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公开(公告)号:US4902684A
公开(公告)日:1990-02-20
申请号:US353806
申请日:1989-05-22
申请人: David M. Floyd , John T. Hunt , Spencer D. Kimball , John Krapcho , Jagabandhu Das , George C. Rovnyak , Joel C. Barrish
发明人: David M. Floyd , John T. Hunt , Spencer D. Kimball , John Krapcho , Jagabandhu Das , George C. Rovnyak , Joel C. Barrish
IPC分类号: A61K31/55 , A61K31/554 , A61P9/08 , C07D223/16 , C07D281/10 , C07D401/04 , C07D401/06 , C07D401/14 , C07D403/04 , C07D403/06 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/06
CPC分类号: C07D223/16 , C07D281/10 , C07D401/06 , C07D403/06 , C07D417/06
摘要: Vasodilating activity is exhibited by compounds having the formula ##STR1## wherein X can be --S--or --CH.sub.2 --; andR.sub.2 is ##STR2##depending upon the definition of X.
摘要翻译: 具有下式的化合物显示出血管舒张活性:其中X可以是-S-或-CH2-; 根据X的定义,R2是
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公开(公告)号:US06953795B2
公开(公告)日:2005-10-11
申请号:US10642040
申请日:2003-08-15
申请人: Joel C. Barrish , Jagabandhu Das , Steven B. Kanner , Chunjian Liu , Steven H. Spergel , John Wityak , Arthur M. P. Doweyko , Joseph A. Furch III
发明人: Joel C. Barrish , Jagabandhu Das , Steven B. Kanner , Chunjian Liu , Steven H. Spergel , John Wityak , Arthur M. P. Doweyko , Joseph A. Furch III
IPC分类号: C07D277/20 , A61K31/438 , A61K31/444 , A61K31/4545 , A61K31/496 , A61K31/506 , A61K31/5377 , A61K31/55 , A61K45/00 , A61P1/04 , A61P9/10 , A61P11/00 , A61P11/02 , A61P11/06 , A61P17/00 , A61P17/06 , A61P19/02 , A61P25/00 , A61P29/00 , A61P35/00 , A61P37/02 , A61P37/06 , A61P37/08 , A61P43/00 , C07D277/32 , C07D277/46 , C07D277/54 , C07D417/12 , C07D417/14 , C07D491/10 , C07D491/107 , C07D419/10 , C07D419/12
CPC分类号: C07D417/12 , C07D277/46 , C07D277/54 , C07D417/14 , C07D491/10
摘要: Novel thiazolyl compounds and salts thereof, pharmaceutical compositions containing such compounds, and methods of using such compounds in the treatment of Tec family tyrosine kinase-associated disorders such as cancer, immunologic disorders and allergic disorders.
摘要翻译: 新的噻唑基化合物及其盐,含有这些化合物的药物组合物,以及使用这些化合物治疗Tec家族酪氨酸激酶相关疾病如癌症,免疫学障碍和过敏性疾病的方法。
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公开(公告)号:US06706717B2
公开(公告)日:2004-03-16
申请号:US10027982
申请日:2001-12-20
申请人: Joel C. Barrish , Jagabandhu Das , Steven B. Kanner , Chunjian Liu , Steven H. Spergel , John Wityak , Arthur M. P. Doweyko , Joseph A. Furch, III
发明人: Joel C. Barrish , Jagabandhu Das , Steven B. Kanner , Chunjian Liu , Steven H. Spergel , John Wityak , Arthur M. P. Doweyko , Joseph A. Furch, III
IPC分类号: A61K31496
CPC分类号: C07D417/12 , C07D277/46 , C07D277/54 , C07D417/14 , C07D491/10
摘要: Novel thiazolyl compounds and salts thereof, pharmaceutical compositions containing such compounds, and methods of using such compounds in the treatment of Tec family tyrosine kinase-associated disorders such as cancer, immunologic disorders and allergic disorders.
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公开(公告)号:US08716323B2
公开(公告)日:2014-05-06
申请号:US11271626
申请日:2005-11-10
申请人: Jagabandhu Das , Ramesh Padmanabha , Ping Chen , Derek J. Norris , Arthur M. P. Doweyko , Joel C. Barrish , John Wityak
发明人: Jagabandhu Das , Ramesh Padmanabha , Ping Chen , Derek J. Norris , Arthur M. P. Doweyko , Joel C. Barrish , John Wityak
IPC分类号: A61K31/426 , C07D277/18
CPC分类号: C07D277/56 , C07C233/65 , C07C237/40 , C07D213/81 , C07D213/82 , C07D231/38 , C07D233/90 , C07D239/42 , C07D263/48 , C07D409/12 , C07D417/06 , C07D417/12 , C07D417/14 , C07D471/04 , C07D491/113
摘要: Novel cyclic compounds and salts thereof, pharmaceutical compositions containing such compounds, and methods of using such compounds in the treatment of protein tyrosine kinase-associated disorders such as immunologic and oncologic disorders.
摘要翻译: 新的环状化合物及其盐,含有这些化合物的药物组合物,以及使用这些化合物治疗蛋白质酪氨酸激酶相关疾病如免疫学和肿瘤学疾病的方法。
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公开(公告)号:US06956045B2
公开(公告)日:2005-10-18
申请号:US10641876
申请日:2003-08-15
申请人: Joel C. Barrish , Jagabandhu Das , Steven B. Kanner , Chunjian Liu , Steven H. Spergel , John Wityak , Arthur M. P. Doweyko , Joseph A. Furch, III
发明人: Joel C. Barrish , Jagabandhu Das , Steven B. Kanner , Chunjian Liu , Steven H. Spergel , John Wityak , Arthur M. P. Doweyko , Joseph A. Furch, III
IPC分类号: C07D277/20 , A61K31/438 , A61K31/444 , A61K31/4545 , A61K31/496 , A61K31/506 , A61K31/5377 , A61K31/55 , A61K45/00 , A61P1/04 , A61P9/10 , A61P11/00 , A61P11/02 , A61P11/06 , A61P17/00 , A61P17/06 , A61P19/02 , A61P25/00 , A61P29/00 , A61P35/00 , A61P37/02 , A61P37/06 , A61P37/08 , A61P43/00 , C07D277/32 , C07D277/46 , C07D277/54 , C07D417/12 , C07D417/14 , C07D491/10 , C07D491/107 , A61K31/454 , C07D417/10
CPC分类号: C07D417/12 , C07D277/46 , C07D277/54 , C07D417/14 , C07D491/10
摘要: Novel thiazolyl compounds and salts thereof, pharmaceutical compositions containing such compounds, and methods of using such compounds in the treatment of Tec family tyrosine kinase-associated disorders such as cancer, immunologic disorders and allergic disorders.
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公开(公告)号:US07241781B2
公开(公告)日:2007-07-10
申请号:US11236375
申请日:2005-09-27
申请人: Joel C. Barrish , Jagabandhu Das , Steven B. Kanner , Chunjian Liu , Steven H. Spergel , John Wityak , Arthur M. P. Doweyko , Joseph A. Furch, III
发明人: Joel C. Barrish , Jagabandhu Das , Steven B. Kanner , Chunjian Liu , Steven H. Spergel , John Wityak , Arthur M. P. Doweyko , Joseph A. Furch, III
IPC分类号: C07D417/12 , A61K31/4439
CPC分类号: C07D417/12 , C07D277/46 , C07D277/54 , C07D417/14 , C07D491/10
摘要: Novel thiazolyl compounds and salts thereof, pharmaceutical compositions containing such compounds, and methods of using such compounds in the treatment of Tec family tyrosine kinase-associated disorders such as cancer, immunologic disorders and allergic disorders.
摘要翻译: 新的噻唑基化合物及其盐,含有这些化合物的药物组合物,以及使用这些化合物治疗Tec家族酪氨酸激酶相关疾病如癌症,免疫学障碍和过敏性疾病的方法。
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公开(公告)号:US07153856B2
公开(公告)日:2006-12-26
申请号:US11138942
申请日:2005-05-26
申请人: Joel C. Barrish , John Wityak , Jagabandhu Das , Ping Chen , Derek J. Norris , Gary Schieven
发明人: Joel C. Barrish , John Wityak , Jagabandhu Das , Ping Chen , Derek J. Norris , Gary Schieven
IPC分类号: A61K31/497 , C07D241/02
CPC分类号: C07D277/56 , C07C233/65 , C07C237/40 , C07D213/81 , C07D213/82 , C07D231/38 , C07D233/90 , C07D239/42 , C07D263/48 , C07D409/12 , C07D417/06 , C07D417/12 , C07D417/14 , C07D471/04 , C07D491/113
摘要: Novel cyclic compounds and salts thereof, pharmaceutical compositions containing such compounds, and methods of using such compounds in the treatment of protein tyrosine kinase-associated disorders such as immunologic and oncologic disorders.
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公开(公告)号:US07125875B2
公开(公告)日:2006-10-24
申请号:US10395503
申请日:2003-03-24
申请人: Jagabandhu Das , Ramesh Padmanabha , Ping Chen , Derek J. Norris , Arthur M. P. Doweyko , Joel C. Barrish , John Wityak , Louis J. Lombardo , Francis Y. F. Lee
发明人: Jagabandhu Das , Ramesh Padmanabha , Ping Chen , Derek J. Norris , Arthur M. P. Doweyko , Joel C. Barrish , John Wityak , Louis J. Lombardo , Francis Y. F. Lee
IPC分类号: A61K31/427 , A61K31/496 , A61K31/501
CPC分类号: A61K31/427 , A61K31/506 , C07C237/40 , C07D213/81 , C07D213/82 , C07D231/38 , C07D233/90 , C07D239/42 , C07D263/48 , C07D277/56 , C07D409/12 , C07D417/12 , C07D417/14
摘要: Novel cyclic compounds and salts thereof, pharmaceutical compositions containing such compounds, and methods of using such compounds in the treatment of protein tyrosine kinase-associated disorders such as immunologic and oncologic disorders.
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公开(公告)号:US07091223B2
公开(公告)日:2006-08-15
申请号:US10378461
申请日:2003-03-03
申请人: Jagabandhu Das , Ramesh Padmanabha , Ping Chen , Derek J. Norris , Arthur M. P. Doweyko , Joel C. Barrish , John Wityak
发明人: Jagabandhu Das , Ramesh Padmanabha , Ping Chen , Derek J. Norris , Arthur M. P. Doweyko , Joel C. Barrish , John Wityak
IPC分类号: A61K31/4439 , C07D417/12
CPC分类号: C07D277/56 , C07C233/65 , C07C237/40 , C07D213/81 , C07D213/82 , C07D231/38 , C07D233/90 , C07D239/42 , C07D263/48 , C07D409/12 , C07D417/06 , C07D417/12 , C07D417/14 , C07D471/04 , C07D491/113
摘要: Novel cyclic compounds and salts thereof, pharmaceutical compositions containing such compounds, and methods of using such compounds in the treatment of protein tyrosine kinase-associated disorders such as immunologic and oncologic disorders.
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公开(公告)号:US07037926B2
公开(公告)日:2006-05-02
申请号:US10641535
申请日:2003-08-15
申请人: Joel C. Barrish , Jagabandhu Das , Steven B. Kanner , Chunjian Liu , Steven H. Spergel , John Wityak , Arthur M. P. Doweyko , Joseph A. Furch, III
发明人: Joel C. Barrish , Jagabandhu Das , Steven B. Kanner , Chunjian Liu , Steven H. Spergel , John Wityak , Arthur M. P. Doweyko , Joseph A. Furch, III
IPC分类号: A61K31/4439 , C07D417/14
CPC分类号: C07D417/12 , C07D277/46 , C07D277/54 , C07D417/14 , C07D491/10
摘要: Novel thiazolyl compounds and salts thereof, pharmaceutical compositions containing such compounds, and methods of using such compounds in the treatment of Tec family tyrosine kinase-associated disorders such as cancer, immunologic disorders and allergic disorders.
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