公开(公告)号：US20070174109A1

公开(公告)日：2007-07-26

申请号：US11684002

申请日：2007-03-08

申请人： David Cohn ,  Robert Dill ,  George Galambos ,  Robert Guttman ,  Raman Harishankar ,  David Kress ,  Clifford Pickover ,  Guy Jonathan Rackham ,  John Smith ,  Stephen Smith ,  John Vergo

发明人： David Cohn ,  Robert Dill ,  George Galambos ,  Robert Guttman ,  Raman Harishankar ,  David Kress ,  Clifford Pickover ,  Guy Jonathan Rackham ,  John Smith ,  Stephen Smith ,  John Vergo

IPC分类号： G06Q99/00 ,  G07G1/00 ,  G06F17/30

CPC分类号： G06Q10/06 ,  G06Q10/06316

摘要： A system and method are described for using a Component Business Model (CBM) to transform a business. A CBM map is used to identify components that collaborate to provide a specified capability, and a repository supporting the CBM map is filtered to provide a view of the identified components that highlights how they collaborate. The view is used to identify component features contributing to the specified capability. The specified capability is then enhanced by a transformation strategy that includes re-engineering particular components, identifying a pattern characterizing the collaboration between components and adding a component to perform the collaborative pattern, and/or adding an additional feature to the collaboration and adding component to perform the additional feature. The CBM repository provides exemplar best practices that can be adapted for use in a re-engineered component.

摘要翻译： 描述了使用组件业务模型（CBM）来转换业务的系统和方法。 使用CBM映射来标识协作提供指定功能的组件，并且过滤支持CBM映射的存储库，以提供识别组件的视图，突出显示它们的协作。 该视图用于识别有助于指定功能的组件特征。 然后通过转换策略来增强指定的能力，该转换策略包括重新设计特定组件，识别表征组件之间的协作并添加组件以执行协作模式的模式，和/或向协作添加附加功能并将组件添加到 执行附加功能。 煤层气储存库提供了可用于重新设计的组件中的示例性最佳实践。

公开(公告)号：US20070038627A1

公开(公告)日：2007-02-15

申请号：US11202377

申请日：2005-08-12

申请人： David Cohn ,  Robert Dill ,  David Flaxer ,  George Galambos ,  Robert Guttman ,  Raman Harishankar ,  David Kress ,  Clifford Pickover ,  Guy Rackham ,  Shanker Ramamurthy ,  John Smith ,  Stephen Smith ,  John Vergo

发明人： David Cohn ,  Robert Dill ,  David Flaxer ,  George Galambos ,  Robert Guttman ,  Raman Harishankar ,  David Kress ,  Clifford Pickover ,  Guy Rackham ,  Shanker Ramamurthy ,  John Smith ,  Stephen Smith ,  John Vergo

IPC分类号： G06F17/30

CPC分类号： G06Q10/00 ,  G06Q10/063 ,  G06Q10/06375

摘要： A method and system are described for using the structure and relationships between components in a component business model of an enterprise to assign components providing monitoring data to a management component. In response to the monitoring data, the management component executes a business rule invoking a service that alters a behavior of the enterprise. The management component contains data rules limiting the information provided by the assigned components, analysis rules defining the interaction between components, and report rules for consolidating recommendations for altering behavior of the enterprise, including decisions to invest in certain aspects of the business, to reengineer certain processes of the business, and to alter operation of certain aspects of the business.

摘要翻译： 描述了使用企业的组件业务模型中的组件之间的结构和关系来分配向管理组件提供监控数据的组件的方法和系统。 响应于监视数据，管理组件执行调用改变企业行为的服务的业务规则。 管理组件包含限制分配组件提供的信息的数据规则，定义组件之间的交互的分析规则以及用于整合企业行为改变的建议的报告规则，包括对业务的某些方面投资的决定，重新设计某些 业务流程，并改变企业某些方面的运作。

公开(公告)号：US20070027701A1

公开(公告)日：2007-02-01

申请号：US11182062

申请日：2005-07-15

申请人： David Cohn ,  Robert Dill ,  David Flaxer ,  George Galambos ,  Robert Guttman ,  Raman Harishankar ,  David Kress ,  Christopher Murasso ,  Jeffrey Neville ,  Clifford Pickover ,  George Pohle ,  Guy Rackham ,  Shanker Ramamurthy ,  John Smith ,  Stephen Smith ,  Laurie Tropiano ,  John Vergo

发明人： David Cohn ,  Robert Dill ,  David Flaxer ,  George Galambos ,  Robert Guttman ,  Raman Harishankar ,  David Kress ,  Christopher Murasso ,  Jeffrey Neville ,  Clifford Pickover ,  George Pohle ,  Guy Rackham ,  Shanker Ramamurthy ,  John Smith ,  Stephen Smith ,  Laurie Tropiano ,  John Vergo

IPC分类号： G06Q10/00 ,  G06Q50/00

CPC分类号： G06Q10/06 ,  G06Q10/0637 ,  Y02P90/86

摘要： A system and method is described for using a component business model to partition a business into non-overlapping components, and then allocating different components to appropriate organizing strategies, based on attribute values assigned to each component. In the best mode of implementation there are two attributes: whether or not the component differentiates the business within the market place; and whether the component is industry standard or is tailored by the organization. These attributes and their values map the components of the business to a matrix. Based on the combination of attribute values in each cell of the matrix, available organizing strategies are also mapped to the matrix, thereby identifying for each component an appropriate organizing strategy.

摘要翻译： 描述了一种系统和方法，用于使用组件业务模型将业务划分为非重叠组件，然后基于分配给每个组件的属性值，将不同的组件分配到适当的组织策略。 在最佳实施模式中，有两个属性：组件是否区分市场中的业务; 以及组件是行业标准还是由组织量身定制。 这些属性及其值将业务的组件映射到矩阵。 基于矩阵的每个单元格中的属性值的组合，可用的组织策略也被映射到矩阵，从而为每个组件识别适当的组织策略。

公开(公告)号：US20070033211A1

公开(公告)日：2007-02-08

申请号：US11196484

申请日：2005-08-04

申请人： Saul Berman ,  David Kress ,  Jeffrey Neville ,  George Pohle ,  Guy Rackham ,  Stephen Smith ,  Laurie Tropiano ,  Stephen Wood

发明人： Saul Berman ,  David Kress ,  Jeffrey Neville ,  George Pohle ,  Guy Rackham ,  Stephen Smith ,  Laurie Tropiano ,  Stephen Wood

IPC分类号： G06F7/00

CPC分类号： G06Q10/10 ,  G06Q10/06375

摘要： A method of combining businesses by creating a target component map based on the business strategy of the resulting company, and using that target map to generate a component map for each constituent company in the combination. The constituent component map describes the current state of each component instantiated in the constituent company. Where there is no overlap between constituent companies with respect to components in the target map, those component instantiations are carried over to the resulting company. Where there is overlap, a comparative analysis is done and a ‘best fit’ component is recommended for inclusion in the resulting company. A transformation plan is developed to build the resulting company from those component instances selected for inclusion, in accordance with the target component map. Where the business strategy for building the resulting company includes a divestiture, the transformation plan provides alignment of the components to be divested in order to optimize the divestiture.

摘要翻译： 通过基于所生成的公司的业务策略创建目标分量图并且使用该目标图来为组合中的每个组成公司生成分量图来组合企业的方法。 组成部分图描述了在组成公司中实例化的每个组件的当前状态。 如果组合公司在目标地图中的组件之间没有重叠，则将这些组件实例化转移到生成的公司。 如果存在重叠，则进行比较分析，并建议将“最佳拟合”组件包含在生成的公司中。 根据目标组件图，开发了一种转换计划，以从选定包含的组件实例构建生成的公司。 如果建立由此产生的公司的业务战略包括剥离，则转型计划将对要分拆的组件进行整合，以优化剥离。

公开(公告)号：US20220224993A2

公开(公告)日：2022-07-14

申请号：US17114186

申请日：2020-12-07

申请人： Brick Eksten ,  Stephen Smith ,  Yuval Fisher ,  Steven Reynolds

发明人： Brick Eksten ,  Stephen Smith ,  Yuval Fisher ,  Steven Reynolds

IPC分类号： H04N21/845 ,  H04N21/262 ,  H04N21/2343 ,  H04N21/24 ,  H04L29/06 ,  H04N21/458 ,  H04N21/488

摘要： A system for producing fragmented video content is provided. The system includes a processing device, a non-transitory data store, and a memory storage device having at least a Manifest Processing Service (MPS) unit stored therein. The MPS unit is configured to generate at least one master manifest and store the master manifest in the non-transitory data store, the master manifest comprising a timing reference for a video fragment of the fragmented video content, wherein the timing reference indicates a temporal boundary of processing for the video fragment.

公开(公告)号：US09035030B2

公开(公告)日：2015-05-19

申请号：US13401559

申请日：2012-02-21

申请人： Jochen Salfeld ,  Michael Roguska ,  Michael Paskind ,  Subhashis Banerjee ,  Daniel Tracey ,  Michael White ,  Zehra Kaymakcalan ,  Boris Labkovsky ,  Paul Sakorafas ,  Geertruida M. Veldman ,  Amy Venturini ,  Angela Widom ,  Stuart Friedrich ,  Nicholas W. Warne ,  Angela Myles ,  John Gawain Elvin ,  Alexander Robert Duncan ,  Elaine Joy Derbyshire ,  Sara Carmen ,  Stephen Smith ,  Thor Las Holtet ,  Sarah Leila Du Fou

发明人： Jochen Salfeld ,  Michael Roguska ,  Michael Paskind ,  Subhashis Banerjee ,  Daniel Tracey ,  Michael White ,  Zehra Kaymakcalan ,  Boris Labkovsky ,  Paul Sakorafas ,  Geertruida M. Veldman ,  Amy Venturini ,  Angela Widom ,  Stuart Friedrich ,  Nicholas W. Warne ,  Angela Myles ,  John Gawain Elvin ,  Alexander Robert Duncan ,  Elaine Joy Derbyshire ,  Sara Carmen ,  Stephen Smith ,  Thor Las Holtet ,  Sarah Leila Du Fou

IPC分类号： C07K16/24 ,  C12P21/08 ,  A61K39/395 ,  A61K39/00 ,  C07K16/18 ,  C07K16/00 ,  C07K14/54 ,  A61K38/20

CPC分类号： C07K16/244 ,  A61K9/0019 ,  A61K38/208 ,  A61K39/00 ,  A61K39/3955 ,  A61K39/39591 ,  A61K45/06 ,  A61K47/20 ,  A61K47/22 ,  A61K47/26 ,  A61K2039/505 ,  C07K14/5434 ,  C07K16/00 ,  C07K16/18 ,  C07K2317/21 ,  C07K2317/565 ,  C07K2317/73 ,  C07K2317/76 ,  C07K2317/94 ,  Y10S514/863 ,  Y10S514/885 ,  Y10S514/886

摘要： Human antibodies, preferably recombinant human antibodies, that specifically bind to human interleukin-12 (hIL-12) are disclosed. Preferred antibodies have high affinity for hIL-12 and neutralize hIL-12 activity in vitro and in vivo. An antibody of the invention can be a full-length antibody or an antigen-binding portion thereof. The antibodies, or antibody portions, of the invention are useful for detecting hIL-12 and for inhibiting hIL-12 activity, e.g., in a human subject suffering from a disorder in which hIL-12 activity is detrimental. Nucleic acids, vectors and host cells for expressing the recombinant human antibodies of the invention, and methods of synthesizing the recombinant human antibodies, are also encompassed by the invention.

摘要翻译： 公开了特异性结合人白细胞介素-12（hIL-12）的人抗体，优选重组人抗体。 优选的抗体对hIL-12具有高亲和力，并在体外和体内中和hIL-12活性。 本发明的抗体可以是全长抗体或其抗原结合部分。 本发明的抗体或抗体部分可用于检测hIL-12和抑制hIL-12活性，例如在患有hIL-12活性有害的病症的人类受试者中。 用于表达本发明的重组人抗体的核酸，载体和宿主细胞以及合成重组人抗体的方法也包括在本发明中。

公开(公告)号：US08765918B2

公开(公告)日：2014-07-01

申请号：US13429104

申请日：2012-03-23

申请人： Jochen G. Salfeld ,  Michael Roguska ,  Michael Paskind ,  Subhashis Banerjee ,  Daniel Edward Tracey ,  Michael White ,  Zehra Kaymakcalan ,  Boris Labkovsky ,  Paul Sakorafas ,  Geertruida M. Veldman ,  Amy Venturini ,  Angela Widom ,  Stuart Friedrich ,  Nicholas W. Warne ,  Angela Myles ,  John Gawain Elvin ,  Alexander Robert Duncan ,  Elaine Joy Derbyshire ,  Sara Carmen ,  Stephen Smith ,  Thor Las Holtet ,  Sarah Leila Du Fou

发明人： Jochen G. Salfeld ,  Michael Roguska ,  Michael Paskind ,  Subhashis Banerjee ,  Daniel Edward Tracey ,  Michael White ,  Zehra Kaymakcalan ,  Boris Labkovsky ,  Paul Sakorafas ,  Geertruida M. Veldman ,  Amy Venturini ,  Angela Widom ,  Stuart Friedrich ,  Nicholas W. Warne ,  Angela Myles ,  John Gawain Elvin ,  Alexander Robert Duncan ,  Elaine Joy Derbyshire ,  Sara Carmen ,  Stephen Smith ,  Thor Las Holtet ,  Sarah Leila Du Fou

IPC分类号： C07K16/24 ,  A61K39/395 ,  A61K38/00

CPC分类号： C07K16/244 ,  A61K9/0019 ,  A61K38/208 ,  A61K39/00 ,  A61K39/3955 ,  A61K39/39591 ,  A61K45/06 ,  A61K47/20 ,  A61K47/22 ,  A61K47/26 ,  A61K2039/505 ,  C07K14/5434 ,  C07K16/00 ,  C07K16/18 ,  C07K2317/21 ,  C07K2317/565 ,  C07K2317/73 ,  C07K2317/76 ,  C07K2317/94 ,  Y10S514/863 ,  Y10S514/885 ,  Y10S514/886

摘要： Human antibodies, preferably recombinant human antibodies, that specifically bind to human interleukin-12 (hIL-12) are disclosed. Preferred antibodies have high affinity for hIL-12 and neutralize hIL-12 activity in vitro and in vivo. An antibody of the invention can be a full-length antibody or an antigen-binding portion thereof. The antibodies, or antibody portions, of the invention are useful for detecting hIL-12 and for inhibiting hIL-12 activity, e.g., in a human subject suffering from a disorder in which hIL-12 activity is detrimental. Nucleic acids, vectors and host cells for expressing the recombinant human antibodies of the invention, and methods of synthesizing the recombinant human antibodies, are also encompassed by the invention.

摘要翻译： 公开了特异性结合人白细胞介素-12（hIL-12）的人抗体，优选重组人抗体。 优选的抗体对hIL-12具有高亲和力，并在体外和体内中和hIL-12活性。 本发明的抗体可以是全长抗体或其抗原结合部分。 本发明的抗体或抗体部分可用于检测hIL-12和抑制hIL-12活性，例如在患有hIL-12活性有害的病症的人类受试者中。 用于表达本发明的重组人抗体的核酸，载体和宿主细胞以及合成重组人抗体的方法也包括在本发明中。

公开(公告)号：US20140155784A1

公开(公告)日：2014-06-05

申请号：US13980320

申请日：2012-01-18

申请人： Stephen Smith

发明人： Stephen Smith

IPC分类号： A61B5/11

CPC分类号： A61B5/1101 ,  A61B5/1125 ,  G06K9/00536 ,  G06K9/6229

摘要： The invention provides signal processing algorithms and apparatus for detecting bradykinesia, tremor, or other symptoms of neurological dysfunction in subjects, using three-dimensional sensors to tract finger and hand position. The invention provides Cartesian Genetic Programming networks and particular function blocks for such networks to enable identification of subjects exhibiting such symptoms.

摘要翻译： 本发明提供用于检测受试者的运动障碍，震颤或其他神经功能障碍症状的信号处理算法和装置，其使用三维传感器来管理手指和手部位置。 本发明提供了笛卡尔基因编程网络和用于这种网络的特定功能块，以使得能够识别表现出这种症状的受试者。

公开(公告)号：US08356696B1

公开(公告)日：2013-01-22

申请号：US12483931

申请日：2009-06-12

申请人： Brian Carroll ,  Michael Neu ,  Chris Petty ,  Dudley Headley ,  David McCoy ,  Stephen Smith

发明人： Brian Carroll ,  Michael Neu ,  Chris Petty ,  Dudley Headley ,  David McCoy ,  Stephen Smith

IPC分类号： F01M1/00 ,  F01M11/00 ,  F16N7/34 ,  B05B5/025 ,  B05B7/00 ,  A61M11/06

CPC分类号： F16N7/32

摘要： A system and method for lubricating components where the lubricant is applied in mist form within a substantially enclosed cavity. The cavity contains a draining aperture which collects excess lubricant for subsequent re-use by the system. The cavity is defined by a spray head that includes a base having attached thereto a cover plate with an opening adapted to receive therethrough a component to be lubricated. The cavity and lubrication chamber prevents the escape of excess lubricant. The collection and reuse of excess lubricant provides a closed loop system that reduces lubricant waste.

摘要翻译： 一种用于润滑部件的系统和方法，其中润滑剂以雾形式施加在基本封闭的腔内。 空腔包含一个排放孔，其收集多余的润滑剂以供系统随后重复使用。 空腔由喷头限定，喷头包括底座，其附接有具有开口的底板，该开口适于容纳待润滑的部件。 空腔和润滑室可防止多余润滑剂溢出。 多余润滑剂的收集和再利用提供了一种减少润滑剂浪费的闭环系统。

公开(公告)号：US20120308514A1

公开(公告)日：2012-12-06

申请号：US13429104

申请日：2012-03-23

申请人： Jochen Salfeld ,  Michael Roguska ,  Michael Paskind ,  Subhashis Banerjee ,  Daniel Tracey ,  Michael White ,  Zehra Kaymakcalan ,  Boris Labkovsky ,  Paul Sakorafas ,  Geertruida M. Veldman ,  Amy Venturini ,  Angela Widom ,  Stuart Friedrich ,  Nicholas W. Warne ,  Angela Myles ,  John Gawain Elvin ,  Alexander Robert Duncan ,  Elaine Joy Derbyshire ,  Sara Carmen ,  Stephen Smith ,  Thor Las Holtet ,  Sarah Leila Du Fou

发明人： Jochen Salfeld ,  Michael Roguska ,  Michael Paskind ,  Subhashis Banerjee ,  Daniel Tracey ,  Michael White ,  Zehra Kaymakcalan ,  Boris Labkovsky ,  Paul Sakorafas ,  Geertruida M. Veldman ,  Amy Venturini ,  Angela Widom ,  Stuart Friedrich ,  Nicholas W. Warne ,  Angela Myles ,  John Gawain Elvin ,  Alexander Robert Duncan ,  Elaine Joy Derbyshire ,  Sara Carmen ,  Stephen Smith ,  Thor Las Holtet ,  Sarah Leila Du Fou

IPC分类号： A61K39/395 ,  A61K38/19 ,  A61P19/02 ,  A61P1/00 ,  A61P1/04 ,  A61P9/10 ,  A61P11/06 ,  A61P13/12 ,  A61P1/16 ,  A61P25/28 ,  A61P25/16 ,  A61K38/20 ,  A61P3/10

CPC分类号： C07K16/244 ,  A61K9/0019 ,  A61K38/208 ,  A61K39/00 ,  A61K39/3955 ,  A61K39/39591 ,  A61K45/06 ,  A61K47/20 ,  A61K47/22 ,  A61K47/26 ,  A61K2039/505 ,  C07K14/5434 ,  C07K16/00 ,  C07K16/18 ,  C07K2317/21 ,  C07K2317/565 ,  C07K2317/73 ,  C07K2317/76 ,  C07K2317/94 ,  Y10S514/863 ,  Y10S514/885 ,  Y10S514/886

摘要： Human antibodies, preferably recombinant human antibodies, that specifically bind to human interleukin-12 (hIL-12) are disclosed. Preferred antibodies have high affinity for hIL-12 and neutralize hIL-12 activity in vitro and in vivo. An antibody of the invention can be a full-length antibody or an antigen-binding portion thereof. The antibodies, or antibody portions, of the invention are useful for detecting hIL-12 and for inhibiting hIL-12 activity, e.g., in a human subject suffering from a disorder in which hIL-12 activity is detrimental. Nucleic acids, vectors and host cells for expressing the recombinant human antibodies of the invention, and methods of synthesizing the recombinant human antibodies, are also encompassed by the invention.