公开(公告)号：US5977302A

公开(公告)日：1999-11-02

申请号：US195049

申请日：1998-11-18

申请人： David C. Palmer ,  Ahmed Abdel-Magid ,  Michael S. Breslav ,  Urs P. Eggmann ,  Bruce Harris ,  Mark L. Haslego ,  Kirk L. Sorgi

发明人： David C. Palmer ,  Ahmed Abdel-Magid ,  Michael S. Breslav ,  Urs P. Eggmann ,  Bruce Harris ,  Mark L. Haslego ,  Kirk L. Sorgi

IPC分类号： C07K5/09 ,  C07K5/103 ,  C07K5/107 ,  C07K7/23 ,  C07K7/06

CPC分类号： C07K5/0815 ,  C07K5/101 ,  C07K5/1013 ,  C07K5/1016 ,  C07K7/23 ,  Y02P20/55

摘要： A liquid phase process for preparing GnRH peptide analogs of the formula:G-AA.sub.1 -(A)D-Phe-AA.sub.3 -AA.sub.4 -(R.sub.2)-AA.sub.5 -AA.sub.6 AA.sub.7 -AA.sub.8 -Pro-AA.sub.10 -NH.sub.2Formula 1which comprises:(a) reacting a peptide of the formula:T-(R.sub.2)AA.sub.5 -AA.sub.6 -Xwhere T is (P.sub.2)AA4 orP.sub.2 and X is AA.sub.7 --OH or is --OH, with a peptide of the formula:X'-AA.sub.8 -Pro-AA.sub.10 -NH.sub.2or acid-addition salt form thereof, where X' is AA.sub.7 when X is absent and X' selected from P-Ala, Gly, GABA, the D- and L- isomers of Ala, amino isobutyric acid, 6-amino-hexanoic acid, Ser, Thr, His, Tyr, Asn, and Gln' is absent when X is AA.sub.7 --OH;in a liquid reaction medium in the presence of a peptide coupling reagent and a strong organic amine base to obtain a product of the formula:T-(R.sub.2)AA.sub.5 -AA.sub.6 -AA.sub.7 -AA.sub.8 -Pro-AA.sub.10 -NH.sub.2(b) removing the P.sub.2 protecting group at the N-terminus, and(c) reacting the product of step (b) or an acid addition salt thereof, with a peptide of the formula:G-AA.sub.1 -(R.sub.1)D-Phe-AA.sub.3 -T'or acid-addition salt form thereof, where T' is AA.sub.4 --OH when T is absent and is absent when T is P2-AA.sub.4, in a liquid reaction medium to obtain a GnRH peptide of the formula:G-AA.sub.1 -(A)D-Phe-AA.sub.3 -AA.sub.4 -(R.sub.2)AA.sub.5 -AA.sub.6 -AA.sub.7 -AA.sub.8 -Pro-AA.sub.10 -NH.sub.2.

摘要翻译： 用于制备下式的GnRH肽类似物的液相方法：G-AA1-（A）D-Phe-AA3-AA4-（R2）-AA5-AA6AA7-AA8-Pro-AA10-NH2式1，其包含：（a ）使下式的肽与下式的肽反应：其中T是（P2）AA4或P2，X是AA7-OH或-OH的式（T-（R2）AA5-AA6-X）肽与下式的肽反应：X'-AA8-Pro -AA10-NH2或其酸加成盐形式，其中当X不存在时X'为AA 7，X'选自P-Ala，Gly，GABA，Ala的D-和L-异构体，氨基异丁酸， 当X是AA7-OH时，氨基己酸，Ser，Thr，His，Tyr，Asn和Gln'不存在; 在液体反应介质中，在肽偶联剂和强有机胺碱的存在下，得到下式的产物：（（R 2）AA 5 -A AA 6 -A AA 7 -A AA 8 -Pro-AA 10 -NH 2（b） P2保护基团，和（c）使步骤（b）的产物或其酸加成盐与下式的肽反应：G-AA1-（R1）D-Phe-AA3-T' 或其酸加成盐形式，其中当T不存在时T'为AA4-OH，当T为P2-AA4时不存在，在液体反应介质中得到G-AA1 - （A）的GnRH肽， D-Phe-AA3-AA4-（R2）AA5-AA6-AA7-AA8-Pro-AA10-NH2。

公开(公告)号：US06235876B1

公开(公告)日：2001-05-22

申请号：US09350231

申请日：1999-07-08

申请人： David C. Palmer ,  Ahmed Abdel-Magid ,  Urs P. Eggmann ,  Bruce Harris ,  Kirk L. Sorgi

发明人： David C. Palmer ,  Ahmed Abdel-Magid ,  Urs P. Eggmann ,  Bruce Harris ,  Kirk L. Sorgi

IPC分类号： C07K704

CPC分类号： C07K5/0815 ,  C07K5/101 ,  C07K5/1013 ,  C07K5/1016 ,  C07K7/23 ,  Y02P20/55

摘要： A liquid phase process for preparing GnRH peptide analogs of the formula: G-AA1-(A)D-Phe-AA3-AA4-(R2-AA5-AA6-AA7-AA8-Pro-AA10-NH2   Formula 1 which comprises: (a) reacting a peptide of the formula: T-(R2)AA5-AA6-X  where T is (P2) AA4 orP2 and X is AA7-OH or is —OH, with a peptide of the formula: X′-AA8-Pro-AA10-NH2  or acid-addition salt form thereof, where X′ is AA7 when X is absent and X′ is absent when X is AA7-OH;  in a liquid reaction medium in the presence of a peptide coupling reagent and a strong organic amine base to obtain a product of the formula: T-(R2)AA5-AA6-AA7-AA8-Pro-AA10-NH2 (b) removing the P2 protecting group at the N-terminus, and (c) reacting the product of step (b) or an acid addition salt thereof, with a peptide of the formula: G-AA1-(R1)D-Phe-AA3-T′  or acid-addition salt form thereof, where T′ is AA4-OH when T is absent and is absent when T is P2-AA4, in a liquid reaction medium to obtain a GnRH peptide of the formula: G-AA1-(A)D-Phe-AA3-AA4-(R2)AA5-AA6-AA7-AA8-Pro-AA10-NH2.

摘要翻译： 用于制备下式的GnRH肽类似物的液相方法：其包括：（a）使下式的肽与其中T是（P2）AA4或P2，X是AA7-OH或-OH的肽反应， 式：或其酸加成盐形式，其中当X不存在时X'为AA 7，X为AA 7 -OH时X'不存在; 在液体反应介质中，在肽偶联剂和强有机胺碱存在下，得到下式的产物：（b）在N末端除去P2保护基，和（c）使步骤 （b）或其酸加成盐与下式的肽或其酸加成盐形式，当T不存在时T'为AA4-OH，当T为P2-AA4时不存在，在液体反应中 培养基以获得下式的GnRH肽：

公开(公告)号：US20060004208A1

公开(公告)日：2006-01-05

申请号：US11215329

申请日：2005-08-30

申请人： Ahmed Abdel-Magid ,  Bruce Harris ,  Cynthia Maryanoff

发明人： Ahmed Abdel-Magid ,  Bruce Harris ,  Cynthia Maryanoff

IPC分类号： C07D231/12

CPC分类号： C07D231/12 ,  C07C51/083 ,  C07C59/88

摘要： A process for making a compound of formula I wherein the substituents are as described in the specification comprising reacting a ketone of formula II with succinic anhydride and an alkoxide base to form a compound of formula III which is reacted with a compound of formula IV to form a compound of V and reacting with an alcohol to form the corresponding ester of formula VI and reacting the ester with N-methylhydroxylamine.

公开(公告)号：US11091966B2

公开(公告)日：2021-08-17

申请号：US16272753

申请日：2019-02-11

申请人： Douglas Mallonee ,  Bruce Harris

发明人： Douglas Mallonee ,  Bruce Harris

IPC分类号： E21B21/01 ,  E21B21/06

摘要： A drill cuttings processing system including a breaker mill. The breaker mill operates to pulverize drill cuttings. The breaker mill includes an outer housing, a drum operatively positioned in the outer housing, hammers operatively positioned in the drum, and a screen configured for discharge of pulverized drill cuttings. A method includes feeding drill cuttings to the breaker mill. The breaker mill is located at a drilling rig site or is attached to a drilling rig. The method includes pulverizing the drill cuttings within the breaker mill.

公开(公告)号：US20100064545A1

公开(公告)日：2010-03-18

申请号：US12560484

申请日：2009-09-16

申请人： Shirley Pollack ,  Bruce Harris ,  Thomas Saliga

发明人： Shirley Pollack ,  Bruce Harris ,  Thomas Saliga

IPC分类号： F26B3/32

CPC分类号： A47K10/48

摘要： A method of treating an infant's bottom while changing diapers and a method employing such device involves a handheld blower and bactericide generator. The blower forces warmed air against the infant's bottom and ultraviolet lights supported in the blower irradiate the infant's body and the heated air to reduce bacteria. The ultraviolet lights are pulsed to enhance the antibacterial action.

摘要翻译： 在改变尿布的同时治疗婴儿的底部的方法和使用这种装置的方法涉及手持式鼓风机和杀菌剂发生器。 鼓风机将加热的空气压在婴儿的底部，并且鼓风机中的紫外线灯照射婴儿的身体和加热的空气以减少细菌。 紫外线灯被脉冲以增强抗菌作用。

公开(公告)号：US07205384B2

公开(公告)日：2007-04-17

申请号：US10902755

申请日：2004-07-29

申请人： Michael Breslav ,  Bruce Harris ,  Birdella Kenney ,  Thomas Maier ,  Armin Roessler ,  Frank Villani ,  Ulrich Weigl ,  Fan Zhang-Plasket ,  Hua Zhong

发明人： Michael Breslav ,  Bruce Harris ,  Birdella Kenney ,  Thomas Maier ,  Armin Roessler ,  Frank Villani ,  Ulrich Weigl ,  Fan Zhang-Plasket ,  Hua Zhong

IPC分类号： A61K38/00

CPC分类号： C07D277/64 ,  C07D417/12

摘要： The present invention relates to novel processes for the preparation of peptidyl heterocyclic ketones of the general formula (I) wherein all variables are as herein defined. The present invention further relates to novel pharmaceutical salts and processes for their preparation. The peptidyl heterocyclic ketones of formula (I) are potent and selective inhibitors of tryptase, useful for the treatment and prevention of inflammatory diseases associated with the respiratory tract, such as asthma and allergic rhinitis.

摘要翻译： 本发明涉及制备通式（I）的肽基杂环酮的新方法，

公开(公告)号：US20190301253A1

公开(公告)日：2019-10-03

申请号：US16272753

申请日：2019-02-11

申请人： Douglas Mallonee ,  Bruce Harris

发明人： Douglas Mallonee ,  Bruce Harris

IPC分类号： E21B21/06 ,  E21B21/01

摘要： A drill cuttings processing system including a breaker mill. The breaker mill operates to pulverize drill cuttings. The breaker mill includes an outer housing, a drum operatively positioned in the outer housing, hammers operatively positioned in the drum, and a screen configured for discharge of pulverized drill cuttings. A method includes feeding drill cuttings to the breaker mill. The breaker mill is located at a drilling rig site or is attached to a drilling rig. The method includes pulverizing the drill cuttings within the breaker mill.

公开(公告)号：US09452543B2

公开(公告)日：2016-09-27

申请号：US12765911

申请日：2010-04-23

申请人： Steven A. Supron ,  David E. Weeks ,  Bruce Harris

发明人： Steven A. Supron ,  David E. Weeks ,  Bruce Harris

IPC分类号： B26D1/08 ,  B26D5/16 ,  B41J11/70 ,  B41J29/02 ,  B26D1/00

CPC分类号： B26D1/085 ,  B26D1/0006 ,  B26D5/16 ,  B26D2001/006 ,  B26D2001/0066 ,  B41J11/70 ,  B41J29/02 ,  Y10T83/04 ,  Y10T83/8748 ,  Y10T83/8749 ,  Y10T83/8785 ,  Y10T83/8843 ,  Y10T83/8844 ,  Y10T83/8854 ,  Y10T83/9447 ,  Y10T83/9454

摘要： A cutter for a printer is provided, together with corresponding methods. The cutter has a fixed blade and a movable blade. The fixed blade is arranged on a cover bracket. The cover bracket is movable between an open and a closed position. The movable blade is arranged on a printer frame. The movable blade is adapted to move from a home position into engagement with the fixed blade for cutting paper media during a cutting action. In the open position of the cover bracket, the fixed blade and movable blade are separated, enabling paper jams to be cleared and paper to be loaded.

摘要翻译： 提供了一种用于打印机的切割机以及相应的方法。 刀具具有固定刀片和可动刀片。 固定刀片布置在盖架上。 盖支架可在打开和关闭位置之间移动。 可动刀片布置在打印机框架上。 可移动刀片适于在初始位置移动以与固定刀片接合，以在切割动作期间切割纸张介质。 在盖支架的打开位置，固定刀片和可动刀片分离，可以清除卡纸并装入纸张。

公开(公告)号：US20090120313A1

公开(公告)日：2009-05-14

申请号：US11985332

申请日：2007-11-13

申请人： Steven A. Supron ,  David E. Weeks ,  Bruce Harris ,  Jeffrey S. Koepele

发明人： Steven A. Supron ,  David E. Weeks ,  Bruce Harris ,  Jeffrey S. Koepele

IPC分类号： B41F13/02

CPC分类号： B41J13/025 ,  B41J13/009

摘要： A dual-purpose printer for printing receipts and validating forms is provided. The printer comprises a receipt drive roller for driving paper through a receipt path, a dual-purpose roller capable of contacting the drive roller, and a validation idler roller adapted to be brought into and out of engagement with the dual-purpose roller. The receipt path is formed between the receipt drive roller and the dual-purpose roller. A validation path is formed between the validation idler roller and the dual-purpose roller. Rotation of the receipt drive roller in a first direction enables driving of paper through the receipt path. When the validation idler roller is in engagement with the dual-purpose roller, rotation of the dual-purpose roller in the first direction enables discharging of a form from the validation path.

摘要翻译： 提供了一种用于打印收据和验证表单的双用途打印机。 打印机包括用于通过收据路径驱动纸张的收据驱动辊，能够接触驱动辊的双重用辊和适于与双用辊接合的确认惰轮。 接收路径形成在收据驱动辊和双用辊之间。 在验证惰辊和双用辊之间形成验证路径。 收据驱动辊在第一方向上的旋转使得能够通过收据路径驱动纸张。 当认证空转辊与双用途辊接合时，双向辊在第一方向上的旋转使得能够从确定路径排出一个形式。

公开(公告)号：US07059794B2

公开(公告)日：2006-06-13

申请号：US10878835

申请日：2004-06-28

申请人： David E. Weeks ,  Bruce Harris ,  Steven P. Hilsdorf

发明人： David E. Weeks ,  Bruce Harris ,  Steven P. Hilsdorf

IPC分类号： B26F3/00

CPC分类号： B41J11/70 ,  B41J15/005 ,  G07B5/02 ,  Y10T225/10 ,  Y10T225/16 ,  Y10T225/20 ,  Y10T225/205

摘要： Methods and apparatus for bursting perforated paper stock are provided. A feed mechanism is provided for feeding perforated paper stock in a feed direction along a paper path in a printer. The perforated paper stock has sections separated by perforations. A loop area is provided in the printer for accumulating one of the sections of the perforated paper stock. A burst element is provided for bursting a perforation of the accumulated section. In order to burst the perforation of the accumulated section, the feed direction is reversed to draw the perforation of the accumulated section against the burst element, thereby separating the section from the perforated paper stock. A paper dispensing mechanism is provided for advancing the separated section out of the loop area and dispensing the section from the printer.

摘要翻译： 提供了用于破裂多孔纸原料的方法和装置。 提供了一种进给机构，用于沿打印机中的纸路径沿进给方向进给穿孔纸料。 穿孔纸料有穿孔分开的部分。 在打印机中设置有循环区域，用于堆积穿孔纸料的一个部分。 提供突发元件用于破裂累积部分的穿孔。 为了突破累积部分的穿孔，进给方向相反，以将累积部分的穿孔拉到爆裂元件上，从而将该部分与穿孔纸料分离。 提供纸分配机构用于将分离的部分推出环形区域并从打印机分配该部分。