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公开(公告)号：US06841547B2
公开(公告)日：2005-01-11
申请号：US10377088
申请日：2003-02-28
申请人： David Brown , Lorne M. Golub , Hsi-Ming Lee , Robert Greenwald , Maria Ryan , Kavita Desai
发明人： David Brown , Lorne M. Golub , Hsi-Ming Lee , Robert Greenwald , Maria Ryan , Kavita Desai
IPC分类号： A61K31/65
CPC分类号： A61K31/65
摘要： The present invention relates to a method for decreasing elevated serum/plasma LDL-cholesterol levels or LDL-cholesterol levels and CRP levels in a mammal in need thereof. The methods comprises administering an effective amount of a tetracycline formulation. In one embodiment, the tetracycline formulation is a non-antibacterial tetracycline. In another embodiment, the tetracycline formulation is an antibacterial tetracycline at a sub-antibacterial amount.
摘要翻译： 本发明涉及降低有需要的哺乳动物中升高的血清/血浆LDL-胆固醇水平或LDL-胆固醇水平和CRP水平的方法。 所述方法包括施用有效量的四环素制剂。 在一个实施方案中，四环素制剂是非抗菌四环素。 在另一个实施方案中，四环素制剂是亚抗菌量的抗菌四环素。
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2.发明授权Method of using tetracycline compounds to enhance interleukin-10 production 有权使用四环素化合物增强白细胞介素-10产生的方法
公开(公告)号：US6015804A
公开(公告)日：2000-01-18
申请号：US151534
申请日：1998-09-11
申请人： Lorne M. Golub , Christopher T. Ritchlin , Robert A. Greenwald , Sally Haas-Smith , Susan A. Moak , Hsi-Ming Lee
发明人： Lorne M. Golub , Christopher T. Ritchlin , Robert A. Greenwald , Sally Haas-Smith , Susan A. Moak , Hsi-Ming Lee
CPC分类号： A61K31/65
摘要： The invention is a method of enhancing endogenous interleukin-10 production in mammalian cells and tissues, which includes administering an effective amount of a tetracycline derivative. The method also includes enhancing interleukin-10 production by administering an effective amount of the tetracycline derivative to a mammal. Preferred tetracycline compounds are tetracycline compounds which have been modified to reduce or eliminate their antimicrobial activity. The method can be used to treat medical conditions in mammals characterized by excessive IL-1 and TNF .alpha. production.
摘要翻译： 本发明是增强哺乳动物细胞和组织中内源性白细胞介素-10产生的方法，其包括施用有效量的四环素衍生物。 该方法还包括通过向哺乳动物施用有效量的四环素衍生物来增强白细胞介素-10的产生。 优选的四环素化合物是已被修饰以减少或消除其抗微生物活性的四环素化合物。 该方法可用于治疗以过量的IL-1和TNFα产生为特征的哺乳动物的医学状况。
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公开(公告)号：US20180036262A1
公开(公告)日：2018-02-08
申请号：US15556441
申请日：2016-03-10
申请人： Ying Gu , Hsi-ming Lee , Lorne M. Golub , Francis Johnson , Guirong Wang , Osama Abdel-Razek , Yongan Xu
发明人： Ying Gu , Hsi-ming Lee , Lorne M. Golub , Francis Johnson , Guirong Wang , Osama Abdel-Razek , Yongan Xu
IPC分类号： A61K31/165
CPC分类号： A61K31/165 , A61K31/12 , A61K31/44 , A61K31/444
摘要： A method of increasing production of one or more lipoxins in a subject in need thereof comprising administering to the subject an amount of a compound having the structure: or a pharmaceutically acceptable salt or ester thereof, so as to thereby increase production of the one or more lipoxins in the subject.
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4.发明申请Use of Low Dose Chemically Modified Tetracylines to Reduce Inflammatory Mediators 审中-公开使用低剂量化学修饰的四酰胺来减少炎症介质公开(公告)号：US20080249072A1
公开(公告)日：2008-10-09
申请号：US11663325
申请日：2005-09-21
申请人： Lorne M. Golub , Maria Emanuel Ryan , Hsi Ming Lee
发明人： Lorne M. Golub , Maria Emanuel Ryan , Hsi Ming Lee
CPC分类号： A61K31/65
摘要： The invention is a method for reducing the production of inflammatory mediators, and/or treating conditions characterized by increased levels of inflammatory mediators, in a mammal in need thereof, by administering a 4-dedimethlaminosancycline to the mammal.
摘要翻译： 本发明是通过向哺乳动物施用4-去谷氨酰胺素环丁西亚，在有需要的哺乳动物中减少炎性介质的产生和/或治疗特征在于增加炎症介质水平的病症的方法。
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公开(公告)号：US06429204B1
公开(公告)日：2002-08-06
申请号：US09542402
申请日：2000-04-03
申请人： Lorne M. Golub , Thomas F. McNamara , Nungavaram S. Ramamurthy , Hsi-Ming Lee , Sanford Simon , Balakrishna L. Lokeshwar , Marie G. Selzer , Norman L. Block
发明人： Lorne M. Golub , Thomas F. McNamara , Nungavaram S. Ramamurthy , Hsi-Ming Lee , Sanford Simon , Balakrishna L. Lokeshwar , Marie G. Selzer , Norman L. Block
IPC分类号： A61K3165
摘要： The invention is a method of inhibiting a sarcoma, such as Kaposi's sarcoma, in a mammal. The method employs 6-demethyl-6-deoxy-4-de(dimethylamino)tetracycline (CMT-3.)
摘要翻译： 本发明是哺乳动物抑制肉瘤如卡波西肉瘤的方法。 该方法采用6-脱甲基-6-脱氧-4-脱（二甲氨基）四环素（CMT-3）
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公开(公告)号：US6100248A
公开(公告)日：2000-08-08
申请号：US7645
申请日：1998-01-15
申请人： Lorne M. Golub , Thomas F. McNamara , Nungavaram S. Ramamurthy , Hsi-Ming Lee , Sanford Simon , Balakrishna L. Lokeshwar , Marie G. Selzer , Norman L. Block
发明人： Lorne M. Golub , Thomas F. McNamara , Nungavaram S. Ramamurthy , Hsi-Ming Lee , Sanford Simon , Balakrishna L. Lokeshwar , Marie G. Selzer , Norman L. Block
摘要： The invention is a method of inhibiting cancer growth, by inhibiting cellular proliferation, invasiveness, or metastasis, or by inducing cytotoxicity against cancer in mammals. The method employs 6-demethyl-6-deoxy-4-de(dimethylamino)tetracycline (CMT-3) and other functionally related chemically modified, preferably non-antibacterial, tetracycline compounds to inhibit cancer growth. The method is particularly effective to inhibit the establishment, growth, and metastasis of solid tumors, such as tumors derived from colon cancer cells, breast cancer cells, melanoma cells, prostatic carcinoma cells, or lung cancer cells.
摘要翻译： 本发明是通过抑制细胞增殖，侵袭或转移，或通过诱导哺乳动物对癌症的细胞毒性来抑制癌症生长的方法。 该方法采用6-脱甲基-6-脱氧-4-脱（二甲基氨基）四环素（CMT-3）和其他功能相关的化学修饰，优选非抗菌四环素化合物以抑制癌症生长。 该方法特别有效地抑制了实体瘤如来自结肠癌细胞，乳腺癌细胞，黑素瘤细胞，前列腺癌细胞或肺癌细胞的肿瘤的建立，生长和转移。
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公开(公告)号：US06277061B1
公开(公告)日：2001-08-21
申请号：US09052222
申请日：1998-03-31
申请人： Lorne M. Golub , Hsi-Ming Lee , Timo Sorsa , Olli Teronen , Tuula Salo
发明人： Lorne M. Golub , Hsi-Ming Lee , Timo Sorsa , Olli Teronen , Tuula Salo
IPC分类号： A61K3165
CPC分类号： A61K31/65
摘要： The invention is a method of inhibiting the activity of membrane-type matrix metalloproteinase (MT-MMP) in biological systems. Accordingly, the invention permits the treatment of medical conditions in mammals that are characterized by MT-MMP activity, and especially those conditions characterized by excessive MT-MMP activity. The method employs a tetracycline compound, preferably a non-antimicrobial tetracycline, and more preferably 6-demethyl-6-deoxy-4-de(dimethylamino)tetracycline (CMT-3) or 6-&agr;-deoxy-5-hydroxy-4-de(dimethylamino)tetracycline (CMT-8) to inhibit the MT-MMP activity.
摘要翻译： 本发明是抑制生物系统中膜型基质金属蛋白酶（MT-MMP）活性的方法。 因此，本发明允许治疗以MT-MMP活性为特征的哺乳动物中的医学病症，特别是以过量MT-MMP活性为特征的那些病症。 该方法采用四环素化合物，优选非抗微生物四环素，更优选6-去甲基-6-脱氧-4-脱（二甲基氨基）四环素（CMT-3）或6-α-脱氧-5-羟基-4- de（二甲基氨基）四环素（CMT-8）抑制MT-MMP活性。
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公开(公告)号：US5837696A
公开(公告)日：1998-11-17
申请号：US783655
申请日：1997-01-15
申请人： Lorne M. Golub , Thomas F. McNamara , Nungavaram S. Ramamurthy , Hsi-Ming Lee , Sanford Simon , Balakrishna L. Lokeshwar , Marie G. Selzer , Norman L. Block
发明人： Lorne M. Golub , Thomas F. McNamara , Nungavaram S. Ramamurthy , Hsi-Ming Lee , Sanford Simon , Balakrishna L. Lokeshwar , Marie G. Selzer , Norman L. Block
摘要： The invention is a method of inhibiting cancer growth, including cellular proliferation, invasiveness, or metastasis in mammals. The method employs 6-demethyl-6-deoxy-4-dedimethylaminotetracycline (CMT-3) and other functionally related chemically modified, preferably non-antibacterial, tetracycline compounds to inhibit cancer growth. The method is particularly effective to inhibit the establishment, growth, and metastasis of solid tumors, such as tumors derived from colon cancer cells, breast cancer cells, melanoma cells, prostatic carcinoma cells, or lung cancer cells.
摘要翻译： 本发明是抑制哺乳动物癌细胞增殖，包括细胞增殖，侵袭或转移的方法。 该方法采用6-脱甲基-6-脱氧-4-脱二甲基氨基四环素（CMT-3）和其他功能相关的化学修饰的，优选非抗菌的四环素化合物以抑制癌症生长。 该方法特别有效地抑制了实体瘤如来自结肠癌细胞，乳腺癌细胞，黑素瘤细胞，前列腺癌细胞或肺癌细胞的肿瘤的建立，生长和转移。
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公开(公告)号：US5977091A
公开(公告)日：1999-11-02
申请号：US157727
申请日：1998-09-21
申请人： Gary Nieman , Anthony Picone , Charles Lutz , David Carney , Louis Gatto , Lorne M. Golub , Sanford Simon , Nungavarm S. Ramamurthy
发明人： Gary Nieman , Anthony Picone , Charles Lutz , David Carney , Louis Gatto , Lorne M. Golub , Sanford Simon , Nungavarm S. Ramamurthy
CPC分类号： A61K31/65
摘要： The invention discloses a novel method for preventing acute lung injury in a mammal following trauma. The method includes treating the mammal with an effective amount of a tetracycline prior to intrapulmonary accumulation of neutrophils.
摘要翻译： 本发明公开了一种在创伤后预防哺乳动物急性肺损伤的新方法。 该方法包括在中性粒细胞的肺内积累之前用有效量的四环素处理哺乳动物。
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公开(公告)号：US5773430A
公开(公告)日：1998-06-30
申请号：US816551
申请日：1997-03-13
CPC分类号： A61K31/65
摘要： A method for inhibiting the activity of serine proteinase in biological systems includes administering to the system a serine proteinase inhibitory amount of a hydrophobic 4-de(dimethylamino)tetracycline. The method reduces tissue destruction during inflammation resulting from the activity of human leukocyte elastase. The method is used for pharmaceutical and cosmetic purposes.
摘要翻译： 用于抑制生物系统中丝氨酸蛋白酶活性的方法包括向系统施用抑制丝氨酸蛋白酶抑制量的疏水性4-脱（二甲基氨基）四环素。 该方法减少了由人类白细胞弹性蛋白酶活性引起的炎症期间的组织破坏。 该方法用于制药和化妆品目的。
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