公开(公告)号：US06665060B1

公开(公告)日：2003-12-16

申请号：US09430117

申请日：1999-10-29

申请人： David J. Zahniser ,  Matthew S. Zelinski ,  Thomas Dolash ,  Garrick L. Maenle ,  Mark Fleming ,  John Laudo

发明人： David J. Zahniser ,  Matthew S. Zelinski ,  Thomas Dolash ,  Garrick L. Maenle ,  Mark Fleming ,  John Laudo

IPC分类号： G01N3348

CPC分类号： G01N21/3151 ,  G01N1/30 ,  G01N15/147 ,  G01N15/1475 ,  G01N15/1484 ,  G01N2015/1472 ,  G01N2015/1488

摘要： The present invention relates to the analysis of cytological material. Specifically, the invention relates to stains and methods of producing the stains, methods of staining cells for cytological or histological analysis to contrast the nuclear portion of the cell from the cytoplasmic portion, and systems and methods for illuminating a cytological sample. The analysis can be automated or manual.

公开(公告)号：US20060114553A1

公开(公告)日：2006-06-01

申请号：US11261105

申请日：2005-10-27

申请人： John Laudo

发明人： John Laudo

IPC分类号： G02B21/00

CPC分类号： G01N33/5094 ,  B01L9/06 ,  B01L2200/025 ,  G02B21/002 ,  G02B21/06 ,  G02B21/248 ,  G02B21/365 ,  G02B27/095 ,  G02B27/48

摘要： A microscope system (10, 10′, 10″, 10′″) includes a laser (18) or light emitting diode (18′″) that generates source light having a non-uniform spatial distribution. An optical system includes an objective (40) defining a field of view, and an optical train (22, 22′, 22″, 22′″) configured to convert the source light into an enlarged-diameter collimated light, to spatially homogenize the enlarged-diameter collimated light, and to couple the homogenized enlarged-diameter collimated light into the objective to provide substantially uniform static illumination of the field of view. A camera system (56) is statically optically coupled by the objective with at least most of the field of view.

摘要翻译： 显微镜系统（10,10'，10“，10”）包括产生具有不均匀空间分布的源光的激光器（18）或发光二极管（18“）。 光学系统包括限定视野的物镜（40）和被配置为将源光转换成放大直径准直光的光学系统（22,22'，22“，22”'） 均匀化扩大直径的准直光，并将均匀化的扩大直径的准直光耦合到物镜中，以提供视野的基本上均匀的静态照明。 相机系统（56）通过至少大部分视野被物镜静态光耦合。