公开(公告)号：US20050044961A1

公开(公告)日：2005-03-03

申请号：US10648115

申请日：2003-08-26

申请人： David King ,  William Wittig

发明人： David King ,  William Wittig

IPC分类号： F16C19/54 ,  F16C35/06 ,  F16H57/12 ,  F16B31/02

CPC分类号： F16C19/54 ,  F16C35/06 ,  F16H57/0025 ,  F16H2057/0062

摘要： A delashing assembly includes a tightening device for tightening a nut in relation to a main shaft supported on bearings and a wireless interface, wherein torque information is received by the tightening device over the wireless interface. A main shaft and main nut assembly, as well as a steering system, may include the delashing assembly. A method of delashing the main shaft and main nut assembly includes providing a tightening device on a first end of the main shaft and sending torque information from a second end of the main shaft to the tightening device over the wireless interface.

摘要翻译： 脱落组件包括用于相对于支撑在轴承上的主轴紧固螺母的紧固装置和无线接口，其中扭矩信息由紧固装置通过无线接口接收。 主轴和主螺母组件以及转向系统可以包括脱屑组件。 一种使主轴和主螺母组件脱屑的方法包括在主轴的第一端上设置一个紧固装置，并通过无线接口将扭矩信息从主轴的第二端传递到紧固装置。

公开(公告)号：US10779515B1

公开(公告)日：2020-09-22

申请号：US16007159

申请日：2018-06-13

申请人： David King ,  Ray Stewart

发明人： David King ,  Ray Stewart

IPC分类号： A01K61/00 ,  A01K61/78 ,  F16B9/00 ,  A01K61/10

摘要： The present invention is an anchor for an artificial structure for attracting fish within a body of water. The structure is comprised of a base and has a central attachment post, a central column configured to secure to the attachment post, and a protective plate.

公开(公告)号：US20130202591A1

公开(公告)日：2013-08-08

申请号：US13814262

申请日：2011-08-02

申请人： Robert Horlick ,  David King ,  Peter Bowers ,  Jennifer Dalton ,  Betty Wu ,  Traci Roberts ,  Xue Zhang ,  Laurence Altobell, III

发明人： Robert Horlick ,  David King ,  Peter Bowers ,  Jennifer Dalton ,  Betty Wu ,  Traci Roberts ,  Xue Zhang ,  Laurence Altobell, III

IPC分类号： C07K16/24

CPC分类号： C07K16/244 ,  A61K2039/505 ,  C07K2317/21 ,  C07K2317/76 ,  C07K2317/92

摘要： The disclosure relates to an isolated IL-17-binding agent which comprises an immunoglobulin heavy chain polypeptide comprising SEQ ID NO: 1 and optionally an immunoglobulin light chain polypeptide comprising SEQ ID NO: 23, except that one or more specific of residues of SEQ ID NO: 1 and SEQ ID NO: 23 are replaced with a different residue. The disclosure also provides vectors, compositions, and methods of using the IL-17-binding agent to treat an IL-17-mediated disease.

摘要翻译： 本公开涉及分离的IL-17结合剂，其包含包含SEQ ID NO：1的免疫球蛋白重链多肽和任选的包含SEQ ID NO：23的免疫球蛋白轻链多肽，除了SEQ ID NO：23的一个或多个特异性残基 NO：1和SEQ ID NO：23被不同的残基取代。 本公开还提供了使用IL-17结合剂治疗IL-17介导的疾病的载体，组合物和方法。

公开(公告)号：US08475797B2

公开(公告)日：2013-07-02

申请号：US13211092

申请日：2011-08-16

申请人： Alison Witte ,  Denise Williams ,  Josphine M Cardelli ,  David King ,  David Passmore

发明人： Alison Witte ,  Denise Williams ,  Josphine M Cardelli ,  David King ,  David Passmore

IPC分类号： A61K39/395

CPC分类号： C07K16/249 ,  A61K51/1021 ,  A61K2039/505 ,  C07K16/24 ,  C07K2317/21 ,  C07K2317/55 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/74 ,  C07K2317/76

摘要： The present invention provides isolated anti-interferon alpha monoclonal antibodies, particularly human monoclonal antibodies, that inhibit the biological activity of multiple interferon (IFN) alpha subtypes but do not substantially inhibit the biological activity of IFN alpha 21 or the biological activity of either IFN beta or IFN omega. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of the invention are also provided. The invention also provides methods for inhibiting the biological activity of IFN alpha using the antibodies of the invention, as well as methods of treating disease or disorders mediated by IFN alpha, such as autoimmune diseases, transplant rejection and graft versus host disease, by administering the antibodies of the invention.

摘要翻译： 本发明提供分离的抗干扰素α单克隆抗体，特别是人单克隆抗体，其抑制多种干扰素（IFN）α亚型的生物学活性，但基本上不抑制IFNα21的生物活性或IFNβ的生物学活性 或IFNγ。 还提供了免疫偶联物，双特异性分子和包含本发明抗体的药物组合物。 本发明还提供了使用本发明的抗体抑制IFNα的生物学活性的方法，以及通过施用本发明的抗体来治疗由IFNα介导的疾病或病症的方法，例如自身免疫疾病，移植排斥反应和移植物抗宿主病 本发明的抗体。

公开(公告)号：US08290147B2

公开(公告)日：2012-10-16

申请号：US12609888

申请日：2009-10-30

申请人： Gerardo Orlando ,  David King ,  Mark Krumpoch

发明人： Gerardo Orlando ,  David King ,  Mark Krumpoch

IPC分类号： H04L9/28

CPC分类号： H04L9/0637 ,  H03M13/09 ,  H04L9/3236 ,  H04L2209/12

摘要： Systems and methods efficiently process digests, hashes or other results by performing multiplicative functions in parallel with each other. In various embodiments, successive processing stages are provided, with each stage performing parallel multiplicative functions and also combining input terms to reduce the total number of terms that remain to be processed. By progressively combining the active terms into a smaller number of terms for subsequent processing, the time needed to process a result can be significantly reduced.

摘要翻译： 系统和方法通过彼此并行执行乘法函数来有效地处理摘要，散列或其他结果。 在各种实施例中，提供了连续的处理阶段，每个阶段执行并行乘法函数，并且还组合输入项以减少待处理的项的总数。 通过将活动术语逐渐组合成较少数量的术语以用于后续处理，可以显着减少处理结果所需的时间。

公开(公告)号：USD655752S1

公开(公告)日：2012-03-13

申请号：US29384871

申请日：2011-02-04

申请人： David King ,  David Harbinson

设计人： David King ,  David Harbinson

公开(公告)号：USD625471S1

公开(公告)日：2010-10-12

申请号：US29316174

申请日：2009-08-31

申请人： David King

设计人： David King

公开(公告)号：US20080034895A1

公开(公告)日：2008-02-14

申请号：US11503766

申请日：2006-08-14

申请人： Shaun David McCarthy ,  Michael Andrew Daly ,  Alan Simpson ,  Ciaran Mythen ,  Martin Flood ,  Guillaume Reux ,  David King

发明人： Shaun David McCarthy ,  Michael Andrew Daly ,  Alan Simpson ,  Ciaran Mythen ,  Martin Flood ,  Guillaume Reux ,  David King

IPC分类号： G01L3/02

CPC分类号： G01L3/10 ,  G01M13/025

摘要： A test system for measuring a rotary load comprises a stepper motor drives a gear box that is mounted at one end of a frame. A torque sensor provides a measurement signal transmission. The gear box's output shaft is connected to one of the torque sensor's stubs by means of a universal joint coupling. On the other side of the torque sensor a second universal joint coupling connects the sensor to a stainless steel shaft. A low friction flange bearing is used to provide support for the shaft. An angle encoder is disposed on the end of the shaft distal to the gear box. The gear box's output shaft, the torque sensor's cylindrical shaft hubs and associated couplings are arranged such that they are directly aligned with the shaft. The test system has been designed to take automated torque and angle readings from a shaft capable of rotary motion. The measurement arm configuration with the stepper motor directly connects the torque and angle sensors to a PC based data acquisition card for acquisition and processing of data. The system operates according to a method used to make a true torque measurement of a rotary actuated shaft or wheel in a process where a first data set is acquired with the system unloaded as the shaft or wheel is actuated through the defined travel path. The actuation force applied by the stepper motor is accurately controlled through a computer interface. Torque data is measured at each angular step as the wheel is actuated in a first direction. Torque data is then measured at each angular step as the wheel is actuated in the opposite direction. A load is then placed on the test system. With the load on the system, torque data is acquired/measured at each angular step through the defined travel path. Torque data is then measured at each angular step as the wheel is actuated in the opposite direction through the defined travel path. Ultimately, the true torque, i.e. torque less the effects of friction and the system baseline mechanical profile, is determined by adjusting measurement data to virtually eliminate these two effects.

公开(公告)号：US20070091136A1

公开(公告)日：2007-04-26

申请号：US11254456

申请日：2005-10-20

申请人： Lucas Barkley ,  David King ,  Randall Mayo ,  George Parish

发明人： Lucas Barkley ,  David King ,  Randall Mayo ,  George Parish

IPC分类号： B41J29/393

CPC分类号： B41J19/145 ,  B41J2/2132 ,  G06K15/107

摘要： Printheads configured to operate in accordance with a plurality of print modes. For example, one of the plurality of print modes can be selected in accordance with a bit of address data received by the printhead. In an exemplary embodiment, the selection of print mode can be accomplished by switching one or more actuator (e.g., heater) circuit addresses on the printhead.

摘要翻译： 打印头被配置为根据多种打印模式进行操作。 例如，可以根据由打印头接收到的地址数据的位来选择多个打印模式之一。 在示例性实施例中，可以通过切换打印头上的一个或多个致动器（例如，加热器）电路地址来实现打印模式的选择。

公开(公告)号：US20070070126A1

公开(公告)日：2007-03-29

申请号：US11238559

申请日：2005-09-29

申请人： David King

发明人： David King

IPC分类号： B41J2/05

CPC分类号： B41J2/14072

摘要： A heater chip for use in a printing device that includes a first heater array with a left side and a right side and a first ink via placed on the left side of the first heater array. The chip also includes a second heater array with a left side and a right side, where a right side of the first heater array faces the left side of the second heater array, a second ink via placed on the right side of the second heater array, and at least one logic array is disposed between the first heater array and the second heater array.

摘要翻译： 一种用于打印装置的加热器芯片，包括具有左侧和右侧的第一加热器阵列和位于第一加热器阵列左侧的第一墨水通道。 芯片还包括具有左侧和右侧的第二加热器阵列，其中第一加热器阵列的右侧面向第二加热器阵列的左侧，第二墨通孔设置在第二加热器阵列的右侧 并且至少一个逻辑阵列设置在第一加热器阵列和第二加热器阵列之间。