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    Compounds that bind to the interferon-gamma, preparation method thereof and medicaments containing same
    2.
    发明申请
    Compounds that bind to the interferon-gamma, preparation method thereof and medicaments containing same 审中-公开
    与干扰素-γ结合的化合物，其制备方法和含有其的药物

    公开(公告)号：US20060166927A1

    公开(公告)日：2006-07-27

    申请号：US10518177

    申请日：2003-06-18

    申请人： David Bonnaffe ,  Andre Lubineau ,  Jocelyne Alais ,  Olivier Gavard ,  Anna Dilhas ,  Hugues Lortat-Jacob

    发明人： David Bonnaffe ,  Andre Lubineau ,  Jocelyne Alais ,  Olivier Gavard ,  Anna Dilhas ,  Hugues Lortat-Jacob

    IPC分类号： A61K31/737 ,  C08B37/00

    CPC分类号： C08B37/00 ,  A61K31/727 ,  A61K47/61 ,  C08B37/006

    摘要： Compound capable of binding to gamma-interferon (γ-IFN), chosen from the molecules corresponding to formula (I) below: in which X is a divalent spacer group that is sufficiently long to allow the two oligosaccharide fragments A and B to each bind to one of the peptide sequences 125 to 143 of the C-terminal ends of a γ-interferon (γ-IFN) homodimer, n represents an integer from 0 to 10, and for example equal to 0, 1, 2, 3, 4 or 5, and each R independently represents a hydrogen atom, an SO3− group or a phosphate group, on the condition that no SO3− group is in the 3-position of the glucosamine units of compound (I). The invention also relates to the process for preparing these compounds, to the complexes formed by these compounds and gamma-interferon, and to the medicaments comprising these compounds or complexes.

    摘要翻译： 选自相应于下式（I）的分子的能够结合γ-干扰素（γ-IFN）的化合物：其中X是足够长以允许两个寡糖片段A和B各自结合的二价间隔基团 至γ-干扰素（γ-IFN）同二聚体的C-末端的肽序列125至143之一，n表示0至10的整数，例如等于0,1,2,3,4 或5，并且每个R独立地表示氢原子，SO 3 - SO 2 - 或磷酸酯基团，条件是不含SO 3 - 化合物（I）的氨基葡萄糖单元位于3位。 本发明还涉及由这些化合物和γ-干扰素形成的复合物以及包含这些化合物或复合物的药物制备这些化合物的方法。

    CD4-RECEPTOR-DERIVED PEPTIDES AND METHOD FOR THE PREPARATION THEREOF
    9.
    发明申请
    CD4-RECEPTOR-DERIVED PEPTIDES AND METHOD FOR THE PREPARATION THEREOF 审中-公开
    CD4受体衍生肽及其制备方法

    公开(公告)号：US20110015368A1

    公开(公告)日：2011-01-20

    申请号：US12375545

    申请日：2007-08-03

    申请人： Françoise Baleux ,  David Bonnaffe ,  Hugues Lortat-Jacob

    发明人： Françoise Baleux ,  David Bonnaffe ,  Hugues Lortat-Jacob

    IPC分类号： C07K14/00 ,  C07K1/113

    CPC分类号： C07K14/70514

    摘要： The present invention relates to an activated peptide derived from the CD4 receptor, which is capable of coupling by covalent bonding to an organic molecule and thus makes it possible to generate multiple potentially antiviral derivatives. The present invention also relates to a conjugated molecule comprising the CD4-receptor-derived peptide and an organic molecule, preferably the GPR1 peptide or a polyanion. Such a conjugated molecule can in particular be used in antiviral treatments, in particular the treatment of AIDS. The invention also relates to the methods for preparing the activated peptide derived from the CD4 receptor and the conjugated molecule.

    摘要翻译： 本发明涉及从CD4受体衍生的活化肽，其能够通过共价键与有机分子偶联，从而使得可能产生多种潜在的抗病毒衍生物。 本发明还涉及包含CD4受体来源的肽和有机分子，优选GPR1肽或聚阴离子的共轭分子。 这种共轭分子特别可用于抗病毒治疗，特别是AIDS的治疗。 本发明还涉及制备衍生自CD4受体和共轭分子的活化肽的方法。

    Molecular spacer arm, process for the production thereof and uses on an analytical chip comprising molecules or biomolecules
    10.
    发明申请
    Molecular spacer arm, process for the production thereof and uses on an analytical chip comprising molecules or biomolecules 审中-公开
    分子间隔臂，其制备方法和用于包含分子或生物分子的分析芯片上

    公开(公告)号：US20070190570A1

    公开(公告)日：2007-08-16

    申请号：US10590137

    申请日：2005-02-22

    申请人： Veronique Peretti ,  Francoise Vinet ,  David Bonnaffe

    发明人： Veronique Peretti ,  Francoise Vinet ,  David Bonnaffe

    IPC分类号： G01N33/53 ,  C08B37/00 ,  C07K14/775 ,  C07K14/47

    CPC分类号： C07H3/02 ,  G01N33/54353 ,  Y02P20/55

    摘要： The present invention relates to a molecular spacer arm, to a process for attachment of a molecular unit to a solid support, and also to the use of this spacer arm on analytical chips comprising molecules or biomolecules. The spacer arm has the formula (I): in which X0, X4=C, O, S, Se, N, P, As; X1-3=C, O, N, S, Se, P, As, or C1-6 aryl or heteroaryl; Z1-2=C—R, Si—R, N, P and As, where R=C1-6 alkyl; R1-3=H, or C1-6 alkyl, aryl or heteroaryl; [Gp]=protective group for >N; n, m and p=integers≧1; [Sup]=H or a silanized solid support; and [mo]=H or a molecular unit intended to be covalently attached to said silanized solid support by means of said spacer arm.

    摘要翻译： 本发明涉及一种分子间隔臂，一种将分子单元连接到固体支持物的方法，以及该分隔器臂在包含分子或生物分子的分析芯片上的用途。 间隔臂具有式（I）：其中X 0，X 4 = C，O，S，Se，N，P，As; X 1〜S 3 = C，O，N，S，Se，P，As或C 1-6芳基或杂芳基; Z 1-2是C-R，Si-R，N，P和As，其中R = C 1-6烷基; R 1-3是H或C 1-6烷基，芳基或杂芳基; [Gp] => N的保护基; n，m和p =整数> = 1; [Sup] = H或硅烷化固体载体; 和[mo] = H或旨在通过所述间隔臂共价连接到所述硅烷化固体支持物上的分子单元。