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    Extended Release Dosage Form
    2.
    发明申请
    Extended Release Dosage Form 有权
    延长释放剂型

    公开(公告)号：US20070128279A1

    公开(公告)日：2007-06-07

    申请号：US11673066

    申请日：2007-02-09

    申请人： David Edgren ,  Patrick Wong ,  Gurdish Bhatti ,  Shu Li ,  Robert Skluzacek

    发明人： David Edgren ,  Patrick Wong ,  Gurdish Bhatti ,  Shu Li ,  Robert Skluzacek

    IPC分类号： A61K31/485 ,  A61K9/24 ,  A61K31/16

    CPC分类号： A61K9/0004 ,  A61K9/2027 ,  A61K9/2031 ,  A61K9/2866 ,  A61K9/2886

    摘要： A membrane system comprising an interior wall, a fluid-permeable exterior wall surrounding the interior wall and an internal compartment defined by the membrane system, wherein fluid permeability of the interior wall is responsive to osmolarity of an osmotic core within the internal compartment are disclosed. A controlled release dosage form comprising the membrane system and a process for delivering an osmotically active formulation from an osmotic pump over an extended period of time are also disclosed.

    摘要翻译： 公开了一种膜系统，其包括内壁，围绕内壁的流体可渗透的外壁和由膜系统限定的内部隔室，其中内壁的流体渗透性响应于内部隔室内的渗透性芯的渗透压。 还公开了一种包含膜系统的控释剂型，以及用于在延长的时间段内从渗透泵输送渗透活性制剂的方法。

    Oral osmotic dosage form having a high flux membrane
    3.
    发明申请
    Oral osmotic dosage form having a high flux membrane 审中-公开
    具有高通量膜的口服渗透剂型

    公开(公告)号：US20060165798A1

    公开(公告)日：2006-07-27

    申请号：US11341251

    申请日：2006-01-27

    申请人： David Edgren ,  Gurdish Bhatti ,  Shu Li ,  Robert Skluzacek

    发明人： David Edgren ,  Gurdish Bhatti ,  Shu Li ,  Robert Skluzacek

    IPC分类号： A61K9/24

    CPC分类号： A61K9/0004

    摘要： Disclosed are oral osmotic dosage forms and methods wherein a semi-permeable membrane of the oral osmotic dosage form includes from about 23 wt % to about 50 wt % of a flux enhancer and from about 0.01 wt % to about 5 wt % of antioxidant, based on the total dry weight of the semi-permeable membrane. Such compositions provide high flux membranes with improved mechanical and transport stability during storage on the shelf.

    摘要翻译： 公开了口服渗透剂型和方法，其中口服渗透剂型的半渗透膜包含约23重量％至约50重量％的助熔剂增强剂和约0.01重量％至约5重量％的抗氧化剂，基于 关于半透膜的总干重。 这样的组合物在储存在架子上时具有改善的机械和运输稳定性的高通量膜。

    Volume Efficient Controlled Release Dosage Form
    6.
    发明申请
    Volume Efficient Controlled Release Dosage Form 审中-公开
    体积有效的控制释放剂型

    公开(公告)号：US20070184112A1

    公开(公告)日：2007-08-09

    申请号：US11684821

    申请日：2007-03-12

    申请人： Patrick Wong ,  Francisco Jao ,  David Edgren ,  Robert Skluzacek ,  Shu Li

    发明人： Patrick Wong ,  Francisco Jao ,  David Edgren ,  Robert Skluzacek ,  Shu Li

    IPC分类号： A61K9/24

    CPC分类号： A61K9/0004

    摘要： A dosage form that facilitates the controlled release of an active agent at a desired release rate or release rate profile includes a bi-layer membrane system and an osmotic core. The bi-layer membrane system includes a semipermeable membrane and an osmosensitive membrane and forms an internal compartment occupied by the osmotic core. The osmotic core includes an active agent composition and a light push layer. A passageway is formed through the bi-layer membrane system and permits expulsion of the active agent composition from the dosage form during operation. The bi-layer membrane system and the osmotic core are formulated and formed to provide controlled release of the active agent included in the active agent composition, while simultaneously facilitating increased loading of active agent within a dosage form of given dimension and increasing the delivery efficiency of such active agent relative to prior osmotic dosage forms including a push layer.

    摘要翻译： 有利于以期望的释放速率或释放速率曲线控制释放活性剂的剂型包括双层膜系统和渗透核。 双层膜系统包括半透膜和渗透膜，并形成由渗透芯占据的内部隔室。 渗透芯包括活性剂组合物和轻推层。 通过双层膜系统形成通道，并允许活性剂组合物在操作期间从剂型中排出。 双层膜系统和渗透芯被配制和形成以提供包含在活性剂组合物中的活性剂的受控释放，同时促进活性剂在给定维度的剂型中的负载增加，并且提高 这种活性剂相对于包括推层的先前的渗透剂型。

    Dosage Form for Time-Varying Patterns of Drug Delivery
    8.
    发明申请
    Dosage Form for Time-Varying Patterns of Drug Delivery 审中-公开
    药物递送时间变化模式的剂型

    公开(公告)号：US20070207204A1

    公开(公告)日：2007-09-06

    申请号：US11744999

    申请日：2007-05-07

    申请人： David Edgren ,  Patrick Wong ,  Shu Li

    发明人： David Edgren ,  Patrick Wong ,  Shu Li

    IPC分类号： A61K9/66

    CPC分类号： A61K9/0004 ,  A61K31/277

    摘要： The present invention provides a multi-release oral drug delivery system that initiates drug release following an initial drug-free release interval, after administration to a subject, and a second drug-free release period before release of another dose of drug. The system has (1) inner compartments enclosed within a semipermeable membrane, and (2) a drug coating on the exterior of the semipermeable membrane surrounded by a microporous membrane, which microporous membrane is permeable to fluid and drug. The drug coating is released after the initial drug-free release interval. An inner compartment drug is released after a second drug-free release interval provided by a drug-free inner compartment.

    摘要翻译： 本发明提供一种多次释放的口服药物递送系统，其在给予受试者之后，在初始无药物释放间隔之后启动药物释放，以及释放另一剂量药物之前的第二无药物释放期。 该系统具有（1）封闭在半透膜内的内隔室，（2）由微孔膜包围的半透膜外部的药物涂层，该微孔膜可渗透流体和药物。 药物涂层在初始无药物释放间隔后释放。 在由无药物的内隔室提供的第二无药物释放间隔后释放内室药物。