公开(公告)号：US20050208047A1

公开(公告)日：2005-09-22

申请号：US11117746

申请日：2005-04-27

申请人： David Anderson ,  Xinzhong Dong ,  Mark Zylka ,  Sang-Kyou Han ,  Melvin Simon

发明人： David Anderson ,  Xinzhong Dong ,  Mark Zylka ,  Sang-Kyou Han ,  Melvin Simon

IPC分类号： C07K14/72 ,  C12Q1/68 ,  A61K39/395 ,  C07H21/04 ,  C07K14/705 ,  C12N15/09

CPC分类号： C07K14/723 ,  C07K2319/00

摘要： A novel G protein-coupled receptor called MrgC11 has been identified that is expressed in dorsal root ganglia and that is activated by RF amide related peptides.

摘要翻译： 已经鉴定了称为MrgC11的新型G蛋白偶联受体，其表达于背根神经节，并被RF酰胺相关肽激活。

公开(公告)号：US20050037468A1

公开(公告)日：2005-02-17

申请号：US10957135

申请日：2004-09-30

申请人： David Anderson ,  Xinzhong Dong ,  Mark Zylka ,  Sang-kyou Han ,  Melvin Simon

发明人： David Anderson ,  Xinzhong Dong ,  Mark Zylka ,  Sang-kyou Han ,  Melvin Simon

IPC分类号： A61K38/00 ,  C07K14/705 ,  C12N15/12

CPC分类号： C07K14/70571 ,  A61K38/00 ,  C07K14/705 ,  G01N33/5041 ,  G01N33/5058 ,  G01N33/5082 ,  G01N33/54366 ,  G01N2333/726 ,  G01N2500/02

摘要： The invention relates generally to novel genes expressed in normal but not Neurogenin-1-deficient animals. The invention relates specifically to a novel family of G protein-coupled receptors and a novel family of two-transmembrane segment proteins that are expressed in dorsal root ganglia, and a method of screening for genes specifically expressed in nociceptive sensory neurons.

摘要翻译： 本发明一般涉及在正常但不是神经元素-1缺陷的动物中表达的新基因。 本发明具体涉及G蛋白偶联受体的新家族和在背根神经节中表达的双跨膜区段蛋白质的新家族，以及筛选在伤害性感觉神经元中特异性表达的基因的方法。

公开(公告)号：US20070196873A1

公开(公告)日：2007-08-23

申请号：US11703062

申请日：2007-02-05

申请人： David Anderson ,  Xinzhong Dong ,  Mark Zylka ,  Sang-kyou Han ,  Melvin Simon

发明人： David Anderson ,  Xinzhong Dong ,  Mark Zylka ,  Sang-kyou Han ,  Melvin Simon

IPC分类号： G01N33/567

CPC分类号： C07K14/70571 ,  A61K38/00 ,  C07K14/705 ,  G01N33/5041 ,  G01N33/5058 ,  G01N33/5082 ,  G01N33/54366 ,  G01N2333/726 ,  G01N2500/02

摘要： The invention relates generally to novel genes expressed in normal but not Neurogenin-1-deficient animals. The invention relates specifically to a novel family of G protein-coupled receptors and a novel family of two-transmembrane segment proteins that are expressed in dorsal root ganglia, and a method of screening for genes specifically expressed in nociceptive sensory neurons.

摘要翻译： 本发明一般涉及在正常但不是神经元素-1缺陷的动物中表达的新基因。 本发明具体涉及G蛋白偶联受体的新家族和在背根神经节中表达的双跨膜区段蛋白质的新家族，以及筛选在伤害性感觉神经元中特异性表达的基因的方法。

公开(公告)号：US20050164288A1

公开(公告)日：2005-07-28

申请号：US11083611

申请日：2005-03-17

申请人： David Anderson ,  Xinzhong Dong ,  Mark Zylka ,  Sang-Kyou Han ,  Melvin Simon

发明人： David Anderson ,  Xinzhong Dong ,  Mark Zylka ,  Sang-Kyou Han ,  Melvin Simon

IPC分类号： A61K38/00 ,  C07K14/705 ,  C12Q1/68 ,  C12N5/06 ,  G01N33/53 ,  G01N33/567

CPC分类号： C07K14/70571 ,  A61K38/00

摘要： The invention relates generally to novel genes expressed in normal but not Neurogenin-1-deficient animals. The invention relates specifically to a novel family of G protein-coupled receptors and a novel family of two-transmembrane segment proteins that are expressed in dorsal root ganglia, and a method of screening for genes specifically expressed in nociceptive sensory neurons.

公开(公告)号：US20080014586A1

公开(公告)日：2008-01-17

申请号：US11777907

申请日：2007-07-13

申请人： Mark Zylka ,  Xinzhong Dong ,  David Anderson

发明人： Mark Zylka ,  Xinzhong Dong ,  David Anderson

IPC分类号： C12Q1/68

CPC分类号： C07K14/705

摘要： The invention relates generally to genes expressed in skin cancer cells, particularly melanoma tumor cells, and their role in migration and metastasis. Methods for identifying melanoma cells are provided, as are methods of treating melanoma. Methods for identifying compounds that are useful in the treatment of melanoma are also provided.

摘要翻译： 本发明一般涉及在皮肤癌细胞，特别是黑素瘤肿瘤细胞中表达的基因及其在迁移和转移中的作用。 提供用于鉴定黑素瘤细胞的方法，以及治疗黑素瘤的方法。 还提供了用于鉴定可用于治疗黑素瘤的化合物的方法。

公开(公告)号：US20050196757A1

公开(公告)日：2005-09-08

申请号：US10601305

申请日：2003-06-19

申请人： Mark Zylka ,  Xinzhong Dong ,  David Anderson

发明人： Mark Zylka ,  Xinzhong Dong ,  David Anderson

IPC分类号： C07K14/705 ,  C12Q1/68 ,  G01N33/574

CPC分类号： C07K14/705

摘要： The invention relates generally to genes expressed in skin cancer cells, particularly melanoma tumor cells, and their role in migration and metastasis. Methods for identifying melanoma cells are provided, as are methods of treating melanoma. Methods for identifying compounds that are useful in the treatment of melanoma are also provided.

摘要翻译： 本发明一般涉及在皮肤癌细胞，特别是黑素瘤肿瘤细胞中表达的基因及其在迁移和转移中的作用。 提供用于鉴定黑素瘤细胞的方法，以及治疗黑素瘤的方法。 还提供了用于鉴定可用于治疗黑素瘤的化合物的方法。

公开(公告)号：US11027382B1

公开(公告)日：2021-06-08

申请号：US16188242

申请日：2018-11-12

申请人： David Anderson

发明人： David Anderson

IPC分类号： B23Q3/10 ,  B23Q1/42 ,  B23Q3/18

摘要： The instant-mount aspect of the present invention allows a user to rapidly accurately dismount a mounted CNC calibration device from a CNC work table, and rapidly replace the CNC calibration device to its previously mounted position within 0.0001, in seconds. The alignment aspect of the present invention allows faster and more robust high-accuracy alignment of a CNC calibration device once it is mounted on a CNC work table. The remote nest aspect of the present invention allows rapid re-positioning of a CNC calibration device within a CNC milling machine cabinet in a way that does not disrupt the data connection between the CNC control computer and the CNC calibration device, and allows for utilization of more of the worktable surface during milling operations.

公开(公告)号：US20200235513A1

公开(公告)日：2020-07-23

申请号：US16745701

申请日：2020-01-17

申请人： David Anderson ,  Myles Keefer ,  Larry Le

发明人： David Anderson ,  Myles Keefer ,  Larry Le

IPC分类号： H01R13/207 ,  H01R13/58 ,  E21B43/12

摘要： A power pin alignment and crimping fixture having a fixture body. The fixture body includes a plurality of channels each having a first open end and a second open end. The plurality of channels are disposed at an angle diverging away from one another in a direction from the first open end to the second open end such that each of the plurality of channels are disposed along a corresponding side edge of a symmetrical shape.

公开(公告)号：US20170361813A1

公开(公告)日：2017-12-21

申请号：US15626772

申请日：2017-06-19

申请人： David Anderson

发明人： David Anderson

IPC分类号： B60S9/04 ,  F16M11/16 ,  B60S9/02

CPC分类号： B60S9/04 ,  B60D1/58 ,  B60S9/02 ,  F16M11/16

摘要： A hitch receiver stand comprises a hitch receiver assembly having a hitch receiver than can removably mount a device having a standard hitch and is removably attached to a framework. The framework may include a number of releasably coupled components.

公开(公告)号：US09435749B2

公开(公告)日：2016-09-06

申请号：US14208990

申请日：2014-03-13

申请人： Wade A. Winchip ,  David Anderson ,  Kelly Pepper ,  Neville Whittle

发明人： Wade A. Winchip ,  David Anderson ,  Kelly Pepper ,  Neville Whittle

IPC分类号： H04N5/235 ,  G01N21/952

CPC分类号： B21B28/04 ,  B24B5/37 ,  B24B49/12 ,  B24B55/02 ,  G01N21/8851 ,  G01N21/952

摘要： A system and method that includes, in an embodiment, a prism, a camera, a light source, and a plate. The system, in an embodiment, is configured for scanning a roll and generating an image of the roll surface. The prism, in an embodiment, is positioned below the camera and above the plate. In an embodiment, the plate is positioned below the prism and above the roll surface. In an embodiment, the light source is positioned above the prism. In an embodiment, the light source and the prism are positioned to provide light to the roll surface at an angle of at least 75 degrees measured from a line normal to the roll surface. In an embodiment, the prism is configured to refract light from the light source, the camera is a line scan camera that includes a row of pixel sensors, and the light source includes light emitting diodes.

摘要翻译： 在一个实施例中包括棱镜，照相机，光源和板的系统和方法。 在一个实施例中，该系统被配置用于扫描辊并产生辊表面的图像。 在一个实施例中，棱镜位于照相机下方和板的上方。 在一个实施例中，板位于棱镜下方并在辊表面上方。 在一个实施例中，光源位于棱镜上方。 在一个实施例中，光源和棱镜被定位成以与垂直于辊表面的线测量的至少75度的角度向辊表面提供光。 在一个实施例中，棱镜被配置为折射来自光源的光，照相机是包括一排像素传感器的行扫描照相机，并且光源包括发光二极管。