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公开(公告)号：US20110086161A1
公开(公告)日：2011-04-14
申请号：US12853776
申请日：2010-08-10
申请人： David Cohen , Rosann Kaylor
发明人： David Cohen , Rosann Kaylor
CPC分类号： G01N33/54373
摘要： A biosensor includes a substrate member with a pattern of active areas of receptive material and a pattern of blocking material layers. The receptive material and blocking material are attached to the substrate member with a photo-reactive crosslinking agent activated in a masking process. The receptive material is specific for an analyte of interest.
摘要翻译： 生物传感器包括具有接受材料的活性区域图案和阻挡材料层图案的基底构件。 接受材料和阻挡材料通过在掩蔽过程中活化的光反应性交联剂附着到基底构件上。 受体材料对于感兴趣的分析物是特异性的。
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公开(公告)号：US07695979B2
公开(公告)日：2010-04-13
申请号：US11800538
申请日：2007-05-07
申请人： Curtis Sayre , David Cohen , Rosann Kaylor
发明人： Curtis Sayre , David Cohen , Rosann Kaylor
IPC分类号： G01N33/553
CPC分类号： G01N33/54373 , G03H1/182
摘要： A biosensor includes a substrate with a layer of receptive material disposed thereon overlying a layer containing a photo-reactive agent. The receptive material is specific for an analyte of interest. A pattern of active and inactive areas of the receptive material are defined in the receptive material layer by a masking process wherein the photo-reactive agent is activated in the exposed regions of the mask.
摘要翻译： 生物传感器包括具有覆盖在含有光反应剂的层的层上的接受材料层的基板。 受体材料对于感兴趣的分析物是特异性的。 受体材料的活性和非活性区域的图案通过掩模过程在接受材料层中限定，其中光敏反应剂在掩模的暴露区域中被活化。
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公开(公告)号：US07485453B2
公开(公告)日：2009-02-03
申请号：US10139018
申请日：2002-05-03
申请人： David Cohen , Rosann Kaylor
发明人： David Cohen , Rosann Kaylor
IPC分类号： C12M1/34
CPC分类号： G01N33/54373 , C12Q1/003
摘要： A biosensor includes a substrate with areas of active receptive material disposed thereon. The receptive material is specific for an analyte of interest. A pattern of the active areas is defined on the substrate by an oxidizing photo-masking process.
摘要翻译： 生物传感器包括其上设置有活性接受材料区域的基底。 受体材料对于感兴趣的分析物是特异性的。 通过氧化光掩模工艺在衬底上限定有源区的图案。
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4.发明申请Biomolecule diagnostic devices and method for producing biomolecule diagnostic devices 有权生物分子诊断装置及生物分子诊断装置的制造方法公开(公告)号：US20080026454A1
公开(公告)日：2008-01-31
申请号：US11800538
申请日：2007-05-07
申请人： Curtis Sayre , David Cohen , Rosann Kaylor
发明人： Curtis Sayre , David Cohen , Rosann Kaylor
IPC分类号： C12M1/00
CPC分类号： G01N33/54373 , G03H1/182
摘要： A biosensor includes a substrate with a layer of receptive material disposed thereon overlying a layer containing a photo-reactive agent. The receptive material is specific for an analyte of interest. A pattern of active and inactive areas of the receptive material are defined in the receptive material layer by a masking process wherein the photo-reactive agent is activated in the exposed regions of the mask.
摘要翻译： 生物传感器包括具有覆盖在含有光反应剂的层的层上的接受材料层的基板。 受体材料对于感兴趣的分析物是特异性的。 受体材料的活性和非活性区域的图案通过掩模过程在接受材料层中限定，其中光敏反应剂在掩模的暴露区域中被活化。
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公开(公告)号：US07223534B2
公开(公告)日：2007-05-29
申请号：US10138598
申请日：2002-05-03
申请人： Rosann Kaylor , David Cohen , Curtis Sayre
发明人： Rosann Kaylor , David Cohen , Curtis Sayre
CPC分类号： B82Y30/00 , B01J2219/00432 , B01J2219/00531 , B01J2219/00596 , B01J2219/00605 , B01J2219/00612 , B01J2219/00617 , B01J2219/00637 , B01J2219/00659 , B01J2219/00677 , B01J2219/00702 , B01J2219/00722 , B01J2219/00725 , B01J2219/0074 , C40B40/06 , C40B40/10 , C40B60/14 , G01N33/54366 , G01N33/54373 , Y10S435/808 , Y10S436/805 , Y10S436/811
摘要： A biosensor includes a substrate with a layer of receptive material disposed thereon. The receptive material is specific for an analyte of interest. A pattern of active and deactivated areas of the receptive material are defined in the receptive material layer by a masking process.
摘要翻译： 生物传感器包括具有设置在其上的接受材料层的基板。 受体材料对于感兴趣的分析物是特异性的。 受体材料的活性和去活化区域的图案通过掩蔽过程限定在接受材料层中。
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公开(公告)号：US20050136553A1
公开(公告)日：2005-06-23
申请号：US10744235
申请日：2003-12-23
申请人： Rosann Kaylor , RameshBabu Boga , Kaiyuan Yang , David Cohen , Herb Velazquez , Amanda O'Connor
发明人： Rosann Kaylor , RameshBabu Boga , Kaiyuan Yang , David Cohen , Herb Velazquez , Amanda O'Connor
IPC分类号： G01N1/02 , G01N33/543 , A61M35/00
CPC分类号： G01N1/02 , C12M33/02 , G01N2001/028 , Y10S435/81 , Y10S435/97 , Y10S436/805 , Y10S436/81
摘要： A diagnostic test unit is provided. The test unit comprises a stem having a first end and a second end, the stem defining at least one flow channel extending between the first end and the second end. A swab is disposed at the first end of the stem, the swab being configured to collect a test sample derived from a biological source that is suspected of containing an analyte. The test unit also comprises a fluid chamber configured to contain a fluid, wherein the fluid chamber is in fluid communication with the swab via the flow channel. The test unit also comprises a rupturable seal that inhibits leakage of the fluid from the fluid chamber prior to use, and an assay for detecting the presence or absence of the analyte. The assay is in fluid communication with the swab, the flow channel, and the fluid chamber.
摘要翻译： 提供诊断测试单元。 测试单元包括具有第一端和第二端的杆，所述杆限定在第一端和第二端之间延伸的至少一个流动通道。 拭子设置在茎的第一端，拭子被配置成收集来自怀疑含有分析物的生物来源的测试样品。 测试单元还包括被配置为容纳流体的流体室，其中流体室经由流动通道与拭子流体连通。 测试单元还包括可破坏的密封，其在使用之前抑制流体从流体室的泄漏，以及用于检测分析物的存在或不存在的测定。 测定与拭子，流动通道和流体室流体连通。
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公开(公告)号：US08158408B2
公开(公告)日：2012-04-17
申请号：US12363987
申请日：2009-02-02
申请人： David Cohen , Rosann Kaylor
发明人： David Cohen , Rosann Kaylor
IPC分类号： C12M1/34
CPC分类号： G01N33/54373 , C12Q1/003
摘要： A biosensor includes a substrate with areas of active receptive material disposed thereon. The receptive material is specific for an analyte of interest. A pattern of the active areas is defined on the substrate by an oxidizing photo-masking process.
摘要翻译： 生物传感器包括其上设置有活性接受材料区域的基底。 受体材料对于感兴趣的分析物是特异性的。 通过氧化光掩模工艺在衬底上限定有源区的图案。
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公开(公告)号：US20050131287A1
公开(公告)日：2005-06-16
申请号：US10736662
申请日：2003-12-16
申请人： Rosann Kaylor , RameshBabu Boga , Kaiyuan Yang , Shawn Feaster , Curtis Sayre , David Cohen , Ning Wei , Chibueze Chidebelu-Eze , Stephen Quirk
发明人： Rosann Kaylor , RameshBabu Boga , Kaiyuan Yang , Shawn Feaster , Curtis Sayre , David Cohen , Ning Wei , Chibueze Chidebelu-Eze , Stephen Quirk
CPC分类号： A61F13/84 , A61B5/00 , A61F2013/8473 , A61F2013/8491
摘要： The premature rupture of amniotic fluid (PROM) may be discovered through a number of inventive means. Methods of evaluating whether PROM is present include; a) through the testing of the pH of vaginal fluids using an irreversible pH test; b) through the detection of analytes (e.g. enzymes) specific to amniotic fluid in the vaginal fluids; c) though the detection of hydrogen peroxide (H2O2) in the vaginal fluid; and d) through the detection of cholesterol in vaginal fluid. While individually indicative of PROM, it is desirable to combine at least two of these techniques to yield a powerful tool of even greater reliability. Test devices and feminine hygiene pads into which the test methods may be incorporated are also included herein.
摘要翻译： 通过许多创造性手段可以发现羊水过早破裂（PROM）。 评估PROM是否存在的方法包括： a）通过使用不可逆的pH测试来测试阴道液的pH值; b）通过检测阴道液中特异于羊水的分析物（例如酶）; c）尽管在阴道液中检测过氧化氢（H 2 O 2 O 2）; 和d）通过检测阴道液中的胆固醇。 虽然单独指示PROM，但是期望将这些技术中的至少两种组合以产生更大可靠性的强大工具。 本文还包括其中可以并入测试方法的测试装置和女性卫生衬垫。
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公开(公告)号：US07771922B2
公开(公告)日：2010-08-10
申请号：US10139025
申请日：2002-05-03
申请人： David Cohen , Rosann Kaylor , Curtis Sayre
发明人： David Cohen , Rosann Kaylor , Curtis Sayre
IPC分类号： C12Q1/00
CPC分类号： G01N33/54373
摘要： A biosensor includes a substrate member with a pattern of active areas of receptive material and a pattern of blocking material layers. The receptive material and blocking material are attached to the substrate member with a photo-reactive crosslinking agent activated in a masking process. The receptive material is specific for an analyte of interest.
摘要翻译： 生物传感器包括具有接受材料的活性区域图案和阻挡材料层图案的基底构件。 接受材料和阻挡材料通过在掩蔽过程中活化的光反应性交联剂附着到基底构件上。 受体材料对于感兴趣的分析物是特异性的。
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公开(公告)号：US07169550B2
公开(公告)日：2007-01-30
申请号：US10256278
申请日：2002-09-26
申请人： Curtis Sayre , Rosann Kaylor , David Cohen
发明人： Curtis Sayre , Rosann Kaylor , David Cohen
IPC分类号： C12Q1/00
CPC分类号： G03H1/182 , G01N21/4788 , G01N33/54373 , Y10S436/805 , Y10S436/815 , Y10S436/82 , Y10S436/901
摘要： A biosensor includes a substrate with a receptive material layer of radiation-absorbing member (RAM)-tagged biomolecules disposed thereon. The receptive material is specific for an analyte of interest. A pattern of active and deactivated areas of the receptive material are defined in the receptive material layer by a masking process wherein areas are exposed through a mask with a light source to induce deactivation.
摘要翻译： 生物传感器包括具有设置在其上的辐射吸收部件（RAM）标记的生物分子的受体材料层的基板。 受体材料对于感兴趣的分析物是特异性的。 受体材料的活性和去活化区域的图案通过掩蔽过程限定在接受材料层中，其中通过具有光源的掩模暴露区域以诱导失活。
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