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公开(公告)号：US07241577B2
公开(公告)日：2007-07-10
申请号：US10225503
申请日：2002-08-20
CPC分类号： A61K38/22 , G01N33/689 , G01N2800/36 , G01N2800/367 , G01N2800/52
摘要： Methods and kits are provided for assessing the ovarian reserve and predicting the ovarian response to fertility treatments in a female subject. The serum levels of MIS are shown to be positively correlated with the production and retrieval of mature oocytes and serve as prognostic indicators for the female response to fertility treatment. The MIS levels can be monitored prior to and during fertility treatment and are useful to adjust the timing and dosage of treatments in order to produce optimal outcome in individual patients, to avoid ovarian hyperstimulation, or to indicate cancellation of an unsuccessful treatment. MIS can also be administered to women to stimulate follicle development and to prevent depletion of ovarian reserve.
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公开(公告)号：US07427486B2
公开(公告)日：2008-09-23
申请号：US11824154
申请日：2007-06-29
CPC分类号： A61K38/22 , G01N33/689 , G01N2800/36 , G01N2800/367 , G01N2800/52
摘要： Methods and kits are provided for assessing the ovarian reserve and predicting the ovarian response to fertility treatments in a female subject. The serum levels of MIS are shown to be positively correlated with the production and retrieval of mature oocytes and serve as prognostic indicators for the female response to fertility treatment. The MIS levels can be monitored prior to and during fertility treatment and are useful to adjust the timing and dosage of treatments in order to produce optimal outcome in individual patients, to avoid ovarian hyperstimulation, or to indicate cancellation of an unsuccessful treatment. MIS can also be administered to women to stimulate follicle development and to prevent depletion of ovarian reserve.
摘要翻译： 提供方法和试剂盒用于评估卵巢储备和预测卵巢对女性受试者的生育治疗反应。 MIS的血清水平显示与成熟卵母细胞的产生和恢复正相关，并且作为女性对生育治疗反应的预后指标。 可以在生殖治疗之前和期间监测MIS水平，并且有助于调整治疗的时间和剂量，以便在个体患者中产生最佳结果，以避免卵巢过度刺激，或指示取消不成功的治疗。 也可以向妇女施用管理信息系统以刺激卵泡发育并防止卵巢储备的消耗。
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公开(公告)号：US07378388B2
公开(公告)日：2008-05-27
申请号：US11243619
申请日：2005-10-05
申请人： David B. Seifer , Robert Shelden , Bo Feng , Cheryl Dreyfus
发明人： David B. Seifer , Robert Shelden , Bo Feng , Cheryl Dreyfus
CPC分类号： A61K31/352 , A61K38/185 , G01N33/74 , G01N2500/10
摘要： Methods and kits are provided for manipulating and predicting the reproductive capacity of a female subject. The presence of endogenous neurotrophins and addition of exogenous neurotrophins, particularly BDNF, NT-4/5, and NGF, increase the reproductive capacity of a female patient by binding to receptors on the oocytes and stimulating maturation of the oocytes. Administration of antagonists act as a contraceptive because the antagonists prevent the neurotrophins from binding to oocyte receptors. Neurotrophins may also be used to stimulate the maturation of oocyte in vitro.
摘要翻译： 提供了方法和试剂盒，用于操纵和预测女性受试者的生殖能力。 内源性神经营养因子的存在和外源性神经营养因子，特别是BDNF，NT-4/5和NGF的添加通过结合卵母细胞上的受体并刺激卵母细胞的成熟来增加女性患者的生殖能力。 拮抗剂的施用作为避孕药，因为拮抗剂可防止神经营养蛋白结合卵母细胞受体。 神经营养蛋白也可用于在体外刺激卵母细胞的成熟。
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公开(公告)号：US20130224771A1
公开(公告)日：2013-08-29
申请号：US13772796
申请日：2013-02-21
IPC分类号： G01N33/74
CPC分类号： G01N33/74
摘要： The present invention provides methods, kits, compositions, and devices for detecting Anti-Mullerian hormone (AMH) in whole blood samples. In certain embodiments, the methods, kits, compositions, and devices employ immunoassays that generate a colorimetric or fluorescent signal (e.g., using antibodies conjugated to gold nanoparticles or fluorescent particles) where the signal generated is proportional to the approximate concentration of AMH in a whole blood sample. In particular embodiments, the present invention provides quantitative or semi-quantitative lateral flow immunoassay devices and kits for detecting AMH at home (e.g., in order for women to estimate their ovarian age or diagnose polycystic ovarian syndrome).
摘要翻译： 本发明提供了用于检测全血样品中的抗穆勒激素（AMH）的方法，试剂盒，组合物和装置。 在某些实施方案中，方法，试剂盒，组合物和装置使用产生比色或荧光信号（例如，使用与金纳米颗粒或荧光颗粒缀合的抗体）的免疫测定法，其中所产生的信号与整体中的AMH的近似浓度成比例 血液样本。 在具体实施方案中，本发明提供用于在家检测AMH的定量或半定量侧流免疫测定装置和试剂盒（例如，为了女性估计卵巢年龄或诊断多囊卵巢综合征）。
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