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公开(公告)号：US20160338952A1
公开(公告)日：2016-11-24
申请号：US15228589
申请日：2016-08-04
CPC分类号： A61K9/107 , A61K9/0048 , B01F17/0028 , B01F17/0064 , B01F17/0085
摘要： The present invention is directed to an ophthalmic emulsion. The emulsion has a unique combination of ingredients that promotes the stability of small oil droplets within the emulsion. The emulsion also includes a mucoadhesive polymer that aid in delivering a lipid to the ocular surface.
摘要翻译： 本发明涉及眼用乳液。 该乳液具有促进乳液中小油滴的稳定性的成分的独特组合。 乳剂还包括有助于将脂质递送到眼表面的粘膜粘附聚合物。
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公开(公告)号：US5564596A
公开(公告)日：1996-10-15
申请号：US405143
申请日：1995-03-16
CPC分类号： B65D83/0055 , B65D47/18 , B65D81/3244
摘要： A multiple fluid dispensing device is provided which includes a plurality of liquid formulations with at least one formulation having a surface tension of less than a specific value. A tip is provided for dispensing of the liquid formulations in a dropwise fashion and an inner bottle, in communication with the tip, contains the liquid formulations in separate compartments, and forces the liquid formulations through the tip when compressed. The inner bottle is configured with a volume for preventing the liquid formulations from flowing out of the bottle through the tip without compression of the inner bottle. An outer bottle is provided and disposed around the inner bottle for compressing the inner bottle. The inner and outer bottles are sized for providing hydraulic advantage in compressing the inner bottle with the hydraulic advantage being manifested by the outer bottle having a greater inner surface area than an outer surface of the inner bottle.
摘要翻译： 提供了一种多流体分配装置，其包括具有至少一种具有小于特定值的表面张力的制剂的多种液体制剂。 提供了用于以液滴方式分配液体制剂的尖端，并且与尖端连通的内瓶在分离的隔室中含有液体制剂，并且当压缩时迫使液体制剂通过尖端。 内瓶配置有用于防止液体制剂通过尖端从瓶中流出而不压缩内瓶的体积。 外瓶设置并设置在内瓶周围以压缩内瓶。 内瓶和外瓶的尺寸适于在压缩内瓶时提供液压优势，其液压优点由具有比内瓶的外表面更大的内表面积的外瓶表现。
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公开(公告)号：US20110275593A1
公开(公告)日：2011-11-10
申请号：US13100439
申请日：2011-05-04
IPC分类号： A61K31/736 , A61P27/04
CPC分类号： A61K31/736 , A61K9/0048 , A61K9/08 , A61K45/06
摘要： The present invention relates to viscosity stabilized ophthalmic formulations and ophthalmic formulations suitable for drug delivery. The formulations comprise galactomannans such as guar or hydroxypropyl guar and a borate source such as boric acid. The formulations further comprise a diol alcohol such as sorbitol and, optionally, a pharmaceutically acceptable divalent cation salt such as magnesium chloride.
摘要翻译： 本发明涉及适用于药物递送的粘度稳定的眼用制剂和眼用制剂。 制剂包含半乳甘露聚糖，例如瓜尔胶或羟丙基瓜尔胶，硼酸盐如硼酸。 制剂还包含二醇醇，例如山梨醇和任选的药学上可接受的二价阳离子盐如氯化镁。
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4.发明授权Use of bis-amines to enhance the antimicrobial activity of aqueous compositions 有权使用双胺来增强含水组合物的抗微生物活性公开(公告)号：US07871602B2
公开(公告)日：2011-01-18
申请号：US12244907
申请日：2008-10-03
IPC分类号： A61K31/74
CPC分类号： C07C215/14 , C07C215/18
摘要： The use of bis-amines to enhance the antimicrobial activity of pharmaceutical compositions is described. The bis-amines are particularly useful for enhancing the antimicrobial activity of aqueous ophthalmic compositions, such as artificial tears or ocular lubricants, and solutions for disinfecting contact lenses.
摘要翻译： 描述了使用双胺来增强药物组合物的抗微生物活性。 双胺特别可用于增强水性眼用组合物如人造眼泪或眼部润滑剂的抗微生物活性，以及消毒隐形眼镜的溶液。
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5.发明授权Method for delivering nonaqueous fluorinated drug delivery vehicle suspensions 失效用于递送非水性氟化药物递送载体悬浮液的方法
公开(公告)号：US5620699A
公开(公告)日：1997-04-15
申请号：US556277
申请日：1995-11-13
申请人： David L. Meadows
发明人： David L. Meadows
CPC分类号： A61K9/0026 , A61K31/02 , A61K31/025 , A61K9/0048 , A61K9/10 , A61K9/1635 , Y10S514/912 , Y10S514/963
摘要： Nonaqueous pharmaceutical compositions for use in aqueous physiological systems are disclosed comprising drug delivery vehicles suspended in nonaqueous perfluorocarbon or fluorinated silicone liquid carriers. The suspended drug delivery vehicles may be water labile or water stable and incorporate therapeutic or diagnostic compounds which remain stable and pharmaceutically effective for extended periods. The pharmaceutical compositions have improved bioavailability, are capable of low dose volume delivery, and do not leach the incorporated therapeutic or diagnostic compounds into the liquid carriers making them well suited for multi-dose packaging and administration.
摘要翻译： 公开了用于水性生理系统的非水性药物组合物，其包含悬浮在非水性全氟化碳或氟化硅氧烷液体载体中的药物递送载体。 悬浮药物递送载体可以是水不稳定的或水稳定的，并且包含长时间保持稳定和药学有效的治疗或诊断化合物。 药物组合物具有改善的生物利用度，能够低剂量体积递送，并且不将所掺入的治疗或诊断化合物浸入液体载体中，使得它们非常适合于多剂量包装和给药。
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公开(公告)号：US5431225A
公开(公告)日：1995-07-11
申请号：US310174
申请日：1994-09-21
IPC分类号： E21B43/02 , E21B43/26 , E21B43/267
CPC分类号： E21B43/26 , E21B43/025 , E21B43/267
摘要： Methods of completing poorly consolidated subterranean formations bounded by one or more consolidated formations to prevent sand production from the poorly consolidated formations are provided. The methods basically comprise the steps of drilling a well bore into the consolidated boundary formation adjacent to the poorly consolidated formation, creating a propped fracture communicating with the well bore in the consolidated boundary formation which extends into the poorly consolidated formation and producing fluids from the poorly consolidated formation into the well bore by way of the propped fracture.
摘要翻译： 提供了完成由一个或多个固结地层限定的不良固结的地层的方法，以防止由较差的组合地层产生砂。 这些方法基本上包括以下步骤：将井眼钻进邻近不良结合地层的固结边界地层中，产生与固结的边界地层中的井眼相通的支撑裂缝，该裂缝延伸到较不固结的地层中并从较差的地层中产生流体 通过支撑骨折将井眼固结成井眼。
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公开(公告)号：US08536325B2
公开(公告)日：2013-09-17
申请号：US13396305
申请日：2012-02-14
IPC分类号： A61K31/736
CPC分类号： A61K36/48 , A61K9/0048 , A61K47/36 , C08B37/0003 , C08B37/0096
摘要： The present invention relates to processes for purifying guar comprising combining borate and guar in an aqueous solution and treating the aqueous solution with an organic solvent to induce precipitation of purified guar. Another embodiment of the present invention is directed to ophthalmic formulations comprising purified guar produced by the processes described.
摘要翻译： 本发明涉及净化瓜尔胶的方法，包括在水溶液中混合硼酸盐和瓜尔胶，并用有机溶剂处理水溶液以诱导纯化的瓜尔胶的沉淀。 本发明的另一个实施方案涉及包含通过所述方法制备的纯化瓜尔胶的眼用制剂。
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8.发明授权Use of synthetic inorganic nanoparticles as carriers for ophthalmic and otic drugs 有权使用合成无机纳米粒子作为眼科和耳用药物的载体公开(公告)号：US08257745B2
公开(公告)日：2012-09-04
申请号：US13186108
申请日：2011-07-19
IPC分类号： A61K9/14 , A61K38/18 , A61P27/06 , A61P25/00 , A61P31/00 , A61P29/00 , A61P37/08 , A61P37/02 , B82Y5/00
CPC分类号： A61K31/575 , A61K9/0012 , A61K9/0048 , A61K47/02
摘要： The use of nanoparticles of inorganic materials (e.g., synthetic smectite clays) in ophthalmic and otic pharmaceutical compositions is described. The nanoparticles are utilized as biologically inert carriers or depots for ophthalmic and otic drugs. The nanoparticles may also be utilized to modify the rheological properties of the compositions, so as to enhance the viscosity or flow characteristics of the compositions and/or increase the retention time of the compositions in the eye or ear.
摘要翻译： 描述了在眼科和耳用药物组合物中使用无机材料的纳米颗粒（例如合成蒙脱石粘土）。 纳米颗粒被用作眼科和耳用药物的生物惰性载体或贮库。 纳米颗粒也可用于改变组合物的流变性质，以便增强组合物的粘度或流动特性和/或增加组合物在眼睛或耳朵中的保留时间。
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公开(公告)号：US20120142630A1
公开(公告)日：2012-06-07
申请号：US13396305
申请日：2012-02-14
IPC分类号： A61K31/736 , A61P27/02 , C08B37/00
CPC分类号： A61K36/48 , A61K9/0048 , A61K47/36 , C08B37/0003 , C08B37/0096
摘要： The present invention relates to processes for purifying guar comprising combining borate and guar in an aqueous solution and treating the aqueous solution with an organic solvent to induce precipitation of purified guar. Another embodiment of the present invention is directed to ophthalmic formulations comprising purified guar produced by the processes described.
摘要翻译： 本发明涉及净化瓜尔胶的方法，包括在水溶液中混合硼酸盐和瓜尔胶，并用有机溶剂处理水溶液以诱导纯化的瓜尔胶的沉淀。 本发明的另一个实施方案涉及包含通过所述方法制备的纯化瓜尔胶的眼用制剂。
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公开(公告)号：US20110094295A1
公开(公告)日：2011-04-28
申请号：US12607560
申请日：2009-10-28
IPC分类号： G01N15/08
CPC分类号： G01N3/08 , G01N3/12 , G01N33/383 , G01N2203/0019 , G01N2203/0048
摘要： Devices and methods for testing cement include: a pressure vessel with a sample container inside an interior working volume of the pressure vessel, the pressure vessel configured to supply a first pressurized fluid to control a pore pressure of a cement sample and to supply a second pressurized fluid to lateral exterior surfaces of the sample container to provide a confining pressure that can be different than the pore pressure.
摘要翻译： 用于测试水泥的装置和方法包括：在压力容器的内部工作体积内具有样品容器的压力容器，压力容器构造成供应第一加压流体以控制水泥样品的孔隙压力并提供第二加压 流体到样品容器的侧向外表面以提供可以不同于孔隙压力的约束压力。
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