公开(公告)号：US4608349A

公开(公告)日：1986-08-26

申请号：US797223

申请日：1985-11-28

申请人： David J. Kerko ,  David W. Morgan ,  David L. Morse

发明人： David J. Kerko ,  David W. Morgan ,  David L. Morse

IPC分类号： G02C7/10 ,  C03C3/093 ,  C03C3/11 ,  C03C4/06 ,  C09K9/00 ,  C03C3/118

CPC分类号： C03C3/093 ,  C03C4/06

摘要： Photochromic glass compositions for thin refractive-index-corrected lens elements consisting essentially of about:______________________________________ SiO.sub.2 54-58% B.sub.2 O.sub.3 18-22% Al.sub.2 O.sub.3 7-8% Li.sub.2 O 3.75-4.5% Na.sub.2 O 0-1% K.sub.2 O 5.5-7.5% TiO.sub.2 0-2% ZrO.sub.2 2-4.5% Ag 0.20-0.33% Cl 0.30-0.50% Br 0.04-0.12% CuO 0.007-0.012% PbO 0-0.08% Sb.sub.2 O.sub.3 0-0.20% ______________________________________ having a Li.sub.2 O:Na.sub.2 O molar ratio of at least 9:1 and exhibiting good darkening, fast fading, good chemical strengthenability and neutral dark-state coloration at thicknesses on the order of 1 mm, are described.

摘要翻译： 用于薄折射率校正透镜元件的光致变色玻璃组合物，其基本上由以下组成：-SiO 2 54-58％-B 2 O 3 18-22％-Al 2 O 3 7-8％-Li 2 O 3.75-4.5％-Na 2 O 0-1％-K 2 O 5.5 -7.5％-TiO 2 0-2％-ZrO2 2-4.5％-Ag 0.20-0.33％-Cl 0.30-0.50％-Br 0.04-0.12％-CuO 0.007-0.012％-PbO 0-0.08％-Sb2O3 0-0.20 ％ - 具有至少9:1的Li 2 O:Na 2 O摩尔比，并且在1mm的厚度下表现出良好的变暗，快速褪色，良好的化学强化性和中性暗态着色。

公开(公告)号：US4549894A

公开(公告)日：1985-10-29

申请号：US617908

申请日：1984-06-06

申请人： Roger J. Araujo ,  George B. Hares ,  David J. Kerko ,  David W. Morgan ,  David L. Morse

发明人： Roger J. Araujo ,  George B. Hares ,  David J. Kerko ,  David W. Morgan ,  David L. Morse

IPC分类号： C03C3/091 ,  C03C4/06

CPC分类号： C03C4/06 ,  C03C3/091

摘要： There is disclosed a method of producing a photochromic glass having a reduced transmittance for ultraviolet radiation while having substantially unimpaired photochromic properties. The method comprises providing a combination of 0.1-1.0% CeO.sub.2 and 0.1-1.5% Sb.sub.2 O.sub.3 and/or As.sub.2 O.sub.3 as part of the glass composition. In an embodiment utilizing minimal silver content, the glass article in thicknesses of 1.3 to 2.0 mm. can be chemically strengthened to surpass the impact specification imposed by the Federal Food and Drug Administration for eyewear, will transmit less than 0.2% of radiation having wavelengths between 290-315 nm, and will demonstrate a darkened luminous transmittance at 20.degree.-25.degree. C. below 35% and a fading rate such that after five minutes the luminous transmittance will be at least 1.75 times that of the darkened transmittance. These glasses consist essentially of:______________________________________ SiO.sub.2 55-61 Ag >0.1-

摘要翻译： 公开了一种具有降低的紫外线辐射透射率而具有基本上未受损的光致变色特性的光致变色玻璃的方法。 该方法包括提供0.1-1.0％CeO 2和0.1-1.5％Sb 2 O 3和/或As 2 O 3的组合作为玻璃组合物的一部分。 在使用最小银含量的实施方案中，玻璃制品的厚度为1.3至2.0mm。 可以化学强化超过联邦食品和药物管理局对眼镜施加的影响规格，将传播波长在290-315 nm之间的辐射不到0.2％，并将在20°-25°C显示变暗的透光率 低于35％，并且褪色速率使得在5分钟后，透光率将至少为透光度变暗的1.75倍。 这些玻璃基本上由以下组成：-SiO2 55-61 Ag> 0.1- <0.2- B2O3 18-21 Cl 0.2-0.6 -Al2O3 5-11 Br 0.05-0.2 -Li2O 1.5-3 CuO 0.003-0.015 -Na2O 2-5 CeO2 0.1-1.0 -K2O 4.5-8 Sb2O3 0.1-1.5 -

公开(公告)号：US4374931A

公开(公告)日：1983-02-22

申请号：US338042

申请日：1982-01-08

申请人： Philippe Courbin ,  David J. Kerko ,  Jean P. Mazeau ,  David L. Morse

发明人： Philippe Courbin ,  David J. Kerko ,  Jean P. Mazeau ,  David L. Morse

IPC分类号： C03C3/11 ,  C03C3/093 ,  C03C4/06 ,  C03C10/00 ,  C03C3/26 ,  C03C3/08 ,  C03C3/10

CPC分类号： C03C3/093 ,  C03C4/06

摘要： The present invention is concerned with the production of photochromic glass compositions consisting essentially, expressed in terms of weight percent on the oxide basis, as calculated from the batch, of______________________________________ SiO.sub.2 52-59 B.sub.2 O.sub.3 18-23 Al.sub.2 O.sub.3 6-8 Li.sub.2 O 1-2.5 Na.sub.2 O 1-3 K.sub.2 O 8-13 ZrO.sub.2 2-6 TiO.sub.2 0-3 ______________________________________ and containing, as analyzed in weight percent, of______________________________________ Ag 0.17-0.22 CuO 0.012-0.019 Cl 0.29-0.35 Br 0.06-0.12 PbO 0.1-0.15 ______________________________________ exhibiting, in 0.4 mm cross section, a clear luminous transmittance in excess of 90%, a darkened luminous transmittance below about 45% at a temperature of 25.degree. C., a darkened luminous transmittance below about 57% at a temperature of 40.degree. C., and a half fading time at both temperatures of about five minutes.

摘要翻译： 本发明涉及光致变色玻璃组合物的制备，其基本上由以批量计算的基于氧化物的重量百分数表示的-SiO 2 52-59 -B 2 O 3 18-23 -Al 2 O 3 6-8 -Li 2 O 1-2.5 -Na2O 1-3-K2O 8-13-ZrO2 2-6-TiO2 0-3 - 并以重量百分比计含有-Ag 0.17-0.22 -CuO 0.012-0.019 -Cl 0.29-0.35 - Br 0.06-0.12 -PbO 0.1-0.15 - 在0.4mm的横截面中显示出超过90％的透明透光率，在25℃的温度下变暗的透光率低于约45％，更暗的透光率低于 在约40℃的温度下为约57％，在约5分钟的温度下为半衰退时间。

公开(公告)号：US4358542A

公开(公告)日：1982-11-09

申请号：US252139

申请日：1981-04-08

申请人： George B. Hares ,  David J. Kerko ,  David L. Morse

发明人： George B. Hares ,  David J. Kerko ,  David L. Morse

IPC分类号： C03C3/108 ,  C03C3/091 ,  C03C3/11 ,  C03C3/118 ,  C03C4/06 ,  C03B23/025 ,  C03B33/02 ,  C03C3/08 ,  C03C3/26

CPC分类号： C03C4/06 ,  C03C3/091

摘要： The instant invention is directed to the production of photochromic glasses having compositions consisting essentially, as analyzed in weight percent on the oxide basis, ofSiO.sub.2 --55-60Al.sub.2 O.sub.3 --9-10B.sub.2 O.sub.3 --19-20.5Li.sub.2 O--2-2.5Na.sub.2 O--2-3K.sub.2 O--6-7PbO--0.1-0.25Ag--0.1-0.15Cl--0.3-0.5Br--0.05-0.15CuO--0.0065-0.01The glasses are capable of being drawn into sheet and articles cut from the sheet simultaneously shaped and photochromic properties developed therein. The glasses display a clear luminous transmittance in excess of 90% when free from tint, a darkened luminous transmittance at 20.degree. C. below 25% when free from tint, and a fading rate at 20.degree. C. such that the glass demonstrates a faded luminous transmittance at least twice that of the darkened transmittance after a five-minute fading interval.

摘要翻译： 本发明涉及制备光致变色玻璃，其具有基本上按氧化物基础重量百分比分析的SiO 2 -55-60 Al 2 O 3 -9-10 B 2 O 3·19-20.5 Li 2 O -2-2.5 Na 2 O-2 -3 K2O-6-7 PbO-0.1-0.25 Ag-0.1-0.15 Cl-0.3-0.5 Br-0.05-0.15 CuO-0.0065-0.01玻璃能够被拉伸成片材，并从同时成形的片材切割制品， 其中发展的光致变色性质。 当没有色调时，眼镜显示出超过90％的透明透光率，20℃时的透光率变暗，低于25％，而在20℃下的褪色速度，使得玻璃显示出褪色 在5分钟衰落间隔后，透光率至少是透光率变暗的两倍。

公开(公告)号：US4407966A

公开(公告)日：1983-10-04

申请号：US418971

申请日：1982-09-16

申请人： David J. Kerko ,  David L. Morse

发明人： David J. Kerko ,  David L. Morse

IPC分类号： C03C3/11 ,  C03C3/093 ,  C03C3/118 ,  C03C4/04 ,  C03C4/06 ,  C03C3/26 ,  C03C3/08

CPC分类号： C03C4/06 ,  C03C3/093

摘要： The present invention is directed to the preparation of photochromic glasses exhibiting a darkened luminous transmittance at 40.degree. C. below 35% and a five-minute fading rate at 40.degree. C. of at least 40 units of transmittance and a darkened transmittance at 25.degree. C. below 25% and a five-minute fading rate at 25.degree. C. of at least 35 units of transmittance. The glasses consist essentially, by weight, of:______________________________________ SiO.sub.2 56-60 Al.sub.2 O.sub.3 6-9 B.sub.2 O.sub.3 18-21 Li.sub.2 O >2.5-3.5 Na.sub.2 O 0.5-2.5 K.sub.2 O 5-7 ZrO.sub.2 3.75-5 PbO 0.1-0.15 Ag >0.15-0.25 Cl 0.2-0.35 Br 0.075-0.15 CuO 0.004-0.02 CeO.sub.2 0-0.5 ______________________________________ wherein the levels of Ag, Br, Cl, and CuO represent values as analyzed in the glass.

摘要翻译： 本发明涉及在40℃下低于35％的遮光透光率和40℃下5分钟褪色速率的光致变色玻璃的制备，其透光率至少为40单位，透明度在25度变暗 低于25％，25℃下5分钟的褪色速率为至少35单位透光率。 玻璃基本上由以下组成：-SiO 2 56-60 -Al 2 O 3 6-9 -B 2 O 3 18-21 -Li 2 O> 2.5-3.5 -Na 2 O 0.5-2.5 -K 2 O 5-7-ZrO 2 3.75-5 -PbO 0.1- 0.15 -Ag> 0.15-0.25 -Cl 0.2-0.35 -Br 0.075-0.15 -CuO 0.004-0.02 -CeO2 0-0.5 - 其中Ag，Br，Cl和CuO的含量表示在玻璃中分析的值。

公开(公告)号：US20140112873A1

公开(公告)日：2014-04-24

申请号：US14117949

申请日：2012-05-17

申请人： Robert J. Gillies ,  David L. Morse ,  Natalie M. Barkey ,  Kevin N. Sill ,  Josef Vagner ,  Narges K. Tafreshi ,  Jonathan L. Sessler ,  Christian Preihs ,  Victor J. Hruby

发明人： Robert J. Gillies ,  David L. Morse ,  Natalie M. Barkey ,  Kevin N. Sill ,  Josef Vagner ,  Narges K. Tafreshi ,  Jonathan L. Sessler ,  Christian Preihs ,  Victor J. Hruby

IPC分类号： C07K7/08 ,  A61K49/18 ,  A61K47/48 ,  A61K49/14 ,  C07K7/06 ,  C07K5/117

CPC分类号： C07K5/1024 ,  A61K38/34 ,  A61K47/48246 ,  A61K47/488 ,  A61K47/64 ,  A61K47/6907 ,  A61K49/0056 ,  A61K49/101 ,  A61K49/1809 ,  C07K7/08 ,  C07K14/68 ,  C07K14/723

摘要： The subject invention pertains to a modified MC1R peptide ligand comprising a peptide that is a melanocortin 1 receptor (MC1R) ligand and a functionality or linker, such as a click functionality, for conjugation to a surface or agent. The modified MC1R peptide ligand can be coupled, e.g., via a click reaction with a complementary click functionality attached, to a moiety to form an MC1R-targeted agent. Drugs, contrast agents, polymers, particles, micelles, surfaces of larger structures, or other moieties can be targeted to the MC1R. The subject invention also pertains to a MC1R peptide ligand-micelle complex comprising a peptide that is a melanocortin 1 receptor ligand connected via a click reaction product to a micelle. The micelle is stable in vivo and can target melanoma tumor cells by association of the peptide ligand with the MC1R or the tumor and selectively provide a detectable and/or therapeutic agent (such as an imageable contrast agent and/or anti-cancer agent) selectively to the tumor cell.

摘要翻译： 本发明涉及包含黑皮质素1受体（MC1R）配体的肽和功能性或连接体的修饰的MC1R肽配体，例如用于与表面或试剂共轭的功能性或接头。 修饰的MC1R肽配体可以例如通过与所连接的互补点击功能的点击反应偶联，以形成MC1R靶向的试剂。 药物，造影剂，聚合物，颗粒，胶束，较大结构的表面或其它部分可以靶向MC1R。 本发明还涉及包含通过点胶反应产物与胶束连接的黑皮质素1受体配体的肽的MC1R肽配体 - 胶束复合物。 胶束在体内是稳定的并且可以通过肽配体与MC1R或肿瘤的缔合来靶向黑素瘤肿瘤细胞，并选择性地提供可检测和/或治疗剂（例如可成像的造影剂和/或抗癌剂） 到肿瘤细胞。

公开(公告)号：US20120277245A1

公开(公告)日：2012-11-01

申请号：US13479638

申请日：2012-05-24

申请人： Robert J. Gillies ,  David L. Morse ,  Ariosto Siqueira Silva ,  Arig A. Ibrahim Hashim ,  Robert A. Gatenby ,  Gary Martinez

发明人： Robert J. Gillies ,  David L. Morse ,  Ariosto Siqueira Silva ,  Arig A. Ibrahim Hashim ,  Robert A. Gatenby ,  Gary Martinez

IPC分类号： A61K31/185 ,  A61K31/4172 ,  A61P35/04 ,  A61K31/14 ,  A61P35/00 ,  A61K31/495 ,  A61K31/198

CPC分类号： A61K31/4172 ,  A61K31/133 ,  A61K31/198 ,  A61K31/255 ,  A61K31/495 ,  A61K45/06 ,  A61K2300/00

摘要： A method of treating cancer or inhibiting metastasis in a subject by increasing intratumoral extracellular pH is presented. The method includes administering to the subject a therapeutically effective amount of a buffer having a pKa greater than 6.1. In an advantageous embodiment the pKa of the buffer is about 7.0. Examples of buffers for increasing extracellular pH include NaHCO3, 2-imidazole-1-yl-3-ethoxycarbonylpropionic acid (IEPA), cholamine chloride, N,N-Bis(2-hydroxyethyl)-2-aminoethanesulfonic acid (BES), N-Tris(hydroxymethyl)methyl-2-aminoethanesulfonic acid (TES) and 4-(2-Hydroxyethyl)piperazine-1-ethanesulfonic acid (HEPES). The method can further include the step of pretreating with one or more chemotherapeutic agents.

摘要翻译： 提出了通过增加瘤内细胞外pH来治疗受试者的癌症或抑制转移的方法。 该方法包括向受试者施用治疗有效量的pKa大于6.1的缓冲液。 在有利的实施方案中，缓冲液的pKa为约7.0。 用于增加细胞外pH的缓冲液的实例包括NaHCO 3，2-咪唑-1-基-3-乙氧基羰基丙酸（IEPA），氯化氯化胺，N，N-双（2-羟乙基）-2-氨基乙磺酸（BES），N- 三（羟甲基）甲基-2-氨基乙磺酸（TES）和4-（2-羟乙基）哌嗪-1-乙磺酸（HEPES）。 该方法还可以包括用一种或多种化学治疗剂预处理的步骤。

公开(公告)号：US4488864A

公开(公告)日：1984-12-18

申请号：US520457

申请日：1983-08-04

申请人： Nicholas F. Borrelli ,  Thomas H. Elmer ,  David L. Morse ,  Paul A. Sachenik

发明人： Nicholas F. Borrelli ,  Thomas H. Elmer ,  David L. Morse ,  Paul A. Sachenik

IPC分类号： C03B8/00 ,  C03B20/00 ,  C03C11/00 ,  C03C23/00 ,  G02B3/00 ,  G03C1/68

CPC分类号： G02B3/0056 ,  C03C23/0095

摘要： There is disclosed an improved integral optical device of the type produced by creating optical patterns in porous glass bodies, especially patterns involving gradient refractive index distributions. The optical strength of an element, such as a lens, in such an optical pattern is increased by treatment with a polymerizable, organo functional silicone fluid while the matrix glass is sealed.

摘要翻译： 公开了通过在多孔玻璃体中产生光学图案而产生的改进的一体光学器件，特别是涉及梯度折射率分布的图案。 通过在将基质玻璃密封的情况下通过可聚合的有机官能的硅氧烷流体的处理来增加这种光学图案中的诸如透镜的元件的光学强度。

公开(公告)号：US4479819A

公开(公告)日：1984-10-30

申请号：US427732

申请日：1982-09-29

申请人： Nicholas F. Borelli ,  Frank Coppola ,  David L. Morse ,  Daniel A. Nolan ,  Thomas P. Seward, III

发明人： Nicholas F. Borelli ,  Frank Coppola ,  David L. Morse ,  Daniel A. Nolan ,  Thomas P. Seward, III

IPC分类号： C03B17/02 ,  C03B23/037 ,  C03B32/00 ,  C03C3/064 ,  C03C3/091 ,  C03C4/06 ,  G02B5/30 ,  C03C3/26 ,  C03B19/00 ,  C03C23/00

CPC分类号： C03B32/00 ,  C03B17/02 ,  C03B23/037 ,  C03C3/064 ,  C03C3/091 ,  C03C4/06 ,  G02B5/3058 ,  Y10S430/165

摘要： The instant invention is directed to the preparation of glass articles exhibiting excellent polarization in the infrared portion of the spectrum from glasses characterized as containing silver halide particles therein selected from the group of AgCl, AgBr, AgI. The inventive method comprises four general steps:(a) a batch for a glass containing silver and at least one halide selected from the group of chloride, bromide, and iodide is melted and the melt shaped into a glass body of a desired geometry;(b) the glass body is subjected to a heat treatment at least above the strain point but not in excess of 50.degree. C. above the softening point of the glass for a period of time adequate to cause the generation of AgCl and/or AgBr and/or AgI particles therein, said particles ranging in size between 200-5000 .ANG.;(c) the glass body is elongated under stress at temperatures above the annealing point, but below that where said glass exhibits a viscosity of about 10.sup.8 poises, such that the particles are elongated to an aspect ratio of at least 5:1; and(d) the elongated glass body is exposed to a reducing environment at temperatures between 250.degree. C. and about 25.degree. above the annealing point of the glass to reduce the silver halide particles in the glass to metallic silver which is deposited in and/or upon the elongated particles.

摘要翻译： 本发明涉及从其中选择AgCl，AgBr，AgI中含有卤化银颗粒的玻璃的红外线部分的红外部分显示优异的玻璃制品的制备。 本发明的方法包括四个一般步骤：（a）用于含有银的玻璃和选自氯化物，溴化物和碘化物中的至少一种卤化物的批料熔化并将其熔化成具有所需几何形状的玻璃体; （b）将玻璃体至少高于应变点，但不超过玻璃软化点50℃以上的热处理足以导致产生AgCl和/或AgBr的时间 和/或AgI颗粒，所述颗粒的尺寸范围为200-5000安培; （c）玻璃体在高于退火点的温度下在应力下伸长，但低于所述玻璃呈现约108泊的粘度，使得该颗粒伸长至至少5:1的纵横比; 和（d）细长玻璃体在比玻璃退火点高250℃至25℃的温度下暴露于还原环境中，以将玻璃中的卤化银颗粒还原为金属银，其沉积在和/ 或在细长的颗粒上。

公开(公告)号：US20200164093A1

公开(公告)日：2020-05-28

申请号：US16565188

申请日：2019-09-09

申请人： David L. Morse ,  Robert J. Gillies ,  Amanda Huynh ,  Josef Vagner

发明人： David L. Morse ,  Robert J. Gillies ,  Amanda Huynh ,  Josef Vagner

IPC分类号： A61K49/00 ,  C07K7/08 ,  C07K7/06

摘要： Cellular targets on cancer cells have been identified that can be used with targeted molecular imaging to detect the cancer cells in vivo. Non-invasive methods for detecting cancer cells, such as metastasized cancer cells, are therefore provided. Also provided are compositions and kits for use in the disclosed methods.