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1.
公开(公告)号:US20120301498A1
公开(公告)日:2012-11-29
申请号:US13458980
申请日:2012-04-27
IPC分类号: A61K39/00 , A61P37/04 , A61P37/06 , A61K39/35 , A61K39/385
摘要: Disclosed are synthetic nanocarrier compositions that provide controlled release of immunosuppressants as well as related methods. The synthetic nanocarrier compositions may also include antigen in some embodiments.
摘要翻译: 公开了提供免疫抑制剂受控释放的合成纳米载体组合物以及相关方法。 在一些实施方案中,合成纳米载体组合物还可以包括抗原。
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公开(公告)号:US20120244222A1
公开(公告)日:2012-09-27
申请号:US13428340
申请日:2012-03-23
IPC分类号: A61K9/51 , A61K31/70 , A61K31/7088 , A61K31/78 , A61K31/08 , A61K38/02 , A61K39/00 , A61K38/22 , A61P31/04 , A61P31/00 , A61K31/7004 , A61K31/7016 , A61K31/702 , A61K31/715 , A61K39/385 , A61K31/785 , A61P29/00 , A61P7/02 , A61K48/00
CPC分类号: A61K9/0004 , A61K9/19 , A61K9/5146 , A61K9/5153 , A61K9/5192 , A61K2039/55555 , A61K2039/60 , C12N15/88
摘要: This invention relates, at least in part, to osmotic mediated release barrier-free synthetic nanocarriers and methods of production and use.
摘要翻译: 本发明至少部分地涉及渗透介导的不含释放屏障的合成纳米载体及其生产和使用方法。
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3.COMPOSITIONS AND METHODS FOR PRODUCING ANTIGEN-SPECIFIC INDUCED TOLEROGENIC DENDRITIC CELLS WITH SYNTHETIC NANOCARRIERS 审中-公开
标题翻译: 用合成纳米颗粒生产抗原特异性诱导的嗜酸性细胞的组合物和方法公开(公告)号:US20130059009A1
公开(公告)日:2013-03-07
申请号:US13457639
申请日:2012-04-27
CPC分类号: A61K38/1816 , A61K38/19 , A61K38/20 , A61K38/21 , A61K38/212 , A61K38/44 , A61K38/47 , A61K38/57 , A61K39/0008 , A61K2035/122 , A61K2039/5154 , A61K2039/577 , C12Y302/01022 , C12Y302/01045
摘要: Disclosed are antigen-specific induced tolerogenic dendritic cells (itDCs) that are produced from combining itDCs with antigen in particulate form, as well as related compositions and methods.
摘要翻译: 公开了通过将itDC与颗粒形式的抗原组合产生的抗原特异性诱导的致耐受性树突状细胞(itDC)以及相关组合物和方法。
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4.SYNTHETIC NANOCARRIERS THAT GENERATE HUMORAL AND CYTOTOXIC T LYMPHOCYTE (CTL) IMMUNE RESPONSES 审中-公开
标题翻译: 产生人体和细胞毒性淋巴细胞(CTL)免疫应答的合成纳米颗粒公开(公告)号:US20130028941A1
公开(公告)日:2013-01-31
申请号:US13560955
申请日:2012-07-27
IPC分类号: A61K39/385 , A61P35/00 , A61P31/00 , A61P31/18 , A61P31/12 , A61P31/16 , A61P31/14 , C07K17/00 , A61K9/00 , A61P33/06 , B82Y5/00
CPC分类号: A61K39/385 , A61K39/39 , A61K47/59 , A61K47/593 , A61K47/645 , A61K2039/55555 , Y02A50/386 , Y02A50/41 , Y02A50/412 , Y10T428/2982
摘要: Disclosed are methods for generating humoral and cytotoxic T lymphocyte (CTL) immune responses in a subject and related compositions.
摘要翻译: 公开了在受试者和相关组合物中产生体液和细胞毒性T淋巴细胞(CTL)免疫应答的方法。
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公开(公告)号:US10933129B2
公开(公告)日:2021-03-02
申请号:US13560955
申请日:2012-07-27
IPC分类号: A61K39/395 , A61K39/385 , A61K39/39 , A61K47/59 , A61K47/64 , A61K39/00
摘要: Disclosed are methods for generating humoral and cytotoxic T lymphocyte (CTL) immune responses in a subject and related compositions.
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公开(公告)号:US20130039954A1
公开(公告)日:2013-02-14
申请号:US13560925
申请日:2012-07-27
IPC分类号: A61K9/00 , A61P37/04 , A61K39/385 , B82Y5/00
CPC分类号: A61K39/385 , A61K39/39 , A61K47/59 , A61K47/593 , A61K47/645 , A61K2039/55555 , Y02A50/386 , Y02A50/41 , Y02A50/412 , Y10T428/2982
摘要: Disclosed are synthetic nanocarrier compositions that comprise B cell antigen for desired antibody production and an off-target response attenuating polymeric coating as well as related methods.
摘要翻译: 公开了包含用于所需抗体产生的B细胞抗原和减弱聚合物涂层的脱靶反应以及相关方法的合成纳米载体组合物。
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7.SYNTHETIC NANOCARRIERS COMPRISING POLYMERS COMPRISING MULTIPLE IMMUNOMODULATORY AGENTS 审中-公开
标题翻译: 包含多重免疫调节剂的聚合物合成纳米颗粒公开(公告)号:US20130028857A1
公开(公告)日:2013-01-31
申请号:US13560943
申请日:2012-07-27
申请人: Yun Gao , David H. Altreuter
发明人: Yun Gao , David H. Altreuter
CPC分类号: A61K39/385 , A61K39/39 , A61K47/59 , A61K47/593 , A61K47/645 , A61K2039/55555 , Y02A50/386 , Y02A50/41 , Y02A50/412 , Y10T428/2982
摘要: This invention relates to compositions, and related methods, of synthetic nanocarriers that comprise polymers that comprise at least two immunomodulatory agent moieties.
摘要翻译: 本发明涉及包含至少两种免疫调节剂部分的聚合物的合成纳米载体的组合物和相关方法。
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8.TARGETED MULTI-EPITOPE DOSAGE FORMS FOR INDUCTION OF AN IMMUNE RESPONSE TO ANTIGENS 审中-公开
标题翻译: 用于诱导针对抗原的免疫应答的靶向多抗原决定子剂型公开(公告)号:US20120070493A1
公开(公告)日:2012-03-22
申请号:US13215537
申请日:2011-08-23
IPC分类号: A61K9/48 , A61K39/00 , C07K7/08 , C07K7/06 , A61P31/12 , C07H21/04 , A61P37/02 , A61P31/04 , A61P31/10 , A61K39/385 , C07K14/00 , B82Y5/00
CPC分类号: C07K14/70539 , A61K9/10 , A61K9/5153 , A61K39/39 , A61K47/34 , A61K47/593 , A61K47/60 , A61K47/6923 , A61K2039/55516 , A61K2039/55555 , A61K2039/6037 , C12N2760/18534 , Y02A50/467
摘要: Provided herein are compositions and methods related to MHC II binding peptides. In some embodiments, the peptides are obtained or derived from a common source. In other embodiment, the peptides are obtained or derived from an infectious agent to which a subject has been repeatedly exposed.
摘要翻译: 本文提供了与MHC II结合肽相关的组合物和方法。 在一些实施方案中,获得或衍生自共同来源的肽。 在其它实施方案中,肽被获得或衍生自受试者已被重复暴露的感染剂。
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