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    Supported polyionic hydrogels
    2.
    发明授权
    Supported polyionic hydrogels 失效
    负载型聚离子水凝胶

    公开(公告)号：US5858392A

    公开(公告)日：1999-01-12

    申请号：US806218

    申请日：1997-02-26

    申请人： Severian Dumitriu ,  Hilda Guttmann ,  Itzhak Kahane

    发明人： Severian Dumitriu ,  Hilda Guttmann ,  Itzhak Kahane

    IPC分类号： A61L15/60 ,  A61K9/70 ,  C12N5/00 ,  C12N11/10 ,  C12N11/12

    CPC分类号： A61L15/60 ,  C12N2533/70 ,  C12N2533/72 ,  Y10S530/813 ,  Y10S530/814

    摘要： A supported polyionic hydrogel is prepared by impregnating a support matel with a solution of anionic polysaccharide and a solution of cationic polysaccharide where the anionic polysaccharide and cationic polysaccharide react with each other to form a polyionic hydrogel impregnated in the support material. The hydrogel may be dried such as by lyophilization. Preferably, the anionic polysaccharide is xanthan, dicarboxystarch or dicarboxycellulose and the cationic polysaccharide is chitosan. Especially preferred is a polyionic hydrogel formed from xanthan and chitosan. A paper material or a textile material can be used as the support material. A dry supported polyionic hydrogel can be formed as a bandage without active material incorporated therein. The supported polyionic hydrogel may be formed containing a biologically active material by having the active material in either polysaccharide solution or in another solution impregnated into the support material. The biologically active materials can be enzymes, antibody-producing cells or water-soluble drugs such as the antimicrobial agent, chlorohexidine.

    摘要翻译： 通过用阴离子多糖溶液和阳离子多糖溶液浸渍载体材料制备负载的聚离子水凝胶，其中阴离子多糖和阳离子多糖彼此反应以形成浸渍在载体材料中的聚离子水凝胶。 水凝胶可以干燥，例如通过冻干。 优选地，阴离子多糖是黄原胶，二羧甲基纤维素或二羧基纤维素，阳离子多糖是壳聚糖。 特别优选的是由黄原胶和壳聚糖形成的聚离子水凝胶。 可以使用纸材料或纺织材料作为支撑材料。 干燥的负载型聚离子水凝胶可以形成为绷带而不含有活性材料。 支撑的聚离子水凝胶可以通过使活性物质在多糖溶液中或在浸渍到载体材料中的另一种溶液中形成而含有生物活性物质。 生物活性物质可以是酶，抗体产生细胞或水溶性药物如抗微生物剂，氯己定。

    Supported polyionic hydrogels containing biologically active material
    3.
    发明授权
    Supported polyionic hydrogels containing biologically active material 失效
    含有生物活性物质的负载聚离子水凝胶

    公开(公告)号：US5648252A

    公开(公告)日：1997-07-15

    申请号：US409264

    申请日：1995-03-22

    申请人： Severian Dumitriu ,  Itzhak Kahane ,  Hilda Guttmann

    发明人： Severian Dumitriu ,  Itzhak Kahane ,  Hilda Guttmann

    IPC分类号： A61L15/60 ,  C12N5/00 ,  C12N11/02 ,  C12N11/04 ,  C12N11/12 ,  C12N11/10 ,  G01N33/544

    CPC分类号： C12N11/04 ,  A61L15/60 ,  C12N11/02 ,  C12N5/0068 ,  C12N2533/70 ,  C12N2533/72 ,  Y10S530/813 ,  Y10S530/814

    摘要： A supported polyionic hydrogel containing biologically active material is epared by impregnating into a porous support material a solution of anionic polysaccharide, a solution of cationic polysaccharide and a biologically active material. The anionic polysaccharide and the cationic polysaccharide react with each other to form a hydrogel containing the biologically active material. The hydrogel may be dried such as by lyophilization. The biologically active material can be in either polysaccharide solution or in another solution impregnated into the porous support material. A paper material or a textile material may be used as the porous support material. Preferably, the anionic polysaccharide is xanthan, dicarboxystarch or dicarboxycellulose and the cationic polysaccharide is chitosan. Especially preferred is a hydrogel formed from xanthan and chitosan. Biologically active materials in the hydrogel can be enzymes, antibody-producing cells or water-soluble drugs such as the antimicrobial agent, chlorohexidine.

    摘要翻译： 通过将阴离子多糖，阳离子多糖溶液和生物活性物质的溶液浸渍到多孔载体材料中制备含有生物活性材料的负载型聚离子水凝胶。 阴离子多糖和阳离子多糖彼此反应形成含有生物活性物质的水凝胶。 水凝胶可以干燥，例如通过冻干。 生物活性物质可以是多糖溶液或浸渍在多孔载体材料中的另一种溶液中。 可以使用纸材料或纺织材料作为多孔载体材料。 优选地，阴离子多糖是黄原胶，二羧甲基纤维素或二羧基纤维素，阳离子多糖是壳聚糖。 特别优选由黄原胶和壳聚糖形成的水凝胶。 水凝胶中的生物活性物质可以是酶，抗体产生细胞或水溶性药物如抗微生物剂，氯己定。