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公开(公告)号：US11903996B2
公开(公告)日：2024-02-20
申请号：US15288830
申请日：2016-10-07
IPC分类号： A61K38/17 , C07K14/47 , A61P37/04 , A61K47/10 , C12N15/62 , C12N15/79 , C12N9/64 , A61K38/00 , C07K14/015
CPC分类号： A61K38/1725 , A61K47/10 , A61P37/04 , C07K14/015 , C07K14/47 , C07K14/472 , C12N15/62 , C12N15/79 , A61K38/00 , C12N9/64 , Y02A50/30
摘要： The invention relates generally to a modified human C3 protein containing a number of single amino acid changes in the α and β-chain of human C3 protein, designed to increase the affinity of the modified protein to factor B or Bb, to decrease the affinity of the modified protein to factor H, and to reduce the immunogenicity of the modified protein as compared to the native human C3 protein, a nucleotide sequence encoding the modified C3 protein, a plasmid or viral vector containing the nucleotide sequence for expression the modified C3 protein, and a host cell containing the plasmid or viral vector. We also present a polyethylene glycol covalently bound to the modified C3 protein for reducing immunogenicity and increasing plasma half-life of the modified C3 protein; a method for depleting complement in a patient by administering the modified C3 protein to the patient in an amount effective to deplete complement; a method of ameliorating effects caused by or disease or a method of ameliorating reperfusion injury in a patient by delivering the modified C3 protein.
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公开(公告)号：US20190016766A1
公开(公告)日：2019-01-17
申请号：US16058867
申请日：2018-08-08
摘要： The invention relates generally to derivatives of human C3 protein containing a number of single amino acid changes in the α- and β-chains of C3, designed to increase the affinity of the modified protein to factor B, to lessen the affinity of the modified protein for factor H, and to reduce the immunogenicity of the modified protein as compared to unmodified protein. The invention also presents methods of using these modified proteins for the treatment of certain cancers.
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公开(公告)号：US20180369328A1
公开(公告)日：2018-12-27
申请号：US15288830
申请日：2016-10-07
摘要： The invention relates generally to a modified human C3 protein containing a number of single amino acid changes in the α and β-chain of human C3 protein, designed to increase the affinity of the modified protein to factor B or Bb, to decrease the affinity of the modified protein to factor H, and to reduce the immunogenicity of the modified protein as compared to the native human C3 protein, a nucleotide sequence encoding the modified C3 protein, a plasmid or viral vector containing the nucleotide sequence for expression the modified C3 protein, and a host cell containing the plasmid or viral vector. We also present a polyethylene glycol covalently bound to the modified C3 protein for reducing immunogenicity and increasing plasma half-life of the modified C3 protein; a method for depleting complement in a patient by administering the modified C3 protein to the patient in an amount effective to deplete complement; a method of ameliorating effects caused by or disease or a method of ameliorating reperfusion injury in a patient by delivering the modified C3 protein.
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公开(公告)号：US20190038571A1
公开(公告)日：2019-02-07
申请号：US16056880
申请日：2018-08-07
IPC分类号： A61K31/09 , A61P25/18 , A61K9/00 , A61K31/724
摘要： The invention relates generally to pterostilbene and a related compound thereof active to inhibit complement at concentrations lower than 1 micromole per liter in human serum. The invention also relates to methods of using these orally active, well tolerated small molecules for the treatment of Alzheimer's disease and to prevent the development of schizophrenia by inhibiting the classical complement pathway. Methods for the treatment of complement-associated inflammatory and non-inflammatory diseases, including those of the skin, are also presented.
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公开(公告)号：US20090265041A1
公开(公告)日：2009-10-22
申请号：US12426132
申请日：2009-04-17
申请人： Daniel E. Benjamin
发明人： Daniel E. Benjamin
CPC分类号： G05B9/02 , G01R19/2513
摘要： In accordance with the present invention, there is provided multiple embodiments of systems and methods monitoring a power system. The system and methods provide a robust and comprehensive monitoring system to accurately assess system performance and identify system interference and power failures. The system is designed to capture parameters capable of being monitored in a power distribution system, such as voltage, current, temperature or the like. A basic embodiment of the present invention includes at least one line monitor for measuring electrical parameters on the line side of a power system, a load monitor for measuring electrical parameters from the load side of a power system, a control panel for compiling the data, and a remote server for providing further analysis of the system and monitoring the system in real time.
摘要翻译： 根据本发明，提供监控电力系统的系统和方法的多个实施例。 该系统和方法提供了一个健全和全面的监控系统，以准确评估系统性能并识别系统干扰和电源故障。 该系统旨在捕获能够在配电系统中监视的参数，例如电压，电流，温度等。 本发明的基本实施例包括至少一个用于测量电力系统的线路侧的电气参数的线路监视器，用于测量来自电力系统的负载侧的电气参数的负载监视器，用于编译数据的控制面板， 以及用于进一步分析系统并实时监控系统的远程服务器。
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