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公开(公告)号：US4519043A
公开(公告)日：1985-05-21
申请号：US400027
申请日：1982-07-20
申请人： David H. La Forge , Peer M. Portner
发明人： David H. La Forge , Peer M. Portner
CPC分类号： A61M1/1053 , A61M1/1048 , A61M1/1055
摘要： A solenoid closure servo control eliminates impact of the solenoid poles against each other upon closure of the device. A model of the device closure is obtained from a parameter of initial gap. During closure of the device, the rate of closure of the gap of the solenoid and the force in balance between the spring and magnetic force is calculated and compared to the model. Imbalances are corrected by applying a corrective voltage to the solenoid coils.
摘要翻译： 螺线管闭合伺服控制器在设备闭合时消除了螺线管电极彼此的冲击。 从初始间隙的参数获得器件闭合的模型。 在闭合装置期间，计算螺线管间隙的关闭速率和弹簧与磁力之间的平衡力，并将其与模型进行比较。 通过对螺线管线圈施加校正电压来校正不平衡。
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公开(公告)号：US4666443A
公开(公告)日：1987-05-19
申请号：US853464
申请日：1986-04-18
申请人： Peer M. Portner
发明人： Peer M. Portner
CPC分类号： A61M1/1086 , A61M1/10 , A61M1/1003 , A61M1/1048 , A61M1/1037 , A61M1/12 , Y10S128/03
摘要： A biventricular circulatory support system for a human patient is described. A mechanical first pump for assuming at least a part of the pumping load of the patient's left ventricle is implanted in the patient. A second pump for assuming at least a part of the pumping load of the patient's right ventricle is also implanted. The second pump includes a surgically prepared skeletal muscle pedicle with nerves and blood supply substantially intact. The muscle pedicle is applied directly to the right ventrical or is applied to an artificial pump sac. Electrical signals are applied to the first and second pumps as appropriate to cause pumping action in a predetermined relationship.
摘要翻译： 描述了用于人类患者的双心室循环支持系统。 用于假设病人左心室的至少一部分泵送负荷的机械第一泵植入患者体内。 还植入用于假设患者右心室的至少一部分泵送负荷的第二泵。 第二个泵包括手术准备的骨骼肌蒂，其神经和血液供应基本上完好无损。 肌肉蒂直接施用于右侧腹腔，或应用于人造泵囊。 电信号适当地施加到第一和第二泵，以引起预定关系的泵送作用。
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公开(公告)号：US4167046A
公开(公告)日：1979-09-11
申请号：US859915
申请日：1977-12-12
申请人： Peer M. Portner , Jal S. Jassawalla
发明人： Peer M. Portner , Jal S. Jassawalla
CPC分类号： A61M1/1037 , A61M1/1048 , A61M1/122 , Y10S128/03
摘要： A blood pumping device is described for internal use in humans or animals and which is particularly suitable for use as a left ventricular assist device. The device is comprised of a unitary pancake-shaped deformable sac of flexible resilient, blood compatible material. A pair of oppositely acting plates on each side of the pancake-shaped sac are moved toward and away from each other by the action of driving means to deform the sac and provide the pumping action. Inlets and outlets are arranged in the annular side wall of the sac.
摘要翻译： 描述了用于人或动物内部使用的血液泵装置，其特别适合用作左心室辅助装置。 该装置由柔性弹性，兼容血液的材料组成的整体的煎饼状可变形囊。 通过驱动装置的作用，在煎饼形囊的每一侧上的一对相对作用的板被移动并彼此远离，以使囊变形并提供泵送作用。 入口和出口布置在囊的环形侧壁中。
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公开(公告)号：US4360019A
公开(公告)日：1982-11-23
申请号：US135219
申请日：1980-03-31
申请人： Peer M. Portner , Jal S. Jassawalla
发明人： Peer M. Portner , Jal S. Jassawalla
CPC分类号： A61M5/14276 , A61M2205/3523 , A61M2209/045
摘要： An infusion system is disclosed for delivering precisely regulated and variable dosages of drugs. The device includes a reservoir for containing the drug, a catheter for delivering drug to the body, and actuating means responsive to a signal applied externally of the body for initiating delivery of a precisely regulated dosage. The actuating means include; a solenoid driven miniature pump which is controlled by an implanted controller and driven by an implanted power source. The implanted controller provides a basal dosage rate which itself may be variable or constant and which may be altered by telemetry signals delivered from outside the body. In addition, the internal device is operable by an external unit which may be set at a different rate from that which the internal or implanted controller is set and which, in addition, provides power for operating the implanted device. The reservoir is maintained at zero gauge or slightly negative gauge pressure to prevent loss of the contents of the reservoir into the body in which the device is implanted in the event of a failure. A tube communicating between the reservoir and the catheter is bent around on itself in such a way as to prevent bubbles from entering the tube. The implanted power and control electronics may be overridden to provide power from an extra corporeal unit and is also programmable from the extra corporeal unit to adjust dosage rates. A bellows is used to maintain a constant pressure within the reservoir, and suitable plates are utilized to produce a capacitive signal indicating the volume remaining of the contents of the reservoir.
摘要翻译： 公开了用于递送精确调节和可变剂量的药物的输注系统。 该装置包括用于容纳药物的储存器，用于将药物输送到身体的导管，以及响应于外部施加于身体外部的信号的致动装置，用于启动精确调节剂量的递送。 致动装置包括： 螺线管驱动的微型泵，其由植入的控制器控制并由植入的动力源驱动。 植入的控制器提供基本剂量率，其本身可以是可变的或恒定的，并且可以通过从身体外部传送的遥测信号来改变。 此外，内部设备可由外部单元操作，该外部单元可以设置为与内部或植入的控制器设置的速率不同的速率，并且另外设置用于操作植入的设备的电力。 储存器保持在零表压或略微负的表压，以防止储存器的内容物在失效的情况下被植入的体内损失。 在储存器和导管之间连通的管弯曲自身，以防止气泡进入管中。 植入的电源和控制电子设备可以被覆盖以从额外的物理单元提供电力，并且还可以从额外的体系单元编程以调整剂量率。 波纹管用于在储存器内保持恒定的压力，并且使用合适的板来产生指示储存器的内容物剩余量的电容信号。
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公开(公告)号：US4152786A
公开(公告)日：1979-05-08
申请号：US859916
申请日：1977-12-12
CPC分类号： A61M1/1037 , A61M1/107 , A61M1/12
摘要： A compensator designed to be implanted within a living body and connected to an implanted reciprocating blood pump. A housing defines a gas-tight chamber which is separated into front and rear portions by a flexible membrane. A piston attached to the membrane guides the movement of the membrane, and a spring mechanism which links the piston and the housing is designed to maintain substantially constant pressure in the front chamber throughout the discharge and fill strokes of the reciprocating blood pump. Two pivoted, diametrically opposed, compression springs are compressed at rest at the end of the fill stroke and exert a force on the membrane which overcomes the differential pressure acting in the opposite direction when the membrane moves so as to expand the rear chamber volume.
摘要翻译： 一种补偿器，设计用于植入生物体内并连接到植入的往复式血液泵上。 壳体限定了气密室，其通过柔性膜分离成前部和后部。 附接到膜的活塞引导膜的移动，并且连接活塞和壳体的弹簧机构被设计成在往复式血泵的整个排出和填充冲程期间在前室中保持基本恒定的压力。 两个旋转的直径相对的压缩弹簧在填充行程结束时被静止地压缩，并且在膜上施加力，克服当膜移动时以相反方向作用的压差，以便扩大后室体积。
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公开(公告)号：US4083367A
公开(公告)日：1978-04-11
申请号：US709428
申请日：1976-07-28
申请人： Peer M. Portner , David H. LaForge
发明人： Peer M. Portner , David H. LaForge
IPC分类号： A61B5/08
CPC分类号： A61B5/0813
摘要： A method and apparatus for analyzing pulmonary function including diffusing capacity and cardiac output or local pulmonary blood flow while necessarily determining alveolar volume in order to complete the above-noted analysis. In order to provide a rapid response in each of the abovenoted analyses or determinations, appropriate gases are caused to be inhaled and exhaled through a sample cell wherein a percentage of each gas may be constantly monitored during inhalation and exhalation by means of non-dispersive infrared absorption techniques, the sample cell and associated components of the pulmonary function analyzing device including additional features to facilitate the abovenoted analyses and determinations, the combination of gases employed for monitoring the pulmonary functions being selected to permit accurate detection by infrared absorption techniques.
摘要翻译： 一种用于分析肺功能的方法和装置，包括扩散能力和心输出量或局部肺血流，同时必须确定肺泡体积以完成上述分析。 为了在每次上述分析或测定中提供快速响应，使合适的气体被吸入并通过样品池呼出，其中每个气体的百分比可以在吸入和呼出期间通过非分散红外线 吸收技术，肺功能分析装置的样品池和相关组分包括用于促进上述分析和测定的附加特征，用于监测肺功能的气体的组合被选择以允许通过红外吸收技术的准确检测。
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公开(公告)号：US4488099A
公开(公告)日：1984-12-11
申请号：US446452
申请日：1982-12-03
申请人： David H. LaForge , Peer M. Portner
发明人： David H. LaForge , Peer M. Portner
IPC分类号： G05B13/02 , A61M1/10 , F04B43/00 , F04B43/04 , G05B20060101 , G05B5/01 , G05D3/12 , H02P5/40
CPC分类号： A61M1/1086 , F04B43/0063 , A61M1/1037
摘要： Real time servo control in a nonlinear, cyclical dynamic system adjusts the energy applied to a prime mover from a source of the energy as a linear function of an error between the measured load characteristics and modeled load characteristics. The modeled load characteristics are linearized as a function of the initial conditions of the load at the beginning of each cycle.
摘要翻译： 非线性循环动态系统中的实时伺服控制可将来自能量源的原动机施加的能量作为测量负载特性与建模负载特性之间的误差的线性函数进行调整。 模型负载特性作为每个循环开始时负载初始条件的函数进行线性化。
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公开(公告)号：US4265241A
公开(公告)日：1981-05-05
申请号：US15927
申请日：1979-02-28
申请人： Peer M. Portner , Jal S. Jassawalla
发明人： Peer M. Portner , Jal S. Jassawalla
CPC分类号： A61M5/14276 , A61M2205/3523 , Y10S128/12
摘要： Multiple embodiments of an implantable infusion device for delivering precisely regulated dosages of drugs are disclosed, each device including reservoir means for containing the drug, catheter means for delivering the drug to the body and an actuating means which is responsive to a signal applied externally of the body for initiating delivery of a precisely regulated dosage. In one embodiment, the device is implanted subcutaneously to permit actuation by a solenoid driven element responsive to coded telemetry signal applied through the skin. In additional embodiments, the reservoir is pressurized for example, by means of vapor pressure or a mechanical spring, the drug under pressure in the reservoir being released in response to an externally applied signal.
摘要翻译： 公开了用于递送精确调节的药物剂量的可植入输注装置的多个实施例，每个装置包括用于容纳药物的储存装置，用于将药物递送到身体的导管装置和响应于外部施加的信号的致动装置 用于启动精确调节剂量的递送。 在一个实施例中，所述装置被皮下植入，以允许通过螺线管驱动的元件致动，响应于通过皮肤施加的编码的遥测信号。 在另外的实施例中，储存器例如通过蒸汽压力或机械弹簧加压，储存器中的压力下的药物响应于外部施加的信号被释放。
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公开(公告)号：US4143661A
公开(公告)日：1979-03-13
申请号：US859914
申请日：1977-12-12
申请人： David H. LaForge , Peer M. Portner
发明人： David H. LaForge , Peer M. Portner
CPC分类号： A61N1/3787 , A61F2250/0001
摘要： A power supply system to operate an implanted electric-powered device such as a blood pump. A secondary coil having a biocompatible covering is implanted to subcutaneously encircle either the abdomen or the thigh at a location close to the exterior skin. The secondary coil is electrically interconnected with an implanted storage battery and the blood pump. A primary coil of overlapping width is worn by the patient at a location radially outward of the secondary coil. An external battery plus an inverter circuit in a pack is attached to a belt having a detachable buckle connector which is conventionally worn about the waist. Efficient magnetic coupling is achieved through the use of two air-core windings of relatively large diameter.
摘要翻译： 用于操作诸如血液泵的植入式电动装置的电源系统。 植入具有生物相容性覆盖物的次级线圈以在接近外部皮肤的位置皮下包围腹部或大腿。 次级线圈与植入的蓄电池和血泵电互连。 重叠宽度的初级线圈由患者在径向向外的次级线圈的位置上穿戴。 一个外部电池加上一个包装中的逆变器电路被连接到一个带上，该皮带具有通常围绕腰部穿着的可拆卸的带扣连接器。 通过使用两个相对较大直径的空心绕组实现高效的磁耦合。
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公开(公告)号：US4756302A
公开(公告)日：1988-07-12
申请号：US933490
申请日：1986-11-20
CPC分类号： A61M1/1086 , A61M1/1037
摘要： A heart-assist system and a method for operating same are described in which a pump is connected to a ventricle to receive output therefrom. An actuator operates to cause the pump to conduct a fill cycle in which it receives output from the ventricle to which it is connected, and to conduct an eject cycle in which the contents of the pump are expelled. The time of initiation of at least one of the fill cycle and the eject cycle is varied in relation to systole of the ventricle to which the pump is connected to thereby vary the loading of the ventricle. Several techniques for detecting termination of systole are described including a compliant stop on the pump.
摘要翻译： 描述了心脏辅助系统及其操作方法，其中将泵连接到心室以接收其输出。 致动器操作以使泵进行填充循环，在该循环中，其接收与其连接的心室的输出，并且进行排出泵的内容物的排出循环。 填充循环和排出循环中的至少一个的起始时间相对于与泵连接的心室的收缩相关而变化，从而改变心室的负荷。 描述了几种用于检测心脏收缩终止的技术，包括在泵上的顺应停止。
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