公开(公告)号：US20080046024A1

公开(公告)日：2008-02-21

申请号：US11609465

申请日：2006-12-12

申请人： David Carlson ,  Eric Panken ,  Touby Drew ,  Jonathan Werder

发明人： David Carlson ,  Eric Panken ,  Touby Drew ,  Jonathan Werder

IPC分类号： A61N1/05

CPC分类号： A61B5/02405 ,  A61B5/0456 ,  A61B5/0476 ,  A61B5/0482 ,  A61B5/4094 ,  A61B5/7221 ,  A61B5/7275 ,  A61N1/36082 ,  A61N2/006 ,  G06F19/00 ,  G06K9/00543

摘要： Systems and methods for detecting and/or treating nervous system disorders, such as seizures, are disclosed. Certain embodiments of the invention relate generally to implantable medical devices (IMDs) adapted to detect and treat nervous system disorders in patients with an IMD. Certain embodiments of the invention include detection of seizures based upon comparisons of long-term and short-term representations of physiological signals. Other embodiments include prediction of seizure activity based upon analysis of physiological signal levels. An embodiment of the invention monitors the quality of physiological signals, and may be able to compensate for signals of low signal quality. A further embodiment of the invention includes detection of seizure activity following the delivery of therapy.

公开(公告)号：US20060195039A1

公开(公告)日：2006-08-31

申请号：US11411712

申请日：2006-04-26

申请人： Touby Drew ,  Jonathan Werder ,  Jonathon Giftakis ,  Eric Panken

发明人： Touby Drew ,  Jonathan Werder ,  Jonathon Giftakis ,  Eric Panken

IPC分类号： A61B5/04

CPC分类号： A61B5/04 ,  A61B5/0006 ,  A61B5/0031 ,  A61B5/04001 ,  A61B5/04012 ,  A61B5/4094 ,  A61B5/7232 ,  A61N1/36135 ,  A61N1/36146 ,  A61N1/36521 ,  A61N1/36585 ,  A61N1/3702 ,  A61N1/37252 ,  A61N1/37282 ,  A61N1/3925 ,  G06F19/00 ,  G06F19/3418 ,  G16H10/60 ,  G16H40/63 ,  G16H50/70

摘要： Methods of generating an extended cluster are disclosed. A first cluster including data representative of a first signal indicative of an abnormal physiological symptom is generated. A second signal is detected as representing a second abnormal physiological symptom and the second abnormal physiological symptom continues after the first abnormal physiological symptom ends. An extended cluster including the data from the first signal and the second signal is generated that extends from the time when the first abnormal physiological symptom occurs to the time when the second abnormal physiological symptom ends. The first and the extended cluster may include data of both the first and second signals the entire period of the clusters. If desired, the first signal or the second signal may be provided from a sensor implanted in a patient's brain tissue.

摘要翻译： 公开了生成扩展簇的方法。 产生包括表示表示异常生理症状的第一信号的数据的第一群集。 检测到第二信号表示第二异常生理症状，第二异常生理症状在第一异常生理症状终止后继续。 产生包括来自第一信号和第二信号的数据的扩展簇，其从第一异常生理症状发生时到第二异常生理症状结束时延伸。 第一和扩展簇可以包括簇的整个周期的第一和第二信号的数据。 如果需要，可以从植入患者脑组织的传感器提供第一信号或第二信号。

公开(公告)号：US20070249953A1

公开(公告)日：2007-10-25

申请号：US11609388

申请日：2006-12-12

申请人： Mark Frei ,  Ivan Osorio ,  David Carlson ,  Eric Panken ,  Touby Drew

发明人： Mark Frei ,  Ivan Osorio ,  David Carlson ,  Eric Panken ,  Touby Drew

IPC分类号： A61B5/04 ,  A61N1/00

CPC分类号： A61N1/36082

摘要： Systems and methods for detecting and/or treating nervous system disorders, such as seizures, are disclosed. Certain embodiments of the invention relate generally to implantable medical devices (IMDs) adapted to detect and treat nervous system disorders in patients with an IMD. Certain embodiments of the invention include detection of seizures based upon comparisons of long-term and short-term representations of physiological signals. Other embodiments include prediction of seizure activity based upon analysis of physiological signal levels. A further embodiment of the invention includes detection of seizure activity following the delivery of therapy.

摘要翻译： 公开了用于检测和/或治疗诸如癫痫发作的神经系统疾病的系统和方法。 本发明的某些实施方案一般涉及适于检测和治疗患有IMD的患者的神经系统疾病的可植入医疗装置（IMD）。 本发明的某些实施方案包括基于生理信号的长期和短期表示的比较来检测癫痫发作。 其他实施方案包括基于生理信号水平的分析预测癫痫发作活动。 本发明的另一个实施方案包括在递送治疗后检测发作活动。

公开(公告)号：US20060224067A1

公开(公告)日：2006-10-05

申请号：US11380462

申请日：2006-04-27

申请人： Jonathon Giftakis ,  Jonathan Werder ,  Nina Graves ,  Eric Panken ,  David Carlson

发明人： Jonathon Giftakis ,  Jonathan Werder ,  Nina Graves ,  Eric Panken ,  David Carlson

IPC分类号： A61B5/02

CPC分类号： A61B5/0402 ,  A61B5/0031 ,  A61B5/02 ,  A61B5/0245 ,  A61B5/0476 ,  A61B5/0816 ,  A61B5/1135 ,  A61B5/4094 ,  A61N1/36064 ,  A61N1/36082 ,  A61N1/3611 ,  A61N1/365 ,  A61N1/36521 ,  A61N1/36585 ,  A61N1/37288 ,  A61N1/3962

摘要： A medical device system that includes a brain monitoring element, cardiac monitoring element and a processor. The processor is configured to receive a brain signal from the brain monitoring element and a cardiac signal from the cardiac monitoring element. The processor is further configured to determine at least one reference point for a brain event time period by evaluation of the brain signal. The processor further identifies a first portion of the cardiac signal based on the at least one reference point of the brain event time period.

摘要翻译： 一种包括脑部监测元件，心脏监测元件和处理器的医疗装置系统。 处理器被配置为从脑监测元件接收脑信号和来自心脏监测元件的心脏信号。 处理器还被配置为通过评估脑信号来确定大脑事件时间段的至少一个参考点。 处理器还基于大脑事件时间段的至少一个参考点识别心脏信号的第一部分。

公开(公告)号：US20070260286A1

公开(公告)日：2007-11-08

申请号：US11796575

申请日：2007-04-27

申请人： Jonathon Giftakis ,  Nina Graves ,  Jonathan Werder ,  Eric Panken

发明人： Jonathon Giftakis ,  Nina Graves ,  Jonathan Werder ,  Eric Panken

IPC分类号： A61N1/05

CPC分类号： A61B5/0402 ,  A61B5/0031 ,  A61B5/0476 ,  A61B5/4094 ,  A61N1/365 ,  A61N1/37288

摘要： A system for regulating or modulating cardiac therapy using brain state information. The modulation may include suppressing standard, prescribed cardiac therapy for a period of time or it may involve modulating the type of cardiac therapy delivered In another embodiment, a system is provided for determining whether a cardiac event is categorized as neurologically matched, and, if so, modulating the therapeutic output to the heart.

公开(公告)号：US20070265677A1

公开(公告)日：2007-11-15

申请号：US11796577

申请日：2007-04-27

申请人： Jonathon Giftakis ,  Nina Graves ,  Jonathan Werder ,  Eric Panken

发明人： Jonathon Giftakis ,  Nina Graves ,  Jonathan Werder ,  Eric Panken

IPC分类号： A61N1/05

CPC分类号： A61B5/0402 ,  A61B5/0031 ,  A61B5/02 ,  A61B5/0245 ,  A61B5/0476 ,  A61B5/0816 ,  A61B5/1135 ,  A61B5/4094 ,  A61N1/36064 ,  A61N1/36082 ,  A61N1/3621 ,  A61N1/365 ,  A61N1/36521 ,  A61N1/36585 ,  A61N1/37288 ,  A61N1/3962

摘要： A system for regulating or modulating cardiac therapy using brain state information. The modulation may include suppressing standard, prescribed cardiac therapy for a period of time or it may involve modulating the type of cardiac therapy delivered In another embodiment, a system is provided for determining whether a cardiac event is categorized as neurologically matched, and, if so, modulating the therapeutic output to the heart.

摘要翻译： 使用脑状态信息调节或调节心脏治疗的系统。 调节可以包括在一段时间内抑制标准的，规定的心脏治疗，或者可以涉及调节递送的心脏治疗的类型。在另一个实施例中，提供了一种用于确定心脏事件是否被分类为神经学匹配的系统，如果是 调节心脏的治疗输出。

公开(公告)号：US20070260147A1

公开(公告)日：2007-11-08

申请号：US11767054

申请日：2007-06-22

申请人： Jonathon Giftakis ,  David Carlson ,  Eric Panken ,  Nina Graves ,  Mark Rise ,  Kevin Bright ,  Chark Stanford

发明人： Jonathon Giftakis ,  David Carlson ,  Eric Panken ,  Nina Graves ,  Mark Rise ,  Kevin Bright ,  Chark Stanford

IPC分类号： A61B5/0205

CPC分类号： A61B5/0452 ,  A61B5/0031 ,  A61B5/02 ,  A61B5/0205 ,  A61B5/0245 ,  A61B5/0402 ,  A61B5/0476 ,  A61B5/053 ,  A61B5/08 ,  A61B5/0816 ,  A61B5/1135 ,  A61B5/4094 ,  A61N1/36064 ,  A61N1/36082 ,  A61N1/3611 ,  A61N1/365 ,  A61N1/36521 ,  A61N1/36585 ,  A61N1/36592 ,  A61N1/37288 ,  A61N1/3962

摘要： A medical device system and method for monitoring cardiac signal activity in patients with nervous system disorders. In some embodiments, a brain signal and a cardiac signal are received by a processor, brain events are identified in the brain signal, and the brain events are used to identify portions of the cardiac signal. In some embodiments, Event portions of the cardiac signal are identified corresponding to brain event time periods, and Inter-event portions are identified corresponding to time periods between brain events. An Inter-event heart-rate variability (HRV) calculation is performed using Inter-event portions of the cardiac signal, and an output of the medical device system is modified based upon the calculated Inter-event HRV according to certain embodiments of the invention. An Event HRV may also be calculated according to certain embodiments, and an output modified based on comparisons of the Event HRV to the Inter-event HRV, for example.

摘要翻译： 用于监测患有神经系统疾病的患者的心脏信号活动的医疗装置系统和方法。 在一些实施例中，脑信号和心脏信号由处理器接收，在脑信号中识别脑事件，并且使用脑事件来识别心脏信号的部分。 在一些实施例中，心脏信号的事件部分被识别为对应于脑事件时间段，并且事件部分被识别为对应于大脑事件之间的时间段。 使用心脏信号的事件间部分来执行事件间心率变异性（HRV）计算，并且基于根据本发明的某些实施例的所计算的事件间HRV，修改医疗装置系统的输出。 还可以根据某些实施例来计算事件HRV，并且例如基于事件HRV与事件间HRV的比较来修改输出。

公开(公告)号：US20070255330A1

公开(公告)日：2007-11-01

申请号：US11380435

申请日：2006-04-27

申请人： Brian Lee ,  Eric Panken ,  Can Cinbis ,  Gerard Hill ,  John Grevious

发明人： Brian Lee ,  Eric Panken ,  Can Cinbis ,  Gerard Hill ,  John Grevious

IPC分类号： A61N1/00

CPC分类号： A61N1/37288 ,  A61N1/3611 ,  A61N1/36135 ,  A61N1/36585 ,  Y10S128/903

摘要： A physiological monitoring or therapy delivery system includes autonomous, wirelessly linked, implantable devices located at different areas to sense physiologic signals and deliver therapy. At least one of the implantable devices can trigger synchronized action (e.g. data capture or therapy delivery) by other implantable devices via a telemetry link.

摘要翻译： 生理监测或治疗递送系统包括位于不同区域的自主的，无线连接的可植入装置，以感测生理信号并递送治疗。 可植入装置中的至少一个可以经由遥测链路触发其它可植入装置的同步动作（例如数据捕获或治疗传递）。

公开(公告)号：US20070270782A1

公开(公告)日：2007-11-22

申请号：US11731355

申请日：2007-03-30

申请人： Keith Miesel ,  Eric Panken

发明人： Keith Miesel ,  Eric Panken

IPC分类号： A61M5/142

CPC分类号： A61M5/16859 ,  A61M5/14276 ,  A61M2205/14 ,  A61M2205/15

摘要： Methods and systems for determining whether a catheter malfunction is present in a catheter by analyzing changes in the pressure of fluids being pumped through the delivery lumen of the catheter. The pressure changes that may be monitored may include, e.g., the peak pressure within the catheter and/or the pressure decay profile. The catheter malfunctions that may be determined using the methods and systems of the invention may include, e.g., leaks, blockages, the presence of gas bubbles, etc.

摘要翻译： 通过分析通过导管的输送腔泵送的流体的压力变化来确定导管故障是否存在于导管中的方法和系统。 可以监测的压力变化可以包括例如导管内的峰值压力和/或压力衰减曲线。 可以使用本发明的方法和系统确定的导管故障可以包括例如泄漏，堵塞，气泡的存在等