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22 条记录 (耗时 0.043 秒)

    Artificial venous valve containing therapeutic agent
    1.
    发明申请
    Artificial venous valve containing therapeutic agent 有权
    含有治疗剂的人造静脉瓣

    公开(公告)号：US20070265699A1

    公开(公告)日：2007-11-15

    申请号：US11789413

    申请日：2007-04-24

    申请人： David Grewe ,  James Purdy

    发明人： David Grewe ,  James Purdy

    IPC分类号： A61F2/06

    CPC分类号： A61F2/2412 ,  A61F2/2418 ,  A61F2/2475 ,  A61F2220/0016 ,  A61F2220/005 ,  A61F2220/0058 ,  A61F2230/0026 ,  A61F2230/0095 ,  A61F2250/0068

    摘要： The invention relates to a prosthetic valve for regulating flow through a body lumen and delivering a therapeutic agent into said lumen. In one embodiment, the prosthesis includes a frame having an exterior wall, a hollow interior space, a valve member, and at least one aperture through the exterior wall that permits a controlled amount of therapeutic agent loaded into the hollow interior into the surrounding body lumen following implantation. In another embodiment, the prosthesis includes a frame having a groove, a valve member, and therapeutic agent loaded in the groove.

    摘要翻译： 本发明涉及一种用于调节通过体腔的流动并将治疗剂输送到所述内腔中的人造瓣膜。 在一个实施例中，假体包括具有外壁，中空内部空间，阀构件和穿过外壁的至少一个孔的框架，其允许将受控量的治疗剂装载到中空内部进入周围体腔 植入后。 在另一个实施例中，假体包括具有凹槽，阀构件和装载在凹槽中的治疗剂的框架。

    Manufacturing methods for covering endoluminal prostheses
    3.
    发明授权
    Manufacturing methods for covering endoluminal prostheses 有权
    用于覆盖腔内假体的制造方法

    公开(公告)号：US08637109B2

    公开(公告)日：2014-01-28

    申请号：US12959023

    申请日：2010-12-02

    申请人： David Grewe ,  Blayne Roeder ,  Steven Charlebois ,  Adam Griebel

    发明人： David Grewe ,  Blayne Roeder ,  Steven Charlebois ,  Adam Griebel

    IPC分类号： B05D1/32 ,  B05D1/16

    CPC分类号： B05D1/007 ,  D01D5/0069 ,  D01D5/0076

    摘要： The disclosure relates to a method for coating a target. The method includes providing a target and an electrospinning apparatus. The target comprises a first surface and an opposing second surface. The electrospinning apparatus comprises a mandrel, a mask including an aperture, a reservoir loaded with a solution, and an orifice fluidly coupled to the reservoir. The mandrel is located adjacent the target second surface. The orifice is located at a distance from the target first surface. The mask is located intermediate the orifice and the target first surface. The solution is electrospun through the mask aperture onto the target first surface. In one example the target is an endoluminal prosthesis.

    摘要翻译： 本公开涉及涂覆靶的方法。 该方法包括提供靶和静电纺丝装置。 靶包括第一表面和相对的第二表面。 静电纺丝装置包括心轴，包括孔的掩模，装有溶液的储存器和流体耦合到储存器的孔。 心轴位于目标第二表面附近。 孔口位于离目标第一表面一定距离处。 掩模位于孔口和目标第一表面之间。 该溶液通过掩模孔电纺到目标第一表面上。 在一个示例中，目标是腔内假体。

    Eluting, implantable medical device
    5.
    发明申请
    Eluting, implantable medical device 审中-公开
    洗脱，植入式医疗器械

    公开(公告)号：US20070073385A1

    公开(公告)日：2007-03-29

    申请号：US11523797

    申请日：2006-09-18

    申请人： Darin Schaeffer ,  David Grewe ,  Patrick Ruane

    发明人： Darin Schaeffer ,  David Grewe ,  Patrick Ruane

    IPC分类号： A61F2/90

    CPC分类号： A61L31/082 ,  A61F2/91 ,  A61F2/915 ,  A61F2002/30322 ,  A61F2002/91508 ,  A61F2002/91516 ,  A61F2002/91525 ,  A61F2002/91533 ,  A61F2002/91575 ,  A61F2230/0054 ,  A61F2250/0023 ,  A61F2250/0026 ,  A61F2250/0068 ,  A61L31/146 ,  A61L31/16 ,  A61L2300/416

    摘要： An intraluminal device is provided with a porous structure. The porous structure may be loaded with a bioactive substance to treat surrounding tissues after the intraluminal device has been implanted. The porous structure may be made by depositing a metal film on a foam structure using chemical vapor deposition. Porous structures may also be made by sintering or applying a ceramic layer to the intraluminal device. An intraluminal device is also provided with a ceramic material applied to generally straight portions of the device structure but not to portions adapted to bend. One advantage is that the ceramic material is less likely to fracture since it is applied to regions that experience less strain.

    摘要翻译： 管腔内装置具有多孔结构。 在植入腔内装置之后，多孔结构可装载生物活性物质以治疗周围组织。 多孔结构可以通过使用化学气相沉积在金属泡沫结构上沉积金属膜来制造。 也可以通过烧结或将陶瓷层施加到腔内装置来制造多孔结构。 管腔内装置还设置有施加到装置结构的大致直线部分的陶瓷材料，但是不适于弯曲的部分。 一个优点是陶瓷材料不太可能破裂，因为它被应用于经历较小应变的区域。

    Rapid-exchange balloon catheter shaft and method
    6.
    发明申请
    Rapid-exchange balloon catheter shaft and method 有权
    快速交换球囊导管轴和方法

    公开(公告)号：US20080147001A1

    公开(公告)日：2008-06-19

    申请号：US12008509

    申请日：2008-01-11

    申请人： Laila Al-Marashi ,  David Grewe ,  Stephen Griffin ,  Elaine Lim ,  David Majercak ,  Roger Stevens

    发明人： Laila Al-Marashi ,  David Grewe ,  Stephen Griffin ,  Elaine Lim ,  David Majercak ,  Roger Stevens

    IPC分类号： A61M25/10 ,  A61F2/84

    CPC分类号： A61M25/10 ,  A61F2/915 ,  A61F2/958 ,  A61F2002/91558 ,  A61F2230/0054 ,  A61F2250/0018 ,  A61M25/0054 ,  A61M2025/0183

    摘要： A balloon catheter or stent delivery system for medical treatment of a patient has a proximal hub, a balloon, and an improved shaft design. The catheter shaft has a rapid-exchange configuration, and a tubular outer body that includes a hypotube extending from the catheter proximal end to a position at or near a proximal leg of the balloon. An inner tubular body defines a guidewire lumen extending from a distal guidewire port at the catheter distal end to a proximal port located at a position between the balloon and the hub. A distal leg of the balloon is directly or indirectly affixed to the inner body, and a proximal leg of the balloon is affixed to the distal end of the outer body. The hypotube has an aperture for accepting the inner body proximal end, and a circumferential cut pattern. The cut pattern adds flexibility, and may extend from the hypotube distal end to a position proximal of the proximal guidewire port. The cut pattern may have any desired shape, including a spiral, a helical undulating path, or an overlapping serpentine path with inflection points, for example. The hypotube has a fluid-tight covering such as a heat-shrink polymer, so the outer body supports pressure of an inflation medium. The proximal guidewire port may be positioned on or between the individual portions of the cut pattern, or at a position beyond the cut pattern.

    摘要翻译： 用于患者医疗的球囊导管或支架输送系统具有近端毂，球囊和改进的轴设计。 导管轴具有快速交换构造，以及管状外体，其包括从导管近端延伸到球囊的近端腿处或附近的位置的海波管。 内部管状体限定从导管远端处的远端导丝端口延伸到位于气囊和轮毂之间的位置的近端口的导丝管腔。 球囊的远端腿直接或间接地固定到内体上，并且气球的近端腿固定到外体的远端。 海波管具有用于接纳内体近端的孔和圆周切割图案。 切割图案增加了柔性，并且可以从海波管远端延伸到近端导丝端口的近端。 切割图案可以具有任何期望的形状，例如包括螺旋形，螺旋形起伏路径或具有拐点的重叠蛇形路径。 海波管具有流体密封的覆盖物，例如热收缩聚合物，因此外壳支撑膨胀介质的压力。 近端导丝端口可以定位在切割图案的各个部分之间或之间，或位于切割图案之外的位置。

    Prosthesis Delivery and Deployment Device
    7.
    发明申请
    Prosthesis Delivery and Deployment Device 有权
    假体交付和部署设备

    公开(公告)号：US20070293934A1

    公开(公告)日：2007-12-20

    申请号：US11764969

    申请日：2007-06-19

    申请人： David Grewe

    发明人： David Grewe

    IPC分类号： A61F2/84

    CPC分类号： A61F2/95 ,  A61F2002/9517

    摘要： A system for delivering and deploying an expandable endoluminal prosthesis comprises a delivery catheter and a sheath. The delivery catheter has a proximal end and a distal end and is slidably disposed within a lumen of the sheath. An operating mechanism comprises a contractible air vessel that couples the sheath and the delivery catheter so that contraction of the air vessel causes the sheath to retract proximally over the delivery catheter. Additional aspects of the invention include a method of deploying an expandable endoluminal prosthesis.

    摘要翻译： 用于递送和展开可扩张腔内假体的系统包括输送导管和鞘。 输送导管具有近端和远端，并且可滑动地设置在护套的内腔内。 操作机构包括可收缩的空气容器，其耦合护套和输送导管，使得空气容器的收缩导致护套在输送导管上向近侧缩回。 本发明的另外的方面包括部署可扩张腔内假体的方法。

    Rotary handle for controlled sequential deployment device
    8.
    发明申请
    Rotary handle for controlled sequential deployment device 有权
    用于受控顺序部署装置的旋转手柄

    公开(公告)号：US20070255390A1

    公开(公告)日：2007-11-01

    申请号：US11789840

    申请日：2007-04-26

    申请人： Werner Ducke ,  David Hartley ,  David Grewe

    发明人： Werner Ducke ,  David Hartley ,  David Grewe

    IPC分类号： A61F2/06

    CPC分类号： A61F2/95 ,  A61F2002/9517 ,  A61F2250/0065 ,  A61M25/0136

    摘要： A stent graft introducer actuation assembly (1) having a fixed handle (3) and at least one sliding handle (5, 7), the sliding handle or handles telescoping within the fixed handle, and a winch arrangement (9) to retract the sliding handle into the fixed handle. There may be provided arrangements to give a mechanical advantage to the winch arrangement.

    摘要翻译： 一种具有固定手柄（3）和至少一个滑动手柄（5,7）的支架移植物导引器致动组件（1），所述滑动手柄或手柄在固定手柄内伸缩，以及绞盘装置（9） 处理固定手柄。 可以提供为绞盘装置提供机械优点的布置。

    Deflectable tip infusion guidewire
    10.
    发明申请
    Deflectable tip infusion guidewire 审中-公开
    可偏转尖端输液导丝

    公开(公告)号：US20070213689A1

    公开(公告)日：2007-09-13

    申请号：US11590536

    申请日：2006-10-31

    申请人： David Grewe ,  Hikmat Hojeibane

    发明人： David Grewe ,  Hikmat Hojeibane

    IPC分类号： A61M25/08

    CPC分类号： A61M25/09 ,  A61M25/0045 ,  A61M25/0138 ,  A61M25/0147 ,  A61M25/0152 ,  A61M25/09033 ,  A61M2025/0042 ,  A61M2025/0046 ,  A61M2025/09083 ,  A61M2025/091 ,  A61M2025/09133

    摘要： A steerable infusion guidewire having a deflectable distal tip which comprises a longitudinal hypotube and an interlocking spring coil which carry an infusion tube which is attached to the distal end of the hypotube and also includes a longitudinally movable deflection member which is attached to the distal end of the spring coil and a tip retaining member which extends from the distal end of the hypotube to the distal end of the spring coil for providing very precise deflection of the distal tip of the guidewire.

    摘要翻译： 一种具有可偏转的远端的可引导输注导线，其包括纵向海波管和携带输注管的互锁弹簧线圈，所述输液管附接到所述海波管的远端，并且还包括可纵向移动的偏转构件， 所述弹簧线圈和从所述海波管的远端延伸到所述弹簧线圈的远端的尖端保持构件，用于提供所述导丝的远侧末端的非常精确的偏转。