公开(公告)号：US6040573A

公开(公告)日：2000-03-21

申请号：US937729

申请日：1997-09-25

Applicant: C. Ray Sporleder ,  David E. Clemmer

Inventor： C. Ray Sporleder ,  David E. Clemmer

IPC: H01J49/02 ,  H01J49/42

CPC classification number: H01J49/025

Abstract: A technique to produce a device for generating an electric field is disclosed. This electric field may be customized to direct movement of charged particles in a predetermined manner. Moreover, this device is readily installed and removed from a charged particle analyzer to facilitate interchange with other devices capable of generating electric fields with different characteristics. The device may be provided by etching an electrically conductive layer clad to a flexible dielectric substrate to define a predetermined conductive pattern. This pattern is then oriented relative to a charged particle pathway and an electric potential applied to generate the desired electric field.

Abstract translation: 公开了一种制造用于产生电场的装置的技术。 该电场可以被定制成以预定方式引导带电粒子的移动。 此外，该装置容易地从带电粒子分析仪安装和移除，以便于与能够产生具有不同特性的电场的其它装置的交换。 该器件可以通过蚀刻包覆到柔性电介质衬底的导电层来限定预定的导电图案来提供。 然后，该图案相对于带电粒子途径取向，并且施加电位以产生所需的电场。

公开(公告)号：US08362420B2

公开(公告)日：2013-01-29

申请号：US12439108

申请日：2007-08-31

Applicant: David E. Clemmer ,  Samuel I. Merenbloom ,  Stormy L. Koeniger ,  Stephen J. Valentine

Inventor： David E. Clemmer ,  Samuel I. Merenbloom ,  Stormy L. Koeniger ,  Stephen J. Valentine

IPC: B01D59/44

CPC classification number: H01J49/42 ,  H01J49/408

Abstract: An apparatus (10) for separating Ions based on ion mobility includes a conduit (12) defining a closed path. The conduit is configured such that a uniform electric field is produced about the closed path upon application of a voltage causing ions within the conduit (12) to move about the closed path and to separate the ions based upon ion mobility. A method of separating a plurality of ions is also disclosed.

Abstract translation: 用于基于离子迁移率分离离子的装置（10）包括限定封闭路径的导管（12）。 导管构造成使得在施加导致离子在导管（12）内的电压围绕封闭路径移动并基于离子迁移率分离离子时，围绕封闭路径产生均匀的电场。 还公开了分离多个离子的方法。

公开(公告)号：US20110121171A1

公开(公告)日：2011-05-26

申请号：US12952109

申请日：2010-11-22

Applicant: David E. Clemmer ,  Ruwan T. Kurulugama ,  Fabiane M. Nachtigall ,  Zachary Henson ,  Samuel I. Merenbloom ,  Stephen J. Valentine

Inventor： David E. Clemmer ,  Ruwan T. Kurulugama ,  Fabiane M. Nachtigall ,  Zachary Henson ,  Samuel I. Merenbloom ,  Stephen J. Valentine

IPC: B01D59/44 ,  H01J49/40

CPC classification number: G01N27/622

Abstract: An ion mobility spectrometer instrument has a drift tube that is partitioned into a plurality of cascaded drift tube segments. A number of electric field activation sources may each be coupled to one or more of the plurality of drift tube segments. A control circuit is configured to control operation of the number of electric field activation sources in a manner that sequentially applies electric fields to the drift tube segments to allow only ions having a predefined ion mobility or range of ion mobilities to travel through the drift tube. The drift tube segments may define a linear drift tube or a closed drift tube with a continuous ion travel path. Techniques are disclosed for operating the ion mobility spectrometer to produce highly resolved ion mobility spectra.

Abstract translation: 离子迁移谱仪具有漂移管，其被分隔成多个级联漂移管段。 多个电场激活源可以各自耦合到多个漂移管段中的一个或多个。 控制电路被配置为以顺序地向漂移管段施加电场以允许具有预定离子迁移率或离子迁移率范围的离子行进穿过漂移管的方式来控制电场激活源的数量的操作。 漂移管段可以限定具有连续离子行进路径的线性漂移管或闭合漂移管。 公开了用于操作离子迁移谱仪以产生高度分辨的离子迁移率光谱的技术。

公开(公告)号：US20100193678A1

公开(公告)日：2010-08-05

申请号：US12439108

申请日：2007-08-31

Applicant: David E. Clemmer ,  Samuel I. Merenbloom ,  Stormy L. Koeniger ,  Stephen J. Valentine

Inventor： David E. Clemmer ,  Samuel I. Merenbloom ,  Stormy L. Koeniger ,  Stephen J. Valentine

IPC: H01J49/02

CPC classification number: H01J49/42 ,  H01J49/408

Abstract: An apparatus (10) for separating Ions based on ion mobility includes a conduit (12) defining a closed path. The conduit is configured such that a uniform electric field is produced about the closed path upon application of a voltage causing ions within the conduit (12) to move about the closed path and to separate the ions based upon ion mobility. A method of separating a plurality of ions is also disclosed.

Abstract translation: 用于基于离子迁移率分离离子的装置（10）包括限定封闭路径的导管（12）。 导管构造成使得在施加导致离子在导管（12）内的电压围绕封闭路径移动并基于离子迁移率分离离子时，围绕封闭路径产生均匀的电场。 还公开了分离多个离子的方法。

公开(公告)号：US08618475B2

公开(公告)日：2013-12-31

申请号：US13038544

申请日：2011-03-02

Applicant: David E. Clemmer ,  Stormy L. Koeniger ,  Stephen J. Valentine

Inventor： David E. Clemmer ,  Stormy L. Koeniger ,  Stephen J. Valentine

IPC: H01J49/40

CPC classification number: G01N27/622

Abstract: An ion mobility spectrometer comprises a drift tube defining a drift tube inlet configured to receive ions and a drift tube outlet. The drift tube is configured to separate ions in time as a function of ion mobility. The drift tube defines a first ion activation region between the drift tube inlet and the drift tube outlet. The first ion activation region is configured to selectively induce structural changes in at least some of the ions.

Abstract translation: 离子迁移谱仪包括漂移管，其限定配置成接收离子的漂移管入口和漂移管出口。 漂移管被配置为随着离子迁移率的时间分离离子。 漂移管限定漂移管入口和漂移管出口之间的第一离子激活区。 第一离子激活区被配置为选择性地诱导至少一些离子的结构变化。

公开(公告)号：US06960761B2

公开(公告)日：2005-11-01

申请号：US09842383

申请日：2001-04-25

Applicant: David E. Clemmer

Inventor： David E. Clemmer

IPC: G01N27/62 ,  G01N27/64 ,  H01J49/26 ,  H01J49/38 ,  H01J49/40 ,  B01D59/44 ,  B01J49/00

CPC classification number: G01N27/622 ,  H01J49/004 ,  H01J49/38

Abstract: An ion separation instrument includes an ion source coupled to at least a first ion mobility spectrometer having an ion outlet coupled to a mass spectrometer. Instrumentation is further included to provide for passage to the mass spectrometer only ions defining a preselected ion mobility range. In one embodiment, the ion mobility spectrometer is provided with electronically controllable inlet and outlet gates, wherein a control circuit is operable to control actuation of the inlet and outlet gates as a function of ion drift time to thereby allow passage therethrough only of ions defining a mobility within the preselected ion mobility range. In another embodiment, an ion trap is disposed between the ion mobility spectrometer and mass spectrometer and is controlled in such a manner so as to collect a plurality of ions defining a mobility within the preselected ion mobility range prior to injection of such ions into the mass spectrometer. In yet another embodiment, an ion inlet of the ion trap may be electronically controlled relative to operation of the ion mobility spectrometer as a function of ion drift time to thereby allow passage therein only of ions defining a mobility within the preselected ion mobility range. The mass spectrometer is preferably a Fourier Transform Ion Cyclotron Resonance mass spectrometer, and the resulting ion separation instrument may further include therein various combinations of ion fragmentation, ion mass filtering, ion trap, charge neutralization and/or mass reaction instrumentation.

Abstract translation: 离子分离仪器包括耦合到具有耦合到质谱仪的离子出口的至少第一离子迁移谱仪的离子源。 进一步包括仪器以提供通过质谱仪只有限定预选离子迁移范围的离子。 在一个实施例中，离子迁移谱仪提供有电子可控的入口和出口门，其中控制电路可操作以控制入口和出口门的致动作为离子漂移时间的函数，从而仅允许通过限定 预选离子迁移范围内的迁移率。 在另一个实施方案中，将离子阱设置在离子迁移谱仪和质谱仪之间，并以这样的方式进行控制，以便在将这样的离子注入质量之前收集限定预选离子迁移率范围内的迁移率的多个离子 光谱仪 在另一个实施方案中，离子阱的离子入口可以相对于离子迁移谱仪的操作而电子控制，作为离子漂移时间的函数，从而允许仅限定在预选离子迁移率范围内的迁移率的离子。 质谱仪优选为傅里叶变换离子回旋共振质谱仪，所得到的离子分离仪器还可以包括离子碎片化，离子质量过滤，离子阱，电荷中和和/或质量反应仪器的各种组合。

公开(公告)号：US5905258A

公开(公告)日：1999-05-18

申请号：US867245

申请日：1997-06-02

Applicant: David E. Clemmer ,  James P. Reilly

Inventor： David E. Clemmer ,  James P. Reilly

IPC: G01N27/64 ,  H01J49/40 ,  H01J49/42

CPC classification number: G01N27/622 ,  H01J49/004 ,  H01J49/40 ,  H01J49/42

Abstract: A hybrid ion mobility and time-of-flight mass spectrometer includes an ion source region coupled to an ion mobility spectrometer (IMS) which feeds directly into an ion accelerating region of a time-of-flight mass spectrometer (TOFMS). In one embodiment, the TOFMS is positioned relative to the IMS so that the flight tube axis of the TOFMS is perpendicular to the drift tube axis of the IMS. In an alternate embodiment, the TOFMS is positioned relative to the IMS so that the flight tube axis of the TOFMS is non-perpendicular to the drift tube axis of the IMS. In the alternate embodiment, a known quadrupole ion trap is positioned between the IMS and the TOFMS to provide the capability of controlling the injection of ion packets into the TOFMS. The ion source may be a MALDI source, an electrospray ionization source, or an ion trap positioned between the IMS and any known ion source. In each case, the IMS, TOFMS and ion sources are preferably controlled by a computer.

Abstract translation: 混合离子迁移率和飞行时间质谱仪包括耦合到离子迁移谱仪（IMS）的离子源区域，其直接进料到飞行时间质谱仪（TOFMS）的离子加速区域。 在一个实施例中，TOFMS相对于IMS定位，使得TOFMS的飞行管轴线垂直于IMS的漂移管轴线。 在替代实施例中，TOFMS相对于IMS定位，使得TOFMS的飞行管轴线不与IMS的漂移管轴线垂直。 在替代实施例中，已知的四极离子阱位于IMS和TOFMS之间，以提供控制将离子包注入到TOFMS中的能力。 离子源可以是位于IMS和任何已知离子源之间的MALDI源，电喷雾离子源或离子阱。 在每种情况下，IMS，TOFMS和离子源优选地由计算机控制。

公开(公告)号：US07838821B2

公开(公告)日：2010-11-23

申请号：US12357198

申请日：2009-01-21

Applicant: David E. Clemmer ,  Ruwan T. Kurulugama ,  Fabiane M. Nachtigall ,  Zachary Henson ,  Samuel I. Merenbloom ,  Stephen J. Valentine

Inventor： David E. Clemmer ,  Ruwan T. Kurulugama ,  Fabiane M. Nachtigall ,  Zachary Henson ,  Samuel I. Merenbloom ,  Stephen J. Valentine

IPC: H01J49/00 ,  B01D59/44

CPC classification number: G01N27/622

Abstract: An ion mobility spectrometer instrument has a drift tube that is partitioned into a plurality of cascaded drift tube segments. A number of electric field activation sources may each be coupled to one or more of the plurality of drift tube segments. A control circuit is configured to control operation of the number of electric field activation sources in a manner that applies switched electric fields at a specified switching rate to the drift tube segments to thereby produce at the ion outlet only ions having a predefined ion mobility or range of ion mobilities.

Abstract translation: 离子迁移谱仪具有漂移管，其被分隔成多个级联漂移管段。 多个电场激活源可以各自耦合到多个漂移管段中的一个或多个。 控制电路被配置为以将规定的开关率的开关电场施加到漂移管段的方式来控制电场激活源的数量的操作，从而在离子出口处仅产生具有预定离子迁移率或范围的离子 的离子迁移率。

公开(公告)号：US20090189070A1

公开(公告)日：2009-07-30

申请号：US12357198

申请日：2009-01-21

Applicant: David E. Clemmer ,  Ruwan T. Kurulugama ,  Fabiane M. Nachtigall ,  Zachary Henson ,  Samuel I. Merenbloom ,  Stephen J. Valentine

Inventor： David E. Clemmer ,  Ruwan T. Kurulugama ,  Fabiane M. Nachtigall ,  Zachary Henson ,  Samuel I. Merenbloom ,  Stephen J. Valentine

IPC: B01D59/44 ,  H01J49/00

CPC classification number: G01N27/622

Abstract: An ion mobility spectrometer instrument has a drift tube that is partitioned into a plurality of cascaded drift tube segments. A number of electric field activation sources may each be coupled to one or more of the plurality of drift tube segments. A control circuit is configured to control operation of the number of electric field activation sources in a manner that applies switched electric fields at a specified switching rate to the drift tube segments to thereby produce at the ion outlet only ions having a predefined ion mobility or range of ion mobilities.

Abstract translation: 离子迁移谱仪具有漂移管，其被分隔成多个级联漂移管段。 多个电场激活源可以各自耦合到多个漂移管段中的一个或多个。 控制电路被配置为以将规定的开关率的开关电场施加到漂移管段的方式来控制电场激活源的数量的操作，从而在离子出口处仅产生具有预定离子迁移率或范围的离子 的离子迁移率。

公开(公告)号：US07077944B2

公开(公告)日：2006-07-18

申请号：US10704742

申请日：2003-11-10

Applicant: David E. Clemmer

Inventor： David E. Clemmer

IPC: H01J49/40

CPC classification number: G01N27/622 ,  H01J49/004 ,  H01J49/38

Abstract: An ion separation instrument includes an ion source coupled to at least a first ion mobility spectrometer having an ion outlet coupled to a mass spectrometer. Instrumentation is further included to provide for passage to the mass spectrometer only ions defining a preselected ion mobility range. In one embodiment, the ion mobility spectrometer is provided with electronically controllable inlet and outlet gates, wherein a control circuit is operable to control actuation of the inlet and outlet gates as a function of ion drift time to thereby allow passage therethrough only of ions defining a mobility within the preselected ion mobility range. In another embodiment, an ion trap is disposed between the ion mobility spectrometer and mass spectrometer and is controlled in such a manner so as to collect a plurality of ions defining a mobility within the preselected ion mobility range prior to injection of such ions into the mass spectrometer. In yet another embodiment, an ion inlet of the ion trap may be electronically controlled relative to operation of the ion mobility spectrometer as a function of ion drift time to thereby allow passage therein only of ions defining a mobility within the preselected ion mobility range. The mass spectrometer is preferably a Fourier Transform Ion Cyclotron Resonance mass spectrometer, and the resulting ion separation instrument may further include therein various combinations of ion fragmentation, ion mass filtering, ion trap, charge neutralization and/or mass reaction instrumentation.