摘要:
The present invention relates to compounds of formula (I): pharmaceutically acceptable salts thereof, corresponding pharmaceutical compositions, use as Raf Kinase Inhibitors and treatment methods for neurotraumatic diseases and cancer.
摘要:
Compounds and their use as pharmaceuticals particularly as Raf kinase inhibitors for the treatment of neurotraumatic diseases, cancer, chronic neurodegeneration, pain, migraine or cardiac hypertrophy.
摘要:
The invention provides compounds of formula (I) or pharmaceutically acceptable salts thereof, wherein Ra, Rb, Rc, Rd, Re, Rf and Y are as defined in the specification. The compounds are partial or full agonists at the growth hormone secretagogue (GHS) receptors. Pharmaceutical compositions comprising the compounds methods of preparing the compounds, uses of the compounds and methods involving the compounds are also provided.
摘要:
An assembly including a tire having beads, said bead axially including outside the turn-up a layer of a material defining a bead outer profile, such that the distance A, between the carcass frame and the bead outer profile, is as defined in formula (Z), B being the distance between the end of the turn-up, said bead including first and second profiles between the carcass frame and the turn-up, the first profile extends from the bead wire and is made of a material having an extension secant modulus at a 10% elongation higher than 20 MPa, a second profile arranged in the bead such as to be in contact with a surface of the first profile and the turn-up, made of a material having an extension secant modulus at a 10% elongation of at least 7 MPa and an extension secant modulus at a 100*% extension of at least 4.5 MPa.
摘要:
A connector clamp, for a hard drive having a first connector for mating with an external connector, having a top clamp and a bottom clamp. The top clamp includes a longitudinal section from which two arms extend, each arm including an integrally formed hole, and a bottom face, wherein a first gasket is attached to the bottom face and contacts the external connector when mated with the first connector. The bottom clamp includes an integrally formed first set of holes to receive a first set of screws for insertion into the hard drive, an integrally formed second set of holes to receive a second set of screws for insertion into the holes of the top clamp, and a top face, wherein a second gasket is attached to the top face and contacts the external connector when mated with the first connector.
摘要:
The present invention is directed to a computer aided design method for producing an implant for a patient prior to operation comprising the steps of: generating data with a non-invasive 3D (3-dimensional) scan of the patient's defect site that digitally represents the area that will receive the implant; designing and validating an implant on a computer based on digital data generated from a volume image of the patient; and fabricating the implant based solely on the implant design data generated on computer.
摘要:
Systems, methods, and other embodiments associated with Tomosurgery are described. One method embodiment includes logically dividing a target volume into treatment slices to be radiated individually by co-planar beams. The method embodiment also includes planning a two dimensional path for moving a shaped isocenter through a treatment slice where the isocenter is produced by the intersection of the co-planar beams. The method embodiment also includes planning a three dimensional path for moving the shaped isocenter through the target volume based, at least in part, on two dimensional paths. The method provides a signal to control a radio surgery device to deliver radiation using the coplanar beams to the target volume based, at least in part, on the three dimensional path.
摘要:
An improved optical collection and transmission surface includes a plastic mold injection surface including staggered multiple transmission sites each with a recessed portion in which incident light is not lost during reflection towards the propagation surface. A device implementing the surfaces is plastic-mold injected of high quality acrylic at in a preferred embodiment and can be economically optionally polished or finished to achieve desired quality surfaces.
摘要:
A ferrule comprising a molded ferrule body defining fiber bores, an end face of a connective end of the ferrule positioned about the fiber bores, and an integral reference surface for determining the angularity of the end face. The integral reference surface is not machined subsequent to a ferrule molding process and is accessible after assembly of the ferrule body into a connector body. A multi-fiber ferrule comprising a connective end defining an end face, a rear non-connective portion defining a protruding shoulder, and an integral reference datum positioned on a surface of the shoulder accessible for determining the angularity of a plane defined by the end face, wherein the integral datum is accessible when the ferrule is received within a connector body.