 更具体地，Mrgpr受体家族的成员的激动剂，特别是MrgprX1的激动剂，可以鉴定和筛选用于治疗持续性疼痛，例如由炎症或神经损伤引起的疼痛。
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