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    Methods and uses of leukotriene B4 hydroxylases to treat diseases
    1.
    发明申请
    Methods and uses of leukotriene B4 hydroxylases to treat diseases 失效
    白三烯B4羟化酶治疗疾病的方法和用途

    公开(公告)号：US20060247200A1

    公开(公告)日：2006-11-02

    申请号：US11414896

    申请日：2006-05-01

    申请人： David Harder ,  James Antczak ,  Lane Brostrom

    发明人： David Harder ,  James Antczak ,  Lane Brostrom

    IPC分类号： A61K48/00 ,  A61K31/7076 ,  A61K38/44

    CPC分类号： A61K38/44 ,  A61K31/7076 ,  A61K45/06 ,  A61K2300/00

    摘要： Methods and uses are described for treating or preventing diseases of humans or non-human animals by reducing the amount of active leukotriene B4 (LTB4) in those in need of such treatment using LTB4 hydroxylases. In certain embodiments, LTB4 hydroxylase is administered in combination with nicotinamide adenine dinucleotide phosphate and/or an NADPH-cytochrome P-450 reductase. The invention is particularly useful for treating or preventing respiratory diseases that are caused or exacerbated by inflammation.

    摘要翻译： 描述了用于治疗或预防人类或非人类动物疾病的方法和用途，通过减少需要这些的那些活性白细胞三烯B 4（LTB 4 N 4）的量 使用LTB 4 羟化酶的治疗。 在某些实施方案中，LTB 4羟化酶与烟酰胺腺嘌呤二核苷酸磷酸酯和/或NADPH-细胞色素P-450还原酶组合施用。 本发明特别可用于治疗或预防炎症引起或加重的呼吸系统疾病。

    Filter assemblies and methods
    3.
    发明申请
    Filter assemblies and methods 审中-公开
    过滤组件和方法

    公开(公告)号：US20060207948A1

    公开(公告)日：2006-09-21

    申请号：US10543238

    申请日：2004-01-27

    申请人： John Hacker ,  David Harder ,  Brent Gulsvig

    发明人： John Hacker ,  David Harder ,  Brent Gulsvig

    IPC分类号： B01D37/00

    CPC分类号： B01D35/153 ,  B01D29/055 ,  B01D29/21 ,  B01D29/605 ,  B01D29/925 ,  B01D29/96 ,  B01D35/16 ,  B01D35/30 ,  B01D36/001 ,  B01D36/003 ,  B01D2201/0415 ,  B01D2201/291 ,  B01D2201/305 ,  B01D2201/34

    摘要： A fluid filter assembly includes a housing, a service cover, a center tube removably secured to the service cover, a filter cartridge removably sealed and circumscribing the center tube, and a seal arrangement. The seal arrangement is between the center tube and portions of the housing to close a drainage channel to the flow of clean fluid flow therethrough, when the fluid filter assembly is operating to filter. During normal operation, the fluid filter assembly operates to allow fluid to flow into the housing through an inlet channel, through the filter cartridge, through openings in the center tube, and out of the housing through the outlet channel. Methods for servicing include removing a service cover from a housing to remove, together with the service cover, a center tube, and open a drainage flow passageway from the housing. Next a filter cartridge is removed from the center tube, and a new filter cartridge is operably mounted on the center tube. Next, the service cover with the center tube having the new filter cartridge is operably mounted in the housing to close the drainage flow passageway. Methods of filtering will direct fluid to be filtered into a housing having a removable and replaceable filter cartridge; then direct the fluid through a tubular region of filter media in the cartridge; then through fluid openings in a center tube; and into a clean fluid flow passageway. Example methods include preventing fluid to bypass the filter media by removably sealing the filter cartridge to the center tube. Example methods will also include preventing fluid from flowing into a drainage passageway by removably sealing the center tube to other portions of the filter housing. Systems utilize filter assemblies as characterized herein include fuel systems, lube systems, and hydraulic systems.

    摘要翻译： 流体过滤器组件包括壳体，维护盖，可拆卸地固定到维修盖的中心管，可拆卸地密封并围绕中心管的过滤器滤芯以及密封装置。 当流体过滤器组件操作以过滤时，密封装置位于中心管和壳体的部分之间以封闭通向其中的清洁流体流动的流动的排水通道。 在正常操作期间，流体过滤器组件操作以允许流体通过入口通道，通过过滤器滤芯，通过中心管中的开口流入壳体，并通过出口通道流出壳体。 维修方法包括从外壳移除服务盖以与服务盖一起移除中心管，并从壳体打开排水流动通道。 接下来，从中心管移除滤筒，并且将新的滤筒可操作地安装在中心管上。 接下来，具有新的过滤器滤芯的具有中心管的维护盖可操作地安装在壳体中以关闭排水流动通道。 过滤方法将将要过滤的流体引导到具有可移除和可更换过滤器滤芯的壳体中; 然后将流体引导通过滤筒中的过滤介质的管状区域; 然后通过中心管中的流体开口; 并进入清洁的流体流动通道。 示例性方法包括通过将滤筒可拆卸地密封到中心管来防止流体绕过过滤介质。 示例性方法还将包括通过将中心管可移除地密封到过滤器壳体的其它部分来防止流体流入排水通道。 系统利用如本文特征的过滤器组件包括燃料系统，润滑系统和液压系统。

    Truck having a front axle oscillatable relative to a rear axle
    4.
    发明授权
    Truck having a front axle oscillatable relative to a rear axle 失效
    具有相对于后轴可摆动的前轴的卡车

    公开(公告)号：US4533010A

    公开(公告)日：1985-08-06

    申请号：US436276

    申请日：1982-12-30

    申请人： David Harder

    发明人： David Harder

    IPC分类号： B62D21/18 ,  B62D53/02

    CPC分类号： B62D21/186 ,  B62D53/02

    摘要： This invention discloses a front axle for a ground engaging vehicle. The front axle is oscillatable relative to a rear axle for enabling all the wheels to contact the ground under adverse terrain conditions. Primarily, the vehicle comprises a main frame having the rear axle attached; and, a sub-frame which is pivotally attached to the main frame and contains the front axle. The vehicle further includes a torque tube on the rear drive shaft having a hydraulic cylinder controlled torque tube for controlling the action of the sub-frame relative to the main frame.

    摘要翻译： 本发明公开了一种用于地面接合车辆的前桥。 前轴相对于后桥可摆动，以使所有车轮在不利的地形条件下接触地面。 主要地，车辆包括具有附接的后轴的主框架; 以及枢转地附接到主框架并且包含前轴的子框架。 车辆还包括在后驱动轴上的扭矩管，具有用于控制副框架相对于主框架的动作的液压缸控制扭矩管。

    ROLLED AXIAL FLOW FILTER AND METHODS
    5.
    发明申请
    ROLLED AXIAL FLOW FILTER AND METHODS 审中-公开
    滚动轴流滤波器和方法

    公开(公告)号：US20080000826A1

    公开(公告)日：2008-01-03

    申请号：US11758183

    申请日：2007-06-05

    申请人： David Harder ,  Gregory LaVallee ,  Jess Nordby

    发明人： David Harder ,  Gregory LaVallee ,  Jess Nordby

    IPC分类号： B01D29/46 ,  B01D63/00 ,  B01D63/06 ,  B01D63/10 ,  B32B37/12 ,  C02F1/44

    CPC分类号： B01D46/527 ,  B01D25/001 ,  B01D25/24 ,  B01D2275/105

    摘要： Filter media includes a first layer of porous filter media having first and second opposite sides and first and second edges; a first porous screen oriented on the second side of the first layer of porous filter media, the first porous screen having first and second edges; a second layer of porous filter media having first and second opposite sides and first and second edges, the second side of the second layer of porous media oriented on the first porous screen, a first sealant securing the first layer, first screen, and second layer together adjacent to the first edges of the first layer, first screen, and second layer; a second screen oriented on the first side of the second layer, the second screen having first and second edges; and a second sealant securing the second screen and the second layer adjacent to the second edges of the second screen and second layer. The filter media can be coiled into a filter element resulting in a plurality of dirty fluid inlets between the first layer second side and second layer second side, and a plurality of clean fluid outlets between the first layer first side and second layer first side. Methods of making filter elements include providing a four layered construction of media, screen, media, and screen, and then coiling it into a filter element.

    摘要翻译： 过滤介质包括具有第一和第二相对侧以及第一和第二边缘的第一层多孔过滤介质; 第一多孔筛，其定向在所述第一多孔过滤介质层的第二侧上，所述第一多孔筛具有第一和第二边缘; 第二层多孔过滤介质，其具有第一和第二相对侧以及第一和第二边缘，第二层多孔介质的第二面定向在第一多孔筛上，第一密封剂固定第一层，第一筛网和第二层 一起邻近第一层的第一边缘，第一屏幕和第二层; 第二屏幕，其定向在第二层的第一侧上，第二屏幕具有第一和第二边缘; 以及第二密封剂，其将所述第二屏幕和所述第二层固定在所述第二屏幕和第二层的第二边缘附近。 过滤介质可以卷绕到过滤元件中，导致在第一层第二侧和第二层第二侧之间的多个脏流体入口，以及在第一层第一侧和第二层第一侧之间的多个清洁流体出口。 制造过滤元件的方法包括提供介质，筛网，介质和筛网的四层结构，然后将其卷绕成过滤元件。