摘要:
9 alpha, 11 beta and 11 beta-substituted estranes are disclosed which exhibit elevated estrogenic and postcoital contraceptive activities. A process for their manufacture and their use in pharmaceuticals is also disclosed.
摘要:
9 alpha, 11 beta and 11 beta-substituted estranes are disclosed which exhibit elevated estrogenic and postcoital contraceptive activities. A process for their manufacture and their use in pharmaceuticals is also disclosed.
摘要:
9 alpha, 11 beta and 11 beta-substituted estranes are disclosed which exhibit elevated estrogenic and postcoital contraceptive activities. A process for their manufacture and their use in pharmaceuticals is also disclosed.
摘要:
Syntheses of steroids such as 3-hydroxy-7α-methyl-21-[2′-methoxy-4′-(diethylaminomethyl)-phenoxy]-19-norpregna-1,3,5(10)triene citrate (“SR 16234”) and analogs thereof are provided, wherein 21-hydroxy-19-norpregna-4-en-3-one serves as a starting material or intermediate. The latter compound may be readily prepared from estrone-3-methyl ether. Certain intermediates in these syntheses also have value as therapeutic agents, for example in the treatment of prostate disorders such as prostatic cancer.
摘要:
A method is provided for treating a patient with a medical condition that involves angiogenesis or HIF-1 overexpression with a compound having the structure of formula (I) wherein Z, x, y, and R1 through R11 are as defined herein.
摘要:
The disclosure relates to a process that includes blending a polyimide resin and a primary alky amine organic compound to produce an aryl amine functionalized polyimide, having aryl amine functionality in excess of any anhydride functionality. The polyimide resin can have a weight average molecular weight (Mw) from 5,000 to 100,000 daltons. The organic compound can include at least one primary aliphatic amine without a direct linkage of a nitrogen to an aryl group and without a functionality selected from a halogen functionality, a hydroxyl functionality, a sulfonic acid functionality, a sulfonic acid salt functionality, and combinations thereof. The disclosure also relates to alkyl imide functionalized polyimides also with aryl amine functionalized polyimides, having aryl amine functionality in excess of any anhydride functionality and articles produced therefrom.
摘要:
An elevator control system to govern elevator movement to avoid or minimize passenger discomfort caused by pressure changes associated with an elevator's movement and to optimize elevator operation. In one exemplary embodiment, the system uses the passenger's natural relief which occurs while the elevator car is stopped to reduce the pressure difference experienced by the passengers' ears as a factor to optimally control the operation of the elevator. In another example, the system obtains input regarding the traveling speed and conditions of the elevator system. This system then simulates individual trips for passengers that includes monitoring the pressure changes being experienced by passengers throughout the elevator's travels in order to ensure that the pressure differential level for each passenger remains below a designated maximum comfortable and safe level. This system uses the parameters of a successful simulation to govern the actual operation of the elevators.
摘要:
The invention provides a system and method for handling power outages in a multiple car elevator system in a building having a plurality of floors. The system includes an energy calculator connected to the elevators, and determines a total energy of the elevator system, a total energy required to handle a power outage, a plan to prepare for a power outage and a plan to handle a power outage. The system also includes a movement controller connected to the elevator(s) and the energy calculator. The movement controller receives the plan to prepare and the plan to handle from the energy calculator, and the movement controller executes the plan to prepare if there is no power outage and the movement controller executes the plan to handle if there is a power outage.
摘要:
A method for making a semiconductor device is provided which comprises (a) providing a source of actinic radiation (601), (b) providing a reticle comprising (i) a substrate having a plurality of structures defined therein, said substrate being essentially transparent to the actinic radiation, and (ii) a layer of attenuating material disposed over at least some of said plurality of structures, wherein the layer of attenuating material has a transmission with respect to the actinic radiation that is within the range of about 5% to about 50%, and wherein the combination of the layer of attenuating material and the substrate imparts to the actinic radiation a phase change within the range of about 165° to about 225° (603), and (c) utilizing the reticle and the source of actinic radiation to impart a pattern to a semiconductor substrate (607, 609).
摘要:
An architecture for robot intelligence enables a robot to learn new behaviors and create new behavior sequences autonomously and interact with a dynamically changing environment. Sensory information is mapped onto a Sensory Ego-Sphere (SES) that rapidly identifies important changes in the environment and functions much like short term memory. Behaviors are stored in a DBAM that creates an active map from the robot's current state to a goal state and functions much like long term memory. A dream state converts recent activities stored in the SES and creates or modifies behaviors in the DBAM.